KEGG   PATHWAY: afb04261
Entry
afb04261                    Pathway                                
Name
Adrenergic signaling in cardiomyocytes - Anoplopoma fimbria (sablefish)
Description
Cardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, and alpha-1C). In the human heart the beta-1-AR is the pre- dominate receptor. Acute sympathetic stimulation of cardiac beta-1-ARs induces positive inotropic and chronotropic effects, the most effective mechanism to acutely increase output of the heart, by coupling to Gs, formation of cAMP by adenylyl cyclase (AC), and PKA- dependent phosphorylation of various target proteins (e.g., ryanodine receptor [RyR]; phospholamban [PLB], troponin I [TnI], and the L-type Ca2+ channel [LTCC]). Chronic beta-1-AR stimulation is detrimental and induces cardiomyocyte hypertrophy and apoptosis. beta-2-AR coupled to Gs exerts a proapoptotic action as well as beta-1-AR, while beta-2-AR coupled to Gi exerts an antiapoptotic action.
Class
Organismal Systems; Circulatory system
Pathway map
afb04261  Adrenergic signaling in cardiomyocytes
afb04261

Other DBs
GO: 0001997
Organism
Anoplopoma fimbria (sablefish) [GN:afb]
Gene
129091184  adrb1; beta-1 adrenergic receptor [KO:K04141]
129090432  adrb2a; adrenoceptor beta 2, surface a [KO:K04142]
129113426  beta-2 adrenergic receptor-like [KO:K04142]
129099344  gnas; guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
129105687  guanine nucleotide-binding protein G(s) subunit alpha-like [KO:K04632]
129094658  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
129088688  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
129109595  adcy2a; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
129097035  adenylate cyclase type 2-like isoform X1 [KO:K08042] [EC:4.6.1.1]
129110257  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
129107005  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
129104443  adcy5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
129099361  LOW QUALITY PROTEIN: adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
129099971  LOW QUALITY PROTEIN: adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
129105651  adcy7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
129112315  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
129107575  si:dkey-206f10.1; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
129095336  adcy9; LOW QUALITY PROTEIN: adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
129098413  adenylate cyclase type 9-like [KO:K08049] [EC:4.6.1.1]
129109950  bves; blood vessel epicardial substance [KO:K21108]
129104684  popdc2; popeye domain-containing 2 [KO:K26206]
129110213  popdc3; popeye domain-containing protein 3 [KO:K26207]
129105815  kcnk2a; potassium channel subfamily K member 2 [KO:K04913]
129107437  kcnk2b; potassium channel subfamily K member 2b [KO:K04913]
129095446  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
129113516  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
129094159  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
129098873  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
129109502  atp1a3b; sodium/potassium-transporting ATPase subunit alpha-3b isoform X1 [KO:K01539] [EC:7.2.2.13]
129089411  atp1a2a; sodium/potassium-transporting ATPase subunit alpha-2 isoform X1 [KO:K01539] [EC:7.2.2.13]
129111940  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
129111941  sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
129097264  atp1a3a; sodium/potassium-transporting ATPase subunit alpha-3a [KO:K01539] [EC:7.2.2.13]
129094314  atp1b1a; sodium/potassium-transporting ATPase subunit beta-1a [KO:K01540]
129090237  atp1b4; protein ATP1B4 [KO:K01540]
129111799  atp1b1b; sodium/potassium-transporting ATPase subunit beta-1b [KO:K01540]
129112746  atp1b3a; sodium/potassium-transporting ATPase subunit beta-3a [KO:K01540]
129113754  atp1b2b; sodium/potassium-transporting ATPase subunit beta-2b isoform X1 [KO:K01540]
129093472  atp1b2a; sodium/potassium-transporting ATPase subunit beta-2a isoform X1 [KO:K01540]
129096760  LOW QUALITY PROTEIN: Na(+)/H(+) exchanger beta-like [KO:K05742]
129109049  slc9a1a; LOW QUALITY PROTEIN: sodium/hydrogen exchanger 1 [KO:K05742]
129105537  kcnq1.1; LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily KQT member 1.1 [KO:K04926]
129108315  kcnq1.2; potassium voltage-gated channel subfamily KQT member 1 [KO:K04926]
129105258  atp2b2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
129106094  LOW QUALITY PROTEIN: plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
129112720  atp2b1a; plasma membrane calcium-transporting ATPase 1a isoform X1 [KO:K05850] [EC:7.2.2.10]
129108878  plasma membrane calcium-transporting ATPase 1-like [KO:K05850] [EC:7.2.2.10]
