KEGG   PATHWAY: bvan03040
Entry
bvan03040                   Pathway                                
Name
Spliceosome - Bombus vancouverensis nearcticus
Description
After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class
Genetic Information Processing; Transcription
Pathway map
bvan03040  Spliceosome
bvan03040

Other DBs
GO: 0005681
Organism
Bombus vancouverensis nearcticus [GN:bvan]
Gene
117161019  U1 spliceosomal RNA [KO:K14276]
117163827  U1 spliceosomal RNA [KO:K14276]
117154899  U2 spliceosomal RNA [KO:K14277]
117161802  U2 spliceosomal RNA [KO:K14277]
117164545  U4 spliceosomal RNA [KO:K14278]
117153764  U4 spliceosomal RNA [KO:K14278]
117163822  U5 spliceosomal RNA [KO:K14279]
117157878  U6 spliceosomal RNA [KO:K14280]
117157748  U6 spliceosomal RNA [KO:K14280]
117155535  probable ATP-dependent RNA helicase DDX46 isoform X1 [KO:K12811] [EC:5.6.2.7]
117163683  ATP-dependent RNA helicase WM6 isoform X1 [KO:K12812] [EC:5.6.2.7]
117162068  pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [KO:K12813] [EC:5.6.2.6]
117154410  pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [KO:K12815] [EC:5.6.2.6]
117159542  pre-mRNA-processing factor 17 [KO:K12816]
117164782  pre-mRNA-splicing factor 18 isoform X1 [KO:K12817]
117154635  ATP-dependent RNA helicase DHX8 [KO:K12818] [EC:5.6.2.6]
117155163  pre-mRNA-splicing factor SLU7 [KO:K12819]
117164440  putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 isoform X1 [KO:K12820] [EC:5.6.2.6]
117159548  small nuclear ribonucleoprotein-associated protein B isoform X1 [KO:K11086]
117164156  probable small nuclear ribonucleoprotein Sm D1 isoform X1 [KO:K11087]
117164615  probable small nuclear ribonucleoprotein Sm D2 [KO:K11096]
117164683  probable small nuclear ribonucleoprotein Sm D2 [KO:K11096]
117161251  small nuclear ribonucleoprotein Sm D3 [KO:K11088]
117162974  small nuclear ribonucleoprotein F [KO:K11098]
117166211  probable small nuclear ribonucleoprotein G [KO:K11099]
117153377  LOW QUALITY PROTEIN: U1 small nuclear ribonucleoprotein 70 kDa-like [KO:K11093]
117156394  U1 small nuclear ribonucleoprotein C [KO:K11095]
117156811  pre-mRNA-processing factor 40 homolog A isoform X1 [KO:K12821]
117160237  RNA-binding protein 25 isoform X1 [KO:K12822]
117164123  DEAD-box ATP-dependent RNA helicase 20-like [KO:K12823] [EC:5.6.2.7]
117156713  ATP-dependent RNA helicase p62-like isoform X1 [KO:K12823] [EC:5.6.2.7]
117164997  ATP-dependent RNA helicase dbp2-like isoform X1 [KO:K12823] [EC:5.6.2.7]
117165025  ATP-dependent RNA helicase dbp2-like isoform X1 [KO:K12823] [EC:5.6.2.7]
117159445  transcription elongation regulator 1 isoform X1 [KO:K12824]
117160922  RNA-binding protein cabeza-like isoform X1 [KO:K13098]
117159177  probable U2 small nuclear ribonucleoprotein A' [KO:K11092]
117157210  U1 small nuclear ribonucleoprotein A [KO:K11094]
117155922  splicing factor 3A subunit 1 [KO:K12825]
117159247  splicing factor 3A subunit 2 [KO:K12826]
117166277  splicing factor 3A subunit 3 [KO:K12827]
117165915  splicing factor 3B subunit 1 isoform X1 [KO:K12828]
117156294  splicing factor 3B subunit 2 isoform X1 [KO:K12829]
117156537  splicing factor 3B subunit 3 [KO:K12830]
117162033  splicing factor 3B subunit 4 [KO:K12831]
117165860  splicing factor 3B subunit 5 [KO:K12832]
117163673  splicing factor 3B subunit 6 [KO:K12833]
117165118  PHD finger-like domain-containing protein 5A [KO:K12834]
117154670  ATP-dependent RNA helicase DDX42 [KO:K12835] [EC:5.6.2.7]
117156968  splicing factor U2af 38 kDa subunit [KO:K12836]
117160697  splicing factor U2AF 50 kDa subunit isoform X1 [KO:K12837]
117166099  poly(U)-binding-splicing factor half pint isoform X1 [KO:K12838]
117165940  survival of motor neuron-related-splicing factor 30 isoform X1 [KO:K12839]
117158850  splicing factor 45 [KO:K12840]
117163561  calcium homeostasis endoplasmic reticulum protein isoform X1 [KO:K12841]
117156427  U2 snRNP-associated SURP motif-containing protein [KO:K12842]
117165064  U6 snRNA-associated Sm-like protein LSm2 [KO:K12621]
117164066  U6 snRNA-associated Sm-like protein LSm3 [KO:K12622]
117163688  U6 snRNA-associated Sm-like protein LSm4 [KO:K12623]
117153245  U6 snRNA-associated Sm-like protein LSm5 [KO:K12624]
117153246  U6 snRNA-associated Sm-like protein LSm6 [KO:K12625]
117160945  U6 snRNA-associated Sm-like protein LSm7 isoform X1 [KO:K12626]
117157296  U6 snRNA-associated Sm-like protein LSm8 [KO:K12627]
117159057  uncharacterized protein LOC117159057 [KO:K12843]
