KEGG   PATHWAY: oro00230
Entry
oro00230                    Pathway                                
Name
Purine metabolism - Odobenus rosmarus divergens (Pacific walrus)
Class
Metabolism; Nucleotide metabolism
Pathway map
oro00230  Purine metabolism
oro00230

Module
oro_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:oro00230]
oro_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:oro00230]
oro_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:oro00230]
oro_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:oro00230]
oro_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:oro00230]
oro_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:oro00230]
oro_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:oro00230]
Other DBs
GO: 0006163 0042278
Organism
Odobenus rosmarus divergens (Pacific walrus) [GN:oro]
Gene
101363943  NUDT9; ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
101364660  LOW QUALITY PROTEIN: ADP-ribose pyrophosphatase, mitochondrial-like [KO:K13988] [EC:3.6.1.13]
101374847  ADPRM; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
101364423  NUDT5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
101379971  PGM1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
101367815  PGM2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
101368785  PRPS1; ribose-phosphate pyrophosphokinase 1 isoform X2 [KO:K00948] [EC:2.7.6.1]
101374406  LOW QUALITY PROTEIN: ribose-phosphate pyrophosphokinase 1-like [KO:K00948] [EC:2.7.6.1]
101370637  PRPS2; ribose-phosphate pyrophosphokinase 2 isoform X1 [KO:K00948] [EC:2.7.6.1]
101382993  PPAT; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
101384632  GART; trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
101379713  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
101383279  PAICS; multifunctional protein ADE2 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
101366282  ADSL; adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
101364100  ATIC; bifunctional purine biosynthesis protein PURH isoform X1 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
101366141  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
101364948  NT5C; 5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
101369893  cytosolic 5'-nucleotidase 1B isoform X1 [KO:K01081] [EC:3.1.3.5]
101376055  NT5M; 5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
101386588  NT5C2; cytosolic purine 5'-nucleotidase isoform X2 [KO:K01081] [EC:3.1.3.5]
101367258  NT5C1A; cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
101363322  NT5DC4; LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
101384645  NT5E; 5'-nucleotidase isoform X1 [KO:K19970] [EC:3.1.3.5]
101378018  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
101368838  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
101365535  LACC1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
101362831  HPRT1; hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
101362606  IMPDH1; inosine-5'-monophosphate dehydrogenase 1 isoform X2 [KO:K00088] [EC:1.1.1.205]
101378451  IMPDH2; inosine-5'-monophosphate dehydrogenase 2 isoform X1 [KO:K00088] [EC:1.1.1.205]
101375946  NME4; nucleoside diphosphate kinase, mitochondrial [KO:K00940] [EC:2.7.4.6]
101364508  NME3; nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
101370603  NME6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
105757063  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
101381906  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
101363445  NME7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
101364915  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
101377757  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
101362305  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
101366828  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 isoform X1 [KO:K01510] [EC:3.6.1.5]
101363814  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
101363791  ENTPD6; LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511] [EC:3.6.1.6]
101374973  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
101364270  NUDT16; U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
101363614  ITPA; LOW QUALITY PROTEIN: inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
101376175  XDH; xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
101367590  NUDT2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
101363575  GMPS; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
101376334  GMPR2; GMP reductase 2 isoform X1 [KO:K00364] [EC:1.7.1.7]
101373455  GMPR; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
101377754  GDA; guanine deaminase isoform X2 [KO:K01487] [EC:3.5.4.3]
101378285  GUK1; guanylate kinase [KO:K00942] [EC:2.7.4.8]
101383805  RRM1; ribonucleoside-diphosphate reductase large subunit [KO:K10807] [EC:1.17.4.1]
101376333  RRM2; ribonucleoside-diphosphate reductase subunit M2 isoform X1 [KO:K10808] [EC:1.17.4.1]
101386612  LOW QUALITY PROTEIN: ribonucleoside-diphosphate reductase subunit M2-like [KO:K10808] [EC:1.17.4.1]
101386058  ribonucleoside-diphosphate reductase subunit M2-like isoform X1 [KO:K10808] [EC:1.17.4.1]
101382329  RRM2B; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
101375861  HDDC2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
101374002  DGUOK; deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
101384844  DCK; deoxycytidine kinase isoform X1 [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
101372169  HDDC3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
101373652  PRUNE; protein prune homolog isoform X1 [KO:K01514] [EC:3.6.1.11]
101379158  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101365382  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101368682  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101374313  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
