KEGG   PATHWAY: oml04910
Entry
oml04910                    Pathway                                
Name
Insulin signaling pathway - Oryzias melastigma (Indian medaka)
Description
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the regulatory subunit of phosphoinositide 3-kinase (PI3K). PI3K activates 3-phosphoinositide-dependent protein kinase 1 (PDK1), which activates Akt, a serine kinase. Akt in turn deactivates glycogen synthase kinase 3 (GSK-3), leading to activation of glycogen synthase (GYS) and thus glycogen synthesis. Activation of Akt also results in the translocation of GLUT4 vesicles from their intracellular pool to the plasma membrane, where they allow uptake of glucose into the cell. Akt also leads to mTOR-mediated activation of protein synthesis by eIF4 and p70S6K. The translocation of GLUT4 protein is also elicited through the CAP/Cbl/TC10 pathway, once Cbl is phosphorylated by INSR.
Other signal transduction proteins interact with IRS including GRB2. GRB2 is part of the cascade including SOS, RAS, RAF and MEK that leads to activation of mitogen-activated protein kinase (MAPK) and mitogenic responses in the form of gene transcription. SHC is another substrate of INSR. When tyrosine phosphorylated, SHC associates with GRB2 and can thus activate the RAS/MAPK pathway independently of IRS-1.
Class
Organismal Systems; Endocrine system
Pathway map
oml04910  Insulin signaling pathway
oml04910

Organism
Oryzias melastigma (Indian medaka) [GN:oml]
Gene
112141334  ins; insulin [KO:K04526]
112142690  insulin [KO:K04526]
112153519  insulin isoform X1 [KO:K04526]
112147354  insra; insulin receptor a [KO:K04527] [EC:2.7.10.1]
112150803  insrb; insulin receptor b isoform X1 [KO:K04527] [EC:2.7.10.1]
112142839  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
112155960  si:ch73-335l21.1; insulin receptor substrate 1-B [KO:K16172]
112155149  irs2b; insulin receptor substrate 2 [KO:K07187]
112156084  insulin receptor substrate 2-B [KO:K07187]
112160084  insulin receptor substrate 2 [KO:K07187]
112147562  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
112163049  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
112150193  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
112150308  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
112138447  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
112147412  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112150459  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
112136442  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
112159170  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X3 [KO:K00922] [EC:2.7.1.153]
112154440  pdpk1b; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
112140005  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112154973  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112161991  akt3a; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
112149157  akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112157322  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
112155060  gsk3ba; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
112159256  glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
112146379  gys1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
112139567  glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
112147529  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112154198  ppp1cab; protein phosphatase 1, catalytic subunit, alpha isozyme b [KO:K06269] [EC:3.1.3.16]
112148595  serine/threonine-protein phosphatase PP1-gamma catalytic subunit A [KO:K06269] [EC:3.1.3.16]
112156029  serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
112146006  ppp1caa; protein phosphatase 1, catalytic subunit, alpha isozyme a [KO:K06269] [EC:3.1.3.16]
112141853  protein phosphatase 1 regulatory subunit 3C-B [KO:K07189]
112148733  zgc:77112; protein phosphatase 1 regulatory subunit 3C [KO:K07189]
112155295  ppp1r3aa; uncharacterized protein ppp1r3aa isoform X3 [KO:K07189]
112162233  ppp1r3cb; protein phosphatase 1 regulatory subunit 3C-B [KO:K07189]
112162770  ppp1r3b; protein phosphatase 1 regulatory subunit 3B [KO:K07189]
112145645  ppp1r3db; protein phosphatase 1, regulatory subunit 3Db [KO:K07189]
112159646  si:ch211-167b20.8; protein phosphatase 1 regulatory subunit 3A isoform X1 [KO:K07189]
112160387  protein phosphatase 1 regulatory subunit 3E [KO:K07189]
112154320  phkg2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
112149621  phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
112160584  phka2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
112160596  phkb; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
112155681  phka1a; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
112161269  calml4a; calmodulin-like protein 4a [KO:K02183]
