KEGG   PATHWAY: pmei04068
Entry
pmei04068                   Pathway                                
Name
FoxO signaling pathway - Poecilia mexicana (shortfin molly)
Description
The forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative stress resistance, and longevity. A central regulatory mechanism of FOXO proteins is phosphorylation by the serine-threonine kinase Akt/protein kinase B (Akt/PKB), downstream of phosphatidylinositol 3-kinase (PI3K), in response to insulin or several growth factors. Phosphorylation at three conserved residues results in the export of FOXO proteins from the nucleus to the cytoplasm, thereby decreasing expression of FOXO target genes. In contrast, the stress-activated c-Jun N-terminal kinase (JNK) and the energy sensing AMP-activated protein kinase (AMPK), upon oxidative and nutrient stress stimuli phosphorylate and activate FoxOs. Aside from PKB, JNK and AMPK, FOXOs are regulated by multiple players through several post-translational modifications, including phosphorylation, but also acetylation, methylation and ubiquitylation.
Class
Environmental Information Processing; Signal transduction
Pathway map
pmei04068  FoxO signaling pathway
pmei04068

Other DBs
GO: 0009267
Organism
Poecilia mexicana (shortfin molly) [GN:pmei]
Gene
106919996  transforming growth factor beta-1-like [KO:K13375]
106915805  transforming growth factor beta-2-like [KO:K13376]
106915806  transforming growth factor beta-2-like [KO:K13376]
106919679  transforming growth factor beta-3-like [KO:K13377]
106923532  tgfb3; transforming growth factor beta-3 [KO:K13377]
106907484  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
106915864  tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
106917549  TGF-beta receptor type-2-like isoform X1 [KO:K04388] [EC:2.7.11.30]
106909302  mothers against decapentaplegic homolog 4-like [KO:K04501]
106923107  LOW QUALITY PROTEIN: mothers against decapentaplegic homolog 4-like [KO:K04501]
106923514  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
106924785  mothers against decapentaplegic homolog 3 [KO:K23605]
106905428  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
106933334  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
106926166  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
106924337  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
106906561  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
106927904  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
106921617  prkab1; 5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
106919797  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
106905100  prkag3; 5'-AMP-activated protein kinase subunit gamma-3 isoform X1 [KO:K07200]
106906316  prkag1; 5'-AMP-activated protein kinase subunit gamma-1 [KO:K07200]
106911661  5'-AMP-activated protein kinase subunit gamma-2-like [KO:K07200]
106930974  5'-AMP-activated protein kinase subunit gamma-1-like isoform X1 [KO:K07200]
106911455  serine/threonine-protein kinase NLK2-like [KO:K04468] [EC:2.7.11.24]
106929918  nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
106927045  skp2; S-phase kinase-associated protein 2 isoform X1 [KO:K03875]
106922714  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
106911657  histone-lysine N-methyltransferase SETD7-like [KO:K11431] [EC:2.1.1.364]
106915779  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
106910082  CREB-binding protein-like [KO:K04498] [EC:2.3.1.48]
106933455  histone acetyltransferase p300-like isoform X1 [KO:K04498] [EC:2.3.1.48]
106933952  CREB-binding protein-like isoform X1 [KO:K04498] [EC:2.3.1.48]
106920951  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
106915210  usp7; ubiquitin carboxyl-terminal hydrolase 7 isoform X1 [KO:K11838] [EC:3.4.19.12]
106919125  slc2a4; solute carrier family 2, facilitated glucose transporter member 4 [KO:K07191]
106915127  mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
106917997  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
106920878  mitogen-activated protein kinase 9-like isoform X1 [KO:K04440] [EC:2.7.11.24]
106924329  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
106931957  serine/threonine-protein kinase 4-like [KO:K04411]
106924487  insulin-like growth factor II isoform X1 [KO:K05459]
106925431  igf1; insulin-like growth factor I [KO:K05459]
106920161  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
106915580  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
106908579  insulin isoform X1 [KO:K04526]
106928221  insulin-like [KO:K04526]
106916182  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
106925119  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
106904791  insulin receptor substrate 1-B-like [KO:K16172]
106934130  insulin receptor substrate 1-B-like [KO:K16172]
106906991  insulin receptor substrate 2-like isoform X1 [KO:K07187]
106927476  irs2; insulin receptor substrate 2 [KO:K07187]
106929252  insulin receptor substrate 2-B-like [KO:K07187]
