KEGG   PATHWAY: ola04514
Entry
ola04514                    Pathway                                
Name
Cell adhesion molecules - Oryzias latipes (Japanese medaka)
Description
Cell adhesion molecules (CAMs) are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
ola04514  Cell adhesion molecules
ola04514

Other DBs
GO: 0050839
Organism
Oryzias latipes (Japanese medaka) [GN:ola]
Gene
110016495  uncharacterized protein LOC110016495 [KO:K06492]
101158850  cd2; T-cell surface antigen CD2 [KO:K06449]
105358711  hepatocyte cell adhesion molecule isoform X1 [KO:K06449]
101174291  vsir; V-type immunoglobulin domain-containing suppressor of T-cell activation [KO:K23268]
101165580  immunoglobulin superfamily member 11-like [KO:K06791]
101172513  igsf11; immunoglobulin superfamily member 11 [KO:K06791]
101170285  programmed cell death 1 ligand 2 [KO:K06745]
101164241  uncharacterized protein LOC101164241 isoform X1 [KO:K05413]
101173752  cytotoxic T-lymphocyte protein 4 isoform X1 [KO:K06538]
101169102  ICOS ligand-like [KO:K06710]
101156391  H-2 class II histocompatibility antigen, E-S beta chain [KO:K06752]
101156161  RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
101173297  rano class II histocompatibility antigen, A beta chain isoform X1 [KO:K06752]
111948938  HLA class II histocompatibility antigen, DRB1-7 beta chain-like [KO:K06752]
101156150  HLA class II histocompatibility antigen, DP alpha 1 chain [KO:K06752]
101170703  RLA class II histocompatibility antigen, DP alpha-1 chain [KO:K06752]
101163459  mamu class II histocompatibility antigen, DR alpha chain [KO:K06752]
101163710  H-2 class II histocompatibility antigen, E-S beta chain [KO:K06752]
101170740  uncharacterized protein LOC101170740 [KO:K10785]
100125525  carcinoembryonic antigen-related cell adhesion molecule 5 isoform X1 [KO:K06454]
101154961  H-2 class I histocompatibility antigen, L-D alpha chain isoform X1 [KO:K06751]
101166233  class I histocompatibility antigen, F10 alpha chain [KO:K06751]
101167218  orla-uaa; major histocompatibility complex class I-related gene protein-like precursor [KO:K06751]
101166971  orla-uba; major histocompatibility complex class I-related gene protein-like precursor [KO:K06751]
101154781  orla-uha; major histocompatibility complex class I-related gene protein-like precursor [KO:K06751]
101162732  orla-uia1; major histocompatibility complex class I-related gene protein-like [KO:K06751]
101170062  class I histocompatibility antigen, F10 alpha chain-like precursor [KO:K06751]
101175416  class I histocompatibility antigen, F10 alpha chain isoform X1 [KO:K06751]
101157592  HLA class I histocompatibility antigen, Cw-2 alpha chain isoform X1 [KO:K06751]
111948173  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
101165535  BOLA class I histocompatibility antigen, alpha chain BL3-6-like [KO:K06751]
101175175  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
101169825  BOLA class I histocompatibility antigen, alpha chain BL3-7-like isoform X1 [KO:K06751]
101175332  uncharacterized protein LOC101175332 [KO:K06751]
100125537  uncharacterized protein LOC100125537 isoform X1 [KO:K06458]
101173540  uncharacterized protein LOC101173540 isoform X2 [KO:K06459]
101169279  cd276; CD276 antigen [KO:K06746]
100301586  CD40 precursor [KO:K03160]
105355953  tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
