KEGG   PATHWAY: nle00230
Entry
nle00230                    Pathway                                
Name
Purine metabolism - Nomascus leucogenys (northern white-cheeked gibbon)
Class
Metabolism; Nucleotide metabolism
Pathway map
nle00230  Purine metabolism
nle00230

Module
nle_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:nle00230]
nle_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:nle00230]
nle_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:nle00230]
nle_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:nle00230]
nle_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:nle00230]
nle_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:nle00230]
nle_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:nle00230]
Other DBs
GO: 0006163 0042278
Organism
Nomascus leucogenys (northern white-cheeked gibbon) [GN:nle]
Gene
100607477  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
100601662  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
100600434  NUDT5; ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
100596081  PGM1; phosphoglucomutase-1 isoform X2 [KO:K01835] [EC:5.4.2.2]
100600656  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
100582020  PRPS1; ribose-phosphate pyrophosphokinase 1 [KO:K00948] [EC:2.7.6.1]
100605807  PRPS1L1; ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
100585125  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
100580625  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
100585363  GART; trifunctional purine biosynthetic protein adenosine-3 isoform X1 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
100584430  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
100580950  multifunctional protein ADE2 isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
100591638  ADSL; adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
100602552  ATIC; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
100602168  APRT; adenine phosphoribosyltransferase isoform X1 [KO:K00759] [EC:2.4.2.7]
100598503  NT5C2; cytosolic purine 5'-nucleotidase isoform X2 [KO:K01081] [EC:3.1.3.5]
100598992  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial isoform X1 [KO:K01081] [EC:3.1.3.5]
100599643  NT5C1B; cytosolic 5'-nucleotidase 1B isoform X2 [KO:K01081] [EC:3.1.3.5]
100587020  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type isoform X1 [KO:K01081] [EC:3.1.3.5]
100603123  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
100599533  NT5DC4; LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
100607892  NT5E; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
100594696  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
100603555  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
100581397  HPRT1; hypoxanthine-guanine phosphoribosyltransferase isoform X1 [KO:K00760] [EC:2.4.2.8]
100598855  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
100581732  inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
100583696  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
100596511  LOW QUALITY PROTEIN: inosine-5'-monophosphate dehydrogenase 1-like [KO:K00088] [EC:1.1.1.205]
100582337  nucleoside diphosphate kinase B isoform X2 [KO:K00940] [EC:2.7.4.6]
100589554  NME6; nucleoside diphosphate kinase 6 isoform X1 [KO:K00940] [EC:2.7.4.6]
100586165  NME4; nucleoside diphosphate kinase, mitochondrial isoform X4 [KO:K00940] [EC:2.7.4.6]
105737507  NME1; nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
100592128  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
100596874  NME3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
100580218  NME7; nucleoside diphosphate kinase 7 isoform X1 [KO:K00940] [EC:2.7.4.6]
115837088  nucleoside diphosphate kinase B-like isoform X1 [KO:K00940] [EC:2.7.4.6]
100606167  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
100605921  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
100579317  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
100598542  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
100601352  CANT1; soluble calcium-activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
100604246  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
100603393  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
100604959  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
100607601  NUDT16; U8 snoRNA-decapping enzyme isoform X2 [KO:K16855] [EC:3.6.1.62 3.6.1.64]
100594558  ITPA; inosine triphosphate pyrophosphatase isoform X1 [KO:K01519] [EC:3.6.1.66]
100594931  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
100585591  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
100591577  GMPS; GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
100585337  GMPR2; GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
100587606  GMPR; GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
100583169  GDA; guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
100583775  GUK1; guanylate kinase isoform X10 [KO:K00942] [EC:2.7.4.8]
100599741  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
100579408  RRM2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
100599865  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B [KO:K10808] [EC:1.17.4.1]
100586763  HDDC2; HD domain-containing protein 2 isoform X2 [KO:K07023] [EC:3.1.3.89]
100581938  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
100580396  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
100598580  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X1 [KO:K21138] [EC:3.1.7.2]
100584339  PRUNE1; exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
