KEGG   PATHWAY: ajm04151
Entry
ajm04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Artibeus jamaicensis (Jamaican fruit-eating bat)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
ajm04151  PI3K-Akt signaling pathway
ajm04151

Other DBs
GO: 0043491
Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119057431  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
119035804  TGFA; LOW QUALITY PROTEIN: protransforming growth factor alpha [KO:K08774]
119052813  EREG; proepiregulin [KO:K09784]
119052789  AREG; amphiregulin [KO:K09782]
119046588  FGF1; fibroblast growth factor 1 [KO:K18496]
119037695  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
119044632  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
119036213  FGF18; fibroblast growth factor 18 [KO:K04358]
119036918  FGF20; fibroblast growth factor 20 [KO:K04358]
119039457  FGF16; fibroblast growth factor 16 [KO:K04358]
119041822  FGF3; fibroblast growth factor 3 [KO:K04358]
119041829  FGF4; fibroblast growth factor 4 [KO:K04358]
119059701  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
119054793  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
119054857  FGF6; fibroblast growth factor 6 [KO:K04358]
119056409  FGF9; fibroblast growth factor 9 [KO:K04358]
119049154  FGF10; fibroblast growth factor 10 [KO:K04358]
119056920  FGF5; fibroblast growth factor 5 [KO:K04358]
119057632  FGF7; fibroblast growth factor 7 [KO:K04358]
119041821  FGF19; fibroblast growth factor 19 [KO:K22603]
119058291  FGF21; fibroblast growth factor 21 [KO:K22429]
119054853  FGF23; fibroblast growth factor 23 [KO:K22428]
119041752  NGF; beta-nerve growth factor [KO:K02582]
119049902  BDNF; brain-derived neurotrophic factor [KO:K04355]
119060567  NTF3; neurotrophin-3 [KO:K04356]
119045988  NTF4; neurotrophin-4 [KO:K12457]
119057541  INS; insulin [KO:K04526]
119060308  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
119057543  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
119043762  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
119060441  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
119034635  PDGFC; platelet-derived growth factor C [KO:K05450]
119046553  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
119054540  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
119036386  KITLG; kit ligand isoform X1 [KO:K05461]
119046007  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
119055590  VEGFA; vascular endothelial growth factor A [KO:K05448]
119045456  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
119035599  PGF; placenta growth factor isoform X1 [KO:K16859]
119050320  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
119058362  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
119044937  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
119054343  ANGPT1; angiopoietin-1 [KO:K05465]
119040807  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
119047700  ANGPT4; angiopoietin-4 [KO:K05467]
119044163  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
119044339  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
119039785  EFNA1; ephrin-A1 isoform X1 [KO:K05462]
119061805  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
119061821  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
119037029  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
119063782  NRTN; neurturin [KO:K25414]
119052424  ARTN; artemin isoform X1 [KO:K25415]
119063729  PSPN; persephin [KO:K25416]
119057339  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119048554  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
119044331  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
119065040  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
119063507  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
119035526  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
119035149  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
119052652  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
119039739  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
119060018  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
119045329  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
119049802  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
119054288  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
119061365  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
119061405  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
119054285  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
119064963  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
119041773  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
119064949  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
119042619  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
119044890  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
119038260  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
119046176  TEK; angiopoietin-1 receptor [KO:K05121] [EC:2.7.10.1]
119049953  EPHA2; ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
119038025  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
119058521  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
119052051  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
119056966  SOS2; son of sevenless homolog 2 [KO:K03099]
119062206  HRAS; GTPase HRas isoform X1 [KO:K02833]
119048987  KRAS; GTPase KRas isoform X1 [KO:K07827]
119041711  NRAS; GTPase NRas [KO:K07828]
119044815  RAF1; RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
119057101  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119063754  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
119040930  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119059157  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119044737  IRS1; insulin receptor substrate 1 [KO:K16172]
119065905  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
119056324  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
119041500  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
