KEGG   PATHWAY: pspa04371
Entry
pspa04371                   Pathway                                
Name
Apelin signaling pathway - Polyodon spathula (Mississippi paddlefish)
Description
Apelin is an endogenous peptide capable of binding the apelin receptor (APJ), which was originally described as an orphan G-protein-coupled receptor. Apelin and APJ are widely expressed in various tissues and organ systems. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, cell proliferation and energy metabolism regulation. On the other hand, this ligand receptor couple is also involved in several pathologies including diabetes, obesity, cardiovascular disease and cancer.
Class
Environmental Information Processing; Signal transduction
Pathway map
pspa04371  Apelin signaling pathway
pspa04371

Other DBs
GO: 0060183
Organism
Polyodon spathula (Mississippi paddlefish) [GN:pspa]
Gene
121313146  adenylate cyclase type 1-like [KO:K08041] [EC:4.6.1.1]
121314511  adenylate cyclase type 1-like isoform X1 [KO:K08041] [EC:4.6.1.1]
121314788  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
121309305  adenylate cyclase type 2-like [KO:K08042] [EC:4.6.1.1]
121316002  adcy3a; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
121305249  adenylate cyclase type 2-like [KO:K08044] [EC:4.6.1.1]
121307360  adenylate cyclase type 2-like isoform X1 [KO:K08044] [EC:4.6.1.1]
121322506  adenylate cyclase type 5-like isoform X1 [KO:K08045] [EC:4.6.1.1]
121322974  adenylate cyclase type 5-like [KO:K08045] [EC:4.6.1.1]
121309011  adcy6a; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
121296167  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
121325516  adenylate cyclase type 2-like isoform X1 [KO:K08047] [EC:4.6.1.1]
121309014  adcy8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
121300452  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
121330489  adenylate cyclase type 9-like isoform X1 [KO:K08049] [EC:4.6.1.1]
121321955  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
121326749  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121310175  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
121331016  cAMP-dependent protein kinase catalytic subunit beta-like isoform X1 [KO:K04345] [EC:2.7.11.11]
121299176  lipeb; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
121304208  hormone-sensitive lipase-like isoform X1 [KO:K07188] [EC:3.1.1.79]
121295791  apelin-like [KO:K05225]
121318822  apln; apelin [KO:K05225]
121295347  apelin receptor early endogenous ligand-like [KO:K25355]
121299886  apelin receptor early endogenous ligand-like [KO:K25355]
121296851  apelin receptor A-like [KO:K04174]
121299585  apelin receptor A-like [KO:K04174]
121302454  apelin receptor B-like [KO:K04174]
121297680  guanine nucleotide-binding protein G(i) subunit alpha-2-like [KO:K04630]
121299816  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
121299890  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
121329128  guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
121318357  guanine nucleotide-binding protein G(i) subunit alpha-1-like [KO:K04630]
121319742  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
121328534  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
121328840  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
121305576  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
121326288  gnb3a; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3a isoform X1 [KO:K07825]
121326732  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
121322888  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
121298779  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
121294306  guanine nucleotide-binding protein subunit beta-5-like [KO:K04539]
121330216  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
121324695  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
121306241  gng3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1 [KO:K04540]
121316076  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4-like [KO:K04541]
121317202  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
121326923  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
121331046  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
121309181  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10-like [KO:K04542]
121300716  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
121301457  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
121303899  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8-like [KO:K04544]
121304981  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8-like [KO:K04544]
121303318  gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
121326893  gng12b; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