101157718  CD166 antigen homolog [KO:K06547]
101169470  CD166 antigen homolog A isoform X2 [KO:K06547]
105355155  T-cell differentiation antigen CD6 isoform X1 [KO:K06456]
101168503  cd226; CD226 antigen isoform X1 [KO:K06567]
101173334  nectin2; nectin-2 isoform X1 [KO:K06531]
101175215  integrin alpha-L-like [KO:K05718]
101154755  integrin alpha-L-like [KO:K05718]
105358244  B-cell receptor CD22-like isoform X1 [KO:K06467]
101164620  B-cell receptor CD22-like [KO:K06467]
110015796  B-cell receptor CD22-like isoform X1 [KO:K06467]
105356876  B-cell receptor CD22-like [KO:K06467]
111947741  uncharacterized protein LOC111947741 isoform X1 [KO:K06467]
105356005  Schwann cell myelin protein [KO:K06467]
105356008  B-cell receptor CD22 [KO:K06467]
105355898  B-cell receptor CD22 [KO:K06467]
105355972  B-cell receptor CD22 [KO:K06467]
105356883  LOW QUALITY PROTEIN: hemicentin-1 [KO:K06467]
105358364  uncharacterized protein LOC105358364 [KO:K06467]
111947787  B-cell receptor CD22-like [KO:K06467]
101167945  ptprc; receptor-type tyrosine-protein phosphatase C isoform X1 [KO:K06478] [EC:3.1.3.48]
101170697  nectin-3-like protein isoform X2 [KO:K06592]
101160012  nectin-3-like protein [KO:K06592]
101172570  claudin-34 [KO:K06087]
101167718  claudin-4-like [KO:K06087]
101171811  claudin-10-like [KO:K06087]
101172061  claudin-10-like [KO:K06087]
101172805  putative claudin-24 [KO:K06087]
101175314  cldn19; claudin-19 isoform X2 [KO:K06087]
101165395  claudin-4-like [KO:K06087]
101158284  putative claudin-24 [KO:K06087]
101173553  cldn5; claudin-5 [KO:K06087]
101170187  claudin-4-like [KO:K06087]
101166566  claudin-5 [KO:K06087]
101159211  claudin-3 [KO:K06087]
101159688  claudin-4-like [KO:K06087]
101159933  claudin-4 [KO:K06087]
101160182  claudin-4-like [KO:K06087]
101160429  claudin-4 [KO:K06087]
101160678  claudin-4-like [KO:K06087]
101160928  claudin-4 [KO:K06087]
101174849  claudin-8-like [KO:K06087]
101174121  claudin-like protein ZF-A89 [KO:K06087]
101160754  claudin-3 [KO:K06087]
101160997  claudin-4 [KO:K06087]
101161257  claudin-4-like [KO:K06087]
101161741  claudin-like protein ZF-A89 [KO:K06087]
101161987  claudin-like protein ZF-A89 [KO:K06087]
101162388  claudin-4-like [KO:K06087]
101174524  claudin-15 [KO:K06087]
101158790  claudin-7-B [KO:K06087]
101166151  claudin-23 [KO:K06087]
101168324  cldn15; claudin-15 [KO:K06087]
101156528  claudin-7 [KO:K06087]
101168738  claudin-15 [KO:K06087]
101161011  claudin-7-A [KO:K06087]
101166173  claudin-11 [KO:K06087]
101166512  claudin-10 isoform X2 [KO:K06087]
101161199  claudin-14 [KO:K06087]
101166513  claudin-10-like [KO:K06087]
101166759  claudin-10-like [KO:K06087]
101155569  claudin-19-like [KO:K06087]
101161321  claudin-4-like [KO:K06087]
101163922  claudin-4-like [KO:K06087]
101160501  claudin-3-like [KO:K06087]
101161498  claudin-4-like [KO:K06087]
101164177  claudin-like protein ZF-A89 [KO:K06087]
101164424  claudin-like protein ZF-A89 [KO:K06087]
105356647  cldn11; claudin-11 [KO:K06087]
101169754  claudin-20-like isoform X1 [KO:K06087]
101159455  claudin-4 [KO:K06087]
105356918  claudin-23 [KO:K06087]
101173880  claudin-8 [KO:K06087]
105356944  cldn20; claudin-20 [KO:K06087]
105358118  putative claudin-24 [KO:K06087]
105355932  cldn12; claudin-12 [KO:K06087]
105355443  claudin-34-like [KO:K06087]
101169436  occludin [KO:K06088]
101174753  ocln; occludin [KO:K06088]
