KEGG   PATHWAY: mlx04150
Entry
mlx04150                    Pathway                                
Name
mTOR signaling pathway - Mirounga leonina (Southern elephant seal)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
mlx04150  mTOR signaling pathway
mlx04150

Organism
Mirounga leonina (Southern elephant seal) [GN:mlx]
Gene
118023480  SLC7A5; large neutral amino acids transporter small subunit 1 [KO:K13780]
118015965  SLC3A2; 4F2 cell-surface antigen heavy chain [KO:K06519]
118016793  SLC38A9; sodium-coupled neutral amino acid transporter 9 isoform X1 [KO:K14995]
118007092  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
118022062  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
118007993  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
118015094  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
118007592  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
118002129  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
118025820  ATP6V1E1; V-type proton ATPase subunit E 1 isoform X1 [KO:K02150]
118007470  ATP6V1E2; V-type proton ATPase subunit E 2 isoform X1 [KO:K02150]
118021064  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
118017772  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
118004112  V-type proton ATPase subunit G 1-like [KO:K02152]
118027347  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
118013687  ATP6V1G3; V-type proton ATPase subunit G 3 isoform X1 [KO:K02152]
118014820  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
118003899  LAMTOR1; ragulator complex protein LAMTOR1 [KO:K20397]
118013900  LAMTOR2; ragulator complex protein LAMTOR2 [KO:K20398]
118027031  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
117999404  LAMTOR4; ragulator complex protein LAMTOR4 isoform X1 [KO:K20399]
118019015  LAMTOR5; ragulator complex protein LAMTOR5 [KO:K16344]
118000161  FLCN; folliculin isoform X1 [KO:K09594]
118016611  FNIP1; folliculin-interacting protein 1 isoform X1 [KO:K20400]
118022196  FNIP2; folliculin-interacting protein 2 isoform X1 [KO:K20401]
118001110  RRAGB; ras-related GTP-binding protein B isoform X1 [KO:K16185]
117999034  RRAGA; ras-related GTP-binding protein A [KO:K16185]
118001314  RRAGD; ras-related GTP-binding protein D [KO:K16186]
118019591  RRAGC; ras-related GTP-binding protein C [KO:K16186]
118019801  SESN2; sestrin-2 [KO:K20394]
118018645  CASTOR1; cytosolic arginine sensor for mTORC1 subunit 1 isoform X1 [KO:K23080]
117999513  CASTOR2; cytosolic arginine sensor for mTORC1 subunit 2 isoform X1 [KO:K23081]
118020800  MIOS; GATOR complex protein MIOS [KO:K20407]
118021665  WDR24; GATOR complex protein WDR24 isoform X1 [KO:K20408]
118023570  WDR59; GATOR complex protein WDR59 isoform X1 [KO:K20409]
118006015  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
118018678  DEPDC5; GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
118004884  NPRL2; GATOR complex protein NPRL2 [KO:K20405]
118021644  NPRL3; GATOR complex protein NPRL3 isoform X1 [KO:K20406]
118006346  S-phase kinase-associated protein 2 [KO:K03875]
118006475  S-phase kinase-associated protein 2 [KO:K03875]
118004688  RNF152; E3 ubiquitin-protein ligase RNF152 [KO:K15705] [EC:2.3.2.27]
118024187  RPTOR; regulatory-associated protein of mTOR [KO:K07204]
117998320  AKT1S1; proline-rich AKT1 substrate 1 isoform X1 [KO:K16184]
118020008  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
118015160  DEPTOR; DEP domain-containing mTOR-interacting protein isoform X1 [KO:K20402]
118021723  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
118021694  TELO2; telomere length regulation protein TEL2 homolog isoform X1 [KO:K11137]
118011468  TTI1; TELO2-interacting protein 1 homolog [KO:K20403]
118018421  CLIP1; CAP-Gly domain-containing linker protein 1 isoform X1 [KO:K10421]
118024529  GRB10; growth factor receptor-bound protein 10 [KO:K20064]
118004513  LPIN2; phosphatidate phosphatase LPIN2 [KO:K15728] [EC:3.1.3.4]
118011491  LPIN3; phosphatidate phosphatase LPIN3 isoform X1 [KO:K15728] [EC:3.1.3.4]
118007600  LPIN1; phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
118018362  ULK1; LOW QUALITY PROTEIN: serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
118000121  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
118009966  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
118015501  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
118010310  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
118011934  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
118016129  RPS6KB2; ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
118024673  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
118008810  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
118015851  LOW QUALITY PROTEIN: 40S ribosomal protein S6-like [KO:K02991]
118002114  40S ribosomal protein S6-like [KO:K02991]
118017309  40S ribosomal protein S6-like [KO:K02991]
118018960  40S ribosomal protein S6-like [KO:K02991]
117999029  RPS6; 40S ribosomal protein S6 [KO:K02991]
118024384  STRADA; STE20-related kinase adapter protein alpha isoform X1 [KO:K08271]
118012151  STRADB; STE20-related kinase adapter protein beta isoform X1 [KO:K17532]
118005809  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
118009447  CAB39L; calcium-binding protein 39-like [KO:K08272]
118011960  CAB39; calcium-binding protein 39 [KO:K08272]
118019366  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
