KEGG   PATHWAY: morg04820
Entry
morg04820                   Pathway                                
Name
Cytoskeleton in muscle cells - Microtus oregoni (creeping vole)
Class
Cellular Processes; Cell motility
Pathway map
morg04820  Cytoskeleton in muscle cells
morg04820

Organism
Microtus oregoni (creeping vole) [GN:morg]
Gene
121432295  [KO:K05692]
121432559  Nebl; nebulette isoform X1 [KO:K25865]
121432633  Itga8; integrin alpha-8 [KO:K06584]
121432692  Nid1; nidogen-1 [KO:K06826]
121432705  Actn2; alpha-actinin-2 [KO:K21073]
121432726  Vim; vimentin [KO:K07606]
121432993  [KO:K10653]
121433194  Neb; nebulin [KO:K18267]
121433195  Fmnl2; formin-like protein 2 isoform X1 [KO:K23957]
121433208  Itgb6; integrin beta-6 [KO:K06589]
121433232  [KO:K27381]
121433233  Itga6; integrin alpha-6 isoform X1 [KO:K06485]
121433346  Fn1; fibronectin isoform X1 [KO:K05717]
121433453  Myl1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
121433823  Col27a1; collagen alpha-1(XXVII) chain [KO:K19721]
121433888  Pdlim3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
121433984  Actg2; actin, gamma-enteric smooth muscle [KO:K12315]
121434153  [KO:K10381]
121434370  Syne3; nesprin-3 [KO:K21761]
121434404  Inf2; inverted formin-2 isoform X1 [KO:K23958]
121434799  [KO:K24495]
121434838  Myh6; myosin-6 isoform X1 [KO:K17751]
121434863  Myh7; myosin-7 [KO:K17751]
121435004  Sgcg; gamma-sarcoglycan [KO:K12564]
121435221  Col11a2; collagen alpha-2(XI) chain [KO:K19721]
121435403  Zyx; zyxin isoform X1 [KO:K06273]
121435515  Col6a2; collagen alpha-2(VI) chain [KO:K06238]
121435588  Col6a1; collagen alpha-1(VI) chain [KO:K06238]
121435853  Fbln2; fibulin-2 isoform X1 [KO:K17307]
121435914  Lbr; delta(14)-sterol reductase LBR [KO:K19532] [EC:1.3.1.70]
121435941  [KO:K01689] [EC:4.2.1.11]
121436074  Itgb4; integrin beta-4 [KO:K06525]
121436092  Fmnl1; formin-like protein 1 isoform X1 [KO:K23957]
121436246  Myl4; myosin light chain 4 [KO:K12750]
121436258  Itga2b; integrin alpha-IIb [KO:K06476]
121436323  Itgb3; integrin beta-3 [KO:K06493]
121436627  Diaph2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
121436876  Col4a5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
121436956  [KO:K06237]
121437087  [KO:K05741]
121437118  [KO:K06237]
121437119  [KO:K06237]
121437136  [KO:K08118]
121437220  [KO:K12569]
121437367  Fhl1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
121437491  [KO:K14365]
121437668  Mybpc3; myosin-binding protein C, cardiac-type [KO:K12568]
121437673  Sdc2; syndecan-2 [KO:K16336]
121437872  [KO:K10370]
121437972  Capza1; F-actin-capping protein subunit alpha-1 [KO:K10364]
121437983  Ampd1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
121437994  [KO:K01490] [EC:3.5.4.6]
121437996  Itga10; integrin alpha-10 [KO:K06586]
121438022  Atp1a1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
121438254  Eno2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
121438607  Itgb8; integrin beta-8 isoform X1 [KO:K06591]
121438647  Vcl; vinculin isoform X1 [KO:K05700]
121438661  Myoz1; myozenin-1 [KO:K26050]
121438670  Nid2; nidogen-2 isoform X1 [KO:K06826]
121438934  Sdc1; syndecan-1 [KO:K06257]
121438964  [KO:K10366]
121439150  [KO:K12567] [EC:2.7.11.1]
121439259  Itgav; integrin alpha-V isoform X1 [KO:K06487]
121439279  [KO:K06485]
121439315  Itga4; integrin alpha-4 [KO:K06483]
121439429  Atp1b4; protein ATP1B4 [KO:K01540]
121439707  [KO:K10653]
121440305  [KO:K12569]
