KEGG   PATHWAY: ajm04020
Entry
ajm04020                    Pathway                                
Name
Calcium signaling pathway - Artibeus jamaicensis (Jamaican fruit-eating bat)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
ajm04020  Calcium signaling pathway
ajm04020

Other DBs
GO: 0019722
Organism
Artibeus jamaicensis (Jamaican fruit-eating bat) [GN:ajm]
Gene
119035799  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
119061536  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
119056645  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
119038334  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
119053230  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
119053360  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
119055061  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
119045439  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
119056082  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
119040261  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
119059203  ADORA2A; adenosine receptor A2a [KO:K04266]
119064469  ADORA2B; adenosine receptor A2b [KO:K04267]
119040081  ADRB1; beta-1 adrenergic receptor [KO:K04141]
119061394  ADRB2; beta-2 adrenergic receptor [KO:K04142]
119065031  ADRB3; beta-3 adrenergic receptor [KO:K04143]
119036243  DRD1; D(1A) dopamine receptor [KO:K04144]
119046202  D(1A) dopamine receptor-like [KO:K04144]
119065577  D(1A) dopamine receptor [KO:K04144]
119035602  DRD5; D(1B) dopamine receptor [KO:K05840]
119053034  LOW QUALITY PROTEIN: D(1B) dopamine receptor-like [KO:K05840]
119036230  HRH2; LOW QUALITY PROTEIN: histamine H2 receptor [KO:K04150]
119061402  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
119039290  HTR5A; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 5A [KO:K04161]
119045372  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
119057777  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
119055313  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
119055349  neuroendocrine secretory protein 55-like [KO:K04632]
119051300  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
119057313  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
119049317  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
119050413  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
119037286  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
119046468  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
119064806  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
119056281  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
119062886  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
119049690  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
119036901  PLN; cardiac phospholamban [KO:K05852]
119061343  SLN; sarcolipin [KO:K22642]
119045274  MRLN; myoregulin [KO:K22643]
119058504  SMIM6; small integral membrane protein 6 [KO:K26468]
119040159  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
119045360  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
119048857  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
119046021  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
119042105  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
119046178  stromal interaction molecule 2-like [KO:K16059]
119057814  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
119048683  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
119044708  ORAI2; protein orai-2 isoform X1 [KO:K16057]
119041170  ORAI3; protein orai-3 [KO:K16058]
119051688  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
119041393  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
119059521  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
119060725  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
119049676  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
119036142  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
119049601  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
119037442  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
119058149  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
119060520  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
119049769  neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
119036136  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
119041361  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
119042816  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
119065316  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
119045219  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
119044846  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
119044589  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
119040171  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
119060727  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
119046700  P2RX3; P2X purinoceptor 3 [KO:K05217]
119048805  P2RX4; P2X purinoceptor 4 [KO:K05218]
119040169  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
119038912  P2RX6; LOW QUALITY PROTEIN: P2X purinoceptor 6 [KO:K05221]
119048815  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
119046710  RYR1; LOW QUALITY PROTEIN: ryanodine receptor 1 [KO:K04961]
119065955  ryanodine receptor 2-like [KO:K04962]
119065956  ryanodine receptor 2 [KO:K04962]
119040254  RYR3; ryanodine receptor 3 [KO:K04963]
119045000  TRDN; triadin [KO:K23449]
119048472  CASQ1; calsequestrin-1 [KO:K23468]
119041698  CASQ2; calsequestrin-2 [KO:K23445]
119065411  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
119039443  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
119052925  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
119065196  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
119054379  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
119051203  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
119055972  AGTR1; type-1 angiotensin II receptor isoform X1 [KO:K04166]
119061713  EDNRA; endothelin-1 receptor [KO:K04197]
119055905  EDNRB; endothelin receptor type B [KO:K04198]
119048157  F2R; proteinase-activated receptor 1 [KO:K03914]
119049056  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
119043577  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
119058340  GRPR; gastrin-releasing peptide receptor [KO:K04169]
119044802  HRH1; histamine H1 receptor [KO:K04149]
119037301  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
119054300  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
119060884  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
119055315  NTSR1; neurotensin receptor type 1 [KO:K04211]
119041461  OXTR; oxytocin receptor [KO:K04229]
119045541  AVPR1A; vasopressin V1a receptor [KO:K04226]
119056804  AVPR1B; vasopressin V1b receptor [KO:K04227]
119037310  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
119052335  PTAFR; platelet-activating factor receptor [KO:K04279]
119049696  prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
119045309  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
119051402  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
119037951  BDKRB1; B1 bradykinin receptor [KO:K03915]
119037962  BDKRB2; B2 bradykinin receptor [KO:K03916]
119038421  TACR1; substance-P receptor [KO:K04222]
119038132  TACR2; substance-K receptor [KO:K04223]
119065774  TACR3; neuromedin-K receptor [KO:K04224]
119063780  TBXA2R; thromboxane A2 receptor [KO:K04264]
119064990  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
119057816  CCKAR; cholecystokinin receptor type A [KO:K04194]
119062028  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
119049942  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
119052107  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
119063760  GNA11; guanine nucleotide-binding protein subunit alpha-11 isoform X1 [KO:K04635]
119052105  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
119063752  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
119057431  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
119035804  TGFA; LOW QUALITY PROTEIN: protransforming growth factor alpha [KO:K08774]
119043762  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
119060441  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
119034635  PDGFC; platelet-derived growth factor C [KO:K05450]
119046553  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
119046588  FGF1; fibroblast growth factor 1 [KO:K18496]
119037695  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
119044632  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
119036213  FGF18; fibroblast growth factor 18 [KO:K04358]
