KEGG   PATHWAY: oga04820
Entry
oga04820                    Pathway                                
Name
Cytoskeleton in muscle cells - Otolemur garnettii (small-eared galago)
Class
Cellular Processes; Cell motility
Pathway map
oga04820  Cytoskeleton in muscle cells
oga04820

Organism
Otolemur garnettii (small-eared galago) [GN:oga]
Gene
100940385  PDLIM1; PDZ and LIM domain protein 1 [KO:K23353]
100940607  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100940750  NID1; nidogen-1 [KO:K06826]
100940766  SGCD; delta-sarcoglycan [KO:K12563]
100940990  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
100941107  [KO:K09290]
100941332  TNNI3; troponin I, cardiac muscle isoform X1 [KO:K12044]
100941404  VCL; vinculin isoform X1 [KO:K05700]
100941606  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
100941684  ITGB5; integrin beta-5 [KO:K06588]
100941760  COL9A1; collagen alpha-1(IX) chain isoform X1 [KO:K08131]
100941839  PLEC; plectin isoform X7 [KO:K10388]
100942091  SGCB; beta-sarcoglycan [KO:K12566]
100942142  MYOZ1; myozenin-1 [KO:K26050]
100942147  TPM1; tropomyosin alpha-1 chain isoform X4 [KO:K10373]
100942245  DIAPH2; protein diaphanous homolog 2 isoform X2 [KO:K05741]
100942494  NRAP; nebulin-related-anchoring protein isoform X2 [KO:K24421]
100942538  SPTBN2; spectrin beta chain, non-erythrocytic 2 isoform X1 [KO:K23932]
100942664  MYH14; myosin-14 isoform X2 [KO:K10352]
100943017  LBR; lamin-B receptor [KO:K19532] [EC:1.3.1.70]
100943178  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X2 [KO:K01539] [EC:7.2.2.13]
100943209  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
100943407  CUNH10orf71; uncharacterized protein C10orf71 homolog [KO:K28413]
100943527  ACTN2; alpha-actinin-2 isoform X1 [KO:K21073]
100943772  THBS2; thrombospondin-2 [KO:K04659]
100943781  FHL2; four and a half LIM domains protein 2 [KO:K14380]
100943790  TPM4; tropomyosin alpha-4 chain isoform X2 [KO:K10375]
100943877  ACTC1; actin, alpha cardiac muscle 1 isoform X1 [KO:K12314]
100944053  DTNA; dystrobrevin alpha isoform X2 [KO:K26998]
100944255  FBLN1; fibulin-1 isoform X1 [KO:K17307]
100944362  AMPD2; AMP deaminase 2 [KO:K01490] [EC:3.5.4.6]
100944593  BGN; biglycan [KO:K08118]
100944949  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
100945210  TMOD4; tropomodulin-4 [KO:K10370]
100945220  FBN1; fibrillin-1 [KO:K06825]
100945519  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
100945623  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
100945660  NEBL; nebulette isoform X1 [KO:K25865]
100945835  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
100945899  ITGAV; integrin alpha-V [KO:K06487]
100945936  ITGA9; integrin alpha-9 [KO:K06585]
100945946  DCN; decorin [KO:K04660]
100946421  XIRP2; xin actin-binding repeat-containing protein 2 [KO:K27381]
100946523  ACTG2; actin, gamma-enteric smooth muscle [KO:K12315]
100946614  LMNB2; lamin-B2 [KO:K07611]
100946673  TLN1; talin-1 isoform X2 [KO:K06271]
100946791  ANK3; ankyrin-3 isoform X1 [KO:K09259]
100946809  INF2; inverted formin-2 isoform X1 [KO:K23958]
100946981  PDLIM4; PDZ and LIM domain protein 4 [KO:K23353]
100946987  TPM2; tropomyosin beta chain isoform X2 [KO:K10374]
100947270  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
100947527  MYOM1; myomesin-1 isoform X1 [KO:K24495]
100947660  CAPZA2; F-actin-capping protein subunit alpha-2 [KO:K10364]
100947982  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
100948072  SGCA; alpha-sarcoglycan [KO:K12565]
100948089  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
100948135  ACTN3; alpha-actinin-3 [KO:K21073]
100948167  FN1; fibronectin isoform X2 [KO:K05717]
100948209  NEB; nebulin isoform X1 [KO:K18267]
100948235  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
100948294  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
100948486  SPTAN1; LOW QUALITY PROTEIN: spectrin alpha chain, non-erythrocytic 1 [KO:K06114]
100948656  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
100948685  MYBPHL; myosin-binding protein H-like isoform X1 [KO:K24494]
100948800  THBS4; thrombospondin-4 [KO:K04659]
100948888  TMOD1; tropomodulin-1 [KO:K10370]
100948970  MYOZ3; myozenin-3 [KO:K26050]
100949162  ENO2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
100949247  THBS1; thrombospondin-1 [KO:K16857]
100949430  ITGB3; integrin beta-3 [KO:K06493]
100949511  ITGA2; integrin alpha-2 [KO:K06481]
100949622  MYOZ2; myozenin-2 [KO:K26050]
100949754  MYL4; myosin light chain 4 [KO:K12750]