121304535  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
121300794  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13-like [KO:K04547]
121331014  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13-like isoform X1 [KO:K04547]
121308733  gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
121324940  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2-like [KO:K04549]
121318840  guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [KO:K04634]
121315927  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like [KO:K05858] [EC:3.1.4.11]
121315930  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like isoform X1 [KO:K05858] [EC:3.1.4.11]
121317052  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4-like isoform X1 [KO:K05858] [EC:3.1.4.11]
121310099  plcb3; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
121317660  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1-like [KO:K05858] [EC:3.1.4.11]
121329668  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2-like [KO:K05858] [EC:3.1.4.11]
121323975  plcb2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
121298161  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121328701  inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121318388  inositol 1,4,5-trisphosphate receptor type 2-like [KO:K04959]
121319707  inositol 1,4,5-trisphosphate receptor type 2-like isoform X1 [KO:K04959]
121299669  inositol 1,4,5-trisphosphate receptor type 3-like isoform X1 [KO:K04960]
121304724  inositol 1,4,5-trisphosphate receptor type 3-like isoform X1 [KO:K04960]
121303771  ryanodine receptor 1-like [KO:K04961]
121304837  ryanodine receptor 1-like [KO:K04961]
121315498  ryanodine receptor 2-like [KO:K04962]
121316738  ryanodine receptor 2 isoform X1 [KO:K04962]
121329961  ryanodine receptor 3-like isoform X1 [KO:K04963]
121324952  ryr3; ryanodine receptor 3 isoform X1 [KO:K04963]
121294605  calmodulin-like protein 4 [KO:K02183]
121298942  calml4a; calmodulin-like protein 4a [KO:K02183]
121316330  calmodulin-1 [KO:K02183]
121316692  calmodulin-1 [KO:K02183]
121303849  calm3a; calmodulin 3a (phosphorylase kinase, delta) [KO:K02183]
121329906  calmodulin-1 [KO:K02183]
121323988  calmodulin-1 [KO:K02183]
121304911  calmodulin-1 [KO:K02183]
121296840  nitric oxide synthase, brain-like [KO:K13240] [EC:1.14.13.39]
121299518  nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
121308730  nos2b; nitric oxide synthase 2b, inducible [KO:K13241] [EC:1.14.13.39]
121314660  nitric oxide synthase, endothelial-like [KO:K13242] [EC:1.14.13.39]
121312985  nitric oxide synthase, endothelial-like [KO:K13242] [EC:1.14.13.39]
121316343  protein kinase C epsilon type-like [KO:K18050] [EC:2.7.11.13]
121316681  protein kinase C epsilon type isoform X1 [KO:K18050] [EC:2.7.11.13]
121308281  sodium/hydrogen exchanger 1-like [KO:K05742]
121315787  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
121316889  sodium/calcium exchanger 1-like isoform X1 [KO:K05849]
121310101  slc8a4a; solute carrier family 8 member 4a [KO:K05849]
121303720  sodium/calcium exchanger 2-like [KO:K05849]
121324512  slc8a3; sodium/calcium exchanger 3 [KO:K05849]
121296189  myosin light chain kinase 3-like isoform X1 [KO:K00907] [EC:2.7.11.18]
121297790  myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
121326024  myosin light chain kinase 3-like isoform X1 [KO:K00907] [EC:2.7.11.18]
121301925  mylk5; LOW QUALITY PROTEIN: myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
121322302  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
121323021  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
121313105  myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
121319393  myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
121313945  myosin light chain kinase 2, skeletal/cardiac muscle-like [KO:K00907] [EC:2.7.11.18]
121296803  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
121300097  myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
121303501  myosin light chain 4-like [KO:K12750]
121303508  myosin light chain 4-like [KO:K12750]
121303606  myosin light chain 4-like [KO:K12750]
121303608  myosin light chain 4-like [KO:K12750]
121313371  myosin light chain 1, cardiac muscle-like [KO:K12750]
121325036  myl4; myosin light chain 4 [KO:K12750]
121294911  GTPase HRas [KO:K02833]
121330312  hrasb; HRas proto-oncogene, GTPase b [KO:K02833]
121318385  GTPase KRas isoform X1 [KO:K07827]
121319713  GTPase KRas isoform X1 [KO:K07827]
121300074  GTPase NRas [KO:K07828]
121300091  GTPase NRas [KO:K07828]
121294598  ras-related protein R-Ras2 isoform X1 [KO:K07830]
121329965  ras-related protein R-Ras2 isoform X1 [KO:K07830]
