KEGG   PATHWAY: lve04714
Entry
lve04714                    Pathway                                
Name
Thermogenesis - Lipotes vexillifer (Yangtze River dolphin)
Description
Thermogenesis is essential for warm-blooded animals, ensuring normal cellular and physiological function under conditions of environmental challenge. Thermogenesis in brown and beige adipose tissue is mainly controlled by norepinephrine, which is released from sympathetic nervous system in response to cold or dietary stimuli. The mitochondrial uncoupling protein 1 (UCP1) is responsible for the process whereby chemical energy is converted into heat in these adipocytes. Activation of these adipocytes leads to an increase in calorie consumption and is expected to improve overweight conditions, providing a potential strategy for treating obesity and its related metabolic disorders.
Class
Organismal Systems; Environmental adaptation
Pathway map
lve04714  Thermogenesis
lve04714

Other DBs
GO: 1990845
Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103074465  ADRB3; LOW QUALITY PROTEIN: beta-3 adrenergic receptor [KO:K04143]
103089051  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas-like [KO:K04632]
103085385  neuroendocrine secretory protein 55-like [KO:K04632]
103081539  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
103084817  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
103076182  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
103075499  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
103091169  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
103075153  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
103078677  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
103085845  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
103070451  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
103068449  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
103087922  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
103077464  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
103074112  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
103075978  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
103086171  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
103085711  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
103087008  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
103091030  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
103071696  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
103081811  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
103072534  PRDM16; PR domain zinc finger protein 16 [KO:K22410] [EC:2.1.1.367]
103084094  ZNF516; zinc finger protein 516 [KO:K22411]
103084888  KDM1A; lysine-specific histone demethylase 1A isoform X1 [KO:K11450] [EC:1.14.99.66]
103068645  UCP1; LOW QUALITY PROTEIN: mitochondrial brown fat uncoupling protein 1 [KO:K08769]
103089463  KDM3B; lysine-specific demethylase 3B isoform X1 [KO:K15601] [EC:1.14.11.65]
103072442  KDM3A; lysine-specific demethylase 3A isoform X1 [KO:K15601] [EC:1.14.11.65]
103080451  SMARCA2; probable global transcription activator SNF2L2-like isoform X1 [KO:K11647] [EC:5.6.2.-]
103086661  SMARCA4; transcription activator BRG1 [KO:K11647] [EC:5.6.2.-]
103072102  SMARCB1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 isoform X1 [KO:K11648]
103084073  SMARCC1; SWI/SNF complex subunit SMARCC1 [KO:K11649]
103085379  SMARCC2; SWI/SNF complex subunit SMARCC2 [KO:K11649]
103077190  SMARCD2; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 [KO:K11650]
103088170  SMARCD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 isoform X1 [KO:K11650]
103081289  SMARCD3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 isoform X1 [KO:K11650]
103084730  SMARCE1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 [KO:K11651]
103086383  ACTG1; actin, cytoplasmic 2 [KO:K05692]
103077223  ACTB; actin, cytoplasmic 1 [KO:K05692]
103083367  ACTL6A; actin-like protein 6A isoform X1 [KO:K11340]
103072358  ACTL6B; actin-like protein 6B [KO:K11652]
103090931  ARID1A; AT-rich interactive domain-containing protein 1A [KO:K11653]
103085772  ARID1B; AT-rich interactive domain-containing protein 1B [KO:K11653]
103089246  DPF1; zinc finger protein neuro-d4 isoform X1 [KO:K22198]
103090302  DPF3; zinc finger protein DPF3 [KO:K22198]
103085722  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
103091611  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
103083209  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
103077530  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
103078049  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
103078710  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
103073461  PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
103089070  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
103091498  SIRT6; NAD-dependent protein deacetylase sirtuin-6 isoform X1 [KO:K11416] [EC:2.3.1.286]
103081969  FGF21; fibroblast growth factor 21 [KO:K22429]
103091267  PLIN1; perilipin-1 [KO:K08768]
103074607  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
103080064  PNPLA2; patatin-like phospholipase domain-containing protein 2 [KO:K16816] [EC:3.1.1.3]
103085290  MGLL; monoglyceride lipase isoform X1 [KO:K01054] [EC:3.1.1.23]
103069202  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