112161496  calm2a; calmodulin 2a (phosphorylase kinase, delta) [KO:K02183]
112149305  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
112157736  calmodulin-1 [KO:K02183]
112146516  calm1a; calmodulin-1a [KO:K02183]
112148192  pygl; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
112162260  glycogen phosphorylase, brain form isoform X1 [KO:K00688] [EC:2.4.1.1]
112142987  pygma; glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
112155919  glycogen phosphorylase, muscle form [KO:K00688] [EC:2.4.1.1]
112160759  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
112147433  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
112150651  prkacba; protein kinase, cAMP-dependent, catalytic, beta a isoform X1 [KO:K04345] [EC:2.7.11.11]
112137621  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
112146515  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
112154150  cAMP-dependent protein kinase type I-alpha regulatory subunit isoform X1 [KO:K04739]
112144511  prkar2ab; LOW QUALITY PROTEIN: protein kinase, cAMP-dependent, regulatory, type II, alpha, B [KO:K04739]
112152757  cAMP-dependent protein kinase type II-beta regulatory subunit [KO:K04739]
112159348  prkar2aa; protein kinase, cAMP-dependent, regulatory, type II, alpha A [KO:K04739]
112147004  cAMP-dependent protein kinase type I-beta regulatory subunit isoform X1 [KO:K04739]
112160867  lipea; lipase, hormone-sensitive a [KO:K07188] [EC:3.1.1.79]
112143493  lipeb; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
112141323  prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
112147460  prkci; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
112155675  solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
112149153  flotillin-2 [KO:K07192]
112143682  flot1b; flotillin-1b [KO:K07192]
112145666  flot1a; flotillin-1a [KO:K07192]
112138959  flotillin-2a isoform X1 [KO:K07192]
112149767  SH2B adapter protein 2 [KO:K07193]
112161690  sorbin and SH3 domain-containing protein 1 [KO:K06086]
112142874  E3 ubiquitin-protein ligase CBL isoform X1 [KO:K04707] [EC:2.3.2.27]
112149910  cbl; E3 ubiquitin-protein ligase CBL [KO:K04707] [EC:2.3.2.27]
112140505  cblb; E3 ubiquitin-protein ligase CBL-B-B [KO:K22517] [EC:2.3.2.27]
112143053  adapter molecule crk [KO:K04438]
112149634  crk; adapter molecule crk [KO:K04438]
112163343  crkl; crk-like protein [KO:K04438]
112147904  rap guanine nucleotide exchange factor 1 [KO:K06277]
112162969  rapgef1b; rap guanine nucleotide exchange factor 1b isoform X1 [KO:K06277]
112161950  rho-related GTP-binding protein RhoQ [KO:K07194]
112154032  exoc7; exocyst complex component 7 isoform X1 [KO:K07195]
112137342  trip10b; cdc42-interacting protein 4 homolog isoform X1 [KO:K07196]
112146647  trip10a; cdc42-interacting protein 4 homolog isoform X1 [KO:K07196]
112146484  srebf1; sterol regulatory element-binding protein 1 [KO:K07197]
112143006  acaca; acetyl-CoA carboxylase 1 isoform X2 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
112147886  acacb; acetyl-CoA carboxylase isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
112138867  fasn; fatty acid synthase [KO:K00665] [EC:2.3.1.85]
112160408  hexokinase HKDC1 [KO:K00844] [EC:2.7.1.1]
112160409  hexokinase-1 [KO:K00844] [EC:2.7.1.1]
112141117  hexokinase-2 [KO:K00844] [EC:2.7.1.1]
112148289  hk2; hexokinase-2 [KO:K00844] [EC:2.7.1.1]
112157010  hexokinase-1 isoform X2 [KO:K00844] [EC:2.7.1.1]
112148443  gck; hexokinase-4 [KO:K12407] [EC:2.7.1.2]
112155805  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
112163281  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
112147743  prkab2; 5'-AMP-activated protein kinase subunit beta-2 isoform X1 [KO:K07199]
112148912  prkab1b; 5'-AMP-activated protein kinase subunit beta-1b [KO:K07199]
112163318  prkab1a; 5'-AMP-activated protein kinase subunit beta-1a [KO:K07199]
112147423  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
112155069  prkag3b; 5'-AMP-activated protein kinase subunit gamma-3b [KO:K07200]
112151143  5'-AMP-activated protein kinase subunit gamma-1 isoform X3 [KO:K07200]
112145399  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
112160004  prkag3a; 5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
112142807  forkhead box protein O1-A [KO:K07201]
112149680  foxo1a; forkhead box protein O1-A [KO:K07201]
112155720  ppargc1a; peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
112140444  g6pca.2; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
112140446  g6pca.1; glucose-6-phosphatase a, catalytic subunit, tandem duplicate 1 [KO:K01084] [EC:3.1.3.9]
112154194  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
112155359  glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
112147949  fbp2; fructose-1,6-bisphosphatase isozyme 2 [KO:K03841] [EC:3.1.3.11]
112148874  fructose-1,6-bisphosphatase 1 [KO:K03841] [EC:3.1.3.11]