118006331  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
118006463  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
118017558  TSC1; hamartin isoform X1 [KO:K07206]
118021717  TSC2; tuberin isoform X1 [KO:K07207]
117997420  TBC1 domain family member 7 isoform X1 [KO:K20396]
118026819  RHEB; GTP-binding protein Rheb [KO:K07208]
118021201  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
118008496  WNT1; proto-oncogene Wnt-1 [KO:K03209]
118018995  WNT2B; protein Wnt-2b [KO:K00182]
118021014  WNT2; protein Wnt-2 [KO:K00182]
118026858  WNT3A; protein Wnt-3a [KO:K00312]
118027173  WNT3; proto-oncogene Wnt-3 [KO:K00312]
118019912  WNT4; protein Wnt-4 [KO:K00408]
118025802  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
118005025  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
118011751  WNT6; protein Wnt-6 [KO:K00445]
118005134  WNT7A; protein Wnt-7a [KO:K00572]
117998566  WNT7B; protein Wnt-7b isoform X1 [KO:K00572]
118017183  WNT8A; protein Wnt-8a [KO:K00714]
118024994  WNT8B; protein Wnt-8b [KO:K00714]
118026884  WNT9A; protein Wnt-9a [KO:K01064]
118027171  WNT9B; protein Wnt-9b [KO:K01064]
118008893  WNT10B; protein Wnt-10b [KO:K01357]
118011750  WNT10A; protein Wnt-10a [KO:K01357]
118004067  WNT11; protein Wnt-11 [KO:K01384]
118021382  WNT16; protein Wnt-16 isoform X1 [KO:K01558]
118012141  FZD7; frizzled-7 [KO:K02432]
118020735  FZD1; frizzled-1 [KO:K02432]
118024980  FZD2; frizzled-2 isoform X1 [KO:K02235]
118022125  FZD3; frizzled-3 [KO:K02329]
118003939  FZD4; frizzled-4 [KO:K02354]
118026631  FZD8; frizzled-8 [KO:K02375]
118012097  FZD5; frizzled-5 [KO:K02375]
118015096  FZD6; frizzled-6 [KO:K02376]
118018686  FZD10; frizzled-10 [KO:K02842]
117999200  FZD9; frizzled-9 [KO:K02842]
118016153  LRP5; low-density lipoprotein receptor-related protein 5 [KO:K03068]
118025656  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
117999990  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
118020123  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
118006887  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
118007057  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
118027255  TNF; tumor necrosis factor [KO:K03156]
118025746  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
118009921  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
118015656  INS; insulin [KO:K04526]
117998812  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
118005442  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
118023006  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
118024273  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
118007794  SOS1; son of sevenless homolog 1 [KO:K03099]
118002069  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
118016228  HRAS; GTPase HRas isoform X1 [KO:K02833]
118025572  KRAS; GTPase KRas isoform X1 [KO:K07827]
118000495  NRAS; GTPase NRas [KO:K07828]
118021159  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
118005431  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
118003336  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
118004882  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117999637  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
117999826  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
118001843  ribosomal protein S6 kinase alpha-2-like isoform X1 [KO:K04373] [EC:2.7.11.1]
118001950  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
118026062  RPS6KA6; ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
118019834  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
118007563  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
118011983  IRS1; insulin receptor substrate 1 [KO:K16172]
118016863  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
118019468  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
118006042  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
118004424  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
118020028  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
118006556  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
118012969  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
118021736  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
118022658  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118002024  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
118014553  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
118024839  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
118017676  MAPKAP1; target of rapamycin complex 2 subunit MAPKAP1 isoform X1 [KO:K20410]
118006405  rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
118006531  rapamycin-insensitive companion of mTOR isoform X1 [KO:K08267]
117998580  PRR5; proline-rich protein 5 isoform X1 [KO:K20411]
118015772  PRR5L; proline-rich protein 5-like isoform X1 [KO:K20411]
118005670  RHOA; transforming protein RhoA [KO:K04513]
118024347  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
117999123  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
117997993  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
118000805  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
mlx00561  Glycerolipid metabolism
mlx04010  MAPK signaling pathway
mlx04140  Autophagy - animal
mlx04151  PI3K-Akt signaling pathway
mlx04152  AMPK signaling pathway
mlx04810  Regulation of actin cytoskeleton
mlx04910  Insulin signaling pathway
KO pathway
ko04150   
LinkDB

DBGET integrated database retrieval system