100949900  AMPD1; AMP deaminase 1 isoform X2 [KO:K01490] [EC:3.5.4.6]
100949937  SYNPO2; synaptopodin-2 isoform X1 [KO:K24066]
100950005  LMNA; lamin isoform X2 [KO:K12641]
100950151  FBN2; fibrillin-2 [KO:K23342]
100950457  AMPD3; AMP deaminase 3 isoform X3 [KO:K01490] [EC:3.5.4.6]
100950506  VIM; vimentin [KO:K07606]
100950559  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
100950623  FMNL3; formin-like protein 3 [KO:K23957]
100950802  ITGA3; integrin alpha-3 [KO:K06482]
100950816  SDC1; syndecan-1 isoform X1 [KO:K06257]
100950946  ITGB6; integrin beta-6 isoform X2 [KO:K06589]
100950964  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
100950977  COL4A2; LOW QUALITY PROTEIN: collagen alpha-2(IV) chain [KO:K06237]
100950987  SDC3; syndecan-3 [KO:K16337]
100951140  DAAM2; disheveled-associated activator of morphogenesis 2 [KO:K04512]
100951313  HSPG2; basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
100951353  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
100951428  COL1A1; collagen alpha-1(I) chain [KO:K06236]
100951463  ENO1; alpha-enolase isoform X2 [KO:K01689] [EC:4.2.1.11]
100951652  ITGA2B; integrin alpha-IIb [KO:K06476]
100951727  SUN2; SUN domain-containing protein 2 [KO:K19347]
100951917  FHL3; four and a half LIM domains protein 3 [KO:K24414]
100952189  MYH10; myosin-10 isoform X2 [KO:K10352]
100952596  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
100952638  COL5A1; collagen alpha-1(V) chain isoform X1 [KO:K19721]
100952681  TMOD2; tropomodulin-2 isoform X1 [KO:K10370]
100952704  ITGA8; integrin alpha-8 [KO:K06584]
100952904  COL27A1; collagen alpha-1(XXVII) chain [KO:K19721]
100952936  [KO:K24220]
100952993  TMOD3; tropomodulin-3 [KO:K10370]
100952998  TLN2; talin-2 [KO:K06271]
100953017  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
100953252  [KO:K24220]
100953299  MYBPC1; myosin-binding protein C, slow-type isoform X3 [KO:K12557]
100953441  DSP; desmoplakin isoform X1 [KO:K10381]
100953548  SNTA1; alpha-1-syntrophin isoform X1 [KO:K24063]
100953557  [KO:K24220]
100953710  PDLIM5; PDZ and LIM domain protein 5 isoform X2 [KO:K19867]
100953795  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
100953854  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100953876  MYH8; myosin-8 isoform X1 [KO:K24220]
100954056  COL24A1; collagen alpha-1(XXIV) chain [KO:K19721]
100954113  [KO:K01539] [EC:7.2.2.13]
100954168  EMD; emerin [KO:K12569]
100954199  SSPN; sarcospan [KO:K22194]
100954371  VCAN; versican core protein isoform X1 [KO:K06793]
100954400  SNTB2; beta-2-syntrophin [KO:K24064]
100954524  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
100954531  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
100954535  SYNE1; nesprin-1 isoform X7 [KO:K19326]
100955023  ACTA1; actin, alpha skeletal muscle isoform X1 [KO:K10354]
100955092  CAPZB; F-actin-capping protein subunit beta [KO:K10365]
100955119  TCAP; telethonin [KO:K19879]
100955301  PDLIM7; PDZ and LIM domain protein 7 isoform X2 [KO:K19867]
100955384  COL1A2; collagen alpha-2(I) chain [KO:K06236]
100955666  MYL3; myosin light chain 3 [KO:K12749]
100955745  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100955762  ITGA4; integrin alpha-4 [KO:K06483]
100955879  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
100955920  SGCE; epsilon-sarcoglycan isoform X3 [KO:K27061]
100956014  ANKRD23; ankyrin repeat domain-containing protein 23 [KO:K21438]
100956043  DSG2; desmoglein-2 [KO:K07597]
100956097  SYNE2; nesprin-2 isoform X1 [KO:K19346]
100956236  DAG1; dystroglycan [KO:K06265]
100956317  ANK2; ankyrin-2 isoform X1 [KO:K09255]
100956345  COL11A1; collagen alpha-1(XI) chain isoform X2 [KO:K19721]
100956445  [KO:K17751]
100956478  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X3 [KO:K06115]
100956565  SPTBN4; spectrin beta chain, non-erythrocytic 4 [KO:K06115]
100956818  MYBPH; myosin-binding protein H [KO:K24494]
100956922  NID2; nidogen-2 [KO:K06826]
100956979  [KO:K07601]
100957072  COL3A1; collagen alpha-1(III) chain [KO:K19720]
100957332  AGRN; agrin isoform X1 [KO:K06254]
100957584  COL5A2; collagen alpha-2(V) chain [KO:K19721]
100957773  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
100957790  SDC2; syndecan-2 [KO:K16336]
100957792  MYOM3; myomesin-3 [KO:K24495]
100957922  FMNL1; formin-like protein 1 [KO:K23957]
100957950  PDLIM3; PDZ and LIM domain protein 3 isoform X2 [KO:K23353]
100958037  LMOD3; leiomodin-3 [KO:K22030]