121322484  ras-related protein M-Ras [KO:K07831]
121322602  ras-related protein M-Ras-like isoform X1 [KO:K07831]
121297980  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
121328554  RAF proto-oncogene serine/threonine-protein kinase-like isoform X1 [KO:K04366] [EC:2.7.11.1]
121294557  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
121298929  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121304127  dual specificity mitogen-activated protein kinase kinase 1-like [KO:K04368] [EC:2.7.12.2]
121300828  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
121301294  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
121297147  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
121306857  mapk3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
121307738  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121305215  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
121308414  rps6kb1a; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
121302105  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
121296526  40S ribosomal protein S6 [KO:K02991]
121321685  40S ribosomal protein S6 [KO:K02991]
121298081  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform-like [KO:K21289] [EC:2.7.1.153]
121319794  pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
121295189  phosphoinositide 3-kinase regulatory subunit 6-like isoform X1 [KO:K21290]
121295616  phosphoinositide 3-kinase regulatory subunit 5-like [KO:K21290]
121296261  phosphoinositide 3-kinase regulatory subunit 6-like [KO:K21290]
121296662  phosphoinositide 3-kinase regulatory subunit 5-like [KO:K21290]
121316056  RAC-gamma serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
121317179  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121303838  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121324176  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121330210  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
121304828  RAC-beta serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
121328756  serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
121328834  serine/threonine-protein kinase mTOR-like isoform X1 [KO:K07203] [EC:2.7.11.1]
121297198  early growth response protein 1-like [KO:K09203]
121324492  early growth response protein 1-like [KO:K09203]
121316096  protein jagged-1b-like [KO:K06052]
121317222  protein jagged-1b-like isoform X1 [KO:K06052]
121303822  protein jagged-1 [KO:K06052]
121304885  protein jagged-1-like [KO:K06052]
121304545  notch3; neurogenic locus notch homolog protein 3 [KO:K20995]
121295125  G1/S-specific cyclin-D1 [KO:K04503]
121329999  G1/S-specific cyclin-D1-like [KO:K04503]
121305898  ccndx; cyclin Dx [KO:K04503]
121294654  cGMP-inhibited 3',5'-cyclic phosphodiesterase B-like isoform X1 [KO:K13296] [EC:3.1.4.17]
121329848  cGMP-inhibited 3',5'-cyclic phosphodiesterase B-like [KO:K13296] [EC:3.1.4.17]
121294688  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
121313006  pik3r4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
121301920  becn1; beclin-1 [KO:K08334]
121296354  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
121297854  microtubule-associated proteins 1A/1B light chain 3A-like [KO:K10435]
121325938  microtubule-associated proteins 1A/1B light chain 3B isoform X1 [KO:K10435]
121315306  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
121316557  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
121319430  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
121299544  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
121326929  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
121318564  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
121331275  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
121297106  5'-AMP-activated protein kinase subunit beta-1-like [KO:K07199]
121299815  5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
121327017  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
121330680  5'-AMP-activated protein kinase subunit beta-2-like [KO:K07199]
121321492  5'-AMP-activated protein kinase subunit gamma-3-like [KO:K07200]
121308970  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
121310040  5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
121314051  5'-AMP-activated protein kinase subunit gamma-2-like isoform X1 [KO:K07200]
121294779  perilipin-1-like isoform X1 [KO:K08768]
121299112  perilipin-1-like isoform X1 [KO:K08768]
121329761  peroxisome proliferator-activated receptor gamma coactivator 1-alpha-like isoform X1 [KO:K07202]
121324292  peroxisome proliferator-activated receptor gamma coactivator 1-alpha-like isoform X1 [KO:K07202]
121318159  nuclear respiratory factor 1 isoform X1 [KO:K11831]
