KEGG   PATHWAY: gaf04371
Entry
gaf04371                    Pathway                                
Name
Apelin signaling pathway - Gambusia affinis (western mosquitofish)
Description
Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various tissues and organ systems. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, cell proliferation and energy metabolism regulation. On the other hand, this ligand receptor couple is also involved in several pathologies including diabetes, obesity, cardiovascular disease and cancer.
Class
Environmental Information Processing; Signal transduction
Pathway map
gaf04371  Apelin signaling pathway
gaf04371

Other DBs
GO: 0060183
Organism
Gambusia affinis (western mosquitofish) [GN:gaf]
Gene
122841230  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
122838016  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
122844085  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
122831188  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
122831106  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
122840426  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
122837578  adenylate cyclase type 6-like isoform X1 [KO:K08046] [EC:4.6.1.1]
122839097  adenylate cyclase type 6-like [KO:K08046] [EC:4.6.1.1]
122825208  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
122841663  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
122825293  si:dkey-206f10.1; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
122826983  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
122821683  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
122829319  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
122841257  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
122838694  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
122821901  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
122829699  cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
122830737  lipeb; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
122843462  lipea; lipase, hormone-sensitive a isoform X1 [KO:K07188] [EC:3.1.1.79]
122837499  apln; apelin [KO:K05225]
122830399  apela; apelin receptor early endogenous ligand [KO:K25355]
122846880  aplnrb; apelin receptor B [KO:K04174]
122827816  aplnra; apelin receptor A [KO:K04174]
122835582  aplnr2; apelin receptor 2 [KO:K04174]
122830827  gnai3; guanine nucleotide-binding protein G(i) subunit alpha isoform X1 [KO:K04630]
122826038  gnai1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
122833599  gnai2b; guanine nucleotide-binding protein G(i) subunit alpha-2b [KO:K04630]
122834681  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
122835992  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
122831071  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
122833601  gnb1b; guanine nucleotide binding protein (G protein), beta polypeptide 1b [KO:K04536]
122845188  gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
122830984  gnb3a; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3a [KO:K07825]
122843307  gnb3b; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3b [KO:K07825]
122838672  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
122819842  gnb5b; guanine nucleotide-binding protein subunit beta-5b [KO:K04539]
122835561  guanine nucleotide-binding protein subunit beta-5-like [KO:K04539]
122845851  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
122844357  gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
122842583  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
122838690  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
122821297  si:dkey-204f11.64; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
122829661  si:ch211-286b5.5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
122841059  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
122846240  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04543]
122844445  gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
122846843  gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
122838145  gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
122822430  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
122840542  gng12a; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12a [KO:K04347]
122821409  gng13b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13b [KO:K04547]
122829869  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13-like [KO:K04547]
122843516  gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
122823111  gngt2b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2b [KO:K04549]
122846825  guanine nucleotide-binding protein G(q) subunit alpha-like [KO:K04634]
122828197  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
122846559  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
122825001  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
122825010  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
122820302  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
122842723  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
122833721  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
122833870  inositol 1,4,5-trisphosphate receptor type 1-like isoform X1 [KO:K04958]
122835154  itpr2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
122838832  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
122844448  ryanodine receptor 1-like isoform X1 [KO:K04961]
122833037  ryr1b; ryanodine receptor 1b [KO:K04961]
122842118  ryr2b; ryanodine receptor 2 isoform X1 [KO:K04962]
122822921  ryr2a; ryanodine receptor 2 isoform X1 [KO:K04962]
122845862  ryanodine receptor 3-like [KO:K04963]
122824885  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
122846339  calmodulin-1 [KO:K02183]
122825331  calmodulin-1 [KO:K02183]
122833252  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
122821084  calml4a; calmodulin-like protein 4a [KO:K02183]
122827934  nos1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
122823820  prkcea; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
122842574  protein kinase C epsilon type-like [KO:K18050] [EC:2.7.11.13]
122830810  slc9a1a; Na(+)/H(+) exchanger beta isoform X1 [KO:K05742]
122843173  Na(+)/H(+) exchanger beta-like [KO:K05742]
122845824  slc8a3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
122844329  slc8a4a; solute carrier family 8 member 4a [KO:K05849]
122842431  slc8a1b; sodium/calcium exchanger 1b isoform X1 [KO:K05849]
122844703  slc8a2a; sodium/calcium exchanger 2a isoform X1 [KO:K05849]
122832854  slc8a2b; sodium/calcium exchanger 2b isoform X1 [KO:K05849]
122820783  slc8a4b; solute carrier family 8 member 4b isoform X1 [KO:K05849]
