KEGG   PATHWAY: myb04360
Entry
myb04360                    Pathway                                
Name
Axon guidance - Myotis brandtii (Brandt's bat)
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
Pathway map
myb04360  Axon guidance
myb04360

Other DBs
GO: 0007411
Organism
Myotis brandtii (Brandt's bat) [GN:myb]
Gene
102242621  NTNG1; netrin G1 [KO:K07522]
102254852  NTNG2; netrin G2 [KO:K16359]
102261605  LRRC4C; leucine rich repeat containing 4C [KO:K07523]
102255132  LRRC4; leucine rich repeat containing 4 [KO:K16351]
102246799  NTN1; netrin 1 [KO:K06843]
102239703  NTN3; netrin 3 [KO:K06844]
102247517  NTN4; netrin 4 [KO:K06845]
102252977  DCC; DCC netrin 1 receptor [KO:K06765]
102248243  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
102261553  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
102249830  TRPC1; transient receptor potential cation channel subfamily C member 1 [KO:K04964]
102251383  TRPC3; transient receptor potential cation channel subfamily C member 3 [KO:K04966]
102252171  TRPC4; transient receptor potential cation channel subfamily C member 4 [KO:K04967]
102258816  TRPC5; transient receptor potential cation channel subfamily C member 5 [KO:K04968]
102239842  TRPC6; transient receptor potential cation channel subfamily C member 6 [KO:K04969]
102264111  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
102251300  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
102245752  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
102250711  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
102247129  PPP3R2; protein phosphatase 3 regulatory subunit B, beta [KO:K06268]
102246844  NFATC2; nuclear factor of activated T-cells 2 [KO:K17332]
102249455  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
102247200  NFATC4; nuclear factor of activated T-cells 4 [KO:K17334]
102245460  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
102242533  FYN; FYN proto-oncogene, Src family tyrosine kinase [KO:K05703] [EC:2.7.10.2]
102247553  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
102259160  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
102239988  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
102249503  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
102257260  CDC42; cell division cycle 42 [KO:K04393]
102239987  cell division control protein 42 homolog [KO:K04393]
102246437  ABLIM2; actin binding LIM protein family member 2 [KO:K07520]
102240952  ABLIM1; actin binding LIM protein 1 [KO:K07520]
102251137  ABLIM3; actin binding LIM protein family member 3 [KO:K07520]
102239473  NCK1; NCK adaptor protein 1 [KO:K07365]
102240321  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
102250137  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
102250915  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
102258522  PAK4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1]
102240345  PAK5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
102251863  PAK6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
102244315  RHOA; ras homolog family member A [KO:K04513]
102252747  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
102254781  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
102264120  UNC5A; unc-5 netrin receptor A [KO:K07521]
102260293  UNC5D; unc-5 netrin receptor D [KO:K07521]
102257773  UNC5C; unc-5 netrin receptor C [KO:K07521]
102246826  UNC5B; unc-5 netrin receptor B [KO:K07521]
102251345  PTPN11; protein tyrosine phosphatase, non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
102259675  NEO1; neogenin 1 [KO:K06766]
102256586  MYL5; myosin light chain 5 [KO:K12753]
102251806  myosin regulatory light polypeptide 9 [KO:K12755]
102253999  MYL9; myosin light chain 9 [KO:K12755]
102243369  myosin regulatory light chain 2, smooth muscle major isoform [KO:K12755]
102257812  MYL12B; myosin regulatory light chain 12B [KO:K12757]
102258119  myosin regulatory light polypeptide 9 [KO:K12757]
102243603  ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
102252845  LRIG2; leucine rich repeats and immunoglobulin like domains 2 [KO:K24609]
102238988  EFNA5; ephrin A5 [KO:K05462]
102249824  EFNA1; ephrin A1 [KO:K05462]
102258114  EFNA2; ephrin A2 [KO:K05462]
102253384  EFNA4; ephrin A4 [KO:K05462]
102253687  EFNA3; ephrin A3 [KO:K05462]
102246218  EFNB2; ephrin B2 [KO:K05463]
102245358  EFNB3; ephrin B3 [KO:K05463]
102258970  EFNB1; ephrin B1 [KO:K05463]
102241416  EPHA1; EPH receptor A1 [KO:K05102] [EC:2.7.10.1]
102250877  EPHA2; EPH receptor A2 [KO:K05103] [EC:2.7.10.1]
102245168  ephrin type-A receptor 3 [KO:K05104] [EC:2.7.10.1]
102255650  ephrin type-A receptor 3 [KO:K05104] [EC:2.7.10.1]
102242040  EPHA4; EPH receptor A4 [KO:K05105] [EC:2.7.10.1]
102258026  EPHA5; EPH receptor A5 [KO:K05106] [EC:2.7.10.1]