121440317  [KO:K08118]
121440388  [KO:K08118]
121440398  [KO:K08118]
121440445  [KO:K08118]
121440586  [KO:K26050]
121440617  [KO:K07611]
121440619  [KO:K23342]
121440763  [KO:K12569]
121440803  Col9a3; collagen alpha-3(IX) chain [KO:K08131]
121441492  Sspn; sarcospan isoform X1 [KO:K22194]
121441499  Fmnl3; formin-like protein 3 isoform X1 [KO:K23957]
121441581  Lmod3; leiomodin-3 [KO:K22030]
121441612  Dmd; dystrophin isoform X1 [KO:K10366]
121441803  [KO:K01689] [EC:4.2.1.11]
121441845  [KO:K07597]
121441874  [KO:K07601]
121441888  [KO:K26998]
121442086  Fmn2; formin-2 [KO:K02184]
121442115  Atp1a2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
121442116  [KO:K01539] [EC:7.2.2.13]
121442191  [KO:K19720]
121442196  [KO:K19721]
121442248  [KO:K19875]
121442324  [KO:K19879]
121442411  [KO:K10056]
121442781  [KO:K05637]
121442827  Sgcz; zeta-sarcoglycan [KO:K27062]
121443087  Tmem43; transmembrane protein 43 [KO:K27488]
121443541  [KO:K06254]
121443618  [KO:K07611]
121443619  [KO:K23342]
121444092  [KO:K05692]
121444246  Itgb7; integrin beta-7 [KO:K06590]
121444606  [KO:K05692]
121445227  [KO:K26050]
121445545  Sun1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
121445820  [KO:K19867]
121445839  [KO:K01689] [EC:4.2.1.11]
121445902  Mybpc2; myosin-binding protein C, fast-type [KO:K12558]
121445957  [KO:K05692]
121445960  Mybph; myosin-binding protein H [KO:K24494]
121446237  Tnnt2; troponin T, cardiac muscle isoform X1 [KO:K12045]
121446255  Myl2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
121446390  Eln; elastin isoform X1 [KO:K14211]
121446507  Csrp1; cysteine and glycine-rich protein 1 [KO:K09377]
121446611  Lmod1; leiomodin-1 [KO:K22030]
121446838  Col4a4; collagen alpha-4(IV) chain [KO:K06237]
121446839  Col4a3; collagen alpha-3(IV) chain [KO:K06237]
121446871  Sntb2; beta-2-syntrophin [KO:K24064]
121446915  Acta1; actin, alpha skeletal muscle [KO:K10354]
121446963  Itgb1; integrin beta-1 isoform X1 [KO:K05719]
121447015  Col6a3; collagen alpha-3(VI) chain [KO:K06238]
121447214  Des; desmin [KO:K07610]
121447577  Col11a1; collagen alpha-1(XI) chain isoform X1 [KO:K19721]
121448070  [KO:K06254]
121448110  Hspg2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
121448134  [KO:K01689] [EC:4.2.1.11]
121448150  Sdc3; syndecan-3 [KO:K16337]
121448204  [KO:K01689] [EC:4.2.1.11]
121448282  Trim63; E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
121448466  Capzb; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
121448488  Fhl3; four and a half LIM domains protein 3 [KO:K24414]
121448587  Myom3; myomesin-3 [KO:K24495]
121448750  Col9a2; collagen alpha-2(IX) chain [KO:K08131]
121449044  Ckm; creatine kinase M-type [KO:K27382]
121449158  Sptbn4; spectrin beta chain, non-erythrocytic 4 isoform X1 [KO:K06115]
121449307  Tnnt1; troponin T, slow skeletal muscle isoform X1 [KO:K10372]
121449461  Lama2; laminin subunit alpha-2 isoform X1 [KO:K05637]
121449614  Tnni3; troponin I, cardiac muscle isoform X1 [KO:K12044]
121449997  Myoz2; myozenin-2 isoform X1 [KO:K26050]
121450099  Atp1a3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
121450167  Csrp3; cysteine and glycine-rich protein 3 [KO:K09377]
121450278  Fhl2; four and a half LIM domains protein 2 isoform X1 [KO:K14380]
121450391  Tpm3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
121450533  Daam2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
121450573  Lmna; lamin [KO:K12641]
