KEGG   PATHWAY: lcat04010
Entry
lcat04010                   Pathway                                
Name
MAPK signaling pathway - Lemur catta (Ring-tailed lemur)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
lcat04010  MAPK signaling pathway
lcat04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Lemur catta (Ring-tailed lemur) [GN:lcat]
Gene
123620133  CACNA1G; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1G [KO:K04854]
123620213  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
123620248  TAOK1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
123620293  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
123620303  NF1; neurofibromin isoform X1 [KO:K08052]
123620566  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
123620590  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
123620702  CRK; adapter molecule crk isoform X1 [KO:K04438]
123620742  NGFR; tumor necrosis factor receptor superfamily member 16 isoform X1 [KO:K02583]
123620820  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
123620839  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
123621006  DUSP3; dual specificity protein phosphatase 3 isoform X1 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
123621038  MAP3K14; mitogen-activated protein kinase kinase kinase 14 isoform X1 [KO:K04466] [EC:2.7.11.25]
123621118  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
123621221  MAPK7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
123621224  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
123621227  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
123621580  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
123621678  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
123621799  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123621915  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
123622454  FGF7; fibroblast growth factor 7 [KO:K04358]
123622470  ANGPT4; angiopoietin-4 [KO:K05467]
123622553  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
123622631  STK4; serine/threonine-protein kinase 4 isoform X1 [KO:K04411]
123622909  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
123623160  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
123623167  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
123623206  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123623228  MAPKAPK3; MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
123623233  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
123623468  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
123623815  RRAS; ras-related protein R-Ras [KO:K07829]
123623840  NTF4; neurotrophin-4 [KO:K12457]
123623856  FGF21; fibroblast growth factor 21 [KO:K22429]
123623923  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
123623971  RELB; transcription factor RelB isoform X1 [KO:K09253]
123624079  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
123624185  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
123624322  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123624324  MAP3K10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
123624372  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 isoform X1 [KO:K04408] [EC:2.7.11.1]
123624374  RASGRP4; RAS guanyl-releasing protein 4 [KO:K12363]
123624654  PRKCG; LOW QUALITY PROTEIN: protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
123624656  CACNG7; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
123624657  CACNG6; voltage-dependent calcium channel gamma-6 subunit isoform X1 [KO:K04871]
123624720  EREG; proepiregulin [KO:K09784]
123624721  AREG; amphiregulin [KO:K09782]
123624815  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
123624835  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
123624843  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
123624844  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
123625176  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
123625188  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
123625737  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
123626042  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
123626149  TAOK3; serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
123626228  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123626242  CRKL; crk-like protein isoform X1 [KO:K04438]
123626358  FGF20; fibroblast growth factor 20 [KO:K04358]
123626458  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123626515  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123626572  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
123626609  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
123626670  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123626704  FGF17; fibroblast growth factor 17 [KO:K04358]
123626765  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
123626819  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
123626839  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
123626949  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
123627022  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
123627110  ELK4; ETS domain-containing protein Elk-4 [KO:K04376]
123627136  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
123627174  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
123627206  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123627290  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123627295  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123627360  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
123627370  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
123627457  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
123627492  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
123627566  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
123627755  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
123627989  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
123628106  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
123628455  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
123628474  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
123628484  FLNA; filamin-A isoform X1 [KO:K04437]
123628501  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
123628633  ELK1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
123628637  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
123628833  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
123629407  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
123629770  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
123630043  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
123630054  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
123630120  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
123630132  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
123630238  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
123630347  MAP3K13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
123630388  [KO:K04723]
123630427  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
123631435  CACNA1H; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
123631456  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
123631510  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
123631548  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123631625  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
123631724  TNF; tumor necrosis factor [KO:K03156]
123631726  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
123631751  [KO:K03283]
123631752  [KO:K03283]
123631753  [KO:K03283]
123631832  DAXX; death domain-associated protein 6 [KO:K02308]
123631905  SRF; serum response factor [KO:K04378]
123631928  VEGFA; vascular endothelial growth factor A [KO:K05448]
123632208  FGF22; fibroblast growth factor 22 [KO:K04358]
123632490  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123632491  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
123632534  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123632591  HSPB1; heat shock protein beta-1 [KO:K04455]
123632765  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
123632778  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
123632816  EFNA2; ephrin-A2 [KO:K05462]
123632869  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
123632871  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
123632976  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
123633076  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
123633177  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta isoform X1 [KO:K04402]
123633303  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
123633357  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
123633438  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
123633454  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
123633879  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123634049  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
123634050  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
123634052  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
123634173  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
123634238  ARTN; artemin isoform X1 [KO:K25415]
123634336  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
123634356  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
123634382  STMN1; stathmin isoform X1 [KO:K04381]
123634668  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
123634790  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
123634791  [KO:K03176] [EC:2.7.10.1]
123634793  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
123635010  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
123635037  RAP1A; ras-related protein Rap-1A [KO:K04353]
123635081  NRAS; GTPase NRas [KO:K07828]
123635087  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
123635476  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123635482  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
123635536  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123635537  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
123635592  JUN; transcription factor AP-1 [KO:K04448]
123635850  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
123635868  CDC42; cell division control protein 42 homolog [KO:K04393]
123635942  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