102255541  EPHA6; ephrin type-A receptor 6 [KO:K05107] [EC:2.7.10.1]
102255307  EPHA7; EPH receptor A7 [KO:K05108] [EC:2.7.10.1]
102240280  EPHA8; EPH receptor A8 [KO:K05109] [EC:2.7.10.1]
102241828  EPHB1; EPH receptor B1 [KO:K05110] [EC:2.7.10.1]
102261811  EPHB2; EPH receptor B2 [KO:K05111] [EC:2.7.10.1]
102241792  EPHB3; EPH receptor B3 [KO:K05112] [EC:2.7.10.1]
102259061  EPHB4; EPH receptor B4 [KO:K05113] [EC:2.7.10.1]
102261258  EPHB6; EPH receptor B6 [KO:K05114] [EC:2.7.10.1]
102255271  ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase [KO:K06619] [EC:2.7.10.2]
102241745  ENAH; enabled homolog (Drosophila) [KO:K05746]
102264248  RASA1; RAS p21 protein activator 1 [KO:K04352]
102241419  NGEF; neuronal guanine nucleotide exchange factor [KO:K07525]
102263667  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102244940  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102247606  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102255250  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102245641  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102255056  NCK2; NCK adaptor protein 2 [KO:K19862]
102245888  RGS3; regulator of G-protein signaling 3 [KO:K07524]
102247013  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
102263583  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
102249318  GNAI2; G protein subunit alpha i2 [KO:K04630]
102239557  GNAI3; G protein subunit alpha i3 [KO:K04630]
102256872  GNAI1; G protein subunit alpha i1 [KO:K04630]
102263801  SLIT1; slit guidance ligand 1 [KO:K06838]
102257391  SLIT2; slit guidance ligand 2 [KO:K06839]
102249532  SLIT3; slit guidance ligand 3 [KO:K06850]
102251315  ROBO1; roundabout guidance receptor 1 [KO:K06753]
102249730  ROBO2; roundabout guidance receptor 2 [KO:K06754]
102239402  ROBO3; roundabout guidance receptor 3 [KO:K06755]
102248819  SRGAP2; SLIT-ROBO Rho GTPase activating protein 2 [KO:K07526]
102241359  SRGAP3; SLIT-ROBO Rho GTPase activating protein 3 [KO:K07526]
102246032  SRGAP1; SLIT-ROBO Rho GTPase activating protein 1 [KO:K07526]
102264221  SEMA3B; semaphorin 3B [KO:K06840]
102263906  SEMA3F; semaphorin 3F [KO:K06840]
102246823  SEMA3G; semaphorin 3G [KO:K06840]
102260163  SEMA3C; semaphorin 3C [KO:K06840]
102259163  SEMA3E; semaphorin 3E [KO:K06840]
102258276  SEMA3D; semaphorin 3D [KO:K06840]
102258572  SEMA3A; semaphorin 3A [KO:K06840]
102255928  PLXNA4; plexin A4 [KO:K06820]
102242439  PLXNA3; plexin A3 [KO:K06820]
102251703  PLXNA2; plexin A2 [KO:K06820]
102250223  PLXNA1; plexin A1 [KO:K06820]
102259892  NRP1; neuropilin 1 [KO:K06724]
102260104  L1CAM; L1 cell adhesion molecule [KO:K06550]
102246788  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
102240139  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
102247446  CFL2; cofilin 2 [KO:K05765]
102256765  cofilin-1 [KO:K05765]
102257903  CFL1; cofilin 1 [KO:K05765]
102248814  RHOD; ras homolog family member D [KO:K07530]
102247301  RND1; Rho family GTPase 1 [KO:K07531]
102239439  FES; FES proto-oncogene, tyrosine kinase [KO:K07527] [EC:2.7.10.2]
102261211  DPYSL5; dihydropyrimidinase like 5 [KO:K07529]
102247039  dihydropyrimidinase-related protein 2 [KO:K07528]
102240832  DPYSL2; dihydropyrimidinase-related protein 2 [KO:K07528]
102255036  CDK5; cyclin dependent kinase 5 [KO:K02090] [EC:2.7.11.22]
102248758  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
102263216  SEMA4A; semaphorin 4A [KO:K06521]
102253570  SEMA4G; semaphorin 4G [KO:K06521]
102241278  SEMA4B; semaphorin 4B [KO:K06521]
102241113  SEMA4D; semaphorin 4D [KO:K06521]
102252564  SEMA4C; semaphorin 4C [KO:K06521]
102241430  semaphorin-4F-like [KO:K06521]
102250547  SEMA5A; semaphorin 5A [KO:K06841]
102238913  SEMA5B; semaphorin 5B [KO:K06841]
102260862  SEMA6C; semaphorin 6C [KO:K06842]
102248179  SEMA6D; semaphorin 6D [KO:K06842]
102263745  SEMA6A; semaphorin 6A [KO:K06842]
102243227  SEMA6B; semaphorin 6B [KO:K06842]
102255174  PLXNB1; plexin B1 [KO:K06821]
102263912  PLXNB3; plexin B3 [KO:K06821]
102255219  PLXNB2; plexin B2 [KO:K06821]
102263347  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
102254003  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102239986  SEMA7A; semaphorin 7A (John Milton Hagen blood group) [KO:K06529]
102242683  PLXNC1; plexin C1 [KO:K06572]
102260978  ITGB1; integrin subunit beta 1 [KO:K05719]
102254867  SHH; sonic hedgehog [KO:K11988]
102254605  PTCH1; patched 1 [KO:K06225]
102258432  SMO; smoothened, frizzled class receptor [KO:K06226]
102260557  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102248130  ILK; integrin linked kinase [KO:K06272] [EC:2.7.11.1]
102252803  BOC; BOC cell adhesion associated, oncogene regulated [KO:K20020]
102241642  WNT5B; Wnt family member 5B [KO:K00444]
102240132  WNT5A; Wnt family member 5A [KO:K00444]