129099215  atp2b3b; plasma membrane calcium-transporting ATPase 3b [KO:K05850] [EC:7.2.2.10]
129111514  slc8a2b; sodium/calcium exchanger 2b [KO:K05849]
129113132  slc8a2a; sodium/calcium exchanger 2a isoform X1 [KO:K05849]
129113452  slc8a4a; solute carrier family 8 member 4a isoform X1 [KO:K05849]
129092170  slc8a1b; LOW QUALITY PROTEIN: sodium/calcium exchanger 1b [KO:K05849]
129103169  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
129116808  LOW QUALITY PROTEIN: sodium/calcium exchanger 1-like [KO:K05849]
129093147  slc8a4b; solute carrier family 8 member 4b [KO:K05849]
129088612  LOW QUALITY PROTEIN: sodium/calcium exchanger 1-like [KO:K05849]
129111068  sodium channel protein type 4 subunit alpha-like [KO:K04838]
129088827  sodium channel protein type 4 subunit alpha B-like [KO:K04838]
129109613  scn1ba; sodium channel, voltage-gated, type I, beta a [KO:K04845]
129110081  si:ch211-225p5.8; sodium channel subunit beta-1 [KO:K04845]
129097080  scn1bb; sodium channel, voltage-gated, type I, beta b [KO:K04845]
129095700  scn4ba; sodium channel, voltage-gated, type IV, beta a [KO:K04848]
129114043  scn4bb; sodium channel, voltage-gated, type IV, beta b [KO:K04848]
129112503  cacna1c; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
129106296  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a [KO:K04851]
129099230  cacna1db; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
129099479  cacna1fa; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
129105522  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
129099233  dihydropyridine-sensitive L-type skeletal muscle calcium channel subunit alpha-1-like [KO:K04857]
129097862  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
129110854  cacnb2a; voltage-dependent L-type calcium channel subunit beta-2a isoform X1 [KO:K04863]
129099578  cacnb3b; voltage-dependent L-type calcium channel subunit beta-4 [KO:K04864]
129099976  voltage-dependent L-type calcium channel subunit beta-3-like [KO:K04864]
129105115  cacnb4a; voltage-dependent L-type calcium channel subunit beta-4a [KO:K04865]
129111573  voltage-dependent L-type calcium channel subunit beta-4-like isoform X1 [KO:K04865]
129112268  voltage-dependent calcium channel subunit alpha-2/delta-1-like [KO:K04858]
129108113  voltage-dependent calcium channel subunit alpha-2/delta-1 [KO:K04858]
129105681  voltage-dependent calcium channel subunit alpha-2/delta-2-like [KO:K04859]
129105778  cacna2d2a; voltage-dependent calcium channel subunit alpha-2/delta-2a [KO:K04859]
129099876  cacna2d3a; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
129105810  cacna2d3; voltage-dependent calcium channel subunit alpha-2/delta-3 [KO:K04860]
129112372  cacna2d4a; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
129108643  voltage-dependent calcium channel subunit alpha-2/delta-4-like [KO:K04861]
129096469  voltage-dependent calcium channel gamma-1 subunit-like [KO:K04866]
129099079  cacng1b; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
129096253  voltage-dependent calcium channel gamma-2 subunit-like [KO:K04867]
129098812  cacng2a; calcium channel, voltage-dependent, gamma subunit 2a [KO:K04867]
129096268  cacng3a; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
129098751  cacng3b; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
129095842  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
129098898  voltage-dependent calcium channel gamma-4 subunit-like [KO:K04869]
129096325  voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
129098976  voltage-dependent calcium channel gamma-5 subunit-like [KO:K04870]
129110222  cacng6b; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
129096920  voltage-dependent calcium channel gamma-6 subunit-like [KO:K04871]
129110085  cacng7b; voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
129096896  cacng7a; calcium channel, voltage-dependent, gamma subunit 7a [KO:K04872]
129109960  cacng8b; voltage-dependent calcium channel gamma-4 subunit [KO:K04873]
129096883  voltage-dependent calcium channel gamma-4 subunit-like isoform X1 [KO:K04873]
129091256  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
129106329  LOW QUALITY PROTEIN: calglandulin-like [KO:K02183]
129091919  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
129107506  calmodulin-1 [KO:K02183]
129104018  calm1a; calmodulin-1a [KO:K02183]
129104479  calmodulin-like protein 4 [KO:K02183]
129108648  calml4b; calmodulin-like protein 4 [KO:K02183]
129091211  calcium/calmodulin-dependent protein kinase type II subunit gamma-like isoform X1 [KO:K04515] [EC:2.7.11.17]
129101314  calcium/calmodulin-dependent protein kinase type II subunit beta-like isoform X1 [KO:K04515] [EC:2.7.11.17]