122828924  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
122822833  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
122841247  myosin light chain kinase 3-like isoform X1 [KO:K00907] [EC:2.7.11.18]
122837983  mylk4b; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
122839732  mylka; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122822561  mylk5; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
122834448  myl2a; myosin regulatory light chain 2a [KO:K10351]
122828833  myl2b; myosin, light chain 2b, regulatory, cardiac, slow isoform X1 [KO:K10351]
122841307  myl13; myosin, light chain 13 [KO:K12749]
122819664  myosin light chain 4-like [KO:K12750]
122835505  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
122822359  zgc:55558; GTPase KRas [KO:K07827]
122836263  kras; GTPase KRas isoform X1 [KO:K07827]
122821253  rras; ras-related protein R-Ras [KO:K07830]
122821717  rras2; ras-related protein R-Ras2 [KO:K07830]
122839538  mrasa; ras-related protein M-Ras [KO:K07831]
122832939  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
122835026  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
122839029  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
122821961  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
122828763  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
122844974  rps6kb1a; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
122833320  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
122829839  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
122829408  rps6; 40S ribosomal protein S6 [KO:K02991]
122826268  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
122833586  si:rp71-17i16.5; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
122829970  phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
122830045  pik3r5; phosphoinositide 3-kinase regulatory subunit 5 isoform X1 [KO:K21290]
122822106  phosphoinositide 3-kinase regulatory subunit 5-like isoform X1 [KO:K21290]
122846204  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122830299  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122842084  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
122832319  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
122831342  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
122845437  early growth response protein 1-A-like [KO:K09203]
122837400  egr1; early growth response protein 1 [KO:K09203]
122842404  jag1b; protein jagged-1b [KO:K06052]
122832969  protein jagged-1b [KO:K06052]
122821562  notch3; neurogenic locus notch homolog protein 3 [KO:K20995]
122819633  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
122821733  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
122820367  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
122830772  pik3r4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
122822878  becn1; beclin-1 [KO:K08334]
122836953  map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
122834248  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
122834951  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
122828969  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
122846942  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
122838438  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
122819595  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
122828289  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
122841006  prkab2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
122824506  5'-AMP-activated protein kinase subunit gamma-2-like [KO:K07200]
122826939  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
122834722  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
122839442  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b isoform X1 [KO:K07200]
122841202  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
122820020  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
122826730  nrf1; nuclear respiratory factor 1 [KO:K11831]
122823247  tfam; transcription factor A, mitochondrial [KO:K11830]
122841569  klf2b; Krueppel-like factor 2b [KO:K17845]
122830248  sphingosine kinase 1-like [KO:K04718] [EC:2.7.1.91]
122830556  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
122822302  sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
122821330  gna13b; guanine nucleotide-binding protein subunit alpha-13b [KO:K04639]
122822843  guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639]
122838543  si:ch73-60h1.1; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
122827152  histone deacetylase 4-like isoform X1 [KO:K11406] [EC:3.5.1.98]
122821242  hdac5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
122840133  hdac4; histone deacetylase 4 isoform X1 [KO:K11406] [EC:3.5.1.98]
122835272  mef2aa; myocyte enhancer factor 2aa isoform X1 [KO:K09260]
122838449  mef2b; myocyte-specific enhancer factor 2B [KO:K09261]
122847201  mef2ca; myocyte enhancer factor 2ca [KO:K04454]
122827145  mef2cb; myocyte enhancer factor 2cb isoform X1 [KO:K04454]
122830594  mef2d; myocyte-specific enhancer factor 2D isoform X1 [KO:K09262]
122843081  myocyte-specific enhancer factor 2D homolog isoform X1 [KO:K09262]
122824079  tgfbr1b; TGF-beta receptor type-1b isoform X1 [KO:K04674] [EC:2.7.11.30]
122828856  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
122841641  mothers against decapentaplegic homolog 3 [KO:K23605]
122835161  smad3b; mothers against decapentaplegic homolog 3b [KO:K23605]
122830878  mothers against decapentaplegic homolog 4-like [KO:K04501]
122819501  smad4a; mothers against decapentaplegic homolog 4a isoform X1 [KO:K04501]
122828777  LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 4-like [KO:K04501]
122823402  acta2; actin, aortic smooth muscle [KO:K12313]
122842040  LOW QUALITY PROTEIN: B-cadherin-like [KO:K05689]
122842041  B-cadherin-like isoform X1 [KO:K05689]
122842043  B-cadherin-like isoform X1 [KO:K05689]
122842044  si:busm1-71b9.3; EP-cadherin [KO:K05689]
122842045  cadherin-1-like [KO:K05689]
122819437  LOW QUALITY PROTEIN: cadherin-1-like [KO:K05689]
122835500  B-cadherin [KO:K05689]
122824931  CCN family member 2-like [KO:K06827]
122824568  type-1 angiotensin II receptor-like [KO:K04166]
122820458  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
122826456  plat; tissue-type plasminogen activator isoform X1 [KO:K01343] [EC:3.4.21.68]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00290  Fibrin
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
Reference
PMID:26143239
  Authors
Yang P, Maguire JJ, Davenport AP
  Title
Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system.
