KEGG   PATHWAY: bom00230
Entry
bom00230                    Pathway                                
Name
Purine metabolism - Bos mutus (wild yak)
Class
Metabolism; Nucleotide metabolism
Pathway map
bom00230  Purine metabolism
bom00230

Module
bom_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:bom00230]
bom_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:bom00230]
bom_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:bom00230]
bom_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:bom00230]
bom_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:bom00230]
bom_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:bom00230]
bom_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:bom00230]
Other DBs
GO: 0006163 0042278
Organism
Bos mutus (wild yak) [GN:bom]
Gene
102275356  NUDT9; nudix hydrolase 9 [KO:K13988] [EC:3.6.1.13]
102283155  ADPRM; ADP-ribose/CDP-alcohol diphosphatase, manganese dependent [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
102283030  NUDT5; nudix hydrolase 5 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
102275907  PGM1; phosphoglucomutase 1 [KO:K01835] [EC:5.4.2.2]
102280136  PGM2; phosphoglucomutase 2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
102280556  PRPS2; phosphoribosyl pyrophosphate synthetase 2 [KO:K00948] [EC:2.7.6.1]
102287634  PRPS1; phosphoribosyl pyrophosphate synthetase 1 [KO:K00948] [EC:2.7.6.1]
102279419  PRPS1L1; phosphoribosyl pyrophosphate synthetase 1-like 1 [KO:K00948] [EC:2.7.6.1]
102281820  PPAT; phosphoribosyl pyrophosphate amidotransferase [KO:K00764] [EC:2.4.2.14]
102276357  GART; phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
102278326  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
102281546  PAICS; phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01587] [EC:4.1.1.21 6.3.2.6]
102269000  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
102279895  ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
102269535  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
102283428  NT5C1A; 5'-nucleotidase, cytosolic IA [KO:K01081] [EC:3.1.3.5]
102269212  NT5C2; 5'-nucleotidase, cytosolic II [KO:K01081] [EC:3.1.3.5]
102274425  NT5C; 5', 3'-nucleotidase, cytosolic [KO:K01081] [EC:3.1.3.5]
102273896  NT5C1B; cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
102287390  NT5DC4; 5'-nucleotidase domain containing 4 [KO:K01081] [EC:3.1.3.5]
102273429  NT5E; 5'-nucleotidase ecto [KO:K19970] [EC:3.1.3.5]
102270686  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
102267804  purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
102279845  LACC1; laccase domain containing 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
102287153  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
102277095  HPRT1; hypoxanthine phosphoribosyltransferase 1 [KO:K00760] [EC:2.4.2.8]
102276618  IMPDH2; inosine monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
102278605  IMPDH1; inosine monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
102274826  NME2; nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
102275491  NME1; NME/NM23 nucleoside diphosphate kinase 1 [KO:K00940] [EC:2.7.4.6]
102282220  NME4; NME/NM23 nucleoside diphosphate kinase 4 [KO:K00940] [EC:2.7.4.6]
102270075  NME6; NME/NM23 nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
102270209  NME7; NME/NM23 family member 7 [KO:K00940] [EC:2.7.4.6]
102275074  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
102285509  adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
102273587  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
102270483  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
102269229  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
102272160  CANT1; calcium activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
102283172  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
102278224  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
102264690  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 (putative) [KO:K01511] [EC:3.6.1.6]
102264435  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
102274757  ITPA; inosine triphosphatase [KO:K01519] [EC:3.6.1.66]
102264420  XDH; xanthine dehydrogenase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
102273937  NUDT2; nudix hydrolase 2 [KO:K01518] [EC:3.6.1.17]
102270298  GMPS; guanine monophosphate synthase [KO:K01951] [EC:6.3.5.2]
102271841  GMPR2; guanosine monophosphate reductase 2 [KO:K00364] [EC:1.7.1.7]
102266183  GMPR; guanosine monophosphate reductase [KO:K00364] [EC:1.7.1.7]
102279505  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
102276462  GUK1; guanylate kinase 1 [KO:K00942] [EC:2.7.4.8]
102272609  RRM1; ribonucleotide reductase catalytic subunit M1 [KO:K10807] [EC:1.17.4.1]
102280923  RRM2; ribonucleotide reductase regulatory subunit M2 [KO:K10808] [EC:1.17.4.1]
102267033  RRM2B; ribonucleotide reductase regulatory TP53 inducible subunit M2B [KO:K10808] [EC:1.17.4.1]
102279990  HDDC2; HD domain containing 2 [KO:K07023] [EC:3.1.3.89]
102276277  DGUOK; deoxyguanosine kinase [KO:K00904] [EC:2.7.1.113]
102268258  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
102266566  HDDC3; HD domain containing 3 [KO:K21138] [EC:3.1.7.2]
102265887  PRUNE1; prune exopolyphosphatase [KO:K01514] [EC:3.6.1.11]
102267116  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
102274117  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
102282732  ADCY3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
102286168  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
102276460  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
102265325  ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
102266966  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
102272964  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
102285642  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
102282921  ADCY10; adenylate cyclase 10, soluble [KO:K11265] [EC:4.6.1.1]
102281834  GUCY1A3; guanylate cyclase 1 soluble subunit alpha [KO:K12318] [EC:4.6.1.2]
102280817  GUCY1A2; guanylate cyclase 1 soluble subunit alpha 2 [KO:K12318] [EC:4.6.1.2]
102282106  GUCY1B3; guanylate cyclase 1 soluble subunit beta [KO:K12319] [EC:4.6.1.2]
102285947  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
102284444  GUCY2C; guanylate cyclase 2C [KO:K12320] [EC:4.6.1.2]
102281141  GUCY2D; guanylate cyclase 2D, retinal [KO:K12321] [EC:4.6.1.2]
102267198  olfactory guanylyl cyclase GC-D-like [KO:K12321] [EC:4.6.1.2]
102274513  GUCY2F; guanylate cyclase 2F, retinal [KO:K12322] [EC:4.6.1.2]
102279810  NPR1; natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
102278070  NPR2; natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
102265198  PDE1C; phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
102268455  PDE1B; phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
102275745  PDE1A; phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
102278787  PDE2A; phosphodiesterase 2A [KO:K18283] [EC:3.1.4.17]
102285332  PDE3A; phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
102285991  cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
102282516  PDE5A; phosphodiesterase 5A [KO:K13762] [EC:3.1.4.35]
102271429  PDE6A; phosphodiesterase 6A [KO:K08718] [EC:3.1.4.35]
102284469  PDE6B; phosphodiesterase 6B [KO:K13756] [EC:3.1.4.35]
102268034  PDE6C; phosphodiesterase 6C [KO:K13757] [EC:3.1.4.35]
102286514  PDE6D; phosphodiesterase 6D [KO:K13758]
102285284  PDE6G; phosphodiesterase 6G [KO:K13759]
102287072  PDE6H; phosphodiesterase 6H [KO:K13760]
102266407  PDE9A; phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
102270506  PDE10A; phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
102282288  PDE11A; phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
102269343  ADSS; adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
102282644  ADSSL1; adenylosuccinate synthase like 1 [KO:K01939] [EC:6.3.4.4]
102268750  AMPD1; adenosine monophosphate deaminase 1 [KO:K01490] [EC:3.5.4.6]
102284116  AMPD2; adenosine monophosphate deaminase 2 [KO:K01490] [EC:3.5.4.6]
102277495  AMPD3; adenosine monophosphate deaminase 3 [KO:K01490] [EC:3.5.4.6]
102286067  ADK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
102272399  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
102278611  CECR1; cat eye syndrome chromosome region, candidate 1 [KO:K19572] [EC:3.5.4.4]
102280126  AK5; adenylate kinase 5 [KO:K00939] [EC:2.7.4.3]
102279301  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
102268360  AK4; adenylate kinase 4 [KO:K00939] [EC:2.7.4.3]
102279008  adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
102280423  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
102287105  AK1; adenylate kinase 1 [KO:K00939] [EC:2.7.4.3]
102271572  AK2; adenylate kinase 2 [KO:K00939] [EC:2.7.4.3]
102287009  AK6; adenylate kinase 6 [KO:K18532] [EC:2.7.4.3]
102279433  AK3; adenylate kinase 3 [KO:K00944] [EC:2.7.4.10]
102274413  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
102274649  NTPCR; nucleoside-triphosphatase, cancer-related [KO:K06928] [EC:3.6.1.15]
102266516  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
102266801  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
102287837  PDE4A; phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
102271431  PDE4B; phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
102265275  PDE4C; phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
102286535  PDE4D; phosphodiesterase 4D [KO:K13293] [EC:3.1.4.53]
102275215  PDE7A; phosphodiesterase 7A [KO:K18436] [EC:3.1.4.53]
102277971  PDE7B; phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
102267475  PDE8B; phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
102277153  PDE8A; phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
102283297  FHIT; fragile histidine triad [KO:K01522] [EC:3.6.1.29]
102274093  ENPP4; ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) [KO:K18424] [EC:3.6.1.29]
102279777  PAPSS1; 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
102267914  PAPSS2; 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
102267915  uricase [KO:K00365] [EC:1.7.3.3]
102276165  5-hydroxyisourate hydrolase-like [KO:K07127] [EC:3.5.2.17]
102272391  URAD; ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase [KO:K13485] [EC:4.1.1.97]
102264635  ALLC; allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
bom00030  Pentose phosphate pathway
bom00220  Arginine biosynthesis
bom00250  Alanine, aspartate and glutamate metabolism
bom00260  Glycine, serine and threonine metabolism
bom00340  Histidine metabolism
bom00630  Glyoxylate and dicarboxylate metabolism
bom00730  Thiamine metabolism
bom00740  Riboflavin metabolism
bom00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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