KEGG   PATHWAY: ajm04380
Entry
ajm04380                    Pathway                                
Name
Osteoclast differentiation - Artibeus jamaicensis (Jamaican fruit-eating bat)
Description
The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast.
Class
Organismal Systems; Development and regeneration
Pathway map
ajm04380  Osteoclast differentiation
ajm04380

Other DBs
GO: 0030316
Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119054540  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
119061405  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
119058521  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
119040930  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119059157  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119043036  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119044861  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119064089  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119052227  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119053288  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119046830  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119040479  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119053408  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119063115  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119042309  IFNG; interferon gamma [KO:K04687]
119051850  IFNGR1; interferon gamma receptor 1 [KO:K05132]
119035735  IFNGR2; interferon gamma receptor 2 [KO:K05133]
119062093  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
119065843  IL1A; interleukin-1 alpha [KO:K04383]
119045049  interleukin-1 beta-like [KO:K04519]
119065847  IL1B; interleukin-1 beta [KO:K04519]
119047918  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
119047921  interleukin-1 receptor type 1-like [KO:K04386]
119053704  TNF; tumor necrosis factor isoform X1 [KO:K03156]
119060225  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119058462  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
119045813  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
119045935  TGFBR1; LOW QUALITY PROTEIN: TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
119039725  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
119042868  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
119057577  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147]
119051827  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
119036073  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
119036455  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
119052321  LCK; tyrosine-protein kinase Lck [KO:K05856] [EC:2.7.10.2]
119044480  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
119061562  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
119064546  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
119051344  RELB; transcription factor RelB isoform X1 [KO:K09253]
119059672  NFKB2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
119041421  mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
119060232  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
119057909  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
119053789  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119047140  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
119062929  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
119050282  RELA; transcription factor p65 [KO:K04735]
119057921  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119040619  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
119051373  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
119055662  IFNB1; interferon beta [KO:K05415]
119057101  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119036284  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
119060490  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
119060539  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
119050071  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
119050081  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
119059334  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
119042614  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
119046845  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119062834  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
119049259  FOS; proto-oncogene c-Fos [KO:K04379]
119051329  FOSB; protein fosB isoform X1 [KO:K09029]
119050358  FOSL2; fos-related antigen 2 isoform X1 [KO:K09030]
119041925  FOSL1; fos-related antigen 1 isoform X1 [KO:K04502]
119051654  JUN; transcription factor AP-1 [KO:K04448]
119046836  JUND; transcription factor jun-D [KO:K04449]
119034515  transcription factor jun-B [KO:K09028]
119049652  JUNB; transcription factor jun-B [KO:K09028]
119041500  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
119051762  rho-related BTB domain-containing protein 1-like [KO:K04392]
119047041  cytochrome b-245 light chain isoform X1 [KO:K08009]
119049621  NCF2; neutrophil cytosol factor 2 [KO:K08010]
119042037  NCF1; neutrophil cytosol factor 1 [KO:K08011]
119060311  NCF4; neutrophil cytosol factor 4 isoform X1 [KO:K08012]
119038485  BTK; tyrosine-protein kinase BTK [KO:K07370] [EC:2.7.10.2]
119063474  TEC; tyrosine-protein kinase Tec isoform X1 [KO:K07364] [EC:2.7.10.2]
119035992  OSCAR; LOW QUALITY PROTEIN: osteoclast-associated immunoglobulin-like receptor [KO:K14377]
119058806  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K14377]
119056743  LOW QUALITY PROTEIN: osteoclast-associated immunoglobulin-like receptor [KO:K14377]
119035994  leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512]
119035997  leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512]
119035999  leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512]
119036000  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
