KEGG   PATHWAY: ptg00230
Entry
ptg00230                    Pathway                                
Name
Purine metabolism - Panthera tigris altaica (Amur tiger)
Class
Metabolism; Nucleotide metabolism
Pathway map
ptg00230  Purine metabolism
ptg00230

Module
ptg_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:ptg00230]
ptg_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:ptg00230]
ptg_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:ptg00230]
ptg_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:ptg00230]
ptg_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:ptg00230]
ptg_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:ptg00230]
ptg_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:ptg00230]
Other DBs
GO: 0006163 0042278
Organism
Panthera tigris altaica (Amur tiger) [GN:ptg]
Gene
102953462  NUDT9; nudix hydrolase 9 [KO:K13988] [EC:3.6.1.13]
102965979  ADPRM; ADP-ribose/CDP-alcohol diphosphatase, manganese dependent [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
102950979  NUDT5; nudix hydrolase 5 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
102961330  PGM1; phosphoglucomutase 1 [KO:K01835] [EC:5.4.2.2]
102948905  PGM2; phosphoglucomutase 2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
102968006  PRPS2; phosphoribosyl pyrophosphate synthetase 2 [KO:K00948] [EC:2.7.6.1]
102956585  PRPS1; phosphoribosyl pyrophosphate synthetase 1 [KO:K00948] [EC:2.7.6.1]
102973046  PRPS1L1; phosphoribosyl pyrophosphate synthetase 1-like 1 [KO:K00948] [EC:2.7.6.1]
102951730  PPAT; phosphoribosyl pyrophosphate amidotransferase [KO:K00764] [EC:2.4.2.14]
102956979  GART; phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
102956385  PFAS; phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
102951236  PAICS; phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01587] [EC:4.1.1.21 6.3.2.6]
102952342  ADSL; adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
102969961  ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
102973018  APRT; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
102962499  NT5C1A; 5'-nucleotidase, cytosolic IA [KO:K01081] [EC:3.1.3.5]
102967301  NT5C2; 5'-nucleotidase, cytosolic II [KO:K01081] [EC:3.1.3.5]
102958732  NT5C1B; 5'-nucleotidase, cytosolic IB [KO:K01081] [EC:3.1.3.5]
102962085  NT5C; 5', 3'-nucleotidase, cytosolic [KO:K01081] [EC:3.1.3.5]
102950034  NT5M; 5',3'-nucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
102966455  NT5DC4; 5'-nucleotidase domain containing 4 [KO:K01081] [EC:3.1.3.5]
102965661  NT5E; 5'-nucleotidase ecto [KO:K19970] [EC:3.1.3.5]
102955936  PNP; purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
102955912  LACC1; laccase domain containing 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
102954897  HPRT1; hypoxanthine phosphoribosyltransferase 1 [KO:K00760] [EC:2.4.2.8]
102967384  IMPDH1; inosine monophosphate dehydrogenase 1 [KO:K00088] [EC:1.1.1.205]
102970926  IMPDH2; inosine monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
102963448  NME7; NME/NM23 family member 7 [KO:K00940] [EC:2.7.4.6]
102970480  NME4; NME/NM23 nucleoside diphosphate kinase 4 [KO:K00940] [EC:2.7.4.6]
102962166  NME6; NME/NM23 nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
102967905  NME2; NME/NM23 nucleoside diphosphate kinase 2 [KO:K00940] [EC:2.7.4.6]
102960899  AK9; adenylate kinase 9 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
102960243  ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510] [EC:3.6.1.5]
102962344  ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
102953346  ENTPD8; ectonucleoside triphosphate diphosphohydrolase 8 [KO:K01510] [EC:3.6.1.5]