112163411  fbp1b; fructose-1,6-bisphosphatase 1b [KO:K03841] [EC:3.1.3.11]
112151237  pck2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform X1 [KO:K01596] [EC:4.1.1.32]
112145622  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
112158714  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
112156982  rptor; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
112149160  rps6kb1b; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
112157403  ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
112138696  rps6kb1a; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
112157153  rps6; 40S ribosomal protein S6 [KO:K02991]
112148907  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
112163161  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
112147302  eif4e2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
112161798  eif4e1c; eukaryotic translation initiation factor 4E family member 1c isoform X2 [KO:K03259]
112143537  eif4eb; eukaryotic translation initiation factor 4eb [KO:K03259]
112153013  eukaryotic translation initiation factor 4E-1A [KO:K03259]
112140338  tsc1b; TSC complex subunit 1b [KO:K07206]
112148929  tsc1a; hamartin [KO:K07206]
112137715  hamartin isoform X1 [KO:K07206]
112137256  tsc2; tuberin isoform X1 [KO:K07207]
112141897  GTP-binding protein Rheb [KO:K07208]
112151125  rheb; GTP-binding protein Rheb [KO:K07208]
112144822  rhebl1; ras homolog, mTORC1 binding like 1 isoform X1 [KO:K07208]
112155974  badb; BCL2 associated agonist of cell death b [KO:K02158]
112143897  shc1; SHC-transforming protein 1 isoform X1 [KO:K06279]
112150934  shc2; SHC-transforming protein 2 [KO:K17447]
112163126  shc3; SHC-transforming protein 3 [KO:K17448]
112160361  SHC-transforming protein 3 [KO:K17449]
112146681  grb2b; growth factor receptor-bound protein 2b [KO:K04364]
112148171  sos2; son of sevenless homolog 2 [KO:K03099]
112143420  son of sevenless homolog 1 [KO:K03099]
112151792  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
112152425  kras; GTPase KRas isoform X1 [KO:K07827]
112146394  zgc:55558; GTPase HRas [KO:K07827]
112137697  araf; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
112154271  braf; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
112159520  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X1 [KO:K04366] [EC:2.7.11.1]
112152131  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
112136869  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
112136385  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
112146278  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
112150482  mknk2b; MAP kinase-interacting serine/threonine-protein kinase 2b [KO:K04372] [EC:2.7.11.1]
112150519  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
112158910  elk1; ETS domain-containing protein Elk-3 [KO:K04375]
112137354  suppressor of cytokine signaling 1 [KO:K04694]
112145861  socs1a; suppressor of cytokine signaling 1a [KO:K04694]
112154192  socs2; suppressor of cytokine signaling 2 [KO:K04695]
112154540  socs3b; suppressor of cytokine signaling 3b [KO:K04696]
112145844  socs3a; suppressor of cytokine signaling 3a [KO:K04696]
112138625  socs4; suppressor of cytokine signaling 4 [KO:K04697]
112158996  tyrosine-protein phosphatase non-receptor type 1 [KO:K05696] [EC:3.1.3.48]
112136894  receptor-type tyrosine-protein phosphatase F isoform X1 [KO:K05695] [EC:3.1.3.48]
112147723  receptor-type tyrosine-protein phosphatase F [KO:K05695] [EC:3.1.3.48]
112154188  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112161471  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
112163450  mapk10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
112153234  mapk9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
112148770  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
112142636  inppl1b; inositol polyphosphate phosphatase-like 1b [KO:K15909] [EC:3.1.3.86]
112149409  inppl1a; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2A isoform X1 [KO:K15909] [EC:3.1.3.86]
112161654  inositol polyphosphate-5-phosphatase A isoform X1 [KO:K01106] [EC:3.1.3.56]
112148030  inpp5l; inositol polyphosphate-5-phosphatase A [KO:K01106] [EC:3.1.3.56]
Compound
C00031  D-Glucose
C00369  Starch
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14635525
  Authors
Ogawa W, Kasuga M.
  Title
[Mechanism of insulin action and diabetes mellitus]
  Journal
Seikagaku 75:1332-44 (2003)
Reference
PMID:11282018
  Authors
Bevan P.
  Title
Insulin signalling.
  Journal
J Cell Sci 114:1429-30 (2001)
Reference
PMID:12867054
  Authors
Kanzaki M, Pessin JE.
  Title
Insulin signaling: GLUT4 vesicles exit via the exocyst.
  Journal
Curr Biol 13:R574-6 (2003)
DOI:10.1016/S0960-9822(03)00478-0
Reference
PMID:10196204
  Authors
Moodie SA, Alleman-Sposeto J, Gustafson TA.