106906548  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
106917126  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106920607  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
106928990  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
106930552  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
106907915  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
106908122  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
106917051  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
106910271  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
106919021  phosphatidylinositol 3-kinase regulatory subunit gamma-like isoform X1 [KO:K02649]
106928883  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
106907644  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
106911720  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
106915153  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
106915993  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
106921755  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
106908005  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106929121  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106913936  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106932106  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106933633  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
106927524  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106911072  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
106926752  sgk1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
106929190  serine/threonine-protein kinase Sgk1-like isoform X1 [KO:K13302] [EC:2.7.11.1]
106920121  sgk2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
106903216  sgk3; serine/threonine-protein kinase Sgk3 [KO:K13304] [EC:2.7.11.1]
106914462  forkhead box protein O1-A-like [KO:K07201]
106915730  forkhead box protein O1-B-like [KO:K07201]
106907095  forkhead box protein O3-like [KO:K09408]
106925947  forkhead box protein O3-like [KO:K09408]
106921915  foxo3; forkhead box protein O3 [KO:K09408]
106920289  foxo4; forkhead box protein O4 [KO:K12358]
106907798  forkhead box protein O3-like [KO:K17847]
106928558  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
106928760  metabotropic glutamate receptor 1-like isoform X1 [KO:K04603]
106919687  homer protein homolog 2-like [KO:K15010]
106914651  homer2; homer protein homolog 2 isoform X1 [KO:K15010]
106916213  homer1; homer protein homolog 1 isoform X1 [KO:K15010]
106927377  homer protein homolog 3-like isoform X1 [KO:K15010]
106921283  homer protein homolog 1-like isoform X1 [KO:K15010]
106922737  homer3; homer protein homolog 3 isoform X1 [KO:K15010]
106920721  agap2; arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K17848]
106923267  arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1-like [KO:K17848]
106915477  casein kinase I isoform epsilon [KO:K08960] [EC:2.7.11.1]
106925736  casein kinase I isoform epsilon-like [KO:K08960] [EC:2.7.11.1]
106933920  il10; interleukin-10 [KO:K05443]
106904928  signal transducer and activator of transcription 3 [KO:K04692]
106931289  stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
106929540  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
106903456  melanoma receptor tyrosine-protein kinase [KO:K04361] [EC:2.7.10.1]
106924542  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
106933452  grb2; growth factor receptor-bound protein 2 [KO:K04364]
106912797  son of sevenless homolog 1-like [KO:K03099]
106922076  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
106917342  hras; GTPase HRas [KO:K02833]
106916041  kras; GTPase KRas isoform X1 [KO:K07827]
106931194  GTPase HRas-like [KO:K07827]
106907580  serine/threonine-protein kinase B-raf-like [KO:K04365] [EC:2.7.11.1]
106904980  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
106930520  serine/threonine-protein kinase A-Raf-like [KO:K08845] [EC:2.7.11.1]
106924888  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106915816  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106919524  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106906981  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
106915443  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106907848  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
106917396  mitogen-activated protein kinase 14A isoform X1 [KO:K04441] [EC:2.7.11.24]
106903247  mitogen-activated protein kinase 12-like [KO:K04441] [EC:2.7.11.24]
106922726  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
106922728  mitogen-activated protein kinase 11-like [KO:K04441] [EC:2.7.11.24]
106931374  mitogen-activated protein kinase 14A-like [KO:K04441] [EC:2.7.11.24]
106929452  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
106911713  protein arginine N-methyltransferase 1 isoform X1 [KO:K11434] [EC:2.1.1.319]
106915108  forkhead box protein G1-like [KO:K09385]
106907274  forkhead box protein G1-like [KO:K09385]