119051762  rho-related BTB domain-containing protein 1-like [KO:K04392]
119035131  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
119045362  CD19; B-lymphocyte antigen CD19 isoform X1 [KO:K06465]
119044516  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 [KO:K12230]
119035949  chorionic somatomammotropin hormone 1-like [KO:K05438]
119035950  chorionic somatomammotropin hormone 2-like [KO:K05438]
119036309  somatotropin [KO:K05438]
119038724  PRL; prolactin isoform X1 [KO:K05439]
119055184  OSM; oncostatin-M [KO:K05418]
119037638  IL2; interleukin-2 [KO:K05429]
119037702  IL3; interleukin-3 [KO:K04736]
119042560  IL6; interleukin-6 isoform X1 [KO:K05405]
119037707  IL4; interleukin-4 [KO:K05430]
119052729  IL7; interleukin-7 isoform X1 [KO:K05431]
119058844  interferon alpha-4-like [KO:K05414]
119045866  interferon alpha-7 [KO:K05414]
119045867  interferon alpha-4 [KO:K05414]
119056303  interferon alpha-4-like [KO:K05414]
119049818  interferon alpha-4-like [KO:K05414]
119055662  IFNB1; interferon beta [KO:K05415]
119041558  EPO; erythropoietin isoform X1 [KO:K05437]
119045742  CSF3; granulocyte colony-stimulating factor [KO:K05423]
119044242  GHR; growth hormone receptor [KO:K05080]
119037020  PRLR; prolactin receptor isoform X1 [KO:K05081]
119044237  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
119048017  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
119060429  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
119035395  IL2RG; cytokine receptor common subunit gamma isoform X1 [KO:K05070]
119045748  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
119061811  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
119036993  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
119035720  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
119035719  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
119038871  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
119052448  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
119042494  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
119048039  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
119046817  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
119052647  COL1A1; collagen alpha-1(I) chain [KO:K06236]
119047354  COL1A2; collagen alpha-2(I) chain [KO:K06236]
119042061  COL2A1; collagen alpha-1(II) chain [KO:K19719]
119044741  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
119044742  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
119034569  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
119034570  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
119065191  collagen alpha-5(IV) chain [KO:K06237]
119058770  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
119061014  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
119048300  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
119048301  collagen alpha-4(VI) chain-like isoform X1 [KO:K06238]
119048382  collagen alpha-6(VI) chain-like [KO:K06238]
119058739  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
119059066  COL9A1; LOW QUALITY PROTEIN: collagen alpha-1(IX) chain [KO:K08131]
119052319  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
119055362  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
119034744  LAMA1; laminin subunit alpha-1 [KO:K05637]
119051224  LAMA2; laminin subunit alpha-2 [KO:K05637]
119040973  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
119055338  LAMA5; laminin subunit alpha-5 [KO:K06240]
119038658  LAMA4; laminin subunit alpha-4 [KO:K06241]
119054873  LAMB1; laminin subunit beta-1 [KO:K05636]
119036578  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
119043096  LAMB3; laminin subunit beta-3 [KO:K06244]
119054867  LAMB4; laminin subunit beta-4 [KO:K06245]
119049616  LAMC1; laminin subunit gamma-1 [KO:K05635]
119049617  LAMC2; laminin subunit gamma-2 [KO:K06246]
119059034  LAMC3; laminin subunit gamma-3 [KO:K06247]
119065619  RELN; reelin [KO:K06249] [EC:3.4.21.-]
119048145  THBS1; thrombospondin-1 [KO:K16857]
119038319  THBS4; thrombospondin-4 [KO:K04659]
119039777  THBS3; thrombospondin-3 [KO:K04659]
119035004  THBS2; thrombospondin-2 [KO:K04659]
119046872  cartilage oligomeric matrix protein isoform X1 [KO:K04659]
119062561  FN1; fibronectin isoform X1 [KO:K05717]
119040120  SPP1; osteopontin [KO:K06250]
119062039  VTN; vitronectin [KO:K06251]
119044900  TNC; tenascin [KO:K06252]
119053742  TNXB; tenascin-X [KO:K06252]
119049520  TNN; tenascin-N [KO:K06252]
119049565  TNR; tenascin-R [KO:K06252]
119060255  VWF; von Willebrand factor [KO:K03900]
119040111  bone sialoprotein 2 [KO:K06253]
119049161  ITGA1; integrin alpha-1 [KO:K06480]
119049164  ITGA2; integrin alpha-2 [KO:K06481]
119061593  ITGA2B; integrin alpha-IIb [KO:K06476]
119052612  ITGA3; integrin alpha-3 [KO:K06482]
119037762  ITGA4; integrin alpha-4 [KO:K06483]
119059834  ITGA5; integrin alpha-5 [KO:K06484]
119053637  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
119048528  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
119046313  ITGA8; integrin alpha-8 [KO:K06584]
119051441  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
119049402  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
119057120  ITGA11; integrin alpha-11 [KO:K06587]
119042993  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
119043116  ITGB1; integrin beta-1 [KO:K05719]
119062621  ITGB3; integrin beta-3 [KO:K06493]
119058605  ITGB4; integrin beta-4 [KO:K06525]
119039397  ITGB5; integrin beta-5 isoform X1 [KO:K06588]
119045650  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
119043505  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
119062840  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
119064798  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
