KEGG   PATHWAY: mamb04270
Entry
mamb04270                   Pathway                                
Name
Vascular smooth muscle contraction - Megalobrama amblycephala (Wuchang bream)
Description
The vascular smooth muscle cell (VSMC) is a highly specialized cell whose principal function is contraction. On contraction, VSMCs shorten, thereby decreasing the diameter of a blood vessel to regulate the blood flow and pressure.
The principal mechanisms that regulate the contractile state of VSMCs are changes in cytosolic Ca2+ concentration ([Ca2+]c). In response to vasoconstrictor stimuli, Ca2+ is mobilized from intracellular stores and/or the extracellular space to increase [Ca2+]c in VSMCs. The increase in [Ca2+]c, in turn, activates the Ca2+-CaM-MLCK pathway and stimulates MLC20 phosphorylation, leading to myosin-actin interactions and, hence, the development of contractile force. The sensitivity of contractile myofilaments or MLC20 phosphorylation to Ca2+ can be secondarily modulated by other signaling pathways. During receptor stimulation, the contractile force is greatly enhanced by the inhibition of myosin phosphatase. Rho/Rho kinase, PKC, and arachidonic acid have been proposed to play a pivotal role in this enhancement.
The signaling events that mediate relaxation include the removal of a contractile agonist (passive relaxation) and activation of cyclic nucleotide-dependent signaling pathways in the continued presence of a contractile agonist (active relaxation). Active relaxation occurs through the inhibition of both Ca2+ mobilization and myofilament Ca2+ sensitivity in VSMCs.
Class
Organismal Systems; Circulatory system
Pathway map
mamb04270  Vascular smooth muscle contraction
mamb04270

Other DBs
GO: 0014829
Organism
Megalobrama amblycephala (Wuchang bream) [GN:mamb]
Gene
125279506  adra1aa; adrenoceptor alpha 1Aa [KO:K04135]
125257075  adra1ab; alpha-1A adrenergic receptor [KO:K04135]
125252656  adra1ba; alpha-1A adrenergic receptor [KO:K04136]
125259402  adra1bb; adrenoceptor alpha 1Bb [KO:K04136]
125272051  adra1d; alpha-1D adrenergic receptor [KO:K04137]
125276874  agt; angiotensinogen [KO:K09821]
125258030  agtr1b; type-1 angiotensin II receptor A [KO:K04166]
125250148  agtr1a; LOW QUALITY PROTEIN: type-1B angiotensin II receptor [KO:K04166]
125276189  edn1; endothelin-1 [KO:K16366]
125278293  si:ch211-202p1.5; endothelin-2 [KO:K16367]
125244239  endothelin-2 [KO:K16367]
125275232  edn2; endothelin-2 [KO:K16367]
125257168  endothelin-3 [KO:K05227]
125260713  edn3b; endothelin-3b isoform X1 [KO:K05227]
125272086  ednraa; endothelin receptor type Aa [KO:K04197]
125260611  ednrab; endothelin receptor type Ab [KO:K04197]
125279724  vasopressin-neurophysin 2-copeptin [KO:K05242]
125246073  avpr1ab; arginine vasopressin receptor 1Ab [KO:K04226]
125246861  avpr1aa; arginine vasopressin receptor 1Aa [KO:K04226]
125267894  gnaq; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
125263822  gna11a; guanine nucleotide-binding protein subunit alpha-11a isoform X1 [KO:K04635]
125249962  gna11b; guanine nucleotide-binding protein subunit alpha-11b isoform X1 [KO:K04635]
125270000  pla2g10; group 10 secretory phospholipase A2 isoform X1 [KO:K01047] [EC:3.1.1.4]
125262520  pla2g3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
125280058  phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
125280061  phospholipase A2-like isoform X1 [KO:K01047] [EC:3.1.1.4]
125280062  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
125280063  phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
125249355  proca1; uncharacterized protein proca1 [KO:K01047] [EC:3.1.1.4]
125277443  pla2g12b; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
125261869  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125261870  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125262001  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125278200  pla2g4ab; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
125245073  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125246655  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266030  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266031  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266034  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
125266162  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266251  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266252  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266253  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266254  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125266255  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266256  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266257  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125266258  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125266259  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266261  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125266268  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266277  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125266278  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
125266279  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125266336  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125250122  pla2g4aa; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
125268789  pla2g4f.2; cytosolic phospholipase A2 delta isoform X1 [KO:K16342] [EC:3.1.1.4]
125268790  pla2g4f.1; cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
125253642  pla2g6; 85/88 kDa calcium-independent phospholipase A2 isoform X1 [KO:K16343] [EC:3.1.1.4]
125254972  calcium-activated potassium channel subunit alpha-1-like isoform X1 [KO:K04936]
125276641  kcnma1a; calcium-activated potassium channel subunit alpha-1a isoform X1 [KO:K04936]
125256302  si:ch211-247n2.1; LOW QUALITY PROTEIN: calcium-activated potassium channel subunit beta-2 [KO:K04938]
125251048  kcnmb2; calcium-activated potassium channel subunit beta-2 [KO:K04938]
125251047  kcnmb3; LOW QUALITY PROTEIN: calcium-activated potassium channel subunit beta-3 [KO:K04939]
125245652  cacna1c; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
125280569  cacna1db; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
125256332  cacna1da; calcium channel, voltage-dependent, L type, alpha 1D subunit, a isoform X1 [KO:K04851]
125279615  cacna1fb; calcium channel, voltage-dependent, L type, alpha 1F subunit isoform X1 [KO:K04853]
125280153  cacna1fa; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04853]
125263059  cacna1sa; calcium channel, voltage-dependent, L type, alpha 1S subunit, a isoform X1 [KO:K04857]
125279856  cacna1sb; calcium channel, voltage-dependent, L type, alpha 1S subunit, b [KO:K04857]
125279053  calm1b; calmodulin-1b [KO:K02183]
125264806  calml4a; calmodulin-like protein 4a [KO:K02183]
125253545  calm3b; calmodulin 3b (phosphorylase kinase, delta) [KO:K02183]
125247787  calml4b; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
125248338  calm3a; calmodulin 3a (phosphorylase kinase, delta) isoform X1 [KO:K02183]
125255503  calm2b; calmodulin 2b, (phosphorylase kinase, delta) [KO:K02183]
125268828  calm1a; calmodulin-1a [KO:K02183]
125277263  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
125258353  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
125277903  mylk4b; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
125264921  mylk3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
125274305  mylkb; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
125250022  mylk4a; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
125276812  mylk5; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
125260668  mylk2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
125269878  mylka; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
125273730  myl6; myosin light polypeptide 6 isoform X1 [KO:K12751]
125259866  zgc:153867; myosin light polypeptide 6 isoform X1 [KO:K12751]
125274076  myl9b; myosin regulatory light polypeptide 9b [KO:K12755]
125259918  myl9a; myosin regulatory light polypeptide 9 [KO:K12755]
125270474  myh9b; LOW QUALITY PROTEIN: myosin-9 [KO:K10352]
125274178  myh10; myosin-10 isoform X1 [KO:K10352]
125274181  myh9a; myosin-9a [KO:K10352]
125274211  myh11a; myosin-11a isoform X1 [KO:K10352]
125278656  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
125278657  plcb4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
125265626  plcb3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
125269274  plcb2; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
125269307  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
125269308  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
125273734  itpr1a; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
125256994  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
125254454  itpr2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
125279368  itpr3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
125274046  prkcaa; protein kinase C, alpha, a isoform X1 [KO:K02677] [EC:2.7.11.13]
125268438  prkcab; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
125271228  prkcbb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125272719  prkcba; protein kinase C, beta a isoform X1 [KO:K19662] [EC:2.7.11.13]
125242974  prkcg; protein kinase C alpha type [KO:K19663] [EC:2.7.11.13]
125273755  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
125256482  prkcdb; protein kinase C, delta b [KO:K06068] [EC:2.7.11.13]
125255135  prkcea; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
125277255  prkceb; protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
125277785  prkchb; protein kinase C, eta, b isoform X1 [KO:K18051] [EC:2.7.11.13]
125277076  prkcha; LOW QUALITY PROTEIN: protein kinase C eta type [KO:K18051] [EC:2.7.11.13]
125245039  prkcq; protein kinase C theta type isoform X1 [KO:K18052] [EC:2.7.11.13]
125266490  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
125246121  braf; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
125259699  raf1a; LOW QUALITY PROTEIN: raf-1 proto-oncogene, serine/threonine kinase a [KO:K04366] [EC:2.7.11.1]
125256524  raf1b; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125253954  map2k1; LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125263787  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
125250873  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
125267337  mapk1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
125275450  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
125246230  cald1a; caldesmon 1a isoform X1 [KO:K12327]
125246773  cald1b; caldesmon 1b isoform X1 [KO:K12327]
125247804  lsp1a; non-muscle caldesmon isoform X1 [KO:K12327]
125255373  acta2; actin, aortic smooth muscle isoform X1 [KO:K12313]
125266393  ppp1r14aa; protein phosphatase 1, regulatory (inhibitor) subunit 14Aa isoform X1 [KO:K12328]
125249434  ppp1r14ab; protein phosphatase 1, regulatory (inhibitor) subunit 14Ab [KO:K12328]
125278904  serine/threonine-protein phosphatase PP1-beta catalytic subunit-like [KO:K06269] [EC:3.1.3.16]
125265892  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
125266218  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
125254963  ppp1cab; LOW QUALITY PROTEIN: protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
125268817  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
125276563  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
125246147  ppp1r12a; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
125246847  zmp:0000001167; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
125278121  ppp1r12c; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
125269719  gna12a; guanine nucleotide-binding protein subunit alpha-12a [KO:K04346]
125271647  gna13b; guanine nucleotide-binding protein subunit alpha-13b [KO:K04639]
125255403  gna13a; guanine nucleotide-binding protein subunit alpha-13a [KO:K04639]
125248336  arhgef12a; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
125267681  arhgef12b; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
125280858  arhgef1b; rho guanine nucleotide exchange factor 1b isoform X7 [KO:K12330]
125265268  arhgef11; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 11 [KO:K12331]
125263141  rho-related GTP-binding protein RhoA-B-like [KO:K04513]
125279763  rhocb; rho-related GTP-binding protein RhoA-D [KO:K04513]
125279867  rhoab; rho-related GTP-binding protein RhoA-B [KO:K04513]
125280712  rhoaa; rho-related GTP-binding protein RhoA-A [KO:K04513]
125273530  rhoca; ras homolog family member Ca [KO:K04513]
125260998  rhoac; rho-related GTP-binding protein RhoA-C [KO:K04513]
125250859  rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
125278172  rock2b; rho-associated protein kinase 2b isoform X1 [KO:K17388] [EC:2.7.11.39]
125277100  rock2a; LOW QUALITY PROTEIN: rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.39]
125252569  adora2ab; adenosine A2a receptor b [KO:K04266]
125279693  adora2aa; adenosine A2a receptor a [KO:K04266]
125267957  adora2b; adenosine receptor A2b [KO:K04267]
125248835  ptgir; prostacyclin receptor [KO:K04263]
125264641  calca; calcitonin/calcitonin-related polypeptide, alpha isoform X1 [KO:K12332]
125247289  calcitonin-like isoform X1 [KO:K12332]
125265799  adma; adrenomedullin a [KO:K12333]
125244692  adm2a; protein ADM2a [KO:K25343]
125253893  adm2b; protein ADM2 [KO:K25343]
125270636  calcrla; calcitonin gene-related peptide type 1 receptor [KO:K04577]
125274354  calcrlb; calcitonin gene-related peptide type 1 receptor [KO:K04577]
125259975  calcrl2; calcitonin gene-related peptide type 1 receptor [KO:K04577]
125270281  ramp1; receptor activity-modifying protein 1 [KO:K08447]
125257636  receptor activity-modifying protein 1-like isoform X1 [KO:K08447]
125271847  ramp2; receptor activity-modifying protein 2 [KO:K08448]
125252600  receptor activity-modifying protein 3-like isoform X1 [KO:K08449]
125273564  gnas; guanine nucleotide-binding protein G(s) subunit alpha isoform X1 [KO:K04632]
125279119  adcy1a; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
125251308  adcy1b; adenylate cyclase type 1b [KO:K08041] [EC:4.6.1.1]
125242992  adcy2a; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
125274762  adcy2b; adenylate cyclase type 2b isoform X1 [KO:K08042] [EC:4.6.1.1]
125243356  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
125278498  adenylate cyclase type 3-like [KO:K08043] [EC:4.6.1.1]
125264290  adenylate cyclase type 4-like [KO:K08044] [EC:4.6.1.1]
125270200  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
125259558  adcy6a; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
125260716  adcy6b; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
125265058  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
125278420  si:dkey-206f10.1; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
125250700  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
125269091  si:ch211-132f19.7; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
125262387  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
125263713  adcy9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
125278182  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
125255428  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
125256470  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
125251891  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b [KO:K04345] [EC:2.7.11.11]
125280034  nppa; natriuretic peptides A [KO:K12334]
125243570  npr1b; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
125274726  npr1a; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
125262864  nppc; C-type natriuretic peptide [KO:K12336]
125279962  nppal; natriuretic peptide A-like [KO:K12336]
125251555  C-type natriuretic peptide 4-like [KO:K12336]
125260773  si:ch73-265d7.2; C-type natriuretic peptide 2 [KO:K12336]
125252665  atrial natriuretic peptide receptor 1-like isoform X1 [KO:K12324] [EC:4.6.1.2]
125268014  npr2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
125260715  atrial natriuretic peptide receptor 1-like [KO:K12324] [EC:4.6.1.2]
125254981  prkg1b; cGMP-dependent protein kinase 1 isoform X1 [KO:K07376] [EC:2.7.11.12]
125277225  prkg1a; cGMP-dependent protein kinase 1a isoform X1 [KO:K07376] [EC:2.7.11.12]
125265796  mrvi1; inositol 1,4,5-triphosphate receptor associated 1 isoform X1 [KO:K12337]
125272425  gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
125249277  gucy1a2; LOW QUALITY PROTEIN: guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
125272426  gucy1b1; guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
125248166  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
125256989  gucy1b2; guanylate cyclase soluble subunit beta-2 isoform X1 [KO:K12319] [EC:4.6.1.2]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00212  Adenosine
C00219  Arachidonate
C00238  Potassium cation
C00533  Nitric oxide
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00942  3',5'-Cyclic GMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C14748  20-HETE
C14768  5,6-EET
C14769  8,9-EET
C14770  11,12-EET
C14771  14,15-EET
Reference
PMID:17458653
  Authors
Akata T
  Title
Cellular and molecular mechanisms regulating vascular tone. Part 2: regulatory mechanisms modulating Ca2+ mobilization and/or myofilament Ca2+ sensitivity in vascular smooth muscle cells.
  Journal
J Anesth 21:232-42 (2007)
DOI:10.1007/s00540-006-0488-4
Reference
PMID:12689814
  Authors
Ogut O, Brozovich FV
  Title
Regulation of force in vascular smooth muscle.
  Journal
J Mol Cell Cardiol 35:347-55 (2003)
DOI:10.1016/S0022-2828(03)00045-2
Reference
PMID:16339747
  Authors
Hilgers RH, Webb RC
  Title
Molecular aspects of arterial smooth muscle contraction: focus on Rho.
  Journal
Exp Biol Med (Maywood) 230:829-35 (2005)
DOI:10.1177/153537020523001107
Reference
PMID:12693609
  Authors
Schlossmann J, Feil R, Hofmann F
  Title
Signaling through NO and cGMP-dependent protein kinases.
  Journal
Ann Med 35:21-7 (2003)
DOI:10.1080/07853890310004093
Reference
PMID:16870827
  Authors
Mehta PK, Griendling KK
  Title
Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system.
  Journal
Am J Physiol Cell Physiol 292:C82-97 (2007)
DOI:10.1152/ajpcell.00287.2006
Reference
PMID:19120701
  Authors
Kim HR, Appel S, Vetterkind S, Gangopadhyay SS, Morgan KG
  Title
Smooth muscle signalling pathways in health and disease.
  Journal
J Cell Mol Med 12:2165-80 (2008)
DOI:10.1111/j.1582-4934.2008.00552.x
Reference
PMID:11165670
  Authors
Fukata Y, Amano M, Kaibuchi K
  Title
Rho-Rho-kinase pathway in smooth muscle contraction and cytoskeletal reorganization of non-muscle cells.
  Journal
Trends Pharmacol Sci 22:32-9 (2001)
DOI:10.1016/S0165-6147(00)01596-0
Reference
PMID:17158339
  Authors
Dimopoulos GJ, Semba S, Kitazawa K, Eto M, Kitazawa T
  Title
Ca2+-dependent rapid Ca2+ sensitization of contraction in arterial smooth muscle.
