KEGG   PATHWAY: lww00230
Entry
lww00230                    Pathway                                
Name
Purine metabolism - Leptonychotes weddellii (Weddell seal)
Class
Metabolism; Nucleotide metabolism
Pathway map
lww00230  Purine metabolism
lww00230

Module
lww_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:lww00230]
lww_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:lww00230]
lww_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:lww00230]
lww_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:lww00230]
lww_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:lww00230]
lww_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:lww00230]
lww_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:lww00230]
Other DBs
GO: 0006163 0042278
Organism
Leptonychotes weddellii (Weddell seal) [GN:lww]
Gene
102744984  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
102728358  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
102735906  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
102739406  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
102737164  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
102743701  PRPS2; ribose-phosphate pyrophosphokinase 2 [KO:K00948] [EC:2.7.6.1]
102741852  PRPS1L1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
102746356  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
102750243  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
102730762  PFAS; phosphoribosylformylglycinamidine synthase isoform X2 [KO:K01952] [EC:6.3.5.3]
102746659  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
102751190  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
102732985  ATIC; bifunctional purine biosynthesis protein PURH isoform X1 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
102749565  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
102727013  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
102729656  NT5C2; cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
102738568  cytosolic 5'-nucleotidase 1B [KO:K01081] [EC:3.1.3.5]
102741518  NT5DC4; LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
102750375  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial isoform X3 [KO:K01081] [EC:3.1.3.5]
102731828  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
102741938  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
102750417  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
102726774  laccase domain-containing protein 1-like [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
102740058  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
102734606  hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
102738468  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
102750004  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X2 [KO:K00088] [EC:1.1.1.205]
102735193  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
102734595  NME3; LOW QUALITY PROTEIN: nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
102733648  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
102742077  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
102730153  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
102740450  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
102734788  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 isoform X7 [KO:K01510] [EC:3.6.1.5]
102732996  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
102742087  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
102736694  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X2 [KO:K12305] [EC:3.6.1.6]
102733637  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
102743620  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X2 [KO:K01511] [EC:3.6.1.6]
102731916  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
102727395  ITPA; inosine triphosphate pyrophosphatase isoform X4 [KO:K01519] [EC:3.6.1.66]
102731349  XDH; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
102748665  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
102745306  GMPS; LOW QUALITY PROTEIN: GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
102750355  GMPR2; GMP reductase 2 [KO:K00364] [EC:1.7.1.7]
102739841  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
102750212  guanine deaminase [KO:K01487] [EC:3.5.4.3]
102750686  guanine deaminase-like [KO:K01487] [EC:3.5.4.3]
102730369  GUK1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
102741658  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
102749461  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X2 [KO:K10808] [EC:1.17.4.1]
102739892  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
102745551  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
102739466  deoxyguanosine kinase, mitochondrial-like [KO:K00904] [EC:2.7.1.113]
102732987  DGUOK; deoxyguanosine kinase, mitochondrial isoform X2 [KO:K00904] [EC:2.7.1.113]
102729901  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
102744701  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
102733922  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
102739347  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102741598  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
102729355  adenylate cyclase type 4-like isoform X1 [KO:K08044] [EC:4.6.1.1]
102750941  adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
102734024  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
102732736  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
102733005  adenylate cyclase type 8-like [KO:K08048] [EC:4.6.1.1]
102728665  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102742249  adenylate cyclase type 10-like isoform X1 [KO:K11265] [EC:4.6.1.1]
102736576  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
102742433  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
102726502  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
102738224  LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
102743018  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
102729228  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
102740621  olfactory guanylyl cyclase GC-D-like [KO:K12321] [EC:4.6.1.2]
102740295  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
102736168  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
102734402  LOW QUALITY PROTEIN: guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
102748387  integrator complex subunit 3-like [KO:K12323] [EC:4.6.1.2]
102743744  NPR2; atrial natriuretic peptide receptor 2 isoform X5 [KO:K12324] [EC:4.6.1.2]
102745391  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
102747638  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C-like [KO:K13755] [EC:3.1.4.17]
102746138  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
102746653  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
102737336  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
102737416  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
102751052  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
102748639  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
102726924  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
102735562  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
102736292  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
102727605  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X2 [KO:K13760]
102732183  PDE9A; LOW QUALITY PROTEIN: high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
102738356  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X5 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
102727503  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
102727220  ADSS1; adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
102729177  ADSS2; adenylosuccinate synthetase isozyme 2 isoform X1 [KO:K01939] [EC:6.3.4.4]
102748481  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
102748010  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
102740240  AMPD3; AMP deaminase 3 isoform X2 [KO:K01490] [EC:3.5.4.6]
102748844  ADK; adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
102735768  adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
102744697  ADA2; adenosine deaminase 2 isoform X1 [KO:K19572] [EC:3.5.4.4]
102727845  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
102734605  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
102738512  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
115937697  adenylate kinase isoenzyme 1-like [KO:K00939] [EC:2.7.4.3]
102750385  adenylate kinase 4, mitochondrial-like [KO:K00939] [EC:2.7.4.3]
115945121  probable adenylate kinase 5, chloroplastic [KO:K00939] [EC:2.7.4.3]
102750758  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
102730556  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
102740264  adenylate kinase isoenzyme 6-like [KO:K18532] [EC:2.7.4.3]
102748257  adenylate kinase isoenzyme 6-like [KO:K18532] [EC:2.7.4.3]
102739898  AK6; adenylate kinase isoenzyme 6 isoform X1 [KO:K18532] [EC:2.7.4.3]
102725764  adenylate kinase isoenzyme 6-like [KO:K18532] [EC:2.7.4.3]
102730729  GTP:AMP phosphotransferase AK3, mitochondrial-like isoform X1 [KO:K00944] [EC:2.7.4.10]
102739770  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 isoform X1 [KO:K01509] [EC:3.6.1.-]
102728057  NTPCR; cancer-related nucleoside-triphosphatase isoform X2 [KO:K06928] [EC:3.6.1.15]
102749075  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
102749380  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
102725625  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X3 [KO:K13293] [EC:3.1.4.53]
102745857  cAMP-specific 3',5'-cyclic phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
102749607  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
102746924  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
102740804  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
102730964  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
102737208  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
102736197  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
102740715  bis(5'-adenosyl)-triphosphatase-like [KO:K01522] [EC:3.6.1.29]
102735746  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
102736409  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
102746970  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
102731882  uricase isoform X1 [KO:K00365] [EC:1.7.3.3]
102727956  5-hydroxyisourate hydrolase-like [KO:K07127] [EC:3.5.2.17]
102741444  URAD; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
102745843  LOW QUALITY PROTEIN: probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
lww00030  Pentose phosphate pathway
lww00220  Arginine biosynthesis
lww00250  Alanine, aspartate and glutamate metabolism
lww00260  Glycine, serine and threonine metabolism
lww00340  Histidine metabolism
lww00630  Glyoxylate and dicarboxylate metabolism
lww00730  Thiamine metabolism
lww00740  Riboflavin metabolism
lww00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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