100958068  FLNC; filamin-C isoform X1 [KO:K27393]
100958078  TTN; titin isoform X1 [KO:K12567] [EC:2.7.11.1]
100958104  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
100958142  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
100958348  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
100958465  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
100958753  CKM; creatine kinase M-type [KO:K27382]
100958932  FBLN2; fibulin-2 isoform X1 [KO:K17307]
100958967  CSRP2; cysteine and glycine-rich protein 2 isoform X1 [KO:K09377]
100959015  MYH7B; myosin-7B [KO:K24220]
100959122  DIAPH3; protein diaphanous homolog 3 isoform X1 [KO:K05745]
100959225  MYH11; myosin-11 isoform X2 [KO:K10352]
100959369  TNNT3; troponin T, fast skeletal muscle isoform X2 [KO:K12046]
100959539  ENO3; beta-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
100959640  TRIM54; tripartite motif-containing protein 54 [KO:K10653]
100959678  THBS3; thrombospondin-3 [KO:K04659]
100960085  TMEM43; transmembrane protein 43 [KO:K27488]
100960212  FMN2; LOW QUALITY PROTEIN: formin-2 [KO:K02184]
100960292  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
100960579  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
100960800  ACTB; actin, cytoplasmic 1 [KO:K05692]
100961029  TRIM55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
100961344  FMNL2; formin-like protein 2 isoform X1 [KO:K23957]
100961425  COL11A2; collagen alpha-2(XI) chain isoform X1 [KO:K19721]
100961443  PDLIM2; PDZ and LIM domain protein 2 [KO:K23353]
100961587  TRIM63; E3 ubiquitin-protein ligase TRIM63 [KO:K10655] [EC:2.3.2.27]
100961654  XIRP1; xin actin-binding repeat-containing protein 1 [KO:K27381]
100961744  LMOD1; leiomodin-1 [KO:K22030]
100961761  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
100961952  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
100961957  ZYX; zyxin [KO:K06273]
100962148  SYNE3; nesprin-3 [KO:K21761]
100962201  [KO:K06238]
100962448  TNNT1; troponin T, slow skeletal muscle [KO:K10372]
100962509  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
100962528  ITGA6; integrin alpha-6 [KO:K06485]
100962541  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
100962815  [KO:K06238]
100963041  MYH9; myosin-9 [KO:K10352]
100963124  COMP; cartilage oligomeric matrix protein [KO:K04659]
100963217  DAAM1; disheveled-associated activator of morphogenesis 1 [KO:K04512]
100963425  PKP2; plakophilin-2 [KO:K12642]
100963518  ITGB7; integrin beta-7 [KO:K06590]
100964155  LAMA1; laminin subunit alpha-1 [KO:K05637]
100964289  MYOT; myotilin [KO:K19875]
100964370  CAPN3; calpain-3 isoform X2 [KO:K08573] [EC:3.4.22.54]
100964465  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
100964689  CSRP1; cysteine and glycine-rich protein 1 [KO:K09377]
100964819  MYBPC3; myosin-binding protein C, cardiac-type [KO:K12568]
100964928  LMNB1; lamin-B1 [KO:K07611]
100965127  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
100965274  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
100965293  TNNC2; troponin C, skeletal muscle [KO:K12042]
100965405  SPTBN5; LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 5 [KO:K06115]
100965465  ITGA11; integrin alpha-11 [KO:K06587]
100965477  JUP; junction plakoglobin [KO:K10056]
100965648  SGCZ; zeta-sarcoglycan isoform X1 [KO:K27062]
100965679  MYPN; myopalladin isoform X1 [KO:K22028]
100965732  TNNI1; troponin I, slow skeletal muscle [KO:K10371]
100965761  SNTB1; beta-1-syntrophin [KO:K24064]
100965773  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
100965853  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
100965933  SDC4; syndecan-4 [KO:K16338]
100966050  TNNT2; troponin T, cardiac muscle [KO:K12045]
100966173  MYOM2; myomesin-2 [KO:K24495]
100966287  COL5A3; collagen alpha-3(V) chain [KO:K19721]
100966429  [KO:K05692]
100966446  ANKRD2; ankyrin repeat domain-containing protein 2 isoform X2 [KO:K21434]
100966571  LMOD2; leiomodin-2 [KO:K22030]
100966738  MYBPC2; myosin-binding protein C, fast-type [KO:K12558]
100966908  SGCG; gamma-sarcoglycan [KO:K12564]
100966951  TPM3; tropomyosin alpha-3 chain [KO:K09290]
100967160  DES; desmin [KO:K07610]
105887101  [KO:K24220]
105887102  MYH13; myosin-13 [KO:K24220]
105887375  ELN; elastin isoform X1 [KO:K14211]
105888131  MYL5; myosin light chain 5 [KO:K12753]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
oga04512  ECM-receptor interaction
oga04814  Motor proteins
KO pathway
ko04820   

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