Entry
Name
Cytokine-cytokine receptor interaction - Castor canadensis (American beaver)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
ccan04060 Cytokine-cytokine receptor interaction
Organism
Castor canadensis (American beaver) [GN:
ccan ]
Gene
109674287 Tnfsf12; tumor necrosis factor ligand superfamily member 12 [KO:K05474 ]
109674729 Tnfsf13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475 ]
109675709 Bmp15; LOW QUALITY PROTEIN: bone morphogenetic protein 15 [KO:K05498 ]
109677097 Bmp5; LOW QUALITY PROTEIN: bone morphogenetic protein 5 [KO:K04663 ]
109678566 Csf2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
109679322 Tnfsf18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
109679323 Tnfsf4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
109680736 Edar; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
109681039 Tnfrsf4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
109681050 Tnfrsf18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
109681894 Cntfr; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
109682363 Tnfrsf19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
109682645 Il1rn; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
109682791 Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
109682793 Ltbr; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
109683957 Tnfrsf8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
109683967 Tnfrsf1b; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
109684574 Tnfrsf6b; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
109685173 Tnfrsf25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
109685497 Tnfrsf11a; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
109687308 Ccr10; LOW QUALITY PROTEIN: C-C chemokine receptor type 10 [KO:K04185 ]
109688333 Osmr; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057 ]
109688727 Tnfrsf17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
109688754 Il3ra; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
109688963 Il17re; LOW QUALITY PROTEIN: interleukin-17 receptor E [KO:K05168 ]
109689125 Faslg; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
109689299 Cd40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
109689383 Tnfrsf13c; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151 ]
109690426 Csf3r; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
109690611 Il2ra; LOW QUALITY PROTEIN: interleukin-2 receptor subunit alpha [KO:K05068 ]
109691142 Fas; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390 ]
109691411 Ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
109691446 Tnfrsf14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
109691710 Tnfrsf12a; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
109694303 Tnfsf14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
109694304 Tnfsf9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
109694631 Relt; tumor necrosis factor receptor superfamily member 19L isoform X1 [KO:K05156 ]
109696237 Gdf11; LOW QUALITY PROTEIN: growth/differentiation factor 11 [KO:K22679 ]
109697033 Ifngr1; LOW QUALITY PROTEIN: interferon gamma receptor 1 [KO:K05132 ]
109697452 Cxcl16; LOW QUALITY PROTEIN: C-X-C motif chemokine 16 [KO:K10035 ]
109698101 Eda2r; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163 ]
109698250 Il2rb; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
109698486 Tnfrsf13b; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
109699343 Tnfsf13b; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
109699422 Tnfrsf9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
109699530 Il12rb1; LOW QUALITY PROTEIN: interleukin-12 receptor subunit beta-1 [KO:K05063 ]
109700109 Tnfsf8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
109700348 Tnfsf11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
109701301 Tnfsf15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
109701508 Ccr6; LOW QUALITY PROTEIN: C-C chemokine receptor type 6 [KO:K04181 ]
109702520 Tnfrsf11b; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway