KEGG   PATHWAY: caty04726
Entry
caty04726                   Pathway                                
Name
Serotonergic synapse - Cercocebus atys (sooty mangabey)
Description
Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class
Organismal Systems; Nervous system
Pathway map
caty04726  Serotonergic synapse
caty04726

Other DBs
GO: 0007210
Organism
Cercocebus atys (sooty mangabey) [GN:caty]
Gene
105581034  TPH2; tryptophan 5-hydroxylase 2 [KO:K00502] [EC:1.14.16.4]
105598886  TPH1; tryptophan 5-hydroxylase 1 isoform X1 [KO:K00502] [EC:1.14.16.4]
105588286  DDC; aromatic-L-amino-acid decarboxylase [KO:K01593] [EC:4.1.1.28 4.1.1.105]
105577951  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
105579256  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
105582968  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105585586  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105573107  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105575216  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
105587772  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
105598426  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
105591599  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
105584209  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
105577494  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
105574260  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105582089  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105582092  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105585726  ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105601409  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
105593244  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105599331  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105586076  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105595654  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105598233  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105598850  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105579889  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
105595443  PLA2G4C; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
105574211  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
105574213  PLA2G4E; cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
105574214  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
105574265  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
105587200  cytochrome P450 2C20 [KO:K17718] [EC:1.14.14.1]
105576140  cytochrome P450 2C20-like [KO:K17718] [EC:1.14.14.1]
105576141  cytochrome P450 2C20 isoform X1 [KO:K17718] [EC:1.14.14.1]
105586929  cytochrome P450 2C9-like [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
105586938  cytochrome P450 2C9 [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
105581138  cytochrome P450 2C9-like [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
105575618  cytochrome P450 2C9-like [KO:K17719] [EC:1.14.14.51 1.14.14.52 1.14.14.53 1.14.14.-]
105586945  cytochrome P450 2C18 isoform X1 [KO:K17720] [EC:1.14.14.1]
105581754  cytochrome P450 2C3-like [KO:K07413] [EC:1.14.14.1]
105576142  LOW QUALITY PROTEIN: cytochrome P450 2C3-like [KO:K07413] [EC:1.14.14.1]
105572143  cytochrome P450 2D17 [KO:K17712] [EC:1.14.14.1]
105573227  LOW QUALITY PROTEIN: cytochrome P450 2D17-like [KO:K17712] [EC:1.14.14.1]
105595967  cytochrome P450 2J2 isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
105571708  cytochrome P450 4X1 isoform X1 [KO:K07428] [EC:1.14.14.1]
105576135  ALOX5; arachidonate 5-lipoxygenase [KO:K00461] [EC:1.13.11.34]
105582822  ALOX12; arachidonate 12-lipoxygenase, 12S-type [KO:K00458] [EC:1.13.11.31]
105584566  arachidonate 12-lipoxygenase, epidermal-type-like [KO:K00458] [EC:1.13.11.31]
105581980  ALOX12B; arachidonate 12-lipoxygenase, 12R-type [KO:K08021] [EC:1.13.11.-]
105583615  ALOX15; arachidonate 15-lipoxygenase [KO:K00460] [EC:1.13.11.33]
105581986  ALOX15B; arachidonate 15-lipoxygenase B isoform X1 [KO:K08022] [EC:1.13.11.33 1.13.11.-]
105599950  PTGS1; prostaglandin G/H synthase 1 isoform X1 [KO:K00509] [EC:1.14.99.1]
105579902  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105588662  HTR3A; 5-hydroxytryptamine receptor 3A isoform X1 [KO:K04819]
105588664  HTR3B; 5-hydroxytryptamine receptor 3B [KO:K04819]
105573981  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3C-like [KO:K04819]
105573982  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3E-like [KO:K04819]
105574006  HTR3E; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3E [KO:K04819]
105574007  LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 3C-like [KO:K04819]
105589855  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
105595060  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
105587141  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
105585318  neuroendocrine secretory protein 55 [KO:K04632]
105585319  guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
105589787  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
105593561  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105601580  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105584148  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
105590682  KCNN2; small conductance calcium-activated potassium channel protein 2 isoform X1 [KO:K04943]
105598487  KCND2; potassium voltage-gated channel subfamily D member 2 [KO:K04892]
105592990  GABRB3; gamma-aminobutyric acid receptor subunit beta-3 isoform X1 [KO:K05181]
105596113  GABRB1; gamma-aminobutyric acid receptor subunit beta-1 isoform X1 [KO:K05181]
105581596  GABRB2; gamma-aminobutyric acid receptor subunit beta-2 isoform X1 [KO:K05181]
105580438  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X1 [KO:K08014]
105571836  APP; amyloid beta A4 protein isoform X1 [KO:K04520]
105595008  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
105588051  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
105589010  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
105597614  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
105583587  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
105588141  5-hydroxytryptamine receptor 5B [KO:K04161]
105573085  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
105594342  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
105573715  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
105583233  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
105588486  GNAO1; guanine nucleotide-binding protein G(o) subunit alpha isoform X1 [KO:K04534]
105594434  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
105584442  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