119043036  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119044861  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119064089  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119052227  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119053288  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119046830  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119048157  F2R; proteinase-activated receptor 1 [KO:K03914]
119045439  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
119052925  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
119054717  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
119054785  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
119062890  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
119039478  lysophosphatidic acid receptor 4 [KO:K04275]
119060446  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
119054194  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
119050543  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
119041561  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
119060292  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
119042999  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
119047600  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
119056979  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
119045494  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
119044222  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
119062889  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
119063727  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
119056651  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
119054673  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
119047352  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
119049326  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
119049544  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
119049645  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
119058263  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
119047351  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
119052611  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
119053038  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
119063572  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
119063599  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
119041006  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
119044055  STK11; serine/threonine-protein kinase STK11 isoform X1 [KO:K07298] [EC:2.7.11.1]
119037106  CBL-interacting protein kinase 10-like [KO:K07198] [EC:2.7.11.31]
119044252  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
119041684  serine/threonine protein kinase OSK1-like [KO:K07198] [EC:2.7.11.31]
119051651  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
119061097  CBL-interacting protein kinase 14-like [KO:K07198] [EC:2.7.11.31]
119038162  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
119059019  TSC1; hamartin [KO:K07206]
119058207  TSC2; tuberin isoform X1 [KO:K07207]
119039260  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
119058195  MLST8; target of rapamycin complex subunit LST8 [KO:K08266]
119064071  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
119058513  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
119065028  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
119045012  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
119046526  EIF4E; LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E [KO:K03259]
119054312  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
119062958  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
119065424  LOW QUALITY PROTEIN: eukaryotic translation initiation factor 4E-like [KO:K03259]
119041842  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
119062679  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
119043499  eukaryotic translation initiation factor 4B-like [KO:K03258]
119041634  eukaryotic translation initiation factor 4B [KO:K03258]
119035211  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
119039580  RPS6; LOW QUALITY PROTEIN: 40S ribosomal protein S6 [KO:K02991]
119042644  40S ribosomal protein S6-like [KO:K02991]
119064525  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
119036326  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
119049697  PKN1; serine/threonine-protein kinase N1 [KO:K06071] [EC:2.7.11.13]
119042752  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691] [EC:2.7.11.13]
119052620  PKN3; serine/threonine-protein kinase N3 [KO:K23692] [EC:2.7.11.13]
119039939  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
119063163  SGK2; serine/threonine-protein kinase Sgk2 isoform X1 [KO:K13303] [EC:2.7.11.1]
119051953  serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
119040479  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119053408  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119063115  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119062089  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 [KO:K05631]
119057730  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
119048123  THEM4; acyl-coenzyme A thioesterase THEM4 isoform X1 [KO:K16339] [EC:3.1.2.2]
119036814  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
119053358  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
119038446  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform isoform X1 [KO:K03456]
119042443  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
119061462  protein phosphatase PP2A regulatory subunit A-like [KO:K03456]
119049355  serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
119035534  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
119044233  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform-like [KO:K04354]
119059476  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
119053871  serine/threonine protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
119061390  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
119065166  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
119042351  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma [KO:K11583]