  Journal
Trends Pharmacol Sci 36:560-7 (2015)
DOI:10.1016/j.tips.2015.06.002
Reference
PMID:22140623
  Authors
Andersen CU, Hilberg O, Mellemkjaer S, Nielsen-Kudsk JE, Simonsen U
  Title
Apelin and pulmonary hypertension.
  Journal
Pulm Circ 1:334-46 (2011)
DOI:10.4103/2045-8932.87299
Reference
PMID:25275559
  Authors
Chapman NA, Dupre DJ, Rainey JK
  Title
The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR.
  Journal
Biochem Cell Biol 92:431-40 (2014)
DOI:10.1139/bcb-2014-0072
Reference
PMID:18272138
  Authors
Japp AG, Newby DE
  Title
The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential.
  Journal
Biochem Pharmacol 75:1882-92 (2008)
DOI:10.1016/j.bcp.2007.12.015
Reference
PMID:25652330
  Authors
Folino A, Montarolo PG, Samaja M, Rastaldo R
  Title
Effects of apelin on the cardiovascular system.
  Journal
Heart Fail Rev 20:505-18 (2015)
DOI:10.1007/s10741-015-9475-x
Reference
PMID:23943882
  Authors
O'Carroll AM, Lolait SJ, Harris LE, Pope GR
  Title
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.
  Journal
J Endocrinol 219:R13-35 (2013)
DOI:10.1530/JOE-13-0227
Reference
PMID:23973488
  Authors
Liu QF, Yu HW, You L, Liu MX, Li KY, Tao GZ
  Title
Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1.
  Journal
Biochem Biophys Res Commun 439:235-40 (2013)
DOI:10.1016/j.bbrc.2013.08.051
Reference
PMID:26254105
  Authors
Novakova V, Sandhu GS, Dragomir-Daescu D, Klabusay M
  Title
Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia.
  Journal
Vascul Pharmacol 76:1-10 (2016)
DOI:10.1016/j.vph.2015.08.005
Reference
PMID:21725702
  Authors
Castan-Laurell I, Dray C, Attane C, Duparc T, Knauf C, Valet P
  Title
Apelin, diabetes, and obesity.
  Journal
Endocrine 40:1-9 (2011)
DOI:10.1007/s12020-011-9507-9
Reference
PMID:23924696
  Authors
Li L, Li L, Xie F, Zhang Z, Guo Y, Tang G, Lv D, Lu Q, Chen L, Li J
  Title
Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation.
  Journal
Acta Biochim Biophys Sin (Shanghai) 45:875-81 (2013)
DOI:10.1093/abbs/gmt085
Reference
PMID:24990699
  Authors
Wu D, He L, Chen L
  Title
Apelin/APJ system: a promising therapy target for hypertension.
  Journal
Mol Biol Rep 41:6691-703 (2014)
DOI:10.1007/s11033-014-3552-4
Reference
PMID:20539939
  Authors
Liu C, Su T, Li F, Li L, Qin X, Pan W, Feng F, Chen F, Liao D, Chen L
  Title
PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13.
  Journal
Acta Biochim Biophys Sin (Shanghai) 42:396-402 (2010)
DOI:10.1093/abbs/gmq035
Reference
PMID:26607438
  Authors
Xie F, Liu W, Feng F, Li X, He L, Lv D, Qin X, Li L, Li L, Chen L
  Title
Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy.
  Journal
Acta Biochim Biophys Sin (Shanghai) 47:969-80 (2015)
DOI:10.1093/abbs/gmv111
Reference
PMID:27979574
  Authors
Lu L, Wu D, Li L, Chen L
  Title
Apelin/APJ system: A bifunctional target for cardiac hypertrophy.
  Journal
Int J Cardiol 230:164-170 (2017)
DOI:10.1016/j.ijcard.2016.11.215
Reference
PMID:16182514
  Authors
Carmen GY, Victor SM
  Title
Signalling mechanisms regulating lipolysis.
  Journal
Cell Signal 18:401-8 (2006)
DOI:10.1016/j.cellsig.2005.08.009
Reference
PMID:27650065
  Authors
Hu H, He L, Li L, Chen L
  Title
Apelin/APJ system as a therapeutic target in diabetes and its complications.
  Journal
Mol Genet Metab 119:20-7 (2016)
DOI:10.1016/j.ymgme.2016.07.012
Reference
PMID:25914650
  Authors
Bertrand C, Valet P, Castan-Laurell I
  Title
Apelin and energy metabolism.