101163521  occludin [KO:K06088]
101163673  occludin [KO:K06088]
105355609  junctional adhesion molecule A-like [KO:K06089]
101163141  jam2; junctional adhesion molecule B isoform X1 [KO:K06735]
101171370  junctional adhesion molecule B-like [KO:K06735]
101174688  junctional adhesion molecule C [KO:K06785]
101167309  jam3; junctional adhesion molecule C isoform X1 [KO:K06785]
101172870  esam; endothelial cell-selective adhesion molecule [KO:K06787]
101168638  endothelial cell-selective adhesion molecule-like isoform X2 [KO:K06787]
101174288  cadherin-5 [KO:K06533]
101156223  platelet endothelial cell adhesion molecule isoform X6 [KO:K06471]
101159590  platelet endothelial cell adhesion molecule [KO:K06471]
101168347  CD99 antigen isoform X1 [KO:K06520]
101165510  CD99 antigen-like protein 2 [KO:K06520]
101156923  integrin alpha-M-like [KO:K06461]
110017206  integrin alpha-M-like isoform X1 [KO:K06461]
101175538  integrin alpha-M-like [KO:K06461]
101156687  integrin alpha-M-like [KO:K06461]
101166094  itga4; integrin alpha-4 [KO:K06483]
101175441  itgb1; integrin beta-1 isoform X1 [KO:K05719]
101161001  itga9; integrin alpha-9 [KO:K06585]
101156567  vcam1; vascular cell adhesion protein 1 [KO:K06527]
110014987  sell; L-selectin [KO:K06495]
101160401  cd34; hematopoietic progenitor cell antigen CD34 isoform X1 [KO:K06474]
101157618  uncharacterized protein LOC101157618 [KO:K06474]
101171906  Golgi apparatus protein 1 isoform X1 [KO:K06816]
101160143  Golgi apparatus protein 1 isoform X1 [KO:K06816]
101167563  nectin-1 isoform X1 [KO:K06081]
101170036  nectin1; nectin-1 isoform X8 [KO:K06081]
105358571  nectin-1-like isoform X1 [KO:K06081]
105356850  nectin-1-like [KO:K06081]
110017439  nectin-2-like [KO:K06081]
101173666  poliovirus receptor homolog isoform X1 [KO:K06081]
101172858  poliovirus receptor homolog isoform X1 [KO:K06081]
105356840  nectin-1-like [KO:K06081]
101158262  cadherin-2 [KO:K06736]
101162000  cdh2; cadherin-2 precursor [KO:K06736]
101167636  ncam1; neural cell adhesion molecule 1 isoform X1 [KO:K06491]
101173164  neural cell adhesion molecule 1 isoform X12 [KO:K06491]
101170789  neural cell adhesion molecule 1 [KO:K06491]
101169522  ncam2; neural cell adhesion molecule 2 isoform X1 [KO:K06491]
101164215  neural cell adhesion molecule L1.1 isoform X1 [KO:K06550]
101166379  l1cam; neural cell adhesion molecule L1 [KO:K06550]
101165248  cell adhesion molecule 1 isoform X1 [KO:K06781]
101167886  cell adhesion molecule 1 isoform X1 [KO:K06781]
101174821  negr1; neuronal growth regulator 1 isoform X1 [KO:K06775]
101172203  ntng1; netrin-G1 isoform X1 [KO:K07522]
105357770  netrin-G1 isoform X1 [KO:K07522]
101160634  lrrc4c; leucine-rich repeat-containing protein 4C [KO:K07523]
101165159  netrin-G2 isoform X2 [KO:K16359]
105354799  ntng2; netrin-G2 [KO:K16359]
101167534  lrrc4; leucine-rich repeat-containing protein 4 [KO:K16351]
101168588  leucine-rich repeat-containing protein 4 [KO:K16351]
101157606  ptprf; receptor-type tyrosine-protein phosphatase F isoform X6 [KO:K05695] [EC:3.1.3.48]
101168742  receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
101164310  lrrc4b; leucine-rich repeat-containing protein 4B [KO:K16360]
101159140  leucine-rich repeat-containing protein 4B [KO:K16360]
101169622  syndecan-2-A [KO:K16336]
101156278  syndecan-2-B [KO:K16336]
101155863  sdc3; syndecan-3 [KO:K16337]