119045776  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
119048262  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
119043077  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
119037977  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
119034870  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [KO:K11584]
119056156  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
119050247  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
119037939  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
119041136  LOW QUALITY PROTEIN: putative heat shock protein HSP 90-beta-3 [KO:K04079]
119046156  heat shock protein 90-5, chloroplastic-like [KO:K04079]
119061428  endoplasmin homolog [KO:K04079]
119047198  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
119047665  heat shock protein 81-1 [KO:K04079]
119060253  HSP90B1; endoplasmin [KO:K09487]
119055686  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
119061758  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
119063088  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
119057584  PHLPP1; PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
119037928  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
119055514  MTCP1; protein p13 MTCP-1 [KO:K16837]
119039263  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
119051686  BRCA1; LOW QUALITY PROTEIN: breast cancer type 1 susceptibility protein [KO:K10605] [EC:2.3.2.27]
119059198  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
119042788  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
119046025  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
119037276  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
119040627  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
119047577  phosphoenolpyruvate carboxykinase [GTP], mitochondrial-like [KO:K01596] [EC:4.1.1.32]
119041793  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
119051804  G6PC; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
119045845  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
119064823  MYC; myc proto-oncogene protein [KO:K04377]
119041888  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
119050063  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
119042826  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
119048545  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
119065244  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
119042716  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
119054859  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
119056484  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
119038552  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
119049234  CCNE1; G1/S-specific cyclin-E1 [KO:K06626]
119059362  FOXO3; forkhead box protein O3 [KO:K09408]
119046452  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
119065454  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
119062736  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
119040383  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
119053996  YWHAQ; 14-3-3 protein theta [KO:K16197]
119063235  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
119040658  YWHAE; 14-3-3 protein epsilon [KO:K06630]
119059234  14-3-3-like protein B [KO:K06630]
119059235  14-3-3-like protein B [KO:K06630]
119047645  14-3-3-like protein GF14-A [KO:K06630]
119056042  14-3-3-like protein GF14-D [KO:K06630]
119044697  YWHAG; 14-3-3 protein gamma [KO:K16198]
119064910  YWHAH; 14-3-3 protein eta [KO:K16198]
119045448  BAD; bcl2-associated agonist of cell death isoform X1 [KO:K02158]
119047720  BCL2L1; bcl-2-like protein 1 [KO:K04570]
119057575  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
119049966  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
119064343  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
119057201  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
119060217  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
119045974  activating transcription factor of chaperone-like [KO:K04374]
119061780  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
119048742  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
119063765  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
119064485  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
119065205  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
119035286  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
119053748  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
119045222  induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
119034639  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 isoform X1 [KO:K02539]
119036050  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
119043398  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
119053789  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119064546  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
119047140  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
119050282  RELA; transcription factor p65 [KO:K04735]
119057921  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119062160  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
119052717  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
119059042  cellular tumor antigen p53-like [KO:K04451]
119053542  TP53; cellular tumor antigen p53 [KO:K04451]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
ajm00010  Glycolysis / Gluconeogenesis
ajm04010  MAPK signaling pathway
ajm04012  ErbB signaling pathway
ajm04062  Chemokine signaling pathway
ajm04064  NF-kappa B signaling pathway
ajm04068  FoxO signaling pathway
ajm04110  Cell cycle
ajm04115  p53 signaling pathway
ajm04150  mTOR signaling pathway
ajm04210  Apoptosis
ajm04370  VEGF signaling pathway
ajm04510  Focal adhesion
ajm04620  Toll-like receptor signaling pathway
ajm04630  JAK-STAT signaling pathway
ajm04662  B cell receptor signaling pathway
ajm04910  Insulin signaling pathway
KO pathway
ko04151   
LinkDB

DBGET integrated database retrieval system