103074848  PRKAA1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
103089470  PRKAB2; 5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
103085288  PRKAB1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
103079524  PRKAG3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
103079471  PRKAG2; 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
103079195  PRKAG1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
103087772  GCG; glucagon isoform X1 [KO:K05259]
103089261  bone morphogenetic protein 8B-like [KO:K16622]
103087176  BMP8B; bone morphogenetic protein 8B [KO:K16622]
103079191  bone morphogenetic protein 8B-like [KO:K16622]
103088810  CNR1; cannabinoid receptor 1 isoform X1 [KO:K04277]
103080153  NPPA; natriuretic peptides A [KO:K12334]
103080424  NPPB; natriuretic peptides B [KO:K12335]
103088382  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
103071917  PRKG1; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
103091057  PRKG2; cGMP-dependent protein kinase 2 isoform X1 [KO:K19477] [EC:2.7.11.12]
103074835  KLB; LOW QUALITY PROTEIN: beta-klotho [KO:K22404]
103069902  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
103080325  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
103079766  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
103079242  SOS1; son of sevenless homolog 1 [KO:K03099]
103081084  SOS2; son of sevenless homolog 2-like [KO:K03099]
103076043  HRAS; GTPase HRas isoform X1 [KO:K02833]
103077579  KRAS; GTPase KRas [KO:K07827]
103068734  NRAS; GTPase NRas [KO:K07828]
103072575  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
103086828  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
103078586  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
103087256  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
103088278  TSC1; hamartin isoform X1 [KO:K07206]
103075350  TSC2; tuberin [KO:K07207]
103080271  RHEB; GTP-binding protein Rheb [KO:K07208]
103069618  GTP-binding protein Rheb-like [KO:K07208]
103088660  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
103083889  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103086163  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
103075856  AKT1S1; proline-rich AKT1 substrate 1 [KO:K16184]
103090358  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
103073645  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
103079925  RPS6; 40S ribosomal protein S6 [KO:K02991]
103084659  ACSL5; long-chain-fatty-acid--CoA ligase 5 isoform X1 [KO:K01897] [EC:6.2.1.3]
103088303  ACSL6; long-chain-fatty-acid--CoA ligase 6 isoform X1 [KO:K01897] [EC:6.2.1.3]
103069759  ACSL4; long-chain-fatty-acid--CoA ligase 4 [KO:K01897] [EC:6.2.1.3]
103080328  ACSL3; long-chain-fatty-acid--CoA ligase 3 isoform X1 [KO:K01897] [EC:6.2.1.3]
103074645  ACSL1; LOW QUALITY PROTEIN: acyl-CoA synthetase long-chain family member 1 [KO:K01897] [EC:6.2.1.3]
3802087  ND1; NADH dehydrogenase subunit 1 [KO:K03878] [EC:7.1.1.2]
3802093  ND2; NADH dehydrogenase subunit 2 [KO:K03879] [EC:7.1.1.2]
3802099  ND3; NADH dehydrogenase subunit 3 [KO:K03880] [EC:7.1.1.2]
3802089  ND4; NADH dehydrogenase subunit 4 [KO:K03881] [EC:7.1.1.2]
3802088  ND4L; NADH dehydrogenase subunit 4L [KO:K03882] [EC:7.1.1.2]
3802090  ND5; NADH dehydrogenase subunit 5 [KO:K03883] [EC:7.1.1.2]
103085270  NADH-ubiquinone oxidoreductase chain 6-like [KO:K03884] [EC:7.1.1.2]
3802091  ND6; NADH dehydrogenase subunit 6 [KO:K03884] [EC:7.1.1.2]
103073569  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
103084921  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
103072944  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
103084967  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
103090037  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
103087074  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
103085530  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial [KO:K03940] [EC:7.1.1.2]
103068684  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
103069803  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
103077470  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
103082014  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
103091475  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1-like [KO:K03945]
103078685  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
103085823  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
103072179  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
103071324  NDUFA4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 [KO:K03948]
103083475  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
103071560  NDUFA6; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
103070385  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
103091533  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
103076341  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
103079926  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
103089500  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
103078571  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
103072085  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
103073963  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
103087083  uncharacterized protein LOC103087083 [KO:K03957]
103078980  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