  Title
Identification of the APS protein as a novel insulin receptor substrate.
  Journal
J Biol Chem 274:11186-93 (1999)
DOI:10.1074/jbc.274.16.11186
Reference
PMID:15733744
  Authors
Gual P, Le Marchand-Brustel Y, Tanti JF.
  Title
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation.
  Journal
Biochimie 87:99-109 (2005)
DOI:10.1016/j.biochi.2004.10.019
Reference
PMID:9748166
  Authors
Le Good JA, Ziegler WH, Parekh DB, Alessi DR, Cohen P, Parker PJ.
  Title
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.
  Journal
Science 281:2042-5 (1998)
DOI:10.1126/science.281.5385.2042
Reference
PMID:11742412
  Authors
Saltiel AR, Kahn CR.
  Title
Insulin signalling and the regulation of glucose and lipid metabolism.
  Journal
Nature 414:799-806 (2001)
DOI:10.1038/414799a
Reference
PMID:15624019
  Authors
Inoki K, Corradetti MN, Guan KL.
  Title
Dysregulation of the TSC-mTOR pathway in human disease.
  Journal
Nat Genet 37:19-24 (2005)
DOI:10.1038/ng1494
Reference
PMID:16288289
  Authors
Ruggero D, Sonenberg N.
  Title
The Akt of translational control.
  Journal
Oncogene 24:7426-34 (2005)
DOI:10.1038/sj.onc.1209098
Reference
PMID:10567225
  Authors
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR.
  Title
Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.
  Journal
Biochem J 344 Pt 2:427-31 (1999)
DOI:10.1042/bj3440427
Reference
PMID:9445476
  Authors
Pullen N, Dennis PB, Andjelkovic M, Dufner A, Kozma SC, Hemmings BA, Thomas G.
  Title
Phosphorylation and activation of p70s6k by PDK1.
  Journal
Science 279:707-10 (1998)
DOI:10.1126/science.279.5351.707
Reference
PMID:9609110
  Authors
Ogawa W, Matozaki T, Kasuga M.
  Title
Role of binding proteins to IRS-1 in insulin signalling.
  Journal
Mol Cell Biochem 182:13-22 (1998)
Reference
PMID:9609111
  Authors
Ceresa BP, Pessin JE.
  Title
Insulin regulation of the Ras activation/inactivation cycle.
  Journal
Mol Cell Biochem 182:23-9 (1998)
Reference
PMID:15229476
  Authors
Pollak MN, Schernhammer ES, Hankinson SE.
  Title
Insulin-like growth factors and neoplasia.
  Journal
Nat Rev Cancer 4:505-18 (2004)
DOI:10.1038/nrc1387
Reference
PMID:9346240
  Authors
Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME.
  Title
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.
  Journal
Cell 91:231-41 (1997)
DOI:10.1016/S0092-8674(00)80405-5
Reference
PMID:17344645
  Authors
Ferre P, Foufelle F
  Title
SREBP-1c transcription factor and lipid homeostasis: clinical perspective.
  Journal
Horm Res 68:72-82 (2007)
DOI:10.1159/000100426
Reference
PMID:18291668
  Authors
Raghow R, Yellaturu C, Deng X, Park EA, Elam MB
  Title
SREBPs: the crossroads of physiological and pathological lipid homeostasis.
  Journal
Trends Endocrinol Metab 19:65-73 (2008)
DOI:10.1016/j.tem.2007.10.009
Reference
PMID:11343120
  Authors
Clement S, Krause U, Desmedt F, Tanti JF, Behrends J, Pesesse X, Sasaki T, Penninger J, Doherty M, Malaisse W, Dumont JE, Le Marchand-Brustel Y, Erneux C, Hue L, Schurmans S
  Title
The lipid phosphatase SHIP2 controls insulin sensitivity.
  Journal
Nature 409:92-7 (2001)
DOI:10.1038/35051094
Reference
PMID:12791379
  Authors
Backers K, Blero D, Paternotte N, Zhang J, Erneux C
  Title
The termination of PI3K signalling by SHIP1 and SHIP2 inositol 5-phosphatases.
  Journal
Adv Enzyme Regul 43:15-28 (2003)
DOI:10.1016/S0065-2571(02)00043-2
Related
pathway
oml00010  Glycolysis / Gluconeogenesis
oml00061  Fatty acid biosynthesis
oml00500  Starch and sucrose metabolism
oml04010  MAPK signaling pathway
oml04070  Phosphatidylinositol signaling system
oml04210  Apoptosis
KO pathway
ko04910   
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