121450576  [KO:K10370]
121450608  Mypn; myopalladin [KO:K22028]
121450746  Ampd2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
121450869  Col9a1; collagen alpha-1(IX) chain [KO:K08131]
121450897  Thbs3; thrombospondin-3 [KO:K04659]
121450917  Myh14; myosin-14 isoform X1 [KO:K10352]
121451004  Ank3; ankyrin-3 isoform X1 [KO:K09259]
121451127  Ankrd23; ankyrin repeat domain-containing protein 23 isoform X1 [KO:K21438]
121451438  Mybphl; myosin-binding protein H-like isoform X1 [KO:K24494]
121451802  Col5a3; collagen alpha-3(V) chain isoform X1 [KO:K19721]
121452184  Syne2; nesprin-2 isoform X1 [KO:K19346]
121452218  Daam1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
121452835  Ank2; ankyrin-2 isoform X1 [KO:K09255]
121453248  Pdlim5; PDZ and LIM domain protein 5 isoform X1 [KO:K19867]
121453255  Diaph1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
121453498  [KO:K07601]
121453509  [KO:K19875]
121453587  [KO:K07597]
121453642  [KO:K26998]
121453698  Pdlim7; PDZ and LIM domain protein 7 isoform X1 [KO:K19867]
121453804  Ankrd1; ankyrin repeat domain-containing protein 1 [KO:K21433]
121454166  Actn3; alpha-actinin-3 [KO:K21073]
121454169  [KO:K24421]
121454565  Ankrd2; ankyrin repeat domain-containing protein 2 [KO:K21434]
121454619  Sptbn2; spectrin beta chain, non-erythrocytic 2 [KO:K23932]
121454643  Pdlim1; PDZ and LIM domain protein 1 [KO:K23353]
121454917  CUNH10orf71; cardiac-enriched FHL2-interacting protein [KO:K28413]
121455045  Atp1b1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
121455148  Ldb3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
121455271  Tnnc1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
121455632  Itga1; integrin alpha-1 [KO:K06480]
121455743  Thbs4; thrombospondin-4 [KO:K04659]
121455957  Itga2; integrin alpha-2 [KO:K06481]
121456100  Obscn; obscurin isoform X1 [KO:K17531] [EC:2.7.11.1]
121456160  Myh10; myosin-10 isoform X1 [KO:K10352]
121456298  [KO:K24220]
121456344  Myh13; myosin-13 [KO:K24220]
121456393  [KO:K24220]
121456394  [KO:K24220]
121456395  Myh8; myosin-8 [KO:K24220]
121456396  [KO:K24220]
121456450  Col1a1; collagen alpha-1(I) chain [KO:K06236]
121456530  Itga3; integrin alpha-3 isoform X1 [KO:K06482]
121456560  Eno3; beta-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
121456714  [KO:K19879]
121456732  Atp1b2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
121456788  Pdlim4; PDZ and LIM domain protein 4 isoform X1 [KO:K23353]
121456881  Sgca; alpha-sarcoglycan [KO:K12565]
121457009  Dcn; decorin isoform X1 [KO:K04660]
121457468  Tnnt3; troponin T, fast skeletal muscle isoform X1 [KO:K12046]
121457606  Ampd3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
121457805  Mylpf; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
121457854  Tnni2; troponin I, fast skeletal muscle [KO:K12043]
121458255  Tln1; talin-1 isoform X1 [KO:K06271]
121458282  Tmod1; tropomodulin-1 [KO:K10370]
121458402  Trim55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
121458416  Tpm2; tropomyosin beta chain isoform X1 [KO:K10374]
121458429  Diaph3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
121458703  Itga7; integrin alpha-7 isoform X1 [KO:K06583]
121458908  [KO:K05637]
121458950  [KO:K19720]
121458966  [KO:K19721]
121459076  Synpo2; synaptopodin-2 [KO:K24066]
121459113  [KO:K24495]
121459319  Sptbn1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
121459676  [KO:K06590]