119036001  LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 3 [KO:K06512]
119036002  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform X1 [KO:K06512]
119036003  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform X1 [KO:K06512]
119036006  leukocyte immunoglobulin-like receptor subfamily B member 2 [KO:K06512]
119044893  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
119043604  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
119038792  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
119038793  leukocyte immunoglobulin-like receptor subfamily A member 3 [KO:K06512]
119051828  leukocyte immunoglobulin-like receptor subfamily A member 4 [KO:K06512]
119051829  leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512]
119060069  immunoglobulin superfamily member 1-like [KO:K06512]
119052740  leukocyte immunoglobulin-like receptor subfamily B member 3 [KO:K06512]
119052741  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
119052742  leukocyte immunoglobulin-like receptor subfamily A member 5 isoform X1 [KO:K06512]
119052745  leukocyte immunoglobulin-like receptor subfamily A member 5 [KO:K06512]
119046187  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
119053889  leukocyte immunoglobulin-like receptor subfamily A member 4 [KO:K06512]
119054613  leukocyte immunoglobulin-like receptor subfamily A member 2 [KO:K06512]
119055835  leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512]
119055836  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
119056877  leukocyte immunoglobulin-like receptor subfamily A member 6 isoform X1 [KO:K06512]
119064069  leukocyte immunoglobulin-like receptor subfamily A member 6 [KO:K06512]
119058062  leukocyte immunoglobulin-like receptor subfamily A member 4 [KO:K06512]
119059973  leukocyte immunoglobulin-like receptor subfamily A member 2 [KO:K06512]
119064971  FCGR1A; high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
119052436  low affinity immunoglobulin gamma Fc region receptor III-like isoform X1 [KO:K06472]
119052404  FCGR2B; low affinity immunoglobulin gamma Fc region receptor II-b isoform X1 [KO:K12560]
119052423  low affinity immunoglobulin gamma Fc region receptor III-B-like isoform X1 [KO:K06463]
119055503  TREM2; triggering receptor expressed on myeloid cells 2 [KO:K14378]
119046231  tyrosine-protein phosphatase non-receptor type substrate 1-like [KO:K06551]
119047690  signal-regulatory protein beta-1-like [KO:K06551]
119047691  signal-regulatory protein beta-1-like [KO:K06551]
119047763  signal-regulatory protein beta-1-like [KO:K06551]
119047765  tyrosine-protein phosphatase non-receptor type substrate 1-like [KO:K06551]
119047773  signal-regulatory protein beta-1-like [KO:K06551]
119047774  tyrosine-protein phosphatase non-receptor type substrate 1-like [KO:K06551]
119047775  signal-regulatory protein beta-1-like [KO:K06551]
119044197  TYRO protein tyrosine kinase-binding protein isoform X1 [KO:K07992]
119035131  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
119044513  BLNK; B-cell linker protein isoform X1 [KO:K07371]
119036247  LCP2; lymphocyte cytosolic protein 2 [KO:K07361]
119047103  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
119036740  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
119048995  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
119041225  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
119040159  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
119045360  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
119048857  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
119062262  TMEM64; transmembrane protein 64 [KO:K26770]
119038093  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119054082  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119054654  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119044841  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
119035024  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
119054181  calcineurin B-like protein 2 [KO:K06268]
119063034  calcineurin B-like protein 6 [KO:K06268]
119065119  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
119064343  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
119064460  SPI1; transcription factor PU.1 isoform X1 [KO:K09438]
119045197  MITF; microphthalmia-associated transcription factor isoform X1 [KO:K09455]
119034729  CTSK; cathepsin K [KO:K01371] [EC:3.4.22.38]
119038876  ACP5; tartrate-resistant acid phosphatase type 5 isoform X1 [KO:K14379] [EC:3.1.3.2]
119062154  CALCR; calcitonin receptor [KO:K04576]
119062621  ITGB3; integrin beta-3 [KO:K06493]
119044811  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
119035720  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
119035719  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
119042494  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
119055683  non-receptor tyrosine-protein kinase TYK2-like [KO:K11219] [EC:2.7.10.2]
119040310  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
119037294  IRF9; interferon regulatory factor 9 [KO:K04693]
119053594  SOCS1; suppressor of cytokine signaling 1 [KO:K04694]
119058654  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
119044286  GAB2; GRB2-associated-binding protein 2 [KO:K08091]
119041099  FHL2; four and a half LIM domains protein 2 [KO:K14380]
119046463  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
119042610  SQSTM1; sequestosome-1 [KO:K14381]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:16313349
  Authors
Takayanagi H, Sato K, Takaoka A, Taniguchi T
  Title
Interplay between interferon and other cytokine systems in bone metabolism.
  Journal
Immunol Rev 208:181-93 (2005)
DOI:10.1111/j.0105-2896.2005.00337.x
Reference
PMID:20392226
  Authors
Takayanagi H
  Title
New immune connections in osteoclast formation.