121319947  nuclear respiratory factor 1-like isoform X1 [KO:K11831]
121325960  transcription factor A, mitochondrial-like [KO:K11830]
121322187  transcription factor A, mitochondrial-like [KO:K11830]
121301565  Krueppel-like factor 2 [KO:K17845]
121309262  Krueppel-like factor 2 [KO:K17845]
121309266  Krueppel-like factor 2 [KO:K17845]
121296560  sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
121302056  sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
121295594  guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
121296219  guanine nucleotide-binding protein subunit alpha-13-like [KO:K04639]
121300614  calcium/calmodulin-dependent protein kinase type IV-like isoform X1 [KO:K05869] [EC:2.7.11.17]
121315921  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
121301879  calcium/calmodulin-dependent protein kinase type IV-like [KO:K05869] [EC:2.7.11.17]
121301940  hdac5; histone deacetylase 5 isoform X1 [KO:K11406] [EC:3.5.1.98]
121322045  histone deacetylase 4-like isoform X1 [KO:K11406] [EC:3.5.1.98]
121322676  histone deacetylase 4-like isoform X1 [KO:K11406] [EC:3.5.1.98]
121324493  histone deacetylase 5-like isoform X1 [KO:K11406] [EC:3.5.1.98]
121294709  myocyte-specific enhancer factor 2A-like isoform X1 [KO:K09260]
121299151  myocyte-specific enhancer factor 2A-like isoform X1 [KO:K09260]
121306959  myocyte-specific enhancer factor 2D homolog [KO:K09260]
121300972  myocyte-specific enhancer factor 2B-like isoform X1 [KO:K09261]
121312949  myocyte-specific enhancer factor 2C-like isoform X1 [KO:K04454]
121306116  myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
121309854  mef2d; myocyte-specific enhancer factor 2D [KO:K09262]
121314569  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
121313088  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
121303852  mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
121314339  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
121294921  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
121299241  mothers against decapentaplegic homolog 3 isoform X1 [KO:K23605]
121317857  mothers against decapentaplegic homolog 4-like isoform X1 [KO:K04501]
121304289  mothers against decapentaplegic homolog 4 isoform X1 [KO:K04501]
121321858  actin, aortic smooth muscle [KO:K12313]
121325276  actin, aortic smooth muscle-like [KO:K12313]
121296306  B-cadherin-like isoform X1 [KO:K05689]
121325617  B-cadherin-like [KO:K05689]
121315818  CCN family member 2-like [KO:K06827]
121308310  ccn2b; CCN family member 2b [KO:K06827]
121316931  ccn2a; CCN family member 2a [KO:K06827]
121326489  type-1 angiotensin II receptor-like [KO:K04166]
121323531  type-1 angiotensin II receptor-like [KO:K04166]
121306552  plasminogen activator inhibitor 1-like isoform X1 [KO:K03982]
121305739  serpine1; plasminogen activator inhibitor 1 isoform X1 [KO:K03982]
121302467  tissue-type plasminogen activator-like isoform X1 [KO:K01343] [EC:3.4.21.68]
121303169  tissue-type plasminogen activator-like [KO:K01343] [EC:3.4.21.68]
Compound
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00290  Fibrin
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
Reference
PMID:26143239
  Authors
Yang P, Maguire JJ, Davenport AP
  Title
Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system.
  Journal
Trends Pharmacol Sci 36:560-7 (2015)
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Reference
PMID:22140623
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Andersen CU, Hilberg O, Mellemkjaer S, Nielsen-Kudsk JE, Simonsen U
  Title
Apelin and pulmonary hypertension.
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Pulm Circ 1:334-46 (2011)
DOI:10.4103/2045-8932.87299
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PMID:25275559
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Chapman NA, Dupre DJ, Rainey JK
  Title
The apelin receptor: physiology, pathology, cell signalling, and ligand modulation of a peptide-activated class A GPCR.
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Biochem Cell Biol 92:431-40 (2014)
DOI:10.1139/bcb-2014-0072
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PMID:18272138
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Japp AG, Newby DE
  Title
The apelin-APJ system in heart failure: pathophysiologic relevance and therapeutic potential.
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Biochem Pharmacol 75:1882-92 (2008)
DOI:10.1016/j.bcp.2007.12.015
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PMID:25652330
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Folino A, Montarolo PG, Samaja M, Rastaldo R
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Effects of apelin on the cardiovascular system.