117166403  U4/U6 small nuclear ribonucleoprotein Prp4 [KO:K12662]
117154205  peptidyl-prolyl cis-trans isomerase H [KO:K09567] [EC:5.2.1.8]
117164142  U4/U6 small nuclear ribonucleoprotein Prp31 [KO:K12844]
117166539  NHP2-like protein 1 [KO:K12845]
117166335  U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [KO:K12846]
117164855  U4/U6.U5 tri-snRNP-associated protein 2 [KO:K12847]
117154097  U4/U6.U5 tri-snRNP-associated protein 1 [KO:K11984]
117163349  zinc finger matrin-type protein 2 [KO:K12848]
117156213  pre-mRNA-splicing factor 38 [KO:K12849]
117153803  pre-mRNA-splicing factor 38B isoform X1 [KO:K12850]
117154839  116 kDa U5 small nuclear ribonucleoprotein component [KO:K12852]
117159014  putative U5 small nuclear ribonucleoprotein 200 kDa helicase [KO:K12854] [EC:5.6.2.6]
117156666  pre-mRNA-processing factor 6 [KO:K12855]
117153717  pre-mRNA-processing-splicing factor 8 [KO:K12856]
117160982  U5 small nuclear ribonucleoprotein 40 kDa protein [KO:K12857]
117155130  probable ATP-dependent RNA helicase DDX23 [KO:K12858] [EC:5.6.2.7]
117165897  thioredoxin-like protein 4A [KO:K12859]
117153883  pre-mRNA-processing factor 19 [KO:K10599] [EC:2.3.2.27]
117164848  cell division cycle 5-like protein isoform X1 [KO:K12860]
117166480  pre-mRNA-splicing factor SPF27 [KO:K12861]
117159699  pleiotropic regulator 1 [KO:K12862]
117155995  spliceosome-associated protein CWC15 homolog [KO:K12863]
117156131  beta-catenin-like protein 1 [KO:K12864]
117160055  heat shock 70 kDa protein cognate 4 [KO:K03283]
117153555  heat shock 70 kDa protein cognate 4-like isoform X1 [KO:K03283]
117160791  polyglutamine-binding protein 1 [KO:K12865]
117158705  WW domain-binding protein 11 isoform X1 [KO:K12866]
117164250  puff-specific protein Bx42 [KO:K06063]
117154356  pre-mRNA-splicing factor syf1 homolog [KO:K12867]
117155466  pre-mRNA-splicing factor Syf2 [KO:K12868]
117159681  protein crooked neck [KO:K12869]
117156315  pre-mRNA-splicing factor ISY1 homolog [KO:K12870]
117155564  peptidyl-prolyl cis-trans isomerase-like 1 isoform X1 [KO:K12733] [EC:5.2.1.8]
117163392  peptidyl-prolyl cis-trans isomerase E isoform X1 [KO:K09564] [EC:5.2.1.8]
117157277  coiled-coil domain-containing protein 12 [KO:K12871]
117158273  pre-mRNA-splicing factor RBM22 isoform X1 [KO:K12872]
117165090  protein BUD31 homolog [KO:K12873]
117161980  RNA helicase aquarius isoform X1 [KO:K12874]
117159586  apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
117156371  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
117165040  RNA-binding protein 8A [KO:K12876]
117154221  protein mago nashi homolog [KO:K12877]
117166678  THO complex subunit 1 isoform X1 [KO:K12878]
117161500  THO complex subunit 2 isoform X1 [KO:K12879]
117163327  THO complex subunit 3 [KO:K12880]
117159770  THO complex subunit 4 [KO:K12881]
117166797  nuclear cap-binding protein subunit 1 [KO:K12882]
117159550  nuclear cap-binding protein subunit 2 isoform X1 [KO:K12883]
117163733  heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog isoform X1 [KO:K12741]
117163780  heterogeneous nuclear ribonucleoprotein K isoform X1 [KO:K12886]
117157351  serine/arginine-rich splicing factor 1B [KO:K12890]
117155143  serine/arginine-rich splicing factor 2 [KO:K12891]
117161010  serine-arginine protein 55 isoform X1 [KO:K12893]
117154023  RNA-binding protein 1-like isoform X1 [KO:K12896]
117166232  LOW QUALITY PROTEIN: serine/arginine-rich splicing factor 7-like [KO:K12896]
117156796  transformer-2 protein homolog beta isoform X1 [KO:K12897]
Reference
PMID:19239890
  Authors
Wahl MC, Will CL, Luhrmann R
  Title
The spliceosome: design principles of a dynamic RNP machine.
  Journal
Cell 136:701-18 (2009)
DOI:10.1016/j.cell.2009.02.009
Reference
PMID:10978320
  Authors
Morris DP, Greenleaf AL
  Title
The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
  Journal
J Biol Chem 275:39935-43 (2000)
DOI:10.1074/jbc.M004118200
Reference
PMID:17537823
  Authors
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
  Title
Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
  Journal
Nucleic Acids Res 35:3928-44 (2007)
DOI:10.1093/nar/gkm347
Reference
PMID:19733268
  Authors
Ritchie DB, Schellenberg MJ, MacMillan AM
  Title
Spliceosome structure: piece by piece.
  Journal
Biochim Biophys Acta 1789:624-33 (2009)
DOI:10.1016/j.bbagrm.2009.08.010
KO pathway
ko03040   
LinkDB

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