KEGG   PATHWAY: mthb00230
Entry
mthb00230                   Pathway                                
Name
Purine metabolism - Macaca thibetana thibetana (Pere David's macaque)
Class
Metabolism; Nucleotide metabolism
Pathway map
mthb00230  Purine metabolism
mthb00230

Module
mthb_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:mthb00230]
mthb_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:mthb00230]
mthb_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:mthb00230]
mthb_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:mthb00230]
mthb_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:mthb00230]
mthb_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:mthb00230]
mthb_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:mthb00230]
Other DBs
GO: 0006163 0042278
Organism
Macaca thibetana thibetana (Pere David's macaque) [GN:mthb]
Gene
126954701  ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
126939727  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
126962383  ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
126935012  phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
126954887  phosphopentomutase [KO:K15779] [EC:5.4.2.2 5.4.2.7]
126950005  ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
126946669  ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
126946680  ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
126955446  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
126951660  trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
126939652  phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
126955444  bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
126963600  adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
126932427  bifunctional purine biosynthesis protein ATIC [KO:K00602] [EC:2.1.2.3 3.5.4.10]
126948229  bifunctional purine biosynthesis protein ATIC-like [KO:K00602] [EC:2.1.2.3 3.5.4.10]
126944345  adenine phosphoribosyltransferase isoform X1 [KO:K00759] [EC:2.4.2.7]
126962748  cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
126938818  5'(3')-deoxyribonucleotidase, mitochondrial isoform X1 [KO:K01081] [EC:3.1.3.5]
126933521  LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
126939262  5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
126934188  cytosolic 5'-nucleotidase 1B isoform X1 [KO:K01081] [EC:3.1.3.5]
126960090  cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
126952950  5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
126958301  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
126946828  purine nucleoside phosphorylase-like [KO:K03783] [EC:2.4.2.1]
126940372  purine nucleoside phosphorylase LACC1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
126946697  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
126949778  inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
126945314  inosine-5'-monophosphate dehydrogenase 1-like [KO:K00088] [EC:1.1.1.205]
126948662  inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
126937475  nucleoside diphosphate kinase B-like [KO:K00940] [EC:2.7.4.6]
126944759  nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
126944879  nucleoside diphosphate kinase, mitochondrial isoform X1 [KO:K00940] [EC:2.7.4.6]
126939625  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
126939627  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
126950762  nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
126953145  nucleoside diphosphate kinase A-like [KO:K00940] [EC:2.7.4.6]
126948742  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
126952359  adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
126936976  ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
126948517  ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
126939220  soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
126961249  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
126959522  nucleoside diphosphate phosphatase ENTPD5 isoform X1 [KO:K01511] [EC:3.6.1.6]
126929297  ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
126947206  U8 snoRNA-decapping enzyme-like [KO:K16855] [EC:3.6.1.62 3.6.1.64]
126947217  U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
126929409  inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
126933515  xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
126937430  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
126963246  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]-like [KO:K01518] [EC:3.6.1.17]
126947519  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
126958813  GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
126952910  GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
126937463  guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
126936560  guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
126935035  ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
126933789  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
126960886  LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
126953276  5'-deoxynucleotidase HDDC2 [KO:K07023] [EC:3.1.3.89]
126934062  deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
126955144  deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
126958898  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X1 [KO:K21138] [EC:3.1.7.2]
126932071  exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
126950155  adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
126956053  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
126933644  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
126958798  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
126949094  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
126930150  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
126944901  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
126961343  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
126944580  adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
126941492  adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
126953787  adenylate cyclase type 10-like isoform X1 [KO:K11265] [EC:4.6.1.1]
126936202  guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
126955073  guanylate cyclase soluble subunit alpha-1 isoform X1 [KO:K12318] [EC:4.6.1.2]
126955075  guanylate cyclase soluble subunit beta-1 isoform X1 [KO:K12319] [EC:4.6.1.2]
126940428  LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
126931301  guanylyl cyclase C [KO:K12320] [EC:4.6.1.2]
126939663  retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
126945320  retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
126962281  LOW QUALITY PROTEIN: guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
126933142  atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
126938027  atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
126931111  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
126932070  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
126950875  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
126935032  cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
126930504  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1 [KO:K19021] [EC:3.1.4.17]
126936600  cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1 [KO:K13296] [EC:3.1.4.17]
126955595  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
126956588  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
126954842  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
126962020  cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
126932398  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
126939139  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
126931361  retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
126950622  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
126953763  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
126932091  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
126951151  adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
126959417  adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
126930892  LOW QUALITY PROTEIN: AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
126929361  AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
126935646  AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
126962443  adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
126963117  LOW QUALITY PROTEIN: adenosine deaminase-like [KO:K01488] [EC:3.5.4.4]
126963840  adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
126929635  adenosine deaminase 2 isoform X1 [KO:K19572] [EC:3.5.4.4]
126936434  adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
126942812  adenylate kinase isoenzyme 1-like [KO:K00939] [EC:2.7.4.3]
126936983  adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
126937089  adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
126963108  adenylate kinase isoenzyme 5 isoform X1 [KO:K00939] [EC:2.7.4.3]
126957996  adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
126941135  adenylate kinase 2, mitochondrial-like [KO:K00939] [EC:2.7.4.3]
126959649  adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
126956553  adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
126937569  GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
126936977  ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
126942565  cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
126952044  ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
126952045  ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
126942500  cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
126937167  cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
126956987  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
126942198  cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
126961518  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
126952853  cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
126957576  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
126958057  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
126948839  bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
126953583  bis(5'-adenosyl)-triphosphatase ENPP4 isoform X1 [KO:K18424] [EC:3.6.1.29]
126954927  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
126963331  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
126963640  uricase isoform X1 [KO:K00365] [EC:1.7.3.3]
126943896  uncharacterized protein LOC126943896 isoform X1 [KO:K07127] [EC:3.5.2.17]
126940762  putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
126933866  probable inactive allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
mthb00030  Pentose phosphate pathway
mthb00220  Arginine biosynthesis
mthb00250  Alanine, aspartate and glutamate metabolism
mthb00260  Glycine, serine and threonine metabolism
mthb00340  Histidine metabolism
mthb00630  Glyoxylate and dicarboxylate metabolism
mthb00730  Thiamine metabolism
mthb00740  Riboflavin metabolism
mthb00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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