102968784  CANT1; calcium activated nucleotidase 1 [KO:K12304] [EC:3.6.1.6]
102952970  ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305] [EC:3.6.1.6]
102958703  ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
102966424  ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 (putative) [KO:K01511] [EC:3.6.1.6]
102951403  NUDT16; nudix hydrolase 16 [KO:K16855] [EC:3.6.1.62 3.6.1.64]
102959510  ITPA; inosine triphosphatase [KO:K01519] [EC:3.6.1.66]
102969928  xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
102968333  NUDT2; nudix hydrolase 2 [KO:K01518] [EC:3.6.1.17]
102954094  GMPS; guanine monophosphate synthase [KO:K01951] [EC:6.3.5.2]
102960708  GMPR2; guanosine monophosphate reductase 2 [KO:K00364] [EC:1.7.1.7]
102953436  GMPR; guanosine monophosphate reductase [KO:K00364] [EC:1.7.1.7]
102948799  GDA; guanine deaminase [KO:K01487] [EC:3.5.4.3]
102949751  GUK1; guanylate kinase 1 [KO:K00942] [EC:2.7.4.8]
102953329  RRM1; ribonucleotide reductase catalytic subunit M1 [KO:K10807] [EC:1.17.4.1]
102950840  RRM2B; ribonucleotide reductase regulatory TP53 inducible subunit M2B [KO:K10808] [EC:1.17.4.1]
102950263  RRM2; ribonucleotide reductase regulatory subunit M2 [KO:K10808] [EC:1.17.4.1]
102963354  HDDC2; HD domain containing 2 [KO:K07023] [EC:3.1.3.89]
102959296  DGUOK; deoxyguanosine kinase [KO:K00904] [EC:2.7.1.113]
102949132  DCK; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
102960029  HDDC3; HD domain containing 3 [KO:K21138] [EC:3.1.7.2]
102972492  PRUNE1; prune exopolyphosphatase [KO:K01514] [EC:3.6.1.11]
102961712  ADCY1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
102949732  ADCY2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
102965866  ADCY4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
102969833  ADCY5; adenylate cyclase 5 [KO:K08045] [EC:4.6.1.1]
102949044  ADCY6; adenylate cyclase 6 [KO:K08046] [EC:4.6.1.1]
102972917  ADCY7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
102948581  ADCY8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
102969003  ADCY9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
102960312  ADCY10; adenylate cyclase 10, soluble [KO:K11265] [EC:4.6.1.1]
102963294  adenylate cyclase type 10-like [KO:K11265] [EC:4.6.1.1]
102969669  GUCY1A3; guanylate cyclase 1 soluble subunit alpha [KO:K12318] [EC:4.6.1.2]
102956040  GUCY1A2; guanylate cyclase 1 soluble subunit alpha 2 [KO:K12318] [EC:4.6.1.2]
102963951  GUCY1B3; guanylate cyclase 1 soluble subunit beta [KO:K12319] [EC:4.6.1.2]
102970885  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
102963095  GUCY2C; guanylate cyclase 2C [KO:K12320] [EC:4.6.1.2]
102960287  GUCY2D; guanylate cyclase 2D, retinal [KO:K12321] [EC:4.6.1.2]
102971963  olfactory guanylyl cyclase GC-D-like [KO:K12321] [EC:4.6.1.2]
102949926  GUCY2F; guanylate cyclase 2F, retinal [KO:K12322] [EC:4.6.1.2]
102972759  guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
102949070  NPR2; natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
102969061  PDE1B; phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
102951670  PDE1A; phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
102968598  PDE1C; phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
102955891  PDE2A; phosphodiesterase 2A [KO:K18283] [EC:3.1.4.17]
102969601  PDE3A; phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
102966458  PDE3B; phosphodiesterase 3B [KO:K13296] [EC:3.1.4.17]
102960740  PDE5A; phosphodiesterase 5A [KO:K13762] [EC:3.1.4.35]
102951616  PDE6A; phosphodiesterase 6A [KO:K08718] [EC:3.1.4.35]
