KEGG   PATHWAY: caty04020
Entry
caty04020                   Pathway                                
Name
Calcium signaling pathway - Cercocebus atys (sooty mangabey)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
caty04020  Calcium signaling pathway
caty04020

Other DBs
GO: 0019722
Organism
Cercocebus atys (sooty mangabey) [GN:caty]
Gene
105571365  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105571386  TACR3; neuromedin-K receptor [KO:K04224]
105571434  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105571464  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
105571497  [KO:K26467]
105571572  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
105571784  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
105571937  ADORA2B; adenosine receptor A2b [KO:K04267]
105571983  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
105572097  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
105572154  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
105572732  TRDN; triadin [KO:K23449]
105572851  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
105572960  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
105573085  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
105573107  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105573152  TPCN1; two pore calcium channel protein 1 isoform X1 [KO:K16896]
105573204  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
105573513  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
105573699  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
105573709  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
105573807  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
105573908  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
105574042  [KO:K06856]
105574047  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
105574050  [KO:K06856]
105574052  [KO:K06856]
105574060  [KO:K06856]
105574071  [KO:K06856]
105574077  [KO:K06856]
105574081  [KO:K06856]
105574082  [KO:K06856]
105574084  [KO:K06856]
105574198  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
105574260  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105574405  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
105574647  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
105574679  GRPR; gastrin-releasing peptide receptor [KO:K04169]
105574688  FIGF; vascular endothelial growth factor D [KO:K05449]
105574783  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
105574914  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
105574977  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
105575058  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
105575216  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
105575889  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
105575920  [KO:K06856]
105575923  [KO:K06856]
105575925  [KO:K06856]
105576116  ADORA2A; adenosine receptor A2a isoform X1 [KO:K04266]
105576501  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
105576539  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
105576573  AVPR1B; vasopressin V1b receptor [KO:K04227]
105576625  [KO:K06856]
105576626  [KO:K06856]
105576638  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
105576825  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
105576922  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
105577074  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
105577130  [KO:K06856]
105577139  [KO:K06856]
105577141  [KO:K06856]
105577142  [KO:K06856]
105577143  [KO:K06856]
105577144  [KO:K06856]
105577151  [KO:K06856]
105577303  FGF3; fibroblast growth factor 3 [KO:K04358]
105577304  FGF4; fibroblast growth factor 4 [KO:K04358]
105577305  FGF19; fibroblast growth factor 19 [KO:K22603]
105577494  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
105577498  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
105577528  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105577613  TPCN2; two pore calcium channel protein 2 [KO:K14077]
105577691  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
105577723  SMIM6; small integral membrane protein 6 [KO:K26468]
105577760  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
105577918  ADRB1; beta-1 adrenergic receptor [KO:K04141]
105577985  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
105578529  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
105578815  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
105578974  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
105578976  CCKAR; cholecystokinin receptor type A [KO:K04194]
105579036  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
105579066  DRD5; D(1B) dopamine receptor [KO:K05840]
105579176  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
105579179  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
105579229  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105579245  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
105579393  GNAL; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
105579425  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
105579553  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
105579901  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
105580144  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
105580232  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
105580474  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
105580611  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
105580650  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
105580737  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
105581440  PLN; cardiac phospholamban [KO:K05852]
105581514  MRLN; long intergenic non-protein coding RNA 948 [KO:K22643]
105581580  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
105581649  FGF18; fibroblast growth factor 18 isoform X1 [KO:K04358]
105581684  DRD1; D(1A) dopamine receptor [KO:K04144]
105581689  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
105581716  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
105581752  [KO:K02183]
105581863  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
105581939  FGF16; fibroblast growth factor 16 [KO:K04358]
105582089  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105582092  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105582123  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
105582238  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
105582898  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
105582968  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105582993  FGF23; fibroblast growth factor 23 [KO:K22428]
105583213  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
105583443  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
105583515  FGF10; fibroblast growth factor 10 [KO:K04358]
105583745  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
105583769  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
105583982  NFATC3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
105584148  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
105584208  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
105584209  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
105584243  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
105584508  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
105584618  [KO:K10785]
105584627  P2RX5; P2X purinoceptor 5 [KO:K05219]
105584628  [KO:K10785]
105584734  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
105585090  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
105585127  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
105585190  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
105585318  [KO:K04632]
105585319  [KO:K04632]
105585377  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
105585485  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
105585553  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
105585558  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
105585586  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105585726  ITPR1; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105585741  OXTR; oxytocin receptor [KO:K04229]
105585762  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
105585782  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
105585787  HRH1; histamine H1 receptor [KO:K04149]
105585972  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
105586076  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
105587002  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
105587059  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
