KEGG   PATHWAY: pmei04010
Entry
pmei04010                   Pathway                                
Name
MAPK signaling pathway - Poecilia mexicana (shortfin molly)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
pmei04010  MAPK signaling pathway
pmei04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Poecilia mexicana (shortfin molly) [GN:pmei]
Gene
106903247  [KO:K04441] [EC:2.7.11.24]
106903385  rasgrp3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
106903391  [KO:K05096] [EC:2.7.10.1]
106903397  [KO:K05092] [EC:2.7.10.1]
106903419  [KO:K04353]
106903456  [KO:K04361] [EC:2.7.10.1]
106903612  [KO:K04866]
106903626  [KO:K04869]
106903634  rasgrp1; RAS guanyl-releasing protein 1 [KO:K04350]
106903797  [KO:K05093] [EC:2.7.10.1]
106903849  nfkb2; nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
106904031  [KO:K04348] [EC:3.1.3.16]
106904187  [KO:K04358]
106904272  [KO:K12326]
106904317  tab2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
106904324  [KO:K04461] [EC:3.1.3.16]
106904379  [KO:K04373] [EC:2.7.11.1]
106904457  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106904495  fgf7; fibroblast growth factor 7 [KO:K04358]
106904509  hspa8; heat shock cognate 71 kDa protein [KO:K03283]
106904570  [KO:K04455]
106904598  [KO:K04359]
106904798  [KO:K07861]
106904805  [KO:K04412]
106904838  mknk1; MAP kinase-interacting serine/threonine-protein kinase 1 [KO:K04372] [EC:2.7.11.1]
106904874  mapt; microtubule-associated protein tau isoform X1 [KO:K04380]
106904919  hgf; hepatocyte growth factor isoform X1 [KO:K05460]
106904963  gdnf; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
106904980  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
106905053  map3k3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
106905199  epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
106905226  map4k4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
106905228  [KO:K04393]
106905258  [KO:K13769]
106905273  rps6ka3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
106905356  [KO:K04410] [EC:2.7.11.1]
106905480  [KO:K04358]
106905482  [KO:K04376]
106905603  [KO:K04424] [EC:2.7.11.25]
106905780  [KO:K04856]
106905808  [KO:K04377]
106905942  [KO:K04380]
106905947  [KO:K04849]
106906070  [KO:K04864]
106906076  mapk8ip2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
106906082  [KO:K02187] [EC:3.4.22.56]
106906105  [KO:K04465]
106906189  fgf3; fibroblast growth factor 3 [KO:K04358]
106906228  [KO:K04345] [EC:2.7.11.11]
106906283  [KO:K04417] [EC:2.7.11.25]
106906308  erbb3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
106906347  map4k3; mitogen-activated protein kinase kinase kinase kinase 3 [KO:K04406] [EC:2.7.11.1]
106906386  pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
106906617  [KO:K02583]
106906759  [KO:K03283]
106906966  [KO:K04358]
106906981  [KO:K04371] [EC:2.7.11.24]
106907132  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
106907217  pdgfrb; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
106907219  [KO:K05090] [EC:2.7.10.1]
106907379  [KO:K04390]
106907458  [KO:K04735]
106907484  [KO:K04674] [EC:2.7.11.30]
106907580  [KO:K04365] [EC:2.7.11.1]
106907688  [KO:K04519]
106907785  ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
106907814  [KO:K04374]
106907848  [KO:K04441] [EC:2.7.11.24]
106907882  [KO:K04434]
106908139  [KO:K04449]
106908314  [KO:K04402]
106908390  [KO:K22428]
106908394  fgf6; fibroblast growth factor 6 [KO:K04358]
106908579  [KO:K04526]
106908633  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
106908659  mapk7; mitogen-activated protein kinase 7 isoform X1 [KO:K04464] [EC:2.7.11.24]
106908735  [KO:K03156]
106908826  dusp7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106908864  cacnb1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
106908872  [KO:K05095] [EC:2.7.10.1]