  Journal
Circ Res 100:121-9 (2007)
DOI:10.1161/01.RES.0000253902.90489.df
Reference
PMID:17200683
  Authors
Hynynen MM, Khalil RA
  Title
The vascular endothelin system in hypertension--recent patents and discoveries.
  Journal
Recent Pat Cardiovasc Drug Discov 1:95-108 (2006)
DOI:10.2174/157489006775244263
Reference
PMID:15269340
  Authors
Brain SD, Grant AD
  Title
Vascular actions of calcitonin gene-related peptide and adrenomedullin.
  Journal
Physiol Rev 84:903-34 (2004)
DOI:10.1152/physrev.00037.2003
Reference
PMID:11773611
  Authors
Roman RJ
  Title
P-450 metabolites of arachidonic acid in the control of cardiovascular function.
  Journal
Physiol Rev 82:131-85 (2002)
DOI:10.1152/physrev.00021.2001
Reference
PMID:18040024
  Authors
Surks HK
  Title
cGMP-dependent protein kinase I and smooth muscle relaxation: a tale of two isoforms.
  Journal
Circ Res 101:1078-80 (2007)
DOI:10.1161/CIRCRESAHA.107.165779
Reference
PMID:15026027
  Authors
Vanhoutte PM
  Title
Endothelium-dependent hyperpolarizations: the history.
  Journal
Pharmacol Res 49:503-8 (2004)
DOI:10.1016/j.phrs.2003.11.015
Reference
PMID:10221985
  Authors
Davis MJ, Hill MA
  Title
Signaling mechanisms underlying the vascular myogenic response.
  Journal
Physiol Rev 79:387-423 (1999)
DOI:10.1152/physrev.1999.79.2.387
Reference
PMID:11679404
  Authors
Fleming I.
  Title
Cytochrome p450 and vascular homeostasis.
  Journal
Circ Res 89:753-62 (2001)
DOI:10.1161/hh2101.099268
Reference
PMID:10911373
  Authors
Carvajal JA, Germain AM, Huidobro-Toro JP, Weiner CP
  Title
Molecular mechanism of cGMP-mediated smooth muscle relaxation.
  Journal
J Cell Physiol 184:409-20 (2000)
DOI:10.1002/1097-4652(200009)184:3<409::AID-JCP16>3.0.CO;2-K
Reference
PMID:18552454
  Authors
Ko EA, Han J, Jung ID, Park WS
  Title
Physiological roles of K+ channels in vascular smooth muscle cells.
  Journal
J Smooth Muscle Res 44:65-81 (2008)
DOI:10.1540/jsmr.44.65
Reference
PMID:18703404
  Authors
Woodard GE, Rosado JA
  Title
Natriuretic peptides in vascular physiology and pathology.
  Journal
Int Rev Cell Mol Biol 268:59-93 (2008)
DOI:10.1016/S1937-6448(08)00803-4
Reference
PMID:11709400
  Authors
Berry C, Touyz R, Dominiczak AF, Webb RC, Johns DG
  Title
Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide.
  Journal
Am J Physiol Heart Circ Physiol 281:H2337-65 (2001)
DOI:10.1152/ajpheart.2001.281.6.H2337
Reference
PMID:15725705
  Authors
Hirano K, Hirano M, Kanaide H
  Title
Regulation of myosin phosphorylation and myofilament Ca2+ sensitivity in vascular smooth muscle.
  Journal
J Smooth Muscle Res 40:219-36 (2004)
DOI:10.1540/jsmr.40.219
Reference
PMID:9458738
  Authors
Freeman EJ, Ruehr ML, Dorman RV
  Title
ANG II-induced translocation of cytosolic PLA2 to the nucleus in vascular smooth muscle cells.
  Journal
Am J Physiol 274:C282-8 (1998)
DOI:10.1152/ajpcell.1998.274.1.C282
Reference
PMID:12060106
  Authors
Murphy TV, Spurrell BE, Hill MA
  Title
Cellular signalling in arteriolar myogenic constriction: involvement of tyrosine phosphorylation pathways.
  Journal
Clin Exp Pharmacol Physiol 29:612-9 (2002)
DOI:10.1046/j.1440-1681.2002.03698.x
Related
pathway
mamb00590  Arachidonic acid metabolism
mamb04020  Calcium signaling pathway
KO pathway
ko04270   
LinkDB

DBGET integrated database retrieval system