101380824  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101373816  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
101377421  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101370350  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101364108  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101363792  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
101379936  ADCY10; adenylate cyclase type 10 isoform X2 [KO:K11265] [EC:4.6.1.1]
101369879  GUCY1A2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
101381618  GUCY1A3; guanylate cyclase soluble subunit alpha-3 [KO:K12318] [EC:4.6.1.2]
101365290  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
101380641  GUCY1B3; guanylate cyclase soluble subunit beta-1 isoform X2 [KO:K12319] [EC:4.6.1.2]
101382463  GUCY2C; heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
101377149  olfactory guanylyl cyclase GC-D-like [KO:K12321] [EC:4.6.1.2]
101383563  GUCY2D; retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
101371476  GUCY2F; retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
101367891  LOW QUALITY PROTEIN: guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
101384059  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
101385033  NPR2; atrial natriuretic peptide receptor 2 isoform X1 [KO:K12324] [EC:4.6.1.2]
101365244  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
101380225  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
101363002  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
101368284  PDE2A; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
105757534  LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase A-like [KO:K19021] [EC:3.1.4.17]
101384884  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
101371957  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
101366296  PDE5A; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
101373355  PDE6A; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha [KO:K08718] [EC:3.1.4.35]
101362711  PDE6B; rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta isoform X1 [KO:K13756] [EC:3.1.4.35]
101370460  PDE6C; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
101372354  PDE6D; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta isoform X1 [KO:K13758]
101381575  PDE6G; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
101379642  PDE6H; retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
101362758  PDE9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
101372969  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
101386595  PDE11A; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
101382388  ADSSL1; adenylosuccinate synthetase isozyme 1 isoform X1 [KO:K01939] [EC:6.3.4.4]
101383092  ADSS; adenylosuccinate synthetase isozyme 2 [KO:K01939] [EC:6.3.4.4]
101362692  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
101366223  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
101363811  AMPD1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
101371121  ADK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
101380356  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
101368941  CECR1; adenosine deaminase CECR1 [KO:K19572] [EC:3.5.4.4]
101363750  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
101369666  AK1; adenylate kinase isoenzyme 1 isoform X1 [KO:K00939] [EC:2.7.4.3]
101362994  LOW QUALITY PROTEIN: adenylate kinase [KO:K00939] [EC:2.7.4.3]
101365957  AK4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
101364318  AK2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
101378383  AK5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
101383934  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
102314694  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
101374608  adenylate kinase isoenzyme 6-like [KO:K18532] [EC:2.7.4.3]
101381565  GTP:AMP phosphotransferase AK3, mitochondrial-like isoform X1 [KO:K00944] [EC:2.7.4.10]
101375590  AK3; GTP:AMP phosphotransferase AK3, mitochondrial isoform X1 [KO:K00944] [EC:2.7.4.10]
101374840  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
101366225  NTPCR; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
101371985  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
101372283  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
101383319  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
101372982  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
101367993  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
101367053  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
101367755  PDE7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
101382648  PDE7B; cAMP-specific 3',5'-cyclic phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
101367637  PDE8A; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
101377436  PDE8B; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
105758078  FHIT; bis(5'-adenosyl)-triphosphatase [KO:K01522] [EC:3.6.1.29]
101374240  ENPP4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
101370935  PAPSS1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
101370734  PAPSS2; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
101366343  uricase [KO:K00365] [EC:1.7.3.3]
101373190  5-hydroxyisourate hydrolase-like isoform X1 [KO:K07127] [EC:3.5.2.17]
101382684  URAD; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
101382817  ALLC; probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
oro00030  Pentose phosphate pathway
oro00220  Arginine biosynthesis
oro00250  Alanine, aspartate and glutamate metabolism
oro00260  Glycine, serine and threonine metabolism
oro00340  Histidine metabolism
oro00630  Glyoxylate and dicarboxylate metabolism
oro00730  Thiamine metabolism
oro00740  Riboflavin metabolism
oro00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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