102250456  FZD3; frizzled class receptor 3 [KO:K02329]
102251391  RYK; receptor-like tyrosine kinase [KO:K05128] [EC:2.7.10.1]
102252254  CAMK2D; calcium/calmodulin dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
102262365  CAMK2G; calcium/calmodulin dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
102260966  CAMK2B; calcium/calmodulin dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
102257317  CAMK2A; calcium/calmodulin dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
102240589  WNT4; Wnt family member 4 [KO:K00408]
102260487  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102252921  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102239669  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102258430  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102253405  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102242302  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102262391  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102256516  PARD3; par-3 family cell polarity regulator [KO:K04237]
102238785  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
106726938  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
102250265  protein kinase C zeta type-like [KO:K18952] [EC:2.7.11.13]
102247449  PARD6B; par-6 family cell polarity regulator beta [KO:K06093]
102257439  PARD6A; par-6 family cell polarity regulator alpha [KO:K06093]
102263073  PARD6G; par-6 family cell polarity regulator gamma [KO:K06093]
102243917  SSH3; slingshot protein phosphatase 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102246339  SSH1; slingshot protein phosphatase 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102256626  SSH2; slingshot protein phosphatase 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
102241809  BMP7; bone morphogenetic protein 7 [KO:K16621]
102255023  BMPR2; bone morphogenetic protein receptor type 2 [KO:K04671] [EC:2.7.11.30]
102255240  BMPR1B; bone morphogenetic protein receptor type 1B [KO:K13578] [EC:2.7.11.30]
Compound
C00076  Calcium cation
Reference
PMID:14682358
  Authors
Guan KL, Rao Y.
  Title
Signalling mechanisms mediating neuronal responses to guidance cues.
  Journal
Nat Rev Neurosci 4:941-56 (2003)
DOI:10.1038/nrn1254
Reference
PMID:15630019
  Authors
Govek EE, Newey SE, Van Aelst L.
  Title
The role of the Rho GTPases in neuronal development.
  Journal
Genes Dev 19:1-49 (2005)
DOI:10.1101/gad.1256405
Reference
PMID:12677003
  Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
  Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
  Journal
Annu Rev Neurosci 26:509-63 (2003)
DOI:10.1146/annurev.neuro.26.010302.081139
Reference
PMID:15818466
  Authors
Negishi M, Oinuma I, Katoh H.
  Title
Plexins: axon guidance and signal transduction.
  Journal
Cell Mol Life Sci 62:1363-71 (2005)
DOI:10.1007/s00018-005-5018-2
Reference
PMID:15363605
  Authors
Huot J.
  Title
Ephrin signaling in axon guidance.
  Journal
Prog Neuropsychopharmacol Biol Psychiatry 28:813-8 (2004)
DOI:10.1016/j.pnpbp.2004.05.025
Reference
PMID:11891122
  Authors
Patel BN, Van Vactor DL.
  Title
Axon guidance: the cytoplasmic tail.
  Journal
Curr Opin Cell Biol 14:221-9 (2002)
DOI:10.1016/S0955-0674(02)00308-3
Reference
PMID:11687826
  Authors
Yu TW, Bargmann CI.
  Title
Dynamic regulation of axon guidance.
  Journal
Nat Neurosci 4 Suppl:1169-76 (2001)
DOI:10.1038/nn748
Reference
PMID:12471249
  Authors
Dickson BJ.
  Title
Molecular mechanisms of axon guidance.
  Journal
Science 298:1959-64 (2002)
DOI:10.1126/science.1072165
Reference
PMID:15960985
  Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
  Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
  Journal
Brain Res Brain Res Rev 49:22-47 (2005)
DOI:10.1016/j.brainresrev.2004.11.003
Reference
PMID:15084255
  Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
  Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
  Journal
Cell 117:157-69 (2004)
DOI:10.1016/S0092-8674(04)00303-4
Reference
PMID:25374504
  Authors
Fujita Y, Yamashita T
  Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
  Journal
Front Neurosci 8:338 (2014)
DOI:10.3389/fnins.2014.00338
Reference
PMID:17169551
  Authors
Yamashita T, Mueller BK, Hata K
  Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
  Journal
Curr Opin Neurobiol 17:29-34 (2007)
DOI:10.1016/j.conb.2006.12.001
Reference
PMID:26651291
  Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
  Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
  Journal
Dev Cell 35:537-552 (2015)
DOI:10.1016/j.devcel.2015.11.008
Related
pathway
myb04010  MAPK signaling pathway
myb04060  Cytokine-cytokine receptor interaction
myb04310  Wnt signaling pathway
myb04810  Regulation of actin cytoskeleton
KO pathway
ko04360   
LinkDB

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