KEGG   PATHWAY: aamp00230
Entry
aamp00230                   Pathway                                
Name
Purine metabolism - Arvicola amphibius (Eurasian water vole)
Class
Metabolism; Nucleotide metabolism
Pathway map
aamp00230  Purine metabolism
aamp00230

Module
aamp_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:aamp00230]
aamp_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:aamp00230]
aamp_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:aamp00230]
aamp_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:aamp00230]
aamp_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:aamp00230]
aamp_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:aamp00230]
aamp_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:aamp00230]
Other DBs
GO: 0006163 0042278
Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119799740  Nudt9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
119812200  Adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
119816502  Nudt5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
119816454  Pgm1; phosphoglucomutase-1 [KO:K01835] [EC:5.4.2.2]
119801435  Pgm2; phosphoglucomutase-2 isoform X1 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
119816159  ribose-phosphate pyrophosphokinase 1-like isoform X1 [KO:K00948] [EC:2.7.6.1]
119804677  Prps2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
119804744  Prps1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
119819370  Prps1l1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
119808541  amidophosphoribosyltransferase-like [KO:K00764] [EC:2.4.2.14]
119814219  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
119825547  Gart; trifunctional purine biosynthetic protein adenosine-3 isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
119811958  Pfas; LOW QUALITY PROTEIN: phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
119808557  Paics; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
119810165  multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
119822772  Adsl; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
119813142  LOW QUALITY PROTEIN: adenylosuccinate lyase-like [KO:K01756] [EC:4.3.2.2]
119821175  Atic; bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
119801913  Aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
119807849  Nt5c1b; cytosolic 5'-nucleotidase 1B isoform X1 [KO:K01081] [EC:3.1.3.5]
119817205  Nt5c1a; LOW QUALITY PROTEIN: cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
119812748  Nt5c2; cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
119813308  Nt5m; 5'(3')-deoxyribonucleotidase, mitochondrial isoform X1 [KO:K01081] [EC:3.1.3.5]
119813621  Nt5c; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
119809540  Nt5e; 5'-nucleotidase isoform X1 [KO:K19970] [EC:3.1.3.5]
119799775  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
119800104  Lacc1; purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
119804789  Hprt1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
119809514  Impdh2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
119806859  Impdh1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
119809633  Nme6; LOW QUALITY PROTEIN: nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
119811790  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
119811791  Nme1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
119811919  Nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
119812650  Nme4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
119827291  Nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
119821236  Ak9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
119815710  Entpd1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
119810736  Entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
119818500  Entpd8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
119812504  Cant1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
119800288  Entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
119815521  Entpd6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
119820018  Entpd5; ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [KO:K01511] [EC:3.6.1.6]
119809466  U8 snoRNA-decapping enzyme-like [KO:K16855] [EC:3.6.1.62 3.6.1.64]
119809737  U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
119815516  Itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
119806353  Xdh; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
119803077  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]-like [KO:K01518] [EC:3.6.1.17]
119826791  Nudt2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
119826402  Gmps; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
119816816  Gmpr; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
119799785  Gmpr2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
119827099  Gda; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
119812070  Guk1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
119824709  Rrm1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
119807655  Rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
119822934  Rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
119821658  Hddc2; 5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
119807871  Dguok; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
119820312  Dck; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
119802808  Hddc3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
119800751  Prune1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
119800365  Adcy1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
119809754  Adcy2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
119807554  Adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
119800380  Adcy4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
119824190  Adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
119822579  Adcy6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
119801694  Adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
119823121  Adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
119811771  Adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
119827754  Adcy10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
119810266  Gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
119826642  Gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
119799813  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
119826827  Gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
119806946  Gucy2c; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
119802524  guanylate cyclase D-like [KO:K12321] [EC:4.6.1.2]
119813098  Gucy2d; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
119804380  Gucy2f; LOW QUALITY PROTEIN: retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
119801342  Npr1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
119826330  Npr2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
119823496  Pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
119818682  Pde1a; LOW QUALITY PROTEIN: calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
119807068  Pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
119816206  Pde2a; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
119807627  Pde3a; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
119807439  Pde3b; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
119800995  Pde5a; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
119814684  Pde6a; LOW QUALITY PROTEIN: rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
119819533  Pde6b; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
119802620  Pde6c; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
119820767  Pde6d; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
119812075  Pde6g; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
119808205  Pde6h; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X1 [KO:K13760]
119822929  Pde9a; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
119821575  Pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
119819007  Pde11a; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
119818963  Adss1; adenylosuccinate synthetase isozyme 1 isoform X1 [KO:K01939] [EC:6.3.4.4]
119827580  Adss2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
119800887  Ampd2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
119801022  Ampd1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
119818426  Ampd3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
119799782  Adk; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
119821311  LOW QUALITY PROTEIN: adenosine deaminase-like [KO:K01488] [EC:3.5.4.4]
119815131  Ada; LOW QUALITY PROTEIN: adenosine deaminase [KO:K01488] [EC:3.5.4.4]
119800720  Ak5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
119816246  Ak2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
119816469  Ak4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
119811194  adenylate kinase isoenzyme 1-like [KO:K00939] [EC:2.7.4.3]
119819318  Ak1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
119819354  Ak7; LOW QUALITY PROTEIN: adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
119819416  Ak8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
119809126  Ak6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
119823892  Ak3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
119819372  Entpd2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
119802335  Ntpcr; cancer-related nucleoside-triphosphatase isoform X1 [KO:K06928] [EC:3.6.1.15]
119820783  Enpp1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
119820902  Enpp3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
119809672  Pde4d; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
119809990  Pde4a; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
119816656  Pde4b; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
119812712  Pde4c; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
119821321  Pde7b; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
119826824  Pde7a; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A [KO:K18436] [EC:3.1.4.53]
119809176  Pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
119803089  Pde8a; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
119828114  Fhit; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
119823485  Enpp4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
119800938  Papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
119800214  Papss2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
119801296  uricase [KO:K00365] [EC:1.7.3.3]
119816511  5-hydroxyisourate hydrolase isoform X1 [KO:K07127] [EC:3.5.2.17]
119825322  Urad; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
119808325  Allc; probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
aamp00030  Pentose phosphate pathway
aamp00220  Arginine biosynthesis
aamp00250  Alanine, aspartate and glutamate metabolism
aamp00260  Glycine, serine and threonine metabolism
aamp00340  Histidine metabolism
aamp00630  Glyoxylate and dicarboxylate metabolism
aamp00730  Thiamine metabolism
aamp00740  Riboflavin metabolism
aamp00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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