101162518  syndecan-4 isoform X2 [KO:K16338]
101171049  uncharacterized protein LOC101171049 [KO:K16338]
101174307  itgav; integrin alpha-V [KO:K06487]
101167379  itgb8; integrin beta-8 [KO:K06591]
101164748  itga8; integrin alpha-8 [KO:K06584]
101159771  nrxn1; neurexin-1 isoform X1 [KO:K07377]
101167491  neurexin-1a isoform X1 [KO:K07377]
101169749  neurexin-3a isoform X1 [KO:K07377]
101166255  neurexin-1 isoform X1 [KO:K07377]
101156134  neurexin-3b isoform X1 [KO:K07377]
100415782  nlgn3; neuroligin-3 precursor [KO:K07378]
100529172  nlgn1; neuroligin 1 [KO:K07378]
100529174  nlgn2; neuroligin 2b precursor [KO:K07378]
100529175  nlgn3b; neuroligin 3b [KO:K07378]
100529173  nlgn2; neuroligin-2 isoform X1 [KO:K07378]
101168332  neuroligin-4, X-linked [KO:K07378]
101169564  receptor-type tyrosine-protein phosphatase S isoform X9 [KO:K06778] [EC:3.1.3.48]
101174175  receptor-type tyrosine-protein phosphatase S isoform X1 [KO:K06778] [EC:3.1.3.48]
101159174  slitrk1; SLIT and NTRK-like protein 1 [KO:K25832]
101168629  slitrk2; SLIT and NTRK-like protein 2 [KO:K25833]
101175328  slitrk4; SLIT and NTRK-like protein 4 [KO:K25835]
101159898  slitrk5; SLIT and NTRK-like protein 5 [KO:K25836]
101167752  SLIT and NTRK-like protein 5 [KO:K25836]
101171393  slitrk6; SLIT and NTRK-like protein 6 [KO:K25837]
101165944  receptor-type tyrosine-protein phosphatase delta isoform X1 [KO:K06777] [EC:3.1.3.48]
101165843  receptor-type tyrosine-protein phosphatase delta isoform X1 [KO:K06777] [EC:3.1.3.48]
101164581  slitrk3; SLIT and NTRK-like protein 3 [KO:K25834]
101167411  SLIT and NTRK-like protein 3 [KO:K25834]
101171409  neuronal cell adhesion molecule isoform X1 [KO:K06756]
101156543  neuronal cell adhesion molecule isoform X1 [KO:K06756]
101171162  cntn1; contactin-1 isoform X1 [KO:K06759]
101166021  contactin-1 [KO:K06759]
101173688  ptprm; receptor-type tyrosine-protein phosphatase mu [KO:K05693] [EC:3.1.3.48]
101160890  receptor-type tyrosine-protein phosphatase mu isoform X1 [KO:K05693] [EC:3.1.3.48]
101161878  cntn2; contactin-2 isoform X1 [KO:K06760]
101164207  neurofascin isoform X1 [KO:K06757]
101161628  nfasc; neurofascin isoform X1 [KO:K06757]
101172415  cntnap1; contactin-associated protein 1 [KO:K07379]
101156356  contactin-associated protein-like 2 [KO:K07380]
101164518  cntnap2; contactin-associated protein-like 2 isoform X2 [KO:K07380]
101161749  mpz; myelin protein P0 isoform X1 [KO:K06770]
110016642  sialic acid-binding Ig-like lectin 5 [KO:K06771]
105356074  myelin-associated glycoprotein-like [KO:K06771]
101159465  mag; myelin-associated glycoprotein isoform X1 [KO:K06771]
105355911  sialic acid-binding Ig-like lectin 14 isoform X2 [KO:K06771]
105356009  sialic acid-binding Ig-like lectin 10 [KO:K06771]
101172313  cadherin-1-like [KO:K05689]
105357330  cadherin-1-like [KO:K05689]
111948794  B-cadherin-like [KO:K05689]
105353623  cadherin-1-like [KO:K05689]
101171060  B-cadherin-like [KO:K05689]
105358576  B-cadherin-like [KO:K05689]
101169589  cadherin-1 [KO:K05689]
101172910  integrin alpha-6 [KO:K06485]
101167322  integrin alpha-6 isoform X2 [KO:K06485]
101160120  itga6; integrin alpha-6 isoform X1 [KO:K06485]
101161393  cadherin-4 isoform X2 [KO:K06797]
101175079  cadherin-4 [KO:K06797]
101170500  cdh15; cadherin-15 [KO:K06809]
101164964  neo1; neogenin isoform X1 [KO:K06766]
Reference
PMID:14690046
  Authors
Barclay AN.