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Heart Fail Rev 20:505-18 (2015)
DOI:10.1007/s10741-015-9475-x
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PMID:23943882
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O'Carroll AM, Lolait SJ, Harris LE, Pope GR
  Title
The apelin receptor APJ: journey from an orphan to a multifaceted regulator of homeostasis.
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J Endocrinol 219:R13-35 (2013)
DOI:10.1530/JOE-13-0227
Reference
PMID:23973488
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Liu QF, Yu HW, You L, Liu MX, Li KY, Tao GZ
  Title
Apelin-13-induced proliferation and migration induced of rat vascular smooth muscle cells is mediated by the upregulation of Egr-1.
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Biochem Biophys Res Commun 439:235-40 (2013)
DOI:10.1016/j.bbrc.2013.08.051
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PMID:26254105
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Novakova V, Sandhu GS, Dragomir-Daescu D, Klabusay M
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Apelinergic system in endothelial cells and its role in angiogenesis in myocardial ischemia.
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Vascul Pharmacol 76:1-10 (2016)
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PMID:21725702
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Castan-Laurell I, Dray C, Attane C, Duparc T, Knauf C, Valet P
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Apelin, diabetes, and obesity.
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Endocrine 40:1-9 (2011)
DOI:10.1007/s12020-011-9507-9
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PMID:23924696
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Li L, Li L, Xie F, Zhang Z, Guo Y, Tang G, Lv D, Lu Q, Chen L, Li J
  Title
Jagged-1/Notch3 signaling transduction pathway is involved in apelin-13-induced vascular smooth muscle cells proliferation.
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Acta Biochim Biophys Sin (Shanghai) 45:875-81 (2013)
DOI:10.1093/abbs/gmt085
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PMID:24990699
  Authors
Wu D, He L, Chen L
  Title
Apelin/APJ system: a promising therapy target for hypertension.
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Mol Biol Rep 41:6691-703 (2014)
DOI:10.1007/s11033-014-3552-4
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PMID:20539939
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Liu C, Su T, Li F, Li L, Qin X, Pan W, Feng F, Chen F, Liao D, Chen L
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PI3K/Akt signaling transduction pathway is involved in rat vascular smooth muscle cell proliferation induced by apelin-13.
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Acta Biochim Biophys Sin (Shanghai) 42:396-402 (2010)
DOI:10.1093/abbs/gmq035
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PMID:26607438
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Xie F, Liu W, Feng F, Li X, He L, Lv D, Qin X, Li L, Li L, Chen L
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Apelin-13 promotes cardiomyocyte hypertrophy via PI3K-Akt-ERK1/2-p70S6K and PI3K-induced autophagy.
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Acta Biochim Biophys Sin (Shanghai) 47:969-80 (2015)
DOI:10.1093/abbs/gmv111
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PMID:27979574
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Lu L, Wu D, Li L, Chen L
  Title
Apelin/APJ system: A bifunctional target for cardiac hypertrophy.
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Int J Cardiol 230:164-170 (2017)
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PMID:16182514
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Carmen GY, Victor SM
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Signalling mechanisms regulating lipolysis.
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Cell Signal 18:401-8 (2006)
DOI:10.1016/j.cellsig.2005.08.009
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PMID:27650065
  Authors
Hu H, He L, Li L, Chen L
  Title
Apelin/APJ system as a therapeutic target in diabetes and its complications.
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Mol Genet Metab 119:20-7 (2016)
DOI:10.1016/j.ymgme.2016.07.012
Reference
PMID:25914650
  Authors
Bertrand C, Valet P, Castan-Laurell I
  Title
Apelin and energy metabolism.
  Journal
Front Physiol 6:115 (2015)
DOI:10.3389/fphys.2015.00115
Reference
PMID:26385179
  Authors
Yao F, Lv YC, Zhang M, Xie W, Tan YL, Gong D, Cheng HP, Liu D, Li L, Liu XY, Zheng XL, Tang CK
  Title
Apelin-13 impedes foam cell formation by activating Class III PI3K/Beclin-1-mediated autophagic pathway.