100595636  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100600367  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100586735  ADCY3; adenylate cyclase type 3 isoform X2 [KO:K08043] [EC:4.6.1.1]
100603282  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100580455  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100589304  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
100587036  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100592592  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100599484  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
100601811  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
100592351  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
100581660  GUCY1A1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
100600502  LOW QUALITY PROTEIN: guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
100583335  GUCY1B1; guanylate cyclase soluble subunit beta-1 isoform X2 [KO:K12319] [EC:4.6.1.2]
100594944  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
100585866  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
100587777  LOW QUALITY PROTEIN: olfactory guanylyl cyclase GC-D-like [KO:K12321] [EC:4.6.1.2]
100588933  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
100605363  LOW QUALITY PROTEIN: guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
100601694  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
100595720  NPR2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
100606151  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X2 [KO:K13755] [EC:3.1.4.17]
100606919  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
100604911  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
100587547  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
100583391  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
100600080  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
100581952  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
100596985  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
100594092  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
100597030  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
100604601  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
100603538  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X2 [KO:K13759]
100600699  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma isoform X1 [KO:K13760]
100601936  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
100591667  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
100593480  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A isoform X1 [KO:K13298] [EC:3.1.4.17 3.1.4.35]
100605992  ADSS2; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
100585791  ADSS1; adenylosuccinate synthetase isozyme 1 isoform X1 [KO:K01939] [EC:6.3.4.4]
100590300  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
100584841  AMPD2; AMP deaminase 2 isoform X2 [KO:K01490] [EC:3.5.4.6]
100593142  AMPD3; AMP deaminase 3 isoform X2 [KO:K01490] [EC:3.5.4.6]
100583963  ADK; adenosine kinase isoform X2 [KO:K00856] [EC:2.7.1.20]
100596557  ADA; adenosine deaminase isoform X1 [KO:K01488] [EC:3.5.4.4]
100606523  ADA2; adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
100601608  AK4; adenylate kinase 4, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
100587679  AK8; adenylate kinase 8 isoform X1 [KO:K00939] [EC:2.7.4.3]
100601455  AK2; adenylate kinase 2, mitochondrial isoform X2 [KO:K00939] [EC:2.7.4.3]
100586263  AK1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
100604742  AK5; adenylate kinase isoenzyme 5 isoform X3 [KO:K00939] [EC:2.7.4.3]
100582098  AK7; adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
115833536  adenylate kinase isoenzyme 1-like [KO:K00939] [EC:2.7.4.3]
101179362  AK6; adenylate kinase isoenzyme 6 isoform X1 [KO:K18532] [EC:2.7.4.3]
100587551  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
100606880  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 isoform X1 [KO:K01509] [EC:3.6.1.-]
100583728  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
100603928  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
100584975  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
100587050  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2 [KO:K13293] [EC:3.1.4.53]
100596792  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X4 [KO:K13293] [EC:3.1.4.53]
100599641  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
100604983  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2 [KO:K13293] [EC:3.1.4.53]
100586984  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
100587414  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X4 [KO:K18436] [EC:3.1.4.53]
100581907  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
100579512  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
100587886  FHIT; bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
100587404  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
100603353  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
100595002  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
100597726  LOW QUALITY PROTEIN: uricase-like [KO:K00365] [EC:1.7.3.3]
100588856  URAD; LOW QUALITY PROTEIN: putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
100601456  ALLC; LOW QUALITY PROTEIN: probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
nle00030  Pentose phosphate pathway
nle00220  Arginine biosynthesis
nle00250  Alanine, aspartate and glutamate metabolism
nle00260  Glycine, serine and threonine metabolism
nle00340  Histidine metabolism
nle00630  Glyoxylate and dicarboxylate metabolism
nle00730  Thiamine metabolism
nle00740  Riboflavin metabolism
nle00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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