Entry Name Systemic lupus erythematosus - Castor canadensis (American beaver)
Description Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components, in association with a diverse array of clinical manifestations. The primary pathological findings in patients with SLE are those of inflammation, vasculitis, immune complex deposition, and vasculopathy. Immune complexes comprising autoantibody and self-antigen is deposited particulary in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc{gamma}R-mediated neutrophil and macrophage activation. Activation of complement (C5) leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases.
Class Human Diseases; Immune diseaseBRITE hierarchy
Pathway map Ortholog table Organism Castor canadensis (American beaver) [GN:
ccan ]
Gene 109677605 LOW QUALITY PROTEIN: uncharacterized protein LOC109677605 [KO:K11253 ]
109692892 Snrpb; small nuclear ribonucleoprotein-associated proteins B and B' [KO:K11086 ]
109674702 LOW QUALITY PROTEIN: HLA class II histocompatibility antigen, DRB1-15 beta chain-like [KO:K06752 ]
109674703 HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752 ]
109674664 HLA class II histocompatibility antigen, DR alpha chain [KO:K06752 ]
109674665 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
109685982 HLA class II histocompatibility antigen, DO beta chain [KO:K06752 ]
109686704 HLA class II histocompatibility antigen, DP beta 1 chain [KO:K06752 ]
109686705 HLA class II histocompatibility antigen, DO alpha chain [KO:K06752 ]
109686673 HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752 ]
109686675 HLA class II histocompatibility antigen, DM alpha chain isoform X1 [KO:K06752 ]
109686676 HLA class II histocompatibility antigen, DM beta chain [KO:K06752 ]
109695178 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
109695186 SLA class II histocompatibility antigen, DQ haplotype D alpha chain-like [KO:K06752 ]
109695196 HLA class II histocompatibility antigen, DRB1-4 beta chain-like [KO:K06752 ]
109689299 Cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
109699333 C8g; LOW QUALITY PROTEIN: complement component C8 gamma chain [KO:K03999 ]
109677124 high affinity immunoglobulin gamma Fc receptor I-like isoform X1 [KO:K06498 ]
109693506 Fcgr2a; low affinity immunoglobulin gamma Fc region receptor II-a isoform X1 [KO:K06472 ]
109693505 low affinity immunoglobulin gamma Fc region receptor III-A-like [KO:K06463 ]
Compound Reference Authors Rahman A, Isenberg DA.
Title Systemic lupus erythematosus.
Journal Reference Authors Mok CC, Lau CS.
Title Pathogenesis of systemic lupus erythematosus.
Journal Reference Authors Clatworthy MR, Smith KG.
Title B cells in glomerulonephritis: focus on lupus nephritis.
Journal Reference Authors Couser WG.
Title New insights into mechanisms of immune glomerular injury.
Journal West J Med 160:440-6 (1994)
Reference Authors Cook HT, Botto M.
Title Mechanisms of Disease: the complement system and the pathogenesis of systemic lupus erythematosus.
Journal Reference Authors Carroll MC.
Title A protective role for innate immunity in systemic lupus erythematosus.
Journal Reference Authors Sturfelt G, Truedsson L.
Title Complement and its breakdown products in SLE.
Journal Reference Authors Lu L, Kaliyaperumal A, Boumpas DT, Datta SK.
Title Major peptide autoepitopes for nucleosome-specific T cells of human lupus.
Journal Reference Authors Zieve GW, Khusial PR.
Title The anti-Sm immune response in autoimmunity and cell biology.
Journal Reference Authors Scofield RH, Farris AD, Horsfall AC, Harley JB.
Title Fine specificity of the autoimmune response to the Ro/SSA and La/SSB ribonucleoproteins.
Journal Reference Authors Hoffman RW.
Title T cells in the pathogenesis of systemic lupus erythematosus.
Journal Related ccan04060 Cytokine-cytokine receptor interaction
ccan04610 Complement and coagulation cascades
ccan04612 Antigen processing and presentation
ccan04670 Leukocyte transendothelial migration
KO pathway LinkDB All DBs