129096402  calcium/calmodulin-dependent protein kinase type II delta 2 chain [KO:K04515] [EC:2.7.11.17]
129102112  calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
129113832  LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit alpha-like [KO:K04515] [EC:2.7.11.17]
129092372  camk2g2; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
129093219  camk2d1; calcium/calmodulin-dependent protein kinase type II delta 1 chain [KO:K04515] [EC:2.7.11.17]
129092719  ryr2b; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
129093640  ryr2a; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
129089662  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform-like [KO:K04382] [EC:3.1.3.16]
129100837  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
129113063  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
129100037  ppp2r1bb; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
129089878  ppp2r2ba; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
129089953  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
129096008  ppp2r2ca; protein phosphatase 2, regulatory subunit B, gamma a [KO:K04354]
129101124  ppp2r2aa; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
129102027  ppp2r2ab; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
129092058  ppp2r2d; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
129103131  ppp2r3c; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
129103829  ppp2r3a; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
129104446  ppp2r3b; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [KO:K11583]
129106823  ppp2r5cb; protein phosphatase 2, regulatory subunit B', gamma b isoform X1 [KO:K11584]
129106950  ppp2r5a; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
129092205  ppp2r5d; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform isoform X1 [KO:K11584]
129103093  ppp2r5ca; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
129103117  ppp2r5eb; protein phosphatase 2, regulatory subunit B', epsilon isoform X1 [KO:K11584]
129093059  ppp2r5b; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
129100702  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
129090950  serine/threonine-protein phosphatase alpha-2 isoform-like [KO:K06269] [EC:3.1.3.16]
129106905  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
129102995  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
129097879  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
129093233  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
129099660  troponin C, slow skeletal and cardiac muscles-like [KO:K05865]
129099741  tnnc1a; troponin C type 1a (slow) [KO:K05865]
129099312  tnnt2a; LOW QUALITY PROTEIN: troponin T type 2a (cardiac) [KO:K12045]
129105236  tnnt2b; troponin T, cardiac muscle isoforms [KO:K12045]
129112509  tnnt2c; troponin T2c, cardiac [KO:K12045]
129112842  tnnt2e; troponin T2e, cardiac [KO:K12045]
129108919  tnnt2d; troponin T2d, cardiac isoform X1 [KO:K12045]
129106016  tropomyosin alpha-4 chain-like isoform X1 [KO:K10373]
129102876  tpm2; tropomyosin beta chain isoform X1 [KO:K10373]
129108296  tpm1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
129096829  tpm3; tropomyosin alpha-3 chain isoform X1 [KO:K09290]
129109133  tropomyosin alpha-4 chain-like isoform X1 [KO:K09290]
129089258  tropomyosin alpha-1 chain-like isoform X1 [KO:K10375]
129095068  tpm4a; tropomyosin 4a isoform X1 [KO:K10375]
129095289  acta1a; actin alpha 1, skeletal muscle a [KO:K12314]
129102100  acta1b; actin alpha 1, skeletal muscle b isoform X1 [KO:K12314]
129106946  actc1a; actin, alpha cardiac muscle 1a [KO:K12314]
129102980  actin, alpha cardiac muscle [KO:K12314]
129103982  actin, alpha cardiac muscle-like [KO:K12314]
129110526  myosin-7-like [KO:K17751]
129094146  myosin-7-like [KO:K17751]
129094147  myosin-7 isoform X1 [KO:K17751]
129094149  myosin-7-like [KO:K17751]
129105345  myl2a; myosin regulatory light chain 2a isoform X1 [KO:K10351]
129100863  myl2b; myosin, light chain 2b, regulatory, cardiac, slow [KO:K10351]
129112628  myl13; myosin, light chain 13 [KO:K12749]
129102174  myosin light chain 4-like isoform X1 [KO:K12750]
129111970  pln; cardiac phospholamban [KO:K05852]
129095251  si:dkey-28b4.8; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
129090913  atp2a1l; LOW QUALITY PROTEIN: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1, like [KO:K05853] [EC:7.2.2.10]
129100758  sarcoplasmic/endoplasmic reticulum calcium ATPase 2-like [KO:K05853] [EC:7.2.2.10]
129102473  atp2a2b; sarcoplasmic/endoplasmic reticulum calcium ATPase 2b isoform X1 [KO:K05853] [EC:7.2.2.10]
129114028  atp2a3; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
129097969  atp2a1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
129092290  agt; angiotensinogen [KO:K09821]