105587141  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
105587314  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
105587427  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
105587504  AGTR1; type-1 angiotensin II receptor isoform X1 [KO:K04166]
105587758  CYSLTR2; cysteinyl leukotriene receptor 2 isoform X1 [KO:K04323]
105587772  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
105588141  [KO:K04161]
105588213  FGF7; fibroblast growth factor 7 [KO:K04358]
105588269  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105588320  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
105588369  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
105588401  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
105588491  TNNC2; troponin C, skeletal muscle [KO:K12042]
105588738  SLN; sarcolipin [KO:K22642]
105588762  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
105588798  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
105588901  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
105589157  MCOLN1; LOW QUALITY PROTEIN: mucolipin-1 [KO:K04992]
105589185  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
105589245  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
105589287  CASQ1; calsequestrin-1 [KO:K23468]
105589398  PLCG2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
105589633  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
105589715  [KO:K10785]
105589789  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
105589855  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
105589856  ADRB2; beta-2 adrenergic receptor [KO:K04142]
105589876  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
105589879  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
105590357  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
105590424  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
105590605  CALM2; calmodulin [KO:K02183]
105590623  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
105590787  ADRB3; beta-3 adrenergic receptor [KO:K04143]
105590801  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
105590958  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
105590960  P2RX7; P2X purinoceptor 7 [KO:K05220]
105590966  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
105591224  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
105591502  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
105591599  HTR2B; 5-hydroxytryptamine receptor 2B isoform X1 [KO:K04157]
105591678  FGF22; fibroblast growth factor 22 isoform X1 [KO:K04358]
105591697  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
105591769  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
105591770  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
105591785  TBXA2R; thromboxane A2 receptor [KO:K04264]
105591918  FGF9; fibroblast growth factor 9 [KO:K04358]
105591948  TFEB; transcription factor EB isoform X1 [KO:K15590]
105591984  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
105592013  PDGFRA; LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
105592350  NTSR1; neurotensin receptor type 1 [KO:K04211]
105592428  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
105592744  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
105592965  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
105593014  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105593015  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
105593244  ITPR3; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105593392  ORAI2; protein orai-2 isoform X1 [KO:K16057]
105593561  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
105593577  MCOLN3; mucolipin-3 isoform X1 [KO:K04994]
105593578  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
105593887  [KO:K10784]
105594248  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105594283  [KO:K06856]
105594435  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
105594519  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
105594539  NTRK1; high affinity nerve growth factor receptor isoform X1 [KO:K03176] [EC:2.7.10.1]
105594885  PTAFR; platelet-activating factor receptor [KO:K04279]
105595060  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
105595186  CALM3; calmodulin isoform X1 [KO:K02183]
105595207  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
105595236  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
105595245  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
105595256  FGF21; fibroblast growth factor 21 [KO:K22429]
105595278  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1 [KO:K23450]
105595654  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
105595755  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
105595795  FGF2; fibroblast growth factor 2 [KO:K18497]
105595818  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
105595869  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
105596149  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
105596330  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
105596338  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
105596385  CASQ2; calsequestrin-2 [KO:K23445]
105596420  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
105596502  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
105596563  CALM1; calmodulin [KO:K02183]
105596655  BDKRB2; B2 bradykinin receptor [KO:K03916]
105596657  BDKRB1; B1 bradykinin receptor [KO:K03915]
105596823  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
105596878  TACR1; substance-P receptor [KO:K04222]
105596908  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
105597064  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
105597110  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
105597260  TACR2; substance-K receptor isoform X1 [KO:K04223]
105597312  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
105597329  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105597344  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
105597362  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
105597387  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
105597438  CALML3; calmodulin-like protein 3 [KO:K02183]
105597439  CALML5; calmodulin-like protein 5 [KO:K02183]
105597772  VEGFC; vascular endothelial growth factor C [KO:K05449]
105597890  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
105597934  EDNRB; LOW QUALITY PROTEIN: endothelin B receptor [KO:K04198]
105597990  ITPKC; inositol-trisphosphate 3-kinase C isoform X1 [KO:K00911] [EC:2.7.1.127]
105598256  P2RX6; LOW QUALITY PROTEIN: P2X purinoceptor 6 [KO:K05221]
105598386  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
105598426  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
105598476  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
105598747  [KO:K05850] [EC:7.2.2.10]
105599189  F2R; proteinase-activated receptor 1 [KO:K03914]
105599267  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X1 [KO:K00871] [EC:2.7.11.19]
105599331  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
105599342  ORAI3; protein orai-3 isoform X1 [KO:K16058]
105599763  VDAC1; LOW QUALITY PROTEIN: voltage-dependent anion-selective channel protein 1 [KO:K05862]
105599777  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
105599949  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
105600224  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
105600225  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
105600231  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
105600294  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 isoform X1 [KO:K04809]
105600547  AVPR1A; vasopressin V1a receptor [KO:K04226]
105600621  RYR3; ryanodine receptor 3 isoform X1 [KO:K04963]
105600623  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
105600723  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
105600798  P2RX3; P2X purinoceptor 3 [KO:K05217]
105600970  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
105601381  FGF20; fibroblast growth factor 20 [KO:K04358]
105601409  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
105601562  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
105601580  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
105601588  PTGER1; prostaglandin E2 receptor EP1 subtype isoform X1 [KO:K04258]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
caty04010  MAPK signaling pathway
caty04070  Phosphatidylinositol signaling system
caty04210  Apoptosis
caty04720  Long-term potentiation
caty04730  Long-term depression
KO pathway
ko04020   

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