  Title
Membrane proteins with immunoglobulin-like domains--a master superfamily of interaction molecules.
  Journal
Semin Immunol 15:215-23 (2003)
DOI:10.1016/S1044-5323(03)00047-2
Reference
PMID:11910893
  Authors
Sharpe AH, Freeman GJ.
  Title
The B7-CD28 superfamily.
  Journal
Nat Rev Immunol 2:116-26 (2002)
DOI:10.1038/nri727
Reference
PMID:9597126
  Authors
Grewal IS, Flavell RA.
  Title
CD40 and CD154 in cell-mediated immunity.
  Journal
Annu Rev Immunol 16:111-35 (1998)
DOI:10.1146/annurev.immunol.16.1.111
Reference
PMID:16034094
  Authors
Dardalhon V, Schubart AS, Reddy J, Meyers JH, Monney L, Sabatos CA, Ahuja R, Nguyen K, Freeman GJ, Greenfield EA, Sobel RA, Kuchroo VK.
  Title
CD226 is specifically expressed on the surface of Th1 cells and regulates their expansion and effector functions.
  Journal
J Immunol 175:1558-65 (2005)
DOI:10.4049/jimmunol.175.3.1558
Reference
PMID:12234363
  Authors
Montoya MC, Sancho D, Vicente-Manzanares M, Sanchez-Madrid F.
  Title
Cell adhesion and polarity during immune interactions.
  Journal
Immunol Rev 186:68-82 (2002)
DOI:10.1034/j.1600-065X.2002.18607.x
Reference
PMID:15071551
  Authors
Dejana E.
  Title
Endothelial cell-cell junctions: happy together.
  Journal
Nat Rev Mol Cell Biol 5:261-70 (2004)
DOI:10.1038/nrm1357
Reference
PMID:14519386
  Authors
Bazzoni G.
  Title
The JAM family of junctional adhesion molecules.
  Journal
Curr Opin Cell Biol 15:525-30 (2003)
DOI:10.1016/S0955-0674(03)00104-2
Reference
PMID:10798271
  Authors
Becker BF, Heindl B, Kupatt C, Zahler S.
  Title
Endothelial function and hemostasis.
  Journal
Z Kardiol 89:160-7 (2000)
DOI:10.1007/PL00007320
Reference
PMID:9150551
  Authors
Elangbam CS, Qualls CW Jr, Dahlgren RR.
  Title
Cell adhesion molecules--update.
  Journal
Vet Pathol 34:61-73 (1997)
DOI:10.1177/030098589703400113
Reference
PMID:12810109
  Authors
Muller WA.
  Title
Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response.
  Journal
Trends Immunol 24:327-34 (2003)
DOI:10.1016/S1471-4906(03)00117-0
Reference
PMID:14519398
  Authors
Yamagata M, Sanes JR, Weiner JA.
  Title
Synaptic adhesion molecules.