129110899  agtr1b; type-1 angiotensin II receptor [KO:K04166]
129090218  type-2 angiotensin II receptor-like [KO:K04167]
129101645  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
129102518  adra1ab; alpha-1A adrenergic receptor [KO:K04135]
129089887  alpha-1A adrenergic receptor-like [KO:K04136]
129113234  alpha-1A adrenergic receptor-like [KO:K04136]
129095298  adra1d; alpha-1D adrenergic receptor [KO:K04137]
129101647  guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
129102873  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
129093856  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
129106900  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
129107211  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
129092102  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
129103018  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
129093115  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
129096510  prkcaa; protein kinase C, alpha, a [KO:K02677] [EC:2.7.11.13]
129097995  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
129106442  protein phosphatase 1 regulatory subunit 1A-like [KO:K08050]
129100791  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
129097938  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
129103301  rps6ka5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
129111569  cyclic AMP-responsive element-binding protein 1-like isoform X1 [KO:K05870]
129104181  creb1b; cyclic AMP-responsive element-binding protein 1b [KO:K05870]
129104615  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
129095379  atf4a; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
129098644  atf4b; activating transcription factor 4b [KO:K04374]
129089385  LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 3-B [KO:K09048]
129095103  creb3l3a; cyclic AMP-responsive element-binding protein 3-like protein 3-A [KO:K09048]
129111578  creb3l1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
129101302  creb3l3l; cAMP responsive element binding protein 3-like 3 like [KO:K09048]
129112607  creb3l2; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
129116472  creb3l4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
129109999  creb5b; cyclic AMP-responsive element-binding protein 5 [KO:K09047]
129097363  creb5a; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
129096853  atf6b; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
129117031  bcl2b; LOW QUALITY PROTEIN: apoptosis regulator Bcl-2 [KO:K02161]
129100281  rapgef3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
129112767  rap guanine nucleotide exchange factor 4-like isoform X1 [KO:K04351]
129104187  rapgef4a; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
129099271  mapk13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
129099334  zgc:171775; STKc_p38 domain-containing protein [KO:K04441] [EC:2.7.11.24]
129099803  mapk14a; mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
129105168  mapk14b; mitogen-activated protein kinase 14B isoform X1 [KO:K04441] [EC:2.7.11.24]
129112242  mapk12b; mitogen-activated protein kinase 12b [KO:K04441] [EC:2.7.11.24]
129112696  mapk11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
129108921  mapk12a; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
129112396  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
129106293  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
129106370  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
129107698  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
129099227  gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
129100151  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
129112319  pik3cg; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
129095505  pik3r5; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
129096039  phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
129098241  phosphoinositide 3-kinase regulatory subunit 5-like [KO:K21290]
129099100  pik3r6b; LOW QUALITY PROTEIN: phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
129105750  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129096351  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129091996  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129103636  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
129115847  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
129116975  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00238  Potassium cation
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00788  L-Adrenaline
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C07056  Isoproterenol
Reference
PMID:19883653
  Authors
Grimm M, Brown JH
  Title
Beta-adrenergic receptor signaling in the heart: role of CaMKII.
