KEGG   PATHWAY: ocu04218
Entry
ocu04218                    Pathway                                
Name
Cellular senescence - Oryctolagus cuniculus (rabbit)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
ocu04218  Cellular senescence
ocu04218

Other DBs
GO: 0090398
Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100008645  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
100008733  IL6; interleukin-6 precursor [KO:K05405]
100008751  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100008752  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100008858  [KO:K09183]
100008859  [KO:K17333]
100008939  [KO:K04960]
100009036  [KO:K10151]
100009038  [KO:K10152]
100009039  [KO:K02089] [EC:2.7.11.22]
100009040  [KO:K02091] [EC:2.7.11.22]
100009089  [KO:K01367] [EC:3.4.22.52]
100009092  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100009129  CXCL8; interleukin-8 precursor [KO:K10030]
100009250  IL1A; interleukin-1 alpha [KO:K04383]
100009292  TP53; cellular tumor antigen p53 [KO:K04451]
100009298  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100009316  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100009371  TGFB2; transforming growth factor beta-2 proprotein precursor [KO:K13376]
100009373  ETS1; protein C-ets-1 [KO:K02678]
100009414  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100009423  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
100009438  [KO:K04443] [EC:2.7.11.1]
100009473  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
100009487  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348] [EC:3.1.3.16]
100009505  [KO:K04958]
100009587  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100009588  [KO:K03982]
100134864  [KO:K06626]
100134865  [KO:K02206] [EC:2.7.11.22]
100134866  CCNA2; cyclin-A2 [KO:K06627]
100134867  [KO:K06626]
100327259  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
100327265  MYC; myc proto-oncogene protein [KO:K04377]
100328725  RAD50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
100328967  [KO:K06751]
100337764  [KO:K05863]
100337822  [KO:K00922] [EC:2.7.1.153]
100338695  [KO:K07206]
100338822  [KO:K06751]
100338850  [KO:K07205]
100338989  [KO:K05868]
100338995  TRAF3IP2; E3 ubiquitin ligase TRAF3IP2 [KO:K21124]
100339292  [KO:K08826] [EC:2.7.11.1]
100339430  [KO:K06641] [EC:2.7.11.1]
100339821  [KO:K06751]
100339953  [KO:K04432] [EC:2.7.12.2]
100339977  [KO:K16332]
100340606  [KO:K05864] [EC:5.2.1.8]
100340625  [KO:K06621]
100340737  [KO:K03362]
100341141  [KO:K08826] [EC:2.7.11.1]
100341285  [KO:K21776]
100341372  [KO:K20858]
100341469  [KO:K10752]
100341695  [KO:K04441] [EC:2.7.11.24]
100342157  [KO:K14381]
100342365  [KO:K04681]
100342852  [KO:K04456] [EC:2.7.11.1]
100342972  [KO:K05863]
100343573  [KO:K09408]
100344161  [KO:K04441] [EC:2.7.11.24]
100344241  [KO:K07828]
100344311  [KO:K04682]
100344335  TGFBR2; TGF-beta receptor type-2 precursor [KO:K04388] [EC:2.7.11.30]
100344533  [KO:K06268]
100345181  [KO:K00922] [EC:2.7.1.153]
100345250  [KO:K02649]
100345444  [KO:K08015]
100345526  [KO:K02183]
100345729  [KO:K02216] [EC:2.7.11.1]
100345812  [KO:K04674] [EC:2.7.11.30]
100346212  [KO:K08826] [EC:2.7.11.1]
100346303  [KO:K23605]
100346379  [KO:K09389]
100346477  [KO:K05863]
100346753  [KO:K21769]
100347003  [KO:K17334]
100347345  [KO:K04371] [EC:2.7.11.24]
100347407  [KO:K04366] [EC:2.7.11.1]
100347487  [KO:K07827]
100347701  [KO:K21774]
100347856  [KO:K02183]
100348051  [KO:K04682]
100348057  [KO:K05863]
100348489  [KO:K06625]
100348492  [KO:K07208]
100348561  [KO:K04371] [EC:2.7.11.24]
100348663  [KO:K00922] [EC:2.7.1.153]
100348976  [KO:K04682]
100348995  [KO:K06751]
100349085  [KO:K06751]
100349183  [KO:K18753]
100349247  [KO:K06751]
100349271  [KO:K11411] [EC:2.3.1.286]
100349299  [KO:K04728] [EC:2.7.11.1]
100349426  [KO:K02580]
100349506  [KO:K05862]
100349757  [KO:K06751]
100349768  [KO:K05863]
100350107  [KO:K02183]
100350519  [KO:K03362]
100350614  [KO:K04441] [EC:2.7.11.24]
100350932  [KO:K04982] [EC:2.7.11.1]
100351058  [KO:K04973]
100351567  [KO:K18753]
100351640  [KO:K07207]
100351835  [KO:K02830] [EC:3.1.11.2]
100351874  [KO:K04685]
100352301  [KO:K13375]
100352378  [KO:K04446]
100352392  CALM2; calmodulin [KO:K02183]
100352398  [KO:K10867]
100352785  [KO:K06627]
100352863  [KO:K02087] [EC:2.7.11.22 2.7.11.23]
100353054  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100353085  [KO:K10752]
100353173  [KO:K06620]
100353284  [KO:K04402]
100353706  [KO:K04456] [EC:2.7.11.1]
100353742  [KO:K04402]
100353824  [KO:K17332]
100353949  [KO:K21773]
100354280  [KO:K06645] [EC:3.1.3.48]
100354611  [KO:K06751]
100354802  [KO:K05863]
100354905  [KO:K02183]
100355230  [KO:K04433] [EC:2.7.12.2]
100355380  [KO:K06751]
100355920  [KO:K07830]
100356164  [KO:K07203] [EC:2.7.11.1]
100356245  [KO:K04348] [EC:3.1.3.16]
100356326  [KO:K05863]
100356371  RLA-A3; MHC class I antigen-like precursor [KO:K06751]
100356406  [KO:K21771]
100356526  [KO:K10994] [EC:3.1.11.2]
100356806  [KO:K04959]
100356946  MRE11; double-strand break repair protein MRE11 [KO:K10865]
100356957  [KO:K17454]
100357416  [KO:K21770]
100357431  [KO:K06618]
100357438  [KO:K10903]
100357841  [KO:K02649]
100358182  [KO:K07831]
100358383  [KO:K10995]
100358389  [KO:K06627]
100358471  [KO:K07201]
100358716  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
100358944  [KO:K09406]
100358982  [KO:K13377]
100359062  [KO:K06640] [EC:2.7.11.1]
100359086  [KO:K08826] [EC:2.7.11.1]
100359137  [KO:K04500]
103345165  [KO:K02183]
103345448  [KO:K13375]
103346035  [KO:K04441] [EC:2.7.11.24]
103351685  [KO:K21775]
127485184  [KO:K04735]
127485419  [KO:K10138]
127486116  [KO:K04456] [EC:2.7.11.1]
127486605  [KO:K02833]
127487420  [KO:K02206] [EC:2.7.11.22]
127489175  [KO:K17454]
127489236  [KO:K07827]
127489362  [KO:K07829]
127489461  [KO:K04368] [EC:2.7.12.2]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
ocu04020  Calcium signaling pathway
ocu04068  FoxO signaling pathway
ocu04110  Cell cycle
ocu04115  p53 signaling pathway
ocu04150  mTOR signaling pathway
KO pathway
ko04218   

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