PATHWAY: pvir00020 Help
Entry
Name
Citrate cycle (TCA cycle) - Panicum virgatum (switchgrass)
Description
The citrate cycle (TCA cycle, Krebs cycle) is an important aerobic pathway for the final steps of the oxidation of carbohydrates and fatty acids. The cycle starts with acetyl-CoA, the activated form of acetate, derived from glycolysis and pyruvate oxidation for carbohydrates and from beta oxidation of fatty acids. The two-carbon acetyl group in acetyl-CoA is transferred to the four-carbon compound of oxaloacetate to form the six-carbon compound of citrate. In a series of reactions two carbons in citrate are oxidized to CO2 and the reaction pathway supplies NADH for use in the oxidative phosphorylation and other metabolic processes. The pathway also supplies important precursor metabolites including 2-oxoglutarate. At the end of the cycle the remaining four-carbon part is transformed back to oxaloacetate. According to the genome sequence data, many organisms seem to lack genes for the full cycle [MD:
M00009 ], but contain genes for specific segments [MD:
M00010 M00011 ].
Class
Metabolism; Carbohydrate metabolism
BRITE hierarchy
Pathway map
Ortholog table
Module
Other DBs
Organism
Panicum virgatum (switchgrass) [GN:
pvir ]
Gene
120682094 isocitrate dehydrogenase [NAD] regulatory subunit 1, mitochondrial-like isoform X1 [KO:K00030 ] [EC:1.1.1.41 ]
120640774 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like isoform X1 [KO:K00658 ] [EC:2.3.1.61 ]
120682221 dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 1, mitochondrial-like isoform X1 [KO:K00658 ] [EC:2.3.1.61 ]
120689915 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234 ] [EC:1.3.5.1 ]
120648482 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234 ] [EC:1.3.5.1 ]
120678670 succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234 ] [EC:1.3.5.1 ]
120658839 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial-like [KO:K00235 ] [EC:1.3.5.1 ]
120677575 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial-like isoform X1 [KO:K00235 ] [EC:1.3.5.1 ]
120711244 succinate dehydrogenase [ubiquinone] iron-sulfur subunit 1, mitochondrial isoform X1 [KO:K00235 ] [EC:1.3.5.1 ]
120639704 succinate dehydrogenase subunit 3-1, mitochondrial-like [KO:K00236 ]
120639884 succinate dehydrogenase subunit 3-1, mitochondrial-like [KO:K00236 ]
120711384 succinate dehydrogenase subunit 3-1, mitochondrial-like [KO:K00236 ]
120681998 succinate dehydrogenase subunit 3-1, mitochondrial-like [KO:K00236 ]
120682011 succinate dehydrogenase subunit 3-1, mitochondrial-like [KO:K00236 ]
120654544 succinate dehydrogenase subunit 3-1, mitochondrial-like [KO:K00236 ]
120665701 succinate dehydrogenase subunit 4, mitochondrial-like [KO:K25801 ]
120698912 succinate dehydrogenase subunit 4, mitochondrial-like [KO:K25801 ]
120709191 succinate dehydrogenase subunit 4, mitochondrial-like [KO:K25801 ]
120700153 pyruvate dehydrogenase E1 component subunit beta-3, chloroplastic-like isoform X1 [KO:K00162 ] [EC:1.2.4.1 ]
120660624 dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic-like isoform X1 [KO:K00627 ] [EC:2.3.1.12 ]
120690884 dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
120677768 dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627 ] [EC:2.3.1.12 ]
120649378 dihydrolipoyllysine-residue acetyltransferase component 1 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
120663749 dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627 ] [EC:2.3.1.12 ]
120679143 dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627 ] [EC:2.3.1.12 ]
120696875 dihydrolipoyllysine-residue acetyltransferase component 5 of pyruvate dehydrogenase complex, chloroplastic-like isoform X1 [KO:K00627 ] [EC:2.3.1.12 ]
120666495 dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
120712422 dihydrolipoyllysine-residue acetyltransferase component 4 of pyruvate dehydrogenase complex, chloroplastic-like [KO:K00627 ] [EC:2.3.1.12 ]
120654370 dihydrolipoyllysine-residue acetyltransferase component 3 of pyruvate dehydrogenase complex, mitochondrial-like [KO:K00627 ] [EC:2.3.1.12 ]
Compound
C05125 2-(alpha-Hydroxyethyl)thiamine diphosphate
C05381 3-Carboxy-1-hydroxypropyl-ThPP
C15972 Enzyme N6-(lipoyl)lysine
C15973 Enzyme N6-(dihydrolipoyl)lysine
C16254 [Dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine
C16255 [Dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine
Reference
Authors
Nishizuka Y (ed).
Title
[Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1980)
Reference
Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
Title
[Cellular Functions and Metabolic Maps] (In Japanese)
Journal
Tokyo Kagaku Dojin (1997)
Reference
Authors
Michal G.
Title
Biochemical Pathways
Journal
Wiley (1999)
Related pathway
pvir00250 Alanine, aspartate and glutamate metabolism
pvir00280 Valine, leucine and isoleucine degradation
pvir00630 Glyoxylate and dicarboxylate metabolism
KO pathway
LinkDB
All DBs