106908886  [KO:K05449]
106909317  [KO:K04453]
106909380  [KO:K18019] [EC:3.1.3.48]
106909452  ppm1b; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
106909696  [KO:K04870]
106909699  [KO:K02677] [EC:2.7.11.13]
106909702  elk1; ETS domain-containing protein Elk-1 isoform X1 [KO:K04375]
106909745  [KO:K04853]
106909765  irak1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
106909806  [KO:K04733] [EC:2.7.11.1]
106909855  [KO:K22603]
106910066  [KO:K04358]
106910116  ntf3; neurotrophin-3 [KO:K04356]
106910777  taok1; serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
106911025  [KO:K19662] [EC:2.7.11.13]
106911031  [KO:K02308]
106911171  [KO:K07830]
106911455  [KO:K04468] [EC:2.7.11.24]
106911519  [KO:K06268]
106911536  [KO:K04438]
106911877  [KO:K07830]
106911895  [KO:K04429] [EC:2.7.11.1]
106911966  [KO:K04358]
106912000  [KO:K17614] [EC:3.1.3.16 3.1.3.48]
106912093  [KO:K07830]
106912184  [KO:K05090] [EC:2.7.10.1]
106912221  [KO:K04868]
106912368  [KO:K04360] [EC:2.7.10.1]
106912783  [KO:K03283]
106912797  [KO:K03099]
106912818  [KO:K03283]
106912827  [KO:K07830]
106913886  pla2g4a; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
106913936  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106913976  tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
106914368  crk; adapter molecule crk [KO:K04438]
106914544  [KO:K04855]
106914631  figf; vascular endothelial growth factor D [KO:K05449]
106914723  [KO:K04423] [EC:2.7.11.25]
106914760  [KO:K25414]
106914793  angpt2; angiopoietin-2 [KO:K05466]
106914867  pdgfc; platelet-derived growth factor C isoform X1 [KO:K05450]
106914913  tgfa; protransforming growth factor alpha [KO:K08774]
106914942  [KO:K04859]
106914965  [KO:K04864]
106915078  [KO:K05460]
106915080  [KO:K04858]
106915127  [KO:K04440] [EC:2.7.11.24]
106915153  [KO:K04467] [EC:2.7.11.10]
106915219  cacng3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
106915220  prkcb; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
106915262  [KO:K05462]
106915265  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
106915366  cacnb2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
106915443  [KO:K04441] [EC:2.7.11.24]
106915515  map3k4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
106915580  [KO:K05087] [EC:2.7.10.1]
106915613  [KO:K04358]
106915785  pdgfa; platelet-derived growth factor subunit A [KO:K04359]
106915798  vegfb; vascular endothelial growth factor B [KO:K05448]
106915805  [KO:K13376]
106915806  [KO:K13376]
106915816  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106915846  [KO:K04856]
106915864  tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
106915898  cacna1f; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
106915993  [KO:K04467] [EC:2.7.11.10]
106916041  kras; GTPase KRas isoform X1 [KO:K07827]
106916071  [KO:K04377]
106916182  [KO:K04527] [EC:2.7.10.1]
106916321  [KO:K05103] [EC:2.7.10.1]
106916375  [KO:K04389]
106916398  dusp5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106916502  pak1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
106916531  [KO:K04358]
106916540  [KO:K04873]
106916541  cacng6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
106916736  [KO:K04353]
106916780  dusp8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106916781  [KO:K18018] [EC:3.1.3.48]
106916786  [KO:K05452]
106916969  [KO:K05466]
106916992  [KO:K04465]
106917048  [KO:K03173] [EC:2.3.2.27]
106917088  dusp16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106917189  dusp6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
106917192  [KO:K05461]
106917289  [KO:K04466] [EC:2.7.11.25]
106917297  ptprr; receptor-type tyrosine-protein phosphatase R [KO:K04458] [EC:3.1.3.48]
106917317  rap1b; ras-related protein Rap-1b [KO:K07836]
106917328  map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