  Journal
Front Physiol 6:115 (2015)
DOI:10.3389/fphys.2015.00115
Reference
PMID:26385179
  Authors
Yao F, Lv YC, Zhang M, Xie W, Tan YL, Gong D, Cheng HP, Liu D, Li L, Liu XY, Zheng XL, Tang CK
  Title
Apelin-13 impedes foam cell formation by activating Class III PI3K/Beclin-1-mediated autophagic pathway.
  Journal
Biochem Biophys Res Commun 466:637-43 (2015)
DOI:10.1016/j.bbrc.2015.09.045
Reference
PMID:22842084
  Authors
Than A, Cheng Y, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen P
  Title
Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.
  Journal
Mol Cell Endocrinol 362:227-41 (2012)
DOI:10.1016/j.mce.2012.07.002
Reference
PMID:24055369
  Authors
Yu XH, Tang ZB, Liu LJ, Qian H, Tang SL, Zhang DW, Tian GP, Tang CK
  Title
Apelin and its receptor APJ in cardiovascular diseases.
  Journal
Clin Chim Acta 428:1-8 (2014)
DOI:10.1016/j.cca.2013.09.001
Reference
PMID:25931124
  Authors
Than A, He HL, Chua SH, Xu D, Sun L, Leow MK, Chen P
  Title
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes.
  Journal
J Biol Chem 290:14679-91 (2015)
DOI:10.1074/jbc.M115.643817
Reference
PMID:25139773
  Authors
Fu J, Li Z, Zhang H, Mao Y, Wang A, Wang X, Zou Z, Zhang X
  Title
Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue.
  Journal
Diabetes Metab Res Rev 31:433-52 (2015)
DOI:10.1002/dmrr.2600
Reference
PMID:21464822
  Authors
Aharoni-Simon M, Hann-Obercyger M, Pen S, Madar Z, Tirosh O
  Title
Fatty liver is associated with impaired activity of PPARgamma-coactivator 1alpha (PGC1alpha) and mitochondrial biogenesis in mice.
  Journal
Lab Invest 91:1018-28 (2011)
DOI:10.1038/labinvest.2011.55
Reference
PMID:22995518
  Authors
McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK, Chun HJ
  Title
Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.
  Journal
Arterioscler Thromb Vasc Biol 32:2640-3 (2012)
DOI:10.1161/ATVBAHA.112.300317
Reference
PMID:22028387
  Authors
Pchejetski D, Foussal C, Alfarano C, Lairez O, Calise D, Guilbeau-Frugier C, Schaak S, Seguelas MH, Wanecq E, Valet P, Parini A, Kunduzova O
  Title
Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1.
  Journal
Eur Heart J 33:2360-9 (2012)
DOI:10.1093/eurheartj/ehr389
Reference
PMID:26944568
  Authors
Huang S, Chen L, Lu L, Li L
  Title
The apelin-APJ axis: A novel potential therapeutic target for organ fibrosis.
  Journal
Clin Chim Acta 456:81-8 (2016)
DOI:10.1016/j.cca.2016.02.025
Reference
PMID:19093215
  Authors
Liu G, Han J, Profirovic J, Strekalova E, Voyno-Yasenetskaya TA
  Title
Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis.
  Journal
Angiogenesis 12:1-15 (2009)
DOI:10.1007/s10456-008-9123-3
Reference
PMID:23603510
  Authors
Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ
  Title
Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
  Journal
Circ Res 113:22-31 (2013)
DOI:10.1161/CIRCRESAHA.113.301324
Reference
PMID:25164121
  Authors
Wang LY, Diao ZL, Zhang DL, Zheng JF, Zhang QD, Ding JX, Liu WH
  Title
The regulatory peptide apelin: a novel inhibitor of renal interstitial fibrosis.
  Journal
Amino Acids 46:2693-704 (2014)
DOI:10.1007/s00726-014-1826-8
Reference
PMID:26756969
  Authors
Zhou Y, Deng L, Zhao D, Chen L, Yao Z, Guo X, Liu X, Lv L, Leng B, Xu W, Qiao G, Shan H
  Title
MicroRNA-503 promotes angiotensin II-induced cardiac fibrosis by targeting Apelin-13.
  Journal
J Cell Mol Med 20:495-505 (2016)
DOI:10.1111/jcmm.12754
Reference
PMID:27825851
  Authors
Zhong JC, Zhang ZZ, Wang W, McKinnie SM, Vederas JC, Oudit GY
  Title
Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.
  Journal
Biochim Biophys Acta 1863:1942-1950 (2017)
DOI:10.1016/j.bbadis.2016.11.007
Related
pathway
gaf04010  MAPK signaling pathway
gaf04020  Calcium signaling pathway
gaf04140  Autophagy - animal
gaf04150  mTOR signaling pathway
gaf04270  Vascular smooth muscle contraction
gaf04530  Tight junction
KO pathway
ko04371   
LinkDB

DBGET integrated database retrieval system