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Biochem Biophys Res Commun 466:637-43 (2015)
DOI:10.1016/j.bbrc.2015.09.045
Reference
PMID:22842084
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Than A, Cheng Y, Foh LC, Leow MK, Lim SC, Chuah YJ, Kang Y, Chen P
  Title
Apelin inhibits adipogenesis and lipolysis through distinct molecular pathways.
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Mol Cell Endocrinol 362:227-41 (2012)
DOI:10.1016/j.mce.2012.07.002
Reference
PMID:24055369
  Authors
Yu XH, Tang ZB, Liu LJ, Qian H, Tang SL, Zhang DW, Tian GP, Tang CK
  Title
Apelin and its receptor APJ in cardiovascular diseases.
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Clin Chim Acta 428:1-8 (2014)
DOI:10.1016/j.cca.2013.09.001
Reference
PMID:25931124
  Authors
Than A, He HL, Chua SH, Xu D, Sun L, Leow MK, Chen P
  Title
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes.
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J Biol Chem 290:14679-91 (2015)
DOI:10.1074/jbc.M115.643817
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PMID:25139773
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Fu J, Li Z, Zhang H, Mao Y, Wang A, Wang X, Zou Z, Zhang X
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Molecular pathways regulating the formation of brown-like adipocytes in white adipose tissue.
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Diabetes Metab Res Rev 31:433-52 (2015)
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Aharoni-Simon M, Hann-Obercyger M, Pen S, Madar Z, Tirosh O
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Fatty liver is associated with impaired activity of PPARgamma-coactivator 1alpha (PGC1alpha) and mitochondrial biogenesis in mice.
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Lab Invest 91:1018-28 (2011)
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PMID:22995518
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McLean DL, Kim J, Kang Y, Shi H, Atkins GB, Jain MK, Chun HJ
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Apelin/APJ signaling is a critical regulator of statin effects in vascular endothelial cells--brief report.
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Arterioscler Thromb Vasc Biol 32:2640-3 (2012)
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Apelin prevents cardiac fibroblast activation and collagen production through inhibition of sphingosine kinase 1.
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Eur Heart J 33:2360-9 (2012)
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PMID:26944568
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Huang S, Chen L, Lu L, Li L
  Title
The apelin-APJ axis: A novel potential therapeutic target for organ fibrosis.
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Clin Chim Acta 456:81-8 (2016)
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PMID:19093215
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Liu G, Han J, Profirovic J, Strekalova E, Voyno-Yasenetskaya TA
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Galpha13 regulates MEF2-dependent gene transcription in endothelial cells: role in angiogenesis.
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Angiogenesis 12:1-15 (2009)
DOI:10.1007/s10456-008-9123-3
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PMID:23603510
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Kang Y, Kim J, Anderson JP, Wu J, Gleim SR, Kundu RK, McLean DL, Kim JD, Park H, Jin SW, Hwa J, Quertermous T, Chun HJ
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Apelin-APJ signaling is a critical regulator of endothelial MEF2 activation in cardiovascular development.
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Circ Res 113:22-31 (2013)
DOI:10.1161/CIRCRESAHA.113.301324
Reference
PMID:25164121
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Wang LY, Diao ZL, Zhang DL, Zheng JF, Zhang QD, Ding JX, Liu WH
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The regulatory peptide apelin: a novel inhibitor of renal interstitial fibrosis.
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Amino Acids 46:2693-704 (2014)
DOI:10.1007/s00726-014-1826-8
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PMID:26756969
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Zhou Y, Deng L, Zhao D, Chen L, Yao Z, Guo X, Liu X, Lv L, Leng B, Xu W, Qiao G, Shan H
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MicroRNA-503 promotes angiotensin II-induced cardiac fibrosis by targeting Apelin-13.
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J Cell Mol Med 20:495-505 (2016)
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PMID:27825851
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Zhong JC, Zhang ZZ, Wang W, McKinnie SM, Vederas JC, Oudit GY
  Title
Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.
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Biochim Biophys Acta 1863:1942-1950 (2017)
DOI:10.1016/j.bbadis.2016.11.007
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