106916145  forkhead box protein G1-like [KO:K09385]
106920582  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
106903949  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
106932107  G2/mitotic-specific cyclin-B2-like isoform X1 [KO:K21770]
106911618  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
106910011  G1/S-specific cyclin-D2-like [KO:K10151]
106926112  ccnd2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
106921165  G1/S-specific cyclin-D2-like [KO:K10151]
106922678  cyclin-G2-like [KO:K10146]
106925540  cyclin-G2-like [KO:K10146]
106919335  cyclin-dependent kinase 4 inhibitor B-like [KO:K04685]
106914641  cdkn2d; cyclin-dependent kinase 4 inhibitor D [KO:K06623]
106916628  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
106928197  cyclin-dependent kinase inhibitor 1-like isoform X1 [KO:K06625]
106924292  cyclin-dependent kinase inhibitor 1-like [KO:K06625]
106916622  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
106917157  cyclin-dependent kinase inhibitor 1B-like [KO:K06624]
106921954  retinoblastoma-like protein 2 isoform X1 [KO:K16332]
106908268  plk1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
106916956  plk2; serine/threonine-protein kinase PLK2 [KO:K08861] [EC:2.7.11.21]
106925694  plk3; serine/threonine-protein kinase PLK3 [KO:K08862] [EC:2.7.11.21]
106928495  plk4; serine/threonine-protein kinase PLK4 isoform X1 [KO:K08863] [EC:2.7.11.21]
106920131  growth arrest and DNA damage-inducible protein GADD45 alpha-like [KO:K04402]
106915265  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
106908314  growth arrest and DNA damage-inducible protein GADD45 beta-like [KO:K04402]
106933439  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
106926763  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
106926769  growth arrest and DNA damage-inducible protein GADD45 gamma-like [KO:K04402]
106927097  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
106916375  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
106920845  tumor necrosis factor ligand superfamily member 6-like [KO:K04389]
106930801  bcl2l11; bcl-2-like protein 11 isoform X1 [KO:K16341]
106912519  tnfsf10; LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 10 [KO:K04721]
106933885  tumor necrosis factor ligand superfamily member 10-like isoform X1 [KO:K04721]
106908415  bcl6; B-cell lymphoma 6 protein isoform X1 [KO:K15618]
106929856  B-cell CLL/lymphoma 6 member B protein-like [KO:K15618]
106912535  BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like [KO:K15464]
106914138  bnip3; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
106916553  atg12; ubiquitin-like protein ATG12 [KO:K08336]
106916568  gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
106908845  gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
106919130  gabarap; gamma-aminobutyric acid receptor-associated protein [KO:K08341]
106933752  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
106905011  cat; catalase [KO:K03781] [EC:1.11.1.6]
106906518  sod2; superoxide dismutase [Mn], mitochondrial [KO:K04564] [EC:1.15.1.1]
106928690  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
106909565  phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like isoform X1 [KO:K01596] [EC:4.1.1.32]
106926981  pck1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
106919510  g6pc3; glucose-6-phosphatase 3 [KO:K01084] [EC:3.1.3.9]
106926444  g6pc2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
106933898  g6pc; glucose-6-phosphatase [KO:K01084] [EC:3.1.3.9]
106933899  glucose-6-phosphatase-like [KO:K01084] [EC:3.1.3.9]
106910402  il7r; interleukin-7 receptor subunit alpha [KO:K05072]
106914774  klf2; Krueppel-like factor 2 [KO:K17845]
106922600  s1pr1; sphingosine 1-phosphate receptor 1 [KO:K04288]
106925115  s1pr4; sphingosine 1-phosphate receptor 4 [KO:K04293]
106921869  rag1; V(D)J recombination-activating protein 1 [KO:K10628] [EC:2.3.2.27]
106921868  rag2; V(D)J recombination-activating protein 2 [KO:K10988]
106903668  fbxo25; F-box only protein 25 isoform X1 [KO:K10305]
106923402  fbxo32; F-box only protein 32 [KO:K10305]
Compound
C00008  ADP
C00020  AMP
C00025  L-Glutamate
C00031  D-Glucose
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:17470511
  Authors
Glauser DA, Schlegel W
  Title
The emerging role of FOXO transcription factors in pancreatic beta cells.
  Journal
J Endocrinol 193:195-207 (2007)
DOI:10.1677/JOE-06-0191
Reference
PMID:17522590
  Authors
van der Horst A, Burgering BM
  Title
Stressing the role of FoxO proteins in lifespan and disease.
  Journal
Nat Rev Mol Cell Biol 8:440-50 (2007)
DOI:10.1038/nrm2190
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:23325358
  Authors
Eijkelenboom A, Burgering BM
  Title
FOXOs: signalling integrators for homeostasis maintenance.
  Journal
Nat Rev Mol Cell Biol 14:83-97 (2013)
DOI:10.1038/nrm3507
Reference
PMID:17569704
  Authors
Daitoku H, Fukamizu A
  Title
FOXO transcription factors in the regulatory networks of longevity.