106917342  hras; GTPase HRas [KO:K02833]
106917396  [KO:K04441] [EC:2.7.11.24]
106917430  traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
106917549  [KO:K04388] [EC:2.7.11.30]
106917705  [KO:K05462]
106917728  fgf20; fibroblast growth factor 20 [KO:K04358]
106917925  pla2g4c; cytosolic phospholipase A2 gamma [KO:K16342] [EC:3.1.1.4]
106917997  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
106918048  [KO:K04851]
106918050  [KO:K04860]
106918100  fgf16; fibroblast growth factor 16 [KO:K04358]
106918189  [KO:K05462]
106918190  [KO:K05462]
106918296  crkl; crk-like protein [KO:K04438]
106918373  map4k2; mitogen-activated protein kinase kinase kinase kinase 2 isoform X1 [KO:K04414] [EC:2.7.11.1]
106918379  ecsit; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial isoform X1 [KO:K04405]
106918443  [KO:K04350]
106918504  [KO:K03283]
106918512  erbb4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
106918547  csf1r; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
106918551  [KO:K05089] [EC:2.7.10.1]
106918570  arrb2; beta-arrestin-2 isoform X1 [KO:K04439]
106918698  [KO:K05091] [EC:2.7.10.1]
106918754  fgf21; fibroblast growth factor 21 [KO:K22429]
106918944  hspb1; heat shock protein beta-1 [KO:K04455]
106918948  cdc25b; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
106919032  [KO:K04448]
106919132  tp53; cellular tumor antigen p53 [KO:K04451]
106919164  [KO:K04446]
106919274  [KO:K18496]
106919371  [KO:K05461]
106919440  taok3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
106919456  [KO:K03176] [EC:2.7.10.1]
106919524  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106919573  map3k2; mitogen-activated protein kinase kinase kinase 2 isoform X1 [KO:K04420] [EC:2.7.11.25]
106919679  [KO:K13377]
106919707  [KO:K04873]
106919718  [KO:K04872]
106919728  [KO:K04871]
106919778  [KO:K17386]
106919784  [KO:K04374]
106919891  [KO:K04393]
106919948  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
106919992  [KO:K04381]
106919996  [KO:K13375]
106920010  [KO:K04379]
106920011  [KO:K04379]
106920063  [KO:K04433] [EC:2.7.12.2]
106920131  [KO:K04402]
106920133  [KO:K04347]
106920161  [KO:K05087] [EC:2.7.10.1]
106920173  relb; transcription factor RelB isoform X1 [KO:K09253]
106920433  ppp5c; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
106920511  cacna1g; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
106920571  [KO:K04849]
106920801  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
106920834  cacna1s; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
106920845  [KO:K04389]
106920852  jun; transcription factor AP-1 [KO:K04448]
106920878  [KO:K04440] [EC:2.7.11.24]
106920941  ret; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
106920990  [KO:K02582]
106921034  [KO:K04421] [EC:2.7.11.25]
106921037  myd88; myeloid differentiation primary response protein MyD88 [KO:K04729]
106921375  tnfrsf1a; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
106921410  [KO:K04377]
106921433  [KO:K04349]
106921447  [KO:K04348] [EC:3.1.3.16]
106921534  [KO:K05084] [EC:2.7.10.1]
106921599  [KO:K05462]
106921643  [KO:K04348] [EC:3.1.3.16]
106921645  [KO:K04427] [EC:2.7.11.25]
106921698  [KO:K03158]
106921755  ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
106921931  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106922057  prkaca; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
106922075  [KO:K04850]
106922076  sos2; son of sevenless homolog 2 isoform X1 [KO:K03099]
106922120  ntrk2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
106922138  [KO:K16859]
106922225  cacna2d4; voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
106922236  [KO:K04858]
106922247  [KO:K04393]
106922340  fgf5; fibroblast growth factor 5 [KO:K04358]
106922390  [KO:K04348] [EC:3.1.3.16]
106922419  [KO:K04433] [EC:2.7.12.2]
