KEGG   PATHWAY: ocu04115
Entry
ocu04115                    Pathway                                
Name
p53 signaling pathway - Oryctolagus cuniculus (rabbit)
Description
p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways.
Class
Cellular Processes; Cell growth and death
Pathway map
ocu04115  p53 signaling pathway
ocu04115

Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100008609  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
100008668  IGF1; insulin-like growth factor I precursor [KO:K05459]
100008840  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100008875  BCL2L1; bcl-2-like protein 1 [KO:K04570]
100009036  G1/S-specific cyclin-D2 [KO:K10151]
100009038  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
100009039  cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
100009040  cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
100009292  TP53; cellular tumor antigen p53 [KO:K04451]
100009588  plasminogen activator inhibitor 1 [KO:K03982]
100101592  caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
100134864  G1/S-specific cyclin-E1 [KO:K06626]
100134865  cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
100134867  G1/S-specific cyclin-E2 isoform X3 [KO:K06626]
100337711  ribonucleoside-diphosphate reductase subunit M2 B isoform X2 [KO:K10808] [EC:1.17.4.1]
100338403  serpin B5 [KO:K10139]
100338989  G2/mitotic-specific cyclin-B1 [KO:K05868]
100339430  serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
100340625  cyclin-dependent kinase inhibitor 2A isoform X1 [KO:K06621]
100341050  cytochrome c-like [KO:K08738]
100341175  cytochrome c [KO:K08738]
100341515  cytochrome c-like [KO:K08738]
100342142  RING finger and CHY zinc finger domain-containing protein 1 isoform X1 [KO:K10144] [EC:2.3.2.27]
100342948  quinone oxidoreductase PIG3 [KO:K10133] [EC:1.-.-.-]
100343674  ferroptosis suppressor protein 1 [KO:K22745]
100343949  CD82 antigen [KO:K06509]
100344328  sestrin-1 isoform X1 [KO:K10141]
100345096  p53 apoptosis effector related to PMP-22-like [KO:K10136]
100345729  serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
100346325  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
100346548  RAB6-interacting golgin isoform X1 [KO:K19748]
100348205  LOW QUALITY PROTEIN: relA-associated inhibitor [KO:K27356]
100348477  caspase-8 [KO:K04398] [EC:3.4.22.61]
100348489  cyclin-dependent kinase inhibitor 1 [KO:K06625]
100349299  serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
100350430  thrombospondin-1 [KO:K16857]
100350501  p53 apoptosis effector related to PMP-22 [KO:K10136]
100350564  protein reprimo [KO:K10128]
100350583  cyclin-G2 [KO:K10146]
100351037  cytochrome c-like [KO:K08738]
100351308  etoposide-induced protein 2.4 homolog isoform X1 [KO:K10134]
100351640  tuberin isoform X1 [KO:K07207]
100351683  protein Mdm4 isoform X1 [KO:K10127]
100352386  DNA damage-binding protein 2 [KO:K10140]
100352863  cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100353284  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
100353338  zinc finger protein 385A isoform X2 [KO:K26543]
100353543  sestrin-2 isoform X2 [KO:K20394]
100353673  cytochrome c, testis-specific isoform X1 [KO:K08738]
100353742  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
100354468  cytochrome c-like [KO:K08738]
100354683  metalloreductase STEAP3 isoform X3 [KO:K10142] [EC:1.16.1.-]
100354724  cytochrome c-like [KO:K08738]
100354919  sestrin-3 isoform X1 [KO:K10141]
100355084  cytochrome c [KO:K08738]
100355675  apoptosis regulator BAX isoform X2 [KO:K02159]
100355793  protein shisa-5 isoform X1 [KO:K10135]
100355829  E3 ubiquitin-protein ligase SIAH1 isoform X1 [KO:K04506] [EC:2.3.2.27]
100355991  BH3-interacting domain death agonist [KO:K04726]
100356568  COP1; E3 ubiquitin-protein ligase COP1 isoform X1 [KO:K10143] [EC:2.3.2.27]
100357329  cytochrome c [KO:K08738]
100357416  G2/mitotic-specific cyclin-B2 [KO:K21770]
100357563  cyclin-G1 isoform X1 [KO:K10145]
100357703  bcl-2-binding component 3 [KO:K10132]
100357840  cytochrome c-like [KO:K08738]
100357969  G2 and S phase-expressed protein 1 isoform X5 [KO:K10129]
100358179  14-3-3 protein sigma [KO:K06644]
100358554  protein phosphatase 1D [KO:K10147] [EC:3.1.3.16]
100358716  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100358964  zinc finger matrin-type protein 3 [KO:K10137]
100359062  serine/threonine-protein kinase ATR isoform X2 [KO:K06640] [EC:2.7.11.1]
103347723  cytochrome c-like [KO:K08738]
103348383  apoptotic protease-activating factor 1 [KO:K02084]
103349392  phorbol-12-myristate-13-acetate-induced protein 1 [KO:K10131]
103349397  apoptosis regulator Bcl-2 [KO:K02161]
108175836  cytochrome c, somatic-like [KO:K08738]
108177422  cytochrome c-like [KO:K08738]
108178730  cytochrome c-like [KO:K08738]
127483320  cytochrome c-like [KO:K08738]
127485419  insulin-like growth factor-binding protein 3 [KO:K10138]
127485825  cyclin-G1-like [KO:K10145]
127486117  apoptosis regulatory protein Siva [KO:K22744]
127487420  cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
Reference
PMID:16557269
  Authors
Levine AJ, Hu W, Feng Z.