  Journal
Curr Opin Cell Biol 15:621-32 (2003)
DOI:10.1016/S0955-0674(03)00107-8
Reference
PMID:15882774
  Authors
Ethell IM, Pasquale EB.
  Title
Molecular mechanisms of dendritic spine development and remodeling.
  Journal
Prog Neurobiol 75:161-205 (2005)
DOI:10.1016/j.pneurobio.2005.02.003
Reference
PMID:11050419
  Authors
Benson DL, Schnapp LM, Shapiro L, Huntley GW.
  Title
Making memories stick: cell-adhesion molecules in synaptic plasticity.
  Journal
Trends Cell Biol 10:473-82 (2000)
DOI:10.1016/S0962-8924(00)01838-9
Reference
PMID:11860281
  Authors
Rosdahl JA, Mourton TL, Brady-Kalnay SM.
  Title
Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
  Journal
Mol Cell Neurosci 19:292-306 (2002)
DOI:10.1006/mcne.2001.1071
Reference
PMID:10964748
  Authors
Dunican DJ, Doherty P.
  Title
The generation of localized calcium rises mediated by cell adhesion molecules and their role in neuronal growth cone motility.
  Journal
Mol Cell Biol Res Commun 3:255-63 (2000)
DOI:10.1006/mcbr.2000.0225
Reference
PMID:12367625
  Authors
Girault JA, Peles E.
  Title
Development of nodes of Ranvier.
  Journal
Curr Opin Neurobiol 12:476-85 (2002)
DOI:10.1016/S0959-4388(02)00370-7
Reference
PMID:10664064
  Authors
Arroyo EJ, Scherer SS.
  Title
On the molecular architecture of myelinated fibers.
  Journal
Histochem Cell Biol 113:1-18 (2000)
DOI:10.1007/s004180050001
Reference
PMID:14556710
  Authors
Salzer JL.
  Title
Polarized domains of myelinated axons.
  Journal
Neuron 40:297-318 (2003)
DOI:10.1016/S0896-6273(03)00628-7
Reference
PMID:15561584
  Authors
Irie K, Shimizu K, Sakisaka T, Ikeda W, Takai Y.
  Title
Roles and modes of action of nectins in cell-cell adhesion.
  Journal
Semin Cell Dev Biol 15:643-56 (2004)
DOI:10.1016/j.semcdb.2004.09.002
Reference
PMID:15551862
  Authors
Nakanishi H, Takai Y.
  Title
Roles of nectins in cell adhesion, migration and polarization.
  Journal
Biol Chem 385:885-92 (2004)
DOI:10.1515/BC.2004.116
Reference
PMID:15115723
  Authors
Siu MK, Cheng CY.
  Title
Extracellular matrix: recent advances on its role in junction dynamics in the seminiferous epithelium during spermatogenesis.
  Journal
Biol Reprod 71:375-91 (2004)
DOI:10.1095/biolreprod.104.028225
Reference
PMID:15056568
  Authors
Lee NP, Cheng CY.
  Title
Adaptors, junction dynamics, and spermatogenesis.
  Journal
Biol Reprod 71:392-404 (2004)
DOI:10.1095/biolreprod.104.027268
Reference
PMID:15728677
  Authors
Inagaki M, Irie K, Ishizaki H, Tanaka-Okamoto M, Morimoto K, Inoue E, Ohtsuka T, Miyoshi J, Takai Y.
  Title
Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.
  Journal
Development 132:1525-37 (2005)
DOI:10.1242/dev.01697
Reference
PMID:12500939
  Authors
Marthiens V, Gavard J, Lambert M, Mege RM.
  Title
Cadherin-based cell adhesion in neuromuscular development.
  Journal
Biol Cell 94:315-26 (2002)
DOI:10.1016/S0248-4900(02)00005-9
Reference
PMID:15923648
  Authors
Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS.
  Title
Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact.
  Journal
J Cell Sci 118:2355-62 (2005)
DOI:10.1242/jcs.02397
Related
pathway
ola04520  Adherens junction
ola04530  Tight junction
KO pathway
ko04514   
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