121459683  Itga5; integrin alpha-5 isoform X1 [KO:K06484]
121459703  Myl7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
121459725  Lmnb2; lamin-B2 [KO:K07611]
121460110  Myh7b; myosin-7B [KO:K24220]
121460155  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
121460271  Sdc4; syndecan-4 [KO:K16338]
121460346  Tnnc2; troponin C, skeletal muscle [KO:K12042]
121460543  Snta1; alpha-1-syntrophin isoform X1 [KO:K24063]
121460603  Pdlim2; PDZ and LIM domain protein 2 [KO:K23353]
121460732  Sgcb; beta-sarcoglycan [KO:K12566]
121461063  Csrp2; cysteine and glycine-rich protein 2 [KO:K09377]
121461228  [KO:K14365]
121461258  Fbln1; fibulin-1 isoform X1 [KO:K17307]
121461343  Sun2; SUN domain-containing protein 2 isoform X1 [KO:K19347]
121461503  Sntb1; beta-1-syntrophin [KO:K24064]
121461534  Myh9; myosin-9 isoform X1 [KO:K10352]
121461562  Plec; plectin isoform X1 [KO:K10388]
121461603  Myh15; myosin-15 [KO:K24220]
121461917  Itgb5; integrin beta-5 [KO:K06588]
121462265  Col4a2; collagen alpha-2(IV) chain [KO:K06237]
121462266  Col4a1; collagen alpha-1(IV) chain [KO:K06237]
121462435  Myom2; myomesin-2 [KO:K24495]
121462615  Col5a1; collagen alpha-1(V) chain isoform X1 [KO:K19721]
121462671  Sptan1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
121462685  Tpm4; tropomyosin alpha-4 chain isoform X1 [KO:K10375]
121462777  [KO:K04659]
121463023  [KO:K10365]
121463330  Flnc; filamin-C isoform X1 [KO:K27393]
121463342  Lmod2; leiomodin-2 [KO:K22030]
121463350  Sgce; epsilon-sarcoglycan isoform X1 [KO:K27061]
121463369  Capza2; F-actin-capping protein subunit alpha-2 [KO:K10364]
121463383  Col1a2; collagen alpha-2(I) chain [KO:K06236]
121463629  Myh11; myosin-11 isoform X1 [KO:K10352]
121463734  Sgcd; delta-sarcoglycan [KO:K12563]
121463753  Mybpc1; myosin-binding protein C, slow-type [KO:K12557]
121464154  Col6a6; collagen alpha-6(VI) chain [KO:K06238]
121464179  Dag1; dystroglycan [KO:K06265]
121464249  [KO:K05692]
121464359  Atp1b3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
121464384  Itga9; integrin alpha-9 isoform X1 [KO:K06585]
121464389  [KO:K06238]
121464393  Myl3; myosin light chain 3 [KO:K12749]
121464401  Col6a5; collagen alpha-5(VI) chain [KO:K06238]
121464567  Xirp1; xin actin-binding repeat-containing protein 1 isoform X1 [KO:K27381]
121464696  Fbn3; LOW QUALITY PROTEIN: fibrillin-3 [KO:K23342]
121464845  [KO:K05692]
121464943  Pkp2; plakophilin-2 [KO:K12642]
121465257  [KO:K05692]
121465493  Col24a1; collagen alpha-1(XXIV) chain [KO:K19721]
121465530  Sptbn5; LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 5 [KO:K06115]
121465583  Capza3; F-actin-capping protein subunit alpha-3 [KO:K10364]
121465595  Capn3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
121465615  Fbn1; fibrillin-1 [KO:K06825]
121465637  Thbs1; thrombospondin-1 [KO:K16857]
121465679  Actc1; actin, alpha cardiac muscle 1 [KO:K12314]
121465931  Tln2; talin-2 isoform X1 [KO:K06271]
121466084  Tmod2; tropomodulin-2 [KO:K10370]
121466152  Itga11; integrin alpha-11 [KO:K06587]
121466165  Tmod3; tropomodulin-3 isoform X1 [KO:K10370]
121466184  Tpm1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
121466367  Syne1; nesprin-1 isoform X1 [KO:K19326]
121466624  Thbs2; thrombospondin-2 [KO:K04659]
Reference
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
morg04512  ECM-receptor interaction
morg04814  Motor proteins
KO pathway
ko04820   

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