103076071  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
103072640  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
103082087  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
103078335  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6-like [KO:K03962]
103084259  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
103070606  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
103086990  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
103086643  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
103090568  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
103086989  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial isoform X1 [KO:K11351]
103070556  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
103080397  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
103069843  NDUFAF1; complex I intermediate-associated protein 30, mitochondrial [KO:K18159]
103080388  NDUFAF2; mimitin, mitochondrial [KO:K18160]
103069683  NDUFAF3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 isoform X1 [KO:K09008]
103077677  NDUFAF4; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 [KO:K18161]
103086707  NDUFAF5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 isoform X1 [KO:K18162] [EC:2.1.1.-]
103088279  NDUFAF6; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 [KO:K18163]
103084452  NDUFAF7; NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 isoform X1 [KO:K18164]
103090475  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
103078950  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
103086971  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
103087853  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
103087521  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
103076796  cytochrome b-c1 complex subunit Rieske, mitochondrial-like [KO:K00411] [EC:7.1.1.8]
3802092  CYTB; cytochrome b [KO:K00412]
103081975  cytochrome c1, heme protein, mitochondrial-like [KO:K00413]
103089566  cytochrome b-c1 complex subunit 1, mitochondrial-like [KO:K00414]
103072340  cytochrome b-c1 complex subunit 2, mitochondrial-like [KO:K00415]
103080944  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
103090168  cytochrome b-c1 complex subunit 6, mitochondrial-like [KO:K00416]
103081405  cytochrome b-c1 complex subunit 7-like [KO:K00417]
103079404  cytochrome b-c1 complex subunit 7-like [KO:K00417]
103088883  cytochrome b-c1 complex subunit 8-like [KO:K00418]
103071217  cytochrome b-c1 complex subunit 8-like [KO:K00418]
103085535  cytochrome b-c1 complex subunit 9-like [KO:K00419]
103083511  cytochrome b-c1 complex subunit 10-like [KO:K00420]
103082886  cytochrome b-c1 complex subunit 10-like [KO:K00420]
103068399  cytochrome b-c1 complex subunit 10-like [KO:K00420]
3802094  COX1; cytochrome c oxidase subunit I [KO:K02256] [EC:7.1.1.9]
3802095  COX2; cytochrome c oxidase subunit II [KO:K02261]
3802098  COX3; cytochrome c oxidase subunit III [KO:K02262]
103086428  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
103081720  cytochrome c oxidase subunit 4 isoform 2, mitochondrial-like [KO:K02263]
103074089  cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
103085487  cytochrome c oxidase subunit 5B, mitochondrial-like [KO:K02265]
103073019  cytochrome c oxidase subunit 6A2, mitochondrial-like [KO:K02266]
103080257  cytochrome c oxidase subunit 6A1, mitochondrial-like [KO:K02266]
103072827  cytochrome c oxidase subunit 6B1-like [KO:K02267]
103073864  cytochrome c oxidase subunit 6C-like [KO:K02268]
103072782  cytochrome c oxidase subunit 7A-related protein, mitochondrial-like [KO:K02270]
103076103  cytochrome c oxidase subunit 7A2, mitochondrial-like [KO:K02270]
103081207  cytochrome c oxidase subunit 7A1, mitochondrial-like [KO:K02270]
103082153  cytochrome c oxidase subunit 7B, mitochondrial-like [KO:K02271]
103079623  cytochrome c oxidase subunit 7B2, mitochondrial-like [KO:K02271]
103071977  cytochrome c oxidase subunit 7B, mitochondrial-like isoform X1 [KO:K02271]
103087636  cytochrome c oxidase subunit 8C, mitochondrial-like [KO:K02273]
103072056  protoheme IX farnesyltransferase, mitochondrial-like [KO:K02257] [EC:2.5.1.141]
103084790  cytochrome c oxidase assembly protein COX14-like [KO:K18181]
103088619  cytochrome c oxidase assembly protein COX14-like [KO:K18181]
103082288  cytochrome c oxidase assembly protein COX15 homolog [KO:K02259] [EC:1.17.99.9]
103080698  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial-like isoform X1 [KO:K18182]
103087971  cytochrome c oxidase copper chaperone-like [KO:K02260]
103088683  mitochondrial inner membrane protein COX18-like isoform X1 [KO:K17797]
103090621  cytochrome c oxidase assembly protein COX19-like [KO:K18183]
103077657  cytochrome c oxidase protein 20 homolog [KO:K18184]
103072889  cytochrome c oxidase assembly factor 1 homolog [KO:K18173]
103071531  cytochrome c oxidase assembly factor 3 homolog, mitochondrial-like [KO:K18175]
103074474  cytochrome c oxidase assembly factor 3 homolog, mitochondrial-like [KO:K18175]
103069603  cytochrome c oxidase assembly factor 4 homolog, mitochondrial-like [KO:K18177]
103075222  cytochrome c oxidase assembly factor 5-like [KO:K18178]
103074667  cytochrome c oxidase assembly factor 6 homolog isoform X1 [KO:K18179]
103080028  cytochrome c oxidase assembly factor 7-like [KO:K18180]