  Journal
Ann N Y Acad Sci 1192:117-23 (2010)
DOI:10.1111/j.1749-6632.2009.05303.x
Reference
PMID:19585227
  Authors
Nakashima T, Takayanagi H
  Title
Osteoimmunology: crosstalk between the immune and bone systems.
  Journal
J Clin Immunol 29:555-67 (2009)
DOI:10.1007/s10875-009-9316-6
Reference
PMID:18722561
  Authors
Caetano-Lopes J, Canhao H, Fonseca JE
  Title
Osteoimmunology--the hidden immune regulation of bone.
  Journal
Autoimmun Rev 8:250-5 (2009)
DOI:10.1016/j.autrev.2008.07.038
Reference
PMID:18451259
  Authors
Lorenzo J, Horowitz M, Choi Y
  Title
Osteoimmunology: interactions of the bone and immune system.
  Journal
Endocr Rev 29:403-40 (2008)
DOI:10.1210/er.2007-0038
Reference
PMID:17869613
  Authors
David JP
  Title
Osteoimmunology: a view from the bone.
  Journal
Adv Immunol 95:149-65 (2007)
DOI:10.1016/S0065-2776(07)95005-1
Reference
PMID:16313342
  Authors
Jimi E, Ghosh S
  Title
Role of nuclear factor-kappaB in the immune system and bone.
  Journal
Immunol Rev 208:80-7 (2005)
DOI:10.1111/j.0105-2896.2005.00329.x
Reference
PMID:12748652
  Authors
Boyle WJ, Simonet WS, Lacey DL
  Title
Osteoclast differentiation and activation.
  Journal
Nature 423:337-42 (2003)
DOI:10.1038/nature01658
Reference
PMID:17633024
  Authors
Darnay BG, Besse A, Poblenz AT, Lamothe B, Jacoby JJ
  Title
TRAFs in RANK signaling.
  Journal
Adv Exp Med Biol 597:152-9 (2007)
DOI:10.1007/978-0-387-70630-6_12
Reference
PMID:15122243
  Authors
Baron R
  Title
Arming the osteoclast.
  Journal
Nat Med 10:458-60 (2004)
DOI:10.1038/nm0504-458
Reference
PMID:17380158
  Authors
Takayanagi H
  Title
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.
  Journal
Nat Rev Immunol 7:292-304 (2007)
DOI:10.1038/nri2062
Reference
PMID:20703218
  Authors
Krum SA, Chang J, Miranda-Carboni G, Wang CY
  Title
Novel functions for NFkappaB: inhibition of bone formation.
  Journal
Nat Rev Rheumatol 6:607-11 (2010)
DOI:10.1038/nrrheum.2010.133
Reference
PMID:15817678
  Authors
Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, Kim N, Lee SY
  Title
A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation.
  Journal
Blood 106:852-9 (2005)
DOI:10.1182/blood-2004-09-3662
Reference
PMID:18329366
  Authors
Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H
  Title
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.
  Journal
Cell 132:794-806 (2008)
DOI:10.1016/j.cell.2007.12.037
Reference
PMID:15546140
  Authors
Takayanagi H, Kim S, Koga T, Taniguchi T
  Title
Stat1-mediated cytoplasmic attenuation in osteoimmunology.
  Journal
J Cell Biochem 94:232-40 (2005)
DOI:10.1002/jcb.20316
Reference
PMID:18382763
  Authors
Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W, Wright A, Zhang M, You J, Sun SC
  Title
Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.
  Journal
J Clin Invest 118:1858-66 (2008)
DOI:10.1172/JCI34257
Reference
PMID:16184196
  Authors
Bai S, Kitaura H, Zhao H, Chen J, Muller JM, Schule R, Darnay B, Novack DV, Ross FP, Teitelbaum SL
  Title
FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.
  Journal
J Clin Invest 115:2742-51 (2005)
DOI:10.1172/JCI24921
Reference
PMID:12110142
  Authors
Takayanagi H, Kim S, Taniguchi T
  Title
Signaling crosstalk between RANKL and interferons in osteoclast differentiation.
  Journal
Arthritis Res 4 Suppl 3:S227-32 (2002)
DOI:10.1186/ar581
Related
pathway
ajm04010  MAPK signaling pathway
ajm04020  Calcium signaling pathway
ajm04064  NF-kappa B signaling pathway
ajm04151  PI3K-Akt signaling pathway
ajm04630  JAK-STAT signaling pathway
KO pathway
ko04380   
LinkDB

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