106922470  mecom; MDS1 and EVI1 complex locus protein EVI1 isoform X1 [KO:K04462] [EC:2.1.1.367]
106922497  [KO:K04362] [EC:2.7.10.1]
106922536  fgfr3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
106922626  efna1; ephrin-A1 [KO:K05462]
106922627  efna3; ephrin-A3 [KO:K05462]
106922629  [KO:K05462]
106922646  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
106922726  [KO:K04441] [EC:2.7.11.24]
106922728  [KO:K04441] [EC:2.7.11.24]
106922842  cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
106922882  nfkb1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
106923225  [KO:K04444] [EC:2.7.11.1]
106923310  [KO:K04426] [EC:2.7.11.25]
106923420  [KO:K05085] [EC:2.7.10.1]
106923441  [KO:K04446]
106923532  tgfb3; transforming growth factor beta-3 [KO:K13377]
106923538  [KO:K04379]
106923625  [KO:K04345] [EC:2.7.11.11]
106923645  [KO:K04457] [EC:3.1.3.16]
106923783  [KO:K04344]
106923892  [KO:K07860]
106923896  tab1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
106923898  [KO:K04867]
106924169  kdr; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
106924185  pdgfra; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
106924200  kit; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
106924201  [KO:K04358]
106924228  cacng1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
106924232  cacng4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
106924233  cacng5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
106924234  prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
106924244  [KO:K04373] [EC:2.7.11.1]
106924329  mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
106924454  atf2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
106924487  [KO:K05459]
106924489  [KO:K04437]
106924542  egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
106924591  [KO:K04448]
106924684  taok2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
106924714  mapkapk5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
106924786  map2k5; dual specificity mitogen-activated protein kinase kinase 5 [KO:K04463] [EC:2.7.12.2]
106924838  fgf2; fibroblast growth factor 2 [KO:K18497]
106924851  [KO:K04430] [EC:2.7.12.2]
106924883  pdgfd; platelet-derived growth factor D isoform X1 [KO:K05450]
106924888  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106924896  bdnf; brain-derived neurotrophic factor isoform X1 [KO:K04355]
106925051  cacna2d2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
106925119  [KO:K04527] [EC:2.7.10.1]
106925139  [KO:K04466] [EC:2.7.11.25]
106925431  igf1; insulin-like growth factor I [KO:K05459]
106925564  [KO:K02582]
106925571  [KO:K04861]
106925627  [KO:K18496]
106925704  cacng2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
106925748  [KO:K09784]
106925835  [KO:K04392]
106925836  [KO:K04392]
106925837  [KO:K04392]
106925839  [KO:K04392]
106925852  cacnb4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
106925857  mef2c; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
106925950  mknk2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
106925971  erbb2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
106925996  [KO:K04407] [EC:2.7.11.1]
106926028  [KO:K04454]
106926078  lamtor3; ragulator complex protein LAMTOR3 [KO:K04370]
106926114  fgf23; fibroblast growth factor 23 [KO:K22428]
106926215  mras; ras-related protein M-Ras [KO:K07831]
106926546  [KO:K04865]
106926555  [KO:K05096] [EC:2.7.10.1]
106926661  [KO:K04407] [EC:2.7.11.1]
106926663  [KO:K04386]
106926763  [KO:K04402]
106926769  [KO:K04402]
106926889  map3k5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
106927097  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
106927099  efna2; ephrin-A2 [KO:K05462]
106927114  [KO:K04430] [EC:2.7.12.2]
106927225  map3k10; mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
106927365  mapk8ip1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