102957730  PDE6B; phosphodiesterase 6B [KO:K13756] [EC:3.1.4.35]
102948622  PDE6C; phosphodiesterase 6C [KO:K13757] [EC:3.1.4.35]
102953985  PDE6D; phosphodiesterase 6D [KO:K13758]
102972778  PDE6G; phosphodiesterase 6G [KO:K13759]
102962054  PDE6H; phosphodiesterase 6H [KO:K13760]
102965326  PDE9A; phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
102966722  PDE10A; phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
102961308  PDE11A; phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
102970003  ADSS; adenylosuccinate synthase [KO:K01939] [EC:6.3.4.4]
102968035  ADSSL1; adenylosuccinate synthase like 1 [KO:K01939] [EC:6.3.4.4]
102957680  AMPD3; adenosine monophosphate deaminase 3 [KO:K01490] [EC:3.5.4.6]
102953479  AMPD1; adenosine monophosphate deaminase 1 [KO:K01490] [EC:3.5.4.6]
102949961  AMPD2; adenosine monophosphate deaminase 2 [KO:K01490] [EC:3.5.4.6]
102955082  ADK; adenosine kinase [KO:K00856] [EC:2.7.1.20]
102961564  ADA; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
102954688  CECR1; cat eye syndrome chromosome region, candidate 1 [KO:K19572] [EC:3.5.4.4]
102970088  uncharacterized LOC102970088 [KO:K00939] [EC:2.7.4.3]
102959477  AK5; adenylate kinase 5 [KO:K00939] [EC:2.7.4.3]
102964600  AK8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
102948477  AK2; adenylate kinase 2 [KO:K00939] [EC:2.7.4.3]
102965844  AK1; adenylate kinase 1 [KO:K00939] [EC:2.7.4.3]
102971365  AK7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
102953814  AK4; adenylate kinase 4 [KO:K00939] [EC:2.7.4.3]
102950161  AK6; adenylate kinase 6 [KO:K18532] [EC:2.7.4.3]
102951330  AK3; adenylate kinase 3 [KO:K00944] [EC:2.7.4.10]
102962601  ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
107180370  NTPCR; nucleoside-triphosphatase, cancer-related [KO:K06928] [EC:3.6.1.15]
102949274  ENPP1; ectonucleotide pyrophosphatase/phosphodiesterase 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
102951057  ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
102964227  PDE4D; phosphodiesterase 4D [KO:K13293] [EC:3.1.4.53]
102952909  PDE4A; phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
102957916  PDE4B; phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
102958950  PDE4C; phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
107180324  cAMP-specific 3',5'-cyclic phosphodiesterase 4B-like [KO:K13293] [EC:3.1.4.53]
102964441  PDE7A; phosphodiesterase 7A [KO:K18436] [EC:3.1.4.53]
102960891  PDE7B; phosphodiesterase 7B [KO:K18436] [EC:3.1.4.53]
102964515  PDE8B; phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
102953863  PDE8A; phosphodiesterase 8A [KO:K18437] [EC:3.1.4.53]
102968381  FHIT; fragile histidine triad [KO:K01522] [EC:3.6.1.29]
102971993  ENPP4; ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) [KO:K18424] [EC:3.6.1.29]
102957567  PAPSS2; 3'-phosphoadenosine 5'-phosphosulfate synthase 2 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
102972837  PAPSS1; 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
102971100  uricase [KO:K00365] [EC:1.7.3.3]
102970353  5-hydroxyisourate hydrolase-like [KO:K07127] [EC:3.5.2.17]
102967487  ALLC; allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
ptg00030  Pentose phosphate pathway
ptg00220  Arginine biosynthesis
ptg00250  Alanine, aspartate and glutamate metabolism
ptg00260  Glycine, serine and threonine metabolism
ptg00340  Histidine metabolism
ptg00630  Glyoxylate and dicarboxylate metabolism
ptg00730  Thiamine metabolism
ptg00740  Riboflavin metabolism
ptg00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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