103073988  ATP5A1; ATP synthase subunit alpha, mitochondrial isoform X1 [KO:K02132]
103078143  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
103087229  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
103070384  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
103082578  ATP synthase subunit epsilon, mitochondrial-like [KO:K02135]
103077125  ATP5O; ATP synthase subunit O, mitochondrial [KO:K02137]
3802097  ATP6; ATP synthase F0 subunit 6 [KO:K02126]
103070520  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
103091253  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
103074026  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
103089849  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
103079342  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
103083487  ATP5H; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
103080081  ATP5J2; ATP synthase subunit f, mitochondrial [KO:K02130]
103088939  ATP5J; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
3802096  ATP8; ATP synthase F0 subunit 8 [KO:K02125]
103068805  ATP5L; ATP synthase subunit g, mitochondrial [KO:K02140]
103072106  ATP synthase subunit g, mitochondrial-like [KO:K02140]
103082924  CPT2; carnitine O-palmitoyltransferase 2, mitochondrial isoform X1 [KO:K08766] [EC:2.3.1.21]
103091513  SLC25A20; mitochondrial carnitine/acylcarnitine carrier protein [KO:K15109]
103074218  uncharacterized protein LOC103074218 [KO:K15109]
103068754  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
103073664  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
103073152  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform [KO:K19524] [EC:2.3.1.21]
Compound
C00002  ATP
C00004  NADH
C00008  ADP
C00010  CoA
C00024  Acetyl-CoA
C00040  Acyl-CoA
C00080  H+
C00116  Glycerol
C00162  Fatty acid
C00165  Diacylglycerol
C00318  L-Carnitine
C00422  Triacylglycerol
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00942  3',5'-Cyclic GMP
C00951  Estradiol-17beta
C01352  FADH2
C01885  1-Acylglycerol
C02301  O-Acylcarnitine
C02465  Triiodothyronine
C11695  Anandamide
C13856  2-Arachidonoylglycerol
Reference
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  Title
Transcriptional and epigenetic control of brown and beige adipose cell fate and function.
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Nat Rev Mol Cell Biol 17:480-95 (2016)
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Brown and beige fat: development, function and therapeutic potential.
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Nat Med 19:1252-63 (2013)
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Peripheral cannabinoid 1 receptor blockade activates brown adipose tissue and diminishes dyslipidemia and obesity.
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FASEB J 28:5361-75 (2014)
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Mol Nutr Food Res 60:18-42 (2016)
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  Title
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Trends Mol Med 21:571-9 (2015)
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Trends Endocrinol Metab 26:657-68 (2015)
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Redox Biol 12:854-863 (2017)
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Nutr Res Rev 27:63-93 (2014)
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IUBMB Life 56:379-85 (2004)
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Positive and negative control of Ucp1 gene transcription and the role of beta-adrenergic signaling networks.
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Int J Obes (Lond) 34 Suppl 1:S28-33 (2010)
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Selective activation of mitogen-activated protein (MAP) kinase kinase 3 and p38alpha MAP kinase is essential for cyclic AMP-dependent UCP1 expression in adipocytes.
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Mol Cell Biol 25:5466-79 (2005)
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ASK1 signalling regulates brown and beige adipocyte function.
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Nat Commun 7:11158 (2016)
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Abe Y, Rozqie R, Matsumura Y, Kawamura T, Nakaki R, Tsurutani Y, Tanimura-Inagaki K, Shiono A, Magoori K, Nakamura K, Ogi S, Kajimura S, Kimura H, Tanaka T, Fukami K, Osborne TF, Kodama T, Aburatani H, Inagaki T, Sakai J
  Title
JMJD1A is a signal-sensing scaffold that regulates acute chromatin dynamics via SWI/SNF association for thermogenesis.
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Nat Commun 6:7052 (2015)
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Mol Cell 57:235-46 (2015)
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Cell Rep 15:2536-49 (2016)
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  Title
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Nat Rev Endocrinol 11:617-25 (2015)
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Related
pathway
lve00020  Citrate cycle (TCA cycle)
lve00190  Oxidative phosphorylation
lve04010  MAPK signaling pathway
lve04022  cGMP-PKG signaling pathway
lve04024  cAMP signaling pathway
lve04150  mTOR signaling pathway
lve04923  Regulation of lipolysis in adipocytes
KO pathway
ko04714   
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