119036918  FGF20; fibroblast growth factor 20 [KO:K04358]
119039457  FGF16; fibroblast growth factor 16 [KO:K04358]
119041822  FGF3; fibroblast growth factor 3 [KO:K04358]
119041829  FGF4; fibroblast growth factor 4 [KO:K04358]
119059701  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
119054793  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
119054857  FGF6; fibroblast growth factor 6 [KO:K04358]
119056409  FGF9; fibroblast growth factor 9 [KO:K04358]
119049154  FGF10; fibroblast growth factor 10 [KO:K04358]
119056920  FGF5; fibroblast growth factor 5 [KO:K04358]
119057632  FGF7; fibroblast growth factor 7 [KO:K04358]
119041821  FGF19; fibroblast growth factor 19 [KO:K22603]
119058291  FGF21; fibroblast growth factor 21 [KO:K22429]
119054853  FGF23; fibroblast growth factor 23 [KO:K22428]
119055590  VEGFA; vascular endothelial growth factor A [KO:K05448]
119045456  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
119050320  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
119058362  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
119041752  NGF; beta-nerve growth factor [KO:K02582]
119044937  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
119036636  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
119037029  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
119057339  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
119048554  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
119044331  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
119054288  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
119061365  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
119065040  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
119063507  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
119035526  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
119035149  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
119041773  vascular endothelial growth factor receptor kdr-like [KO:K05096] [EC:2.7.10.1]
119064949  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
119042619  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
119044890  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
119039739  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
119060018  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
119049115  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
119038260  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
119036701  MST1R; macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
119038025  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
119048495  uncharacterized protein LOC119048495 [KO:K10785]
119048496  uncharacterized protein LOC119048496 [KO:K10785]
119039497  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
119042685  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05857] [EC:3.1.4.11]
119051509  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
119061551  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
119057279  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05857] [EC:3.1.4.11]
119045446  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
119061296  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
119057282  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
119063199  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
119047103  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
119047563  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
119042782  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
119036740  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
119048995  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
119041225  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
119035514  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
119040439  TPCN1; two pore calcium channel protein 1 [KO:K16896]
119041892  TPCN2; two pore calcium channel protein 2 [KO:K14077]
119045325  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
119062883  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
119062901  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
119044423  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
119058541  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
119038081  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
119037617  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
119038134  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
119053810  LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 2-like [KO:K15040]
119047138  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
119035353  ADP,ATP carrier protein 1, mitochondrial [KO:K05863]
119036890  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
119037676  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
119045737  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
119046880  ADP,ATP carrier protein [KO:K05863]
119062994  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
119050103  ADP/ATP translocase 3-like [KO:K05863]
119056937  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
119041449  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
119063251  TNNC2; troponin C, skeletal muscle [KO:K12042]
119035940  calmodulin-2/4 [KO:K02183]
119037894  CALM1; calmodulin-1 [KO:K02183]
119053333  calmodulin-2/4 [KO:K02183]
119060885  CALM2; calmodulin-2 [KO:K02183]
119056493  calmodulin-A-like [KO:K02183]
119056633  CALM3; calmodulin-3 [KO:K02183]
119057111  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
119057312  calmodulin-alpha-like [KO:K02183]
119057735  CALML3; calmodulin-like protein 3 [KO:K02183]
119050509  CALML6; calmodulin-like protein 6 [KO:K02183]
119041148  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
119055031  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
119048988  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
119049465  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
119058372  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
119036780  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
119039481  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
119047724  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
119049053  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
119043086  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
119041384  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
119056691  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
119037697  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
119038077  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
119052888  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
119061401  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
119065119  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
119038093  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119054082  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119054654  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119044841  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
119035024  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
119054181  calcineurin B-like protein 2 [KO:K06268]
119063034  calcineurin B-like protein 6 [KO:K06268]
119056576  TFEB; transcription factor EB [KO:K15590]
119051373  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
119040619  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
119061858  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
119037304  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
119057483  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
119062015  NOS2; LOW QUALITY PROTEIN: nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
119039263  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
119035225  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
119038649  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
119059842  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
119044625  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
119044457  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
119040674  ITPKC; inositol-trisphosphate 3-kinase C isoform X1 [KO:K00911] [EC:2.7.1.127]
119061306  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
119036326  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
119043241  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
119036009  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
ajm04010  MAPK signaling pathway
ajm04070  Phosphatidylinositol signaling system
ajm04210  Apoptosis
ajm04720  Long-term potentiation
ajm04730  Long-term depression
KO pathway
ko04020   
LinkDB

DBGET integrated database retrieval system