  Journal
J Mol Cell Cardiol 48:322-30 (2010)
DOI:10.1016/j.yjmcc.2009.10.016
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:17988210
  Authors
Bers DM
  Title
Calcium cycling and signaling in cardiac myocytes.
  Journal
Annu Rev Physiol 70:23-49 (2008)
DOI:10.1146/annurev.physiol.70.113006.100455
Reference
PMID:20923637
  Authors
Soltis AR, Saucerman JJ
  Title
Synergy between CaMKII substrates and beta-adrenergic signaling in regulation of cardiac myocyte Ca(2+) handling.
  Journal
Biophys J 99:2038-47 (2010)
DOI:10.1016/j.bpj.2010.08.016
Reference
PMID:12439640
  Authors
Wallukat G
  Title
The beta-adrenergic receptors.
  Journal
Herz 27:683-90 (2002)
DOI:10.1007/s00059-002-2434-z
Reference
PMID:11604549
  Authors
Xiao RP
  Title
Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins.
  Journal
Sci STKE 2001:re15 (2001)
DOI:10.1126/stke.2001.104.re15
Reference
PMID:10571541
  Authors
Xiao RP, Cheng H, Zhou YY, Kuschel M, Lakatta EG
  Title
Recent advances in cardiac beta(2)-adrenergic signal transduction.
  Journal
Circ Res 85:1092-100 (1999)
DOI:10.1161/01.RES.85.11.1092
Reference
PMID:15979723
  Authors
Zheng M, Zhu W, Han Q, Xiao RP
  Title
Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling.
  Journal
Pharmacol Ther 108:257-68 (2005)
DOI:10.1016/j.pharmthera.2005.04.006
Reference
PMID:17826821
  Authors
Kuzumoto M, Takeuchi A, Nakai H, Oka C, Noma A, Matsuoka S
  Title
Simulation analysis of intracellular Na+ and Cl- homeostasis during beta 1-adrenergic stimulation of cardiac myocyte.
  Journal
Prog Biophys Mol Biol 96:171-86 (2008)
DOI:10.1016/j.pbiomolbio.2007.07.005
Reference
PMID:11805843
  Authors
Bers DM
  Title
Cardiac excitation-contraction coupling.
  Journal
Nature 415:198-205 (2002)
DOI:10.1038/415198a
Reference
PMID:20658186
  Authors
Ho D, Yan L, Iwatsubo K, Vatner DE, Vatner SF
  Title
Modulation of beta-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5.
  Journal
Heart Fail Rev 15:495-512 (2010)
DOI:10.1007/s10741-010-9183-5
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:15765137
  Authors
Yano M, Ikeda Y, Matsuzaki M
  Title
Altered intracellular Ca2+ handling in heart failure.
  Journal
J Clin Invest 115:556-64 (2005)
DOI:10.1172/JCI24159
Reference
PMID:15232578
  Authors
Wehrens XH, Marks AR
  Title
Novel therapeutic approaches for heart failure by normalizing calcium cycling.
  Journal
Nat Rev Drug Discov 3:565-73 (2004)
DOI:10.1038/nrd1440
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:18407781
  Authors
Barry SP, Davidson SM, Townsend PA
  Title
Molecular regulation of cardiac hypertrophy.
  Journal
Int J Biochem Cell Biol 40:2023-39 (2008)
DOI:10.1016/j.biocel.2008.02.020
Related
pathway
afb04020  Calcium signaling pathway
afb04260  Cardiac muscle contraction
KO pathway
ko04261   
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