106927524  [KO:K04456] [EC:2.7.11.1]
106927616  [KO:K04429] [EC:2.7.11.1]
106927626  angpt1; angiopoietin-1 [KO:K05465]
106927682  [KO:K04445] [EC:2.7.11.1]
106927873  [KO:K04362] [EC:2.7.10.1]
106927889  map3k13; mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
106927935  [KO:K04393]
106928125  [KO:K04358]
106928221  [KO:K04526]
106928254  [KO:K04392]
106928258  [KO:K04870]
106928404  ddit3; DNA damage-inducible transcript 3 protein [KO:K04452]
106928535  map3k12; mitogen-activated protein kinase kinase kinase 12 [KO:K04423] [EC:2.7.11.25]
106928887  jund; transcription factor jun-D [KO:K04449]
106929035  [KO:K04358]
106929057  [KO:K04381]
106929113  [KO:K04419] [EC:2.7.11.25]
106929268  [KO:K04852]
106929528  [KO:K05449]
106929540  egf; pro-epidermal growth factor isoform X1 [KO:K04357]
106929549  [KO:K04358]
106929556  [KO:K02582]
106929681  [KO:K05097] [EC:2.7.10.1]
106929685  dusp1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
106929762  [KO:K04439]
106929790  [KO:K04444] [EC:2.7.11.1]
106929905  [KO:K04373] [EC:2.7.11.1]
106929912  nf1; neurofibromin isoform X1 [KO:K08052]
106929918  nlk; serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
106930009  [KO:K04345] [EC:2.7.11.11]
106930036  vegfa; vascular endothelial growth factor A isoform X1 [KO:K05448]
106930125  [KO:K17534] [EC:2.7.11.25]
106930520  [KO:K08845] [EC:2.7.11.1]
106930528  [KO:K03173] [EC:2.3.2.27]
106930645  [KO:K04349]
106930677  met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
106930758  [KO:K04377]
106930773  [KO:K04424] [EC:2.7.11.25]
106930846  [KO:K04852]
106930936  [KO:K04347]
106931018  [KO:K04345] [EC:2.7.11.11]
106931037  [KO:K02187] [EC:3.4.22.56]
106931041  [KO:K19663] [EC:2.7.11.13]
106931042  [KO:K04872]
106931194  [KO:K07827]
106931279  [KO:K04433] [EC:2.7.12.2]
106931374  [KO:K04441] [EC:2.7.11.24]
106931548  [KO:K16510] [EC:2.7.11.1]
106931566  rasa2; ras GTPase-activating protein 2 [KO:K08053]
106931590  srf; serum response factor isoform X1 [KO:K04378]
106931610  [KO:K02583]
106931781  [KO:K04378]
106931957  [KO:K04411]
106931961  [KO:K05465]
106931992  [KO:K05084] [EC:2.7.10.1]
106932106  [KO:K04456] [EC:2.7.11.1]
106932221  [KO:K04348] [EC:3.1.3.16]
106932282  cacna1i; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
106932452  max; protein max isoform X1 [KO:K04453]
106932496  [KO:K08018]
106932534  dusp10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
106932652  [KO:K12326]
106932756  [KO:K25416]
106932887  [KO:K16859]
106932979  rasa1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
106933042  [KO:K04393]
106933173  [KO:K25415]
106933286  [KO:K04860]
106933433  gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
106933439  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
106933452  grb2; growth factor receptor-bound protein 2 [KO:K04364]
106933619  rasgrp2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
106933633  [KO:K04456] [EC:2.7.11.1]
106933678  ppm1a; protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
106933700  il1rap; interleukin-1 receptor accessory protein [KO:K04723]
106933735  [KO:K04358]
106933748  irak4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
106933928  mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
106933982  ngfr; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
106934110  mapk8ip3; C-Jun-amino-terminal kinase-interacting protein 3 [KO:K04436]
106934224  [KO:K04457] [EC:3.1.3.16]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
  Authors
Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
  Title
MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
pmei04070  Phosphatidylinositol signaling system
pmei04110  Cell cycle
pmei04115  p53 signaling pathway
pmei04210  Apoptosis
pmei04310  Wnt signaling pathway
KO pathway
ko04010   

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