105583036  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
105597720  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
105601141  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
105586615  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
105577543  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
105580742  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
105592180  GNG11; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105581531  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
105601524  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
105595886  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
105592179  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
105579462  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
105593734  LOW QUALITY PROTEIN: caspase-3-like [KO:K02187] [EC:3.4.22.56]
105597738  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105581659  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
105577198  HRAS; GTPase HRas isoform X1 [KO:K02833]
105585038  KRAS; GTPase KRas isoform X1 [KO:K07827]
105596344  NRAS; GTPase NRas isoform X1 [KO:K07828]
105590503  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
105589671  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105585803  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105601165  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105601562  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
105580650  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
105575989  KCNJ3; G protein-activated inward rectifier potassium channel 1 isoform X1 [KO:K04997]
105575434  KCNJ6; G protein-activated inward rectifier potassium channel 2 isoform X1 [KO:K05000]
105589290  KCNJ9; G protein-activated inward rectifier potassium channel 3 isoform X1 [KO:K05002]
105582639  KCNJ5; G protein-activated inward rectifier potassium channel 4 [KO:K04999]
105586339  TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
105591559  SLC6A4; sodium-dependent serotonin transporter isoform X1 [KO:K05037]
105590551  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
105590553  amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
Compound
C00076  Calcium cation
C00078  L-Tryptophan
C00165  Diacylglycerol
C00219  Arachidonate
C00238  Potassium cation
C00427  Prostaglandin H2
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00639  Prostaglandin F2alpha
C00643  5-Hydroxy-L-tryptophan
C00696  Prostaglandin D2
C00780  Serotonin
C00909  Leukotriene A4
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C02165  Leukotriene B4
C02166  Leukotriene C4
C02198  Thromboxane A2
C04822  8(R)-HPETE
C05356  5(S)-HPETE
C05635  5-Hydroxyindoleacetate
C05953  Prostaglandin A2
C05954  Prostaglandin B2
C05955  Prostaglandin C2
C05956  Prostaglandin G2
C05957  Prostaglandin J2
C05963  Thromboxane B2
C05964  11-Dehydro-thromboxane B2
C05965  12(S)-HPETE
C05966  15(S)-HPETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
C14772  5,6-DHET
C14773  8,9-DHET
C14774  11,12-DHET
C14775  14,15-DHET
C14812  12(R)-HPETE
C14820  11(R)-HPETE
C14821  9(S)-HPETE
C14823  8(S)-HPETE
Reference
PMID:18676031
  Authors
Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
  Title
Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
  Journal
Trends Pharmacol Sci 29:454-64 (2008)
DOI:10.1016/j.tips.2008.06.007
Reference
PMID:16896947
  Authors
Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
  Title
Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
  Journal
Cell Tissue Res 326:553-72 (2006)
DOI:10.1007/s00441-006-0286-1
Reference
PMID:11916537
  Authors
Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
  Title
Multiplicity of mechanisms of serotonin receptor signal transduction.
  Journal
Pharmacol Ther 92:179-212 (2001)
DOI:10.1016/S0163-7258(01)00169-3
Reference
PMID:15034221
  Authors
Noda M, Higashida H, Aoki S, Wada K
  Title
Multiple signal transduction pathways mediated by 5-HT receptors.
  Journal
Mol Neurobiol 29:31-9 (2004)
DOI:10.1385/MN:29:1:31
Reference
PMID:20561690
  Authors
Daubert EA, Condron BG
  Title
Serotonin: a regulator of neuronal morphology and circuitry.
  Journal
Trends Neurosci 33:424-34 (2010)
DOI:10.1016/j.tins.2010.05.005
Reference
PMID:16826372
  Authors
Chameau P, van Hooft JA
  Title
Serotonin 5-HT(3) receptors in the central nervous system.
  Journal
Cell Tissue Res 326:573-81 (2006)
DOI:10.1007/s00441-006-0255-8
Reference
PMID:9651340
  Authors
Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
  Title
Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
  Journal
J Biol Chem 273:17498-503 (1998)
DOI:10.1074/jbc.273.28.17498
Reference
PMID:19545642
  Authors
Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
  Title
Epoxyeicosanoid signaling in CNS function and disease.
  Journal
Prostaglandins Other Lipid Mediat 91:68-84 (2010)
DOI:10.1016/j.prostaglandins.2009.06.004
Reference
PMID:12676358
  Authors
Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
  Title
The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
  Journal
Biochim Biophys Acta 1640:85-96 (2003)
DOI:10.1016/S0167-4889(03)00023-5
Reference
PMID:11701344
  Authors
Albert PR, Tiberi M
  Title
Receptor signaling and structure: insights from serotonin-1 receptors.
  Journal
Trends Endocrinol Metab 12:453-60 (2001)
DOI:10.1016/S1043-2760(01)00498-2
Reference
PMID:9658404
  Authors
Durham PL, Russo AF
  Title
Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
  Journal
Mol Endocrinol 12:1002-9 (1998)
DOI:10.1210/mend.12.7.0135
Reference
PMID:15710402
  Authors
Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
  Title
Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
  Journal
FEBS Lett 579:1136-42 (2005)
DOI:10.1016/j.febslet.2005.01.010
Reference
PMID:12543273
  Authors
Lezoualc'h F, Robert SJ
  Title
The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
  Journal
Exp Gerontol 38:159-66 (2003)
DOI:10.1016/S0531-5565(02)00157-2
Reference
PMID:11043573
  Authors
Durham PL, Russo AF
  Title
Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
  Journal
Mol Endocrinol 14:1570-82 (2000)
DOI:10.1210/mend.14.10.0529
Reference
PMID:9542727
  Authors
Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
  Title
Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
  Journal
Neurochem Int 32:153-62 (1998)
DOI:10.1016/S0197-0186(97)00087-9
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Related
pathway
caty00380  Tryptophan metabolism
caty00590  Arachidonic acid metabolism
caty04020  Calcium signaling pathway
caty04721  Synaptic vesicle cycle
caty04976  Bile secretion
KO pathway
ko04726   
LinkDB

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