  Title
The P53 pathway: what questions remain to be explored?
  Journal
Cell Death Differ 13:1027-36 (2006)
DOI:10.1038/sj.cdd.4401910
Reference
PMID:15838523
  Authors
Harris SL, Levine AJ.
  Title
The p53 pathway: positive and negative feedback loops.
  Journal
Oncogene 24:2899-908 (2005)
DOI:10.1038/sj.onc.1208615
Reference
PMID:11747320
  Authors
Balint E E, Vousden KH.
  Title
Activation and activities of the p53 tumour suppressor protein.
  Journal
Br J Cancer 85:1813-23 (2001)
DOI:10.1054/bjoc.2001.2128
Reference
PMID:11313928
  Authors
Taylor WR, Stark GR.
  Title
Regulation of the G2/M transition by p53.
  Journal
Oncogene 20:1803-15 (2001)
DOI:10.1038/sj.onc.1204252
Reference
PMID:15116721
  Authors
Hofseth LJ, Hussain SP, Harris CC.
  Title
p53: 25 years after its discovery.
  Journal
Trends Pharmacol Sci 25:177-81 (2004)
DOI:10.1016/j.tips.2004.02.009
Reference
PMID:12505356
  Authors
Pietenpol JA, Stewart ZA.
  Title
Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis.
  Journal
Toxicology 181-182:475-81 (2002)
DOI:10.1016/S0300-483X(02)00460-2
Reference
PMID:10714958
  Authors
Tokino T, Nakamura Y.
  Title
The role of p53-target genes in human cancer.
  Journal
Crit Rev Oncol Hematol 33:1-6 (2000)
DOI:10.1016/S1040-8428(99)00051-7
Reference
PMID:16697662
  Authors
Hermeking H, Benzinger A.
  Title
14-3-3 proteins in cell cycle regulation.
  Journal
Semin Cancer Biol 16:183-92 (2006)
DOI:10.1016/j.semcancer.2006.03.002
Reference
PMID:16915296
  Authors
Sherr CJ.
  Title
Divorcing ARF and p53: an unsettled case.
  Journal
Nat Rev Cancer 6:663-73 (2006)
DOI:10.1038/nrc1954
Reference
PMID:17409411
  Authors
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S, Levine AJ.
  Title
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways.
  Journal
Cancer Res 67:3043-53 (2007)
DOI:10.1158/0008-5472.CAN-06-4149
Reference
PMID:26037915
  Authors
Resnick-Silverman L, Manfredi JJ
  Title
Two Faces of SIVA.
  Journal
Cancer Discov 5:581-3 (2015)
DOI:10.1158/2159-8290.CD-15-0484
Reference
PMID:19584092
  Authors
Resch U, Schichl YM, Winsauer G, Gudi R, Prasad K, de Martin R
  Title
Siva1 is a XIAP-interacting protein that balances NFkappaB and JNK signalling to promote apoptosis.
  Journal
J Cell Sci 122:2651-61 (2009)
DOI:10.1242/jcs.049940
Reference
PMID:19240372
  Authors
Barkinge JL, Gudi R, Sarah H, Chu F, Borthakur A, Prabhakar BS, Prasad KV
  Title
The p53-induced Siva-1 plays a significant role in cisplatin-mediated apoptosis.
  Journal
J Carcinog 8:2 (2009)
DOI:10.4103/1477-3163.45389
Reference
PMID:12135761
  Authors
Ohiro Y, Garkavtsev I, Kobayashi S, Sreekumar KR, Nantz R, Higashikubo BT, Duffy SL, Higashikubo R, Usheva A, Gius D, Kley N, Horikoshi N
  Title
A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF).
  Journal
FEBS Lett 524:163-71 (2002)
DOI:10.1016/S0014-5793(02)03049-1
Reference
PMID:26646590
  Authors
Hu Y, Ge W, Wang X, Sutendra G, Zhao K, Dedeic Z, Slee EA, Baer C, Lu X
  Title
Caspase cleavage of iASPP potentiates its ability to inhibit p53 and NF-kappaB.
  Journal
Oncotarget 6:42478-90 (2015)
DOI:10.18632/oncotarget.6478
Related
pathway
ocu04110  Cell cycle
ocu04210  Apoptosis
ocu04218  Cellular senescence
KO pathway
ko04115   
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