  Journal
J Biochem 141:769-74 (2007)
DOI:10.1093/jb/mvm104
Reference
PMID:19701188
  Authors
Hedrick SM
  Title
The cunning little vixen: Foxo and the cycle of life and death.
  Journal
Nat Immunol 10:1057-63 (2009)
DOI:10.1038/ni.1784
Reference
PMID:15516968
  Authors
Coffer PJ, Burgering BM
  Title
Forkhead-box transcription factors and their role in the immune system.
  Journal
Nat Rev Immunol 4:889-99 (2004)
DOI:10.1038/nri1488
Reference
PMID:22902436
  Authors
Ro SH, Liu D, Yeo H, Paik JH
  Title
FoxOs in neural stem cell fate decision.
  Journal
Arch Biochem Biophys 534:55-63 (2013)
DOI:10.1016/j.abb.2012.07.017
Reference
PMID:18403263
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
OutFOXOing disease and disability: the therapeutic potential of targeting FoxO proteins.
  Journal
Trends Mol Med 14:219-27 (2008)
DOI:10.1016/j.molmed.2008.03.002
Reference
PMID:23801966
  Authors
Hagenbuchner J, Ausserlechner MJ
  Title
Mitochondria and FOXO3: breath or die.
  Journal
Front Physiol 4:147 (2013)
DOI:10.3389/fphys.2013.00147
Reference
PMID:18045156
  Authors
Maiese K, Chong ZZ, Shang YC
  Title
"Sly as a FOXO": new paths with Forkhead signaling in the brain.
  Journal
Curr Neurovasc Res 4:295-302 (2007)
DOI:10.2174/156720207782446306
Reference
PMID:22761423
  Authors
Oh HM, Yu CR, Dambuza I, Marrero B, Egwuagu CE
  Title
STAT3 protein interacts with Class O Forkhead transcription factors in the cytoplasm and regulates nuclear/cytoplasmic localization of FoxO1 and FoxO3a proteins in CD4(+) T cells.
  Journal
J Biol Chem 287:30436-43 (2012)
DOI:10.1074/jbc.M112.359661
Reference
PMID:21238503
  Authors
Huang H, Tindall DJ
  Title
Regulation of FOXO protein stability via ubiquitination and proteasome degradation.
  Journal
Biochim Biophys Acta 1813:1961-4 (2011)
DOI:10.1016/j.bbamcr.2011.01.007
Reference
PMID:16288288
  Authors
Greer EL, Brunet A
  Title
FOXO transcription factors at the interface between longevity and tumor suppression.
  Journal
Oncogene 24:7410-25 (2005)
DOI:10.1038/sj.onc.1209086
Reference
PMID:15084259
  Authors
Seoane J, Le HV, Shen L, Anderson SA, Massague J
  Title
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.
  Journal
Cell 117:211-23 (2004)
DOI:10.1016/S0092-8674(04)00298-3
Reference
PMID:18951090
  Authors
Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A
  Title
Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt.
  Journal
Mol Cell 32:221-31 (2008)
DOI:10.1016/j.molcel.2008.09.013
Reference
PMID:16964248
  Authors
van der Horst A, de Vries-Smits AM, Brenkman AB, van Triest MH, van den Broek N, Colland F, Maurice MM, Burgering BM
  Title
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP.
  Journal
Nat Cell Biol 8:1064-73 (2006)
DOI:10.1038/ncb1469
Reference
PMID:21613825
  Authors
Zhang Y, Gan B, Liu D, Paik JH
  Title
FoxO family members in cancer.
  Journal
Cancer Biol Ther 12:253-9 (2011)
DOI:10.4161/cbt.12.4.15954
Reference
PMID:15005655
  Authors
Van Der Heide LP, Hoekman MF, Smidt MP
  Title
The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation.
  Journal
Biochem J 380:297-309 (2004)
DOI:10.1042/BJ20040167
Related
pathway
pmei00010  Glycolysis / Gluconeogenesis
pmei00020  Citrate cycle (TCA cycle)
pmei00190  Oxidative phosphorylation
pmei04010  MAPK signaling pathway
pmei04110  Cell cycle
pmei04120  Ubiquitin mediated proteolysis
pmei04140  Autophagy - animal
pmei04210  Apoptosis
pmei04350  TGF-beta signaling pathway
pmei04910  Insulin signaling pathway
KO pathway
ko04068   
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