123636107  PSPN; persephin [KO:K25416]
123636470  IL1A; interleukin-1 alpha [KO:K04383]
123636474  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123636477  NRTN; neurturin [KO:K25414]
123636786  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
123636823  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123636828  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
123636864  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
123636996  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
123637024  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
123637104  [KO:K04412]
123637148  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
123637166  IL1B; interleukin-1 beta [KO:K04519]
123637262  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
123637267  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
123637429  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
123637748  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
123637863  CD14; monocyte differentiation antigen CD14 [KO:K04391]
123637917  FGF1; fibroblast growth factor 1 [KO:K18496]
123637948  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
123637959  [KO:K04370]
123637964  FGF18; fibroblast growth factor 18 [KO:K04358]
123638073  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
123638075  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
123638125  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123638516  PDGFC; platelet-derived growth factor C [KO:K05450]
123638526  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
123638644  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
123638671  VEGFC; vascular endothelial growth factor C [KO:K05449]
123638794  [KO:K08018]
123638804  [KO:K08018]
123638827  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
123638832  JUND; transcription factor jun-D [KO:K04449]
123639237  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
123639294  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
123639374  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
123639464  DUSP6; dual specificity protein phosphatase 6 isoform X1 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
123639466  KITLG; kit ligand isoform X1 [KO:K05461]
123639519  PTPRR; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
123639540  RAP1B; ras-related protein Rap-1b [KO:K07836]
123639606  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
123639666  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
123639759  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
123639819  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
123639836  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
123639921  KRAS; GTPase KRas [KO:K07827]
123639995  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123640135  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
123640148  FGF23; fibroblast growth factor 23 [KO:K22428]
123640189  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
123640335  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
123640339  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123640344  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
123640441  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
123640483  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
123640621  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
123640712  NTF3; neurotrophin-3 [KO:K04356]
123640719  FGF6; fibroblast growth factor 6 [KO:K04358]
123640742  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
123640770  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
123640771  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
123641024  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
123641226  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
123641353  RELA; transcription factor p65 isoform X1 [KO:K04735]
123641357  MAP3K11; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
123641408  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
123641412  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
123641419  RPS6KA4; ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
123641432  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
123641667  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
123641878  PDGFD; platelet-derived growth factor D [KO:K05450]
123641892  FGF4; fibroblast growth factor 4 [KO:K04358]
123642170  FGF3; fibroblast growth factor 3 [KO:K04358]
123642172  FGF19; fibroblast growth factor 19 [KO:K22603]
123642301  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
123642472  RRAS2; ras-related protein R-Ras2 [KO:K07830]
123642542  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
123642600  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
123642639  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 [KO:K04434]
123642914  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
123642915  INS; insulin [KO:K04526]
123642937  HRAS; GTPase HRas isoform X1 [KO:K02833]
123642970  DUSP8; dual specificity protein phosphatase 8 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123643354  MAP3K2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
123643408  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
123643468  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
123643488  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
123643797  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123644058  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
123644561  STK3; serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
123644625  MYC; myc proto-oncogene protein [KO:K04377]
123644674  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
123644768  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
123645036  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
123645483  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
123645603  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
123645740  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
123645745  TGFBR1; TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
123645777  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
123645784  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
123645865  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
123646347  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
123646462  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
123646534  FOS; proto-oncogene c-Fos [KO:K04379]
123646604  PGF; placenta growth factor isoform X1 [KO:K16859]
123646854  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
123647164  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
123647169  [KO:K03283]
123647201  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
123647333  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
123647442  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123647642  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
123647856  MAX; protein max isoform X1 [KO:K04453]
123647994  MAP3K1; mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
123648052  EFNA5; ephrin-A5 [KO:K05462]
123648068  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
123648162  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 [KO:K12326]
123648417  FGF10; fibroblast growth factor 10 [KO:K04358]
123648436  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
123648443  RASA1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
123648451  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
123648561  [KO:K03283]
123648918  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
123648920  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
123649197  FGF9; fibroblast growth factor 9 [KO:K04358]
123649468  SOS2; son of sevenless homolog 2 [KO:K03099]
123649762  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
123649926  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123649928  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
123650084  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
123650103  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
123650134  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
123650296  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123650464  FGFR2; LOW QUALITY PROTEIN: fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
123650465  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123650554  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
123650624  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
123650651  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
123650652  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
123650723  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
123650792  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123650900  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
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Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
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Tanoue T, Nishida E.
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Docking interactions in the mitogen-activated protein kinase cascades.
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Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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MAPK pathways in radiation responses.
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Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
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Huang EJ, Reichardt LF.
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Trk receptors: roles in neuronal signal transduction.
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Annu Rev Biochem 72:609-42 (2003)
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Reference
PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
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Yang SH, Sharrocks AD, Whitmarsh AJ.
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Transcriptional regulation by the MAP kinase signaling cascades.
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Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
lcat04070  Phosphatidylinositol signaling system
lcat04110  Cell cycle
lcat04115  p53 signaling pathway
lcat04210  Apoptosis
lcat04310  Wnt signaling pathway
lcat04668  TNF signaling pathway
KO pathway
ko04010   

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