KEGG   PATHWAY: pviv05146
Entry
pviv05146                   Pathway                                
Name
Amoebiasis - Prionailurus viverrinus (fishing cat)
Description
Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response.
Class
Human Diseases; Infectious disease: parasitic
Pathway map
pviv05146  Amoebiasis
pviv05146

Organism
Prionailurus viverrinus (fishing cat) [GN:pviv]
Gene
125162335  IL1B; interleukin-1 beta [KO:K04519]
125162886  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
125161499  IL1R2; interleukin-1 receptor type 2 isoform X1 [KO:K04387]
125163593  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125176511  RELA; transcription factor p65 [KO:K04735]
125154336  HSPB1; heat shock protein beta-1 [KO:K04455]
125146621  MUC2; mucin-2 [KO:K10955]
125158627  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
125161150  COL1A2; collagen alpha-2(I) chain [KO:K06236]
125162119  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
125162130  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
125157295  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
125157548  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
125173315  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
125173316  COL4A3; collagen alpha-3(IV) chain isoform X1 [KO:K06237]
125172662  FN1; fibronectin isoform X1 [KO:K05717]
125165961  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
125148766  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
125161630  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
125148702  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
125166189  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
125151448  LAMB1; laminin subunit beta-1 [KO:K05636]
125148915  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
125155428  LAMB3; laminin subunit beta-3 [KO:K06244]
125151455  LAMB4; laminin subunit beta-4 [KO:K06245]
125155356  LAMC1; laminin subunit gamma-1 [KO:K05635]
125155688  LAMC2; laminin subunit gamma-2 [KO:K06246]
125150287  LAMC3; laminin subunit gamma-3 [KO:K06247]
125163566  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
125168154  uncharacterized protein LOC125168154 [KO:K06856]
125168156  LOW QUALITY PROTEIN: uncharacterized protein LOC125168156 [KO:K06856]
125150317  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
125155799  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
125150695  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
125155794  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
125167322  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
125162218  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
125162435  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
125177240  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
125151135  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
125154310  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125153700  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
125161530  neuroendocrine secretory protein 55 [KO:K04632]
125161813  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
125148870  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
125160918  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
125160305  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
125172461  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
125174851  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
125170850  RAB5B; ras-related protein Rab-5B [KO:K07888]
125158557  RAB5C; ras-related protein Rab-5C [KO:K07889]
125149054  RAB7A; ras-related protein Rab-7a [KO:K07897]
125155810  RAB7B; ras-related protein Rab-7b [KO:K07898]
125163954  TLR2; toll-like receptor 2 [KO:K10159]
125150458  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
125166669  CD14; monocyte differentiation antigen CD14 [KO:K04391]
125152182  IL6; interleukin-6 isoform X1 [KO:K05405]
125163274  growth-regulated protein homolog gamma-like isoform X1 [KO:K05505]
125164606  growth-regulated alpha protein-like isoform X1 [KO:K05505]
125164607  growth-regulated alpha protein-like [KO:K05505]
125164229  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
125163304  CXCL8; interleukin-8 [KO:K10030]
125165327  TNF; tumor necrosis factor [KO:K03156]
125175189  IL12A; interleukin-12 subunit alpha [KO:K05406]
125148412  IL12B; interleukin-12 subunit beta [KO:K05425]
125155333  T-cell surface glycoprotein CD1e, membrane-associated-like [KO:K06448]
125155334  T-cell surface glycoprotein CD1b-like [KO:K06448]
125155361  T-cell surface glycoprotein CD1c-like [KO:K06448]
125155385  T-cell surface glycoprotein CD1a-like [KO:K06448]
125155386  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
125155420  T-cell surface glycoprotein CD1a-like [KO:K06448]
125155612  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
125155831  CD1D; antigen-presenting glycoprotein CD1d [KO:K06448]
125155349  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
125155613  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
125155732  T-cell surface glycoprotein CD1a-like isoform X1 [KO:K06448]
125155733  LOW QUALITY PROTEIN: T-cell surface glycoprotein CD1a-like [KO:K06448]
125170497  IFNG; interferon gamma [KO:K04687]
125172432  COL3A1; collagen alpha-1(III) chain [KO:K19720]
125156382  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
125147417  VCL; vinculin isoform X1 [KO:K05700]
125167278  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
125153089  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
125166043  ARG1; LOW QUALITY PROTEIN: arginase-1 [KO:K01476] [EC:3.5.3.1]
125167353  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
125151438  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
125159095  ITGB2; integrin beta-2 [KO:K06464]
125154610  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
125161995  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125172124  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
125150373  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
125174838  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
125175184  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125172980  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125168724  peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
125173179  PRDX1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
125165992  SERPINB9; LOW QUALITY PROTEIN: serpin B9 [KO:K13963]
125166242  SERPINB6; serpin B6 isoform X1 [KO:K13963]
125149169  SERPINB3; serpin B3 isoform X1 [KO:K13963]
125149204  SERPINB10; serpin B10 [KO:K13963]
125149424  SERPINB13; serpin B13 isoform X1 [KO:K13963]
125168541  cathepsin G-like [KO:K01319] [EC:3.4.21.20]
125155666  IL10; interleukin-10 isoform X1 [KO:K05443]
125152868  TGFB1; transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
125155525  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
125168683  TGFB3; transforming growth factor beta-3 proprotein isoform X1 [KO:K13377]
125173784  C8A; complement component C8 alpha chain [KO:K03997]
125173579  C8B; complement component C8 beta chain [KO:K03998]
125150057  C8G; complement component C8 gamma chain [KO:K03999]
125174696  C9; complement component C9 [KO:K04000]
Compound
C00027  Hydrogen peroxide
C00062  L-Arginine
C00076  Calcium cation
C00165  Diacylglycerol
C00219  Arachidonate
C00533  Nitric oxide
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C01074  N-Acetylgalactosamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01498  Gelatine
C02737  Phosphatidylserine
C18287  Monocyte locomotion inhibitory factor
Reference
PMID:11378035
  Authors
Stanley SL
  Title
Pathophysiology of amoebiasis.
  Journal
Trends Parasitol 17:280-5 (2001)
DOI:10.1016/S1471-4922(01)01903-1
Reference
PMID:10756002
  Authors
Espinosa-Cantellano M, Martinez-Palomo A
  Title
Pathogenesis of intestinal amebiasis: from molecules to disease.
  Journal
Clin Microbiol Rev 13:318-31 (2000)
DOI:10.1128/CMR.13.2.318-331.2000
Reference
PMID:9832261
  Authors
Huston CD, Petri WA Jr
  Title
Host-pathogen interaction in amebiasis and progress in vaccine development.
  Journal
Eur J Clin Microbiol Infect Dis 17:601-14 (1998)
DOI:10.1007/BF01708342
Reference
PMID:14700586
  Authors
Huston CD
  Title
Parasite and host contributions to the pathogenesis of amebic colitis.
  Journal
Trends Parasitol 20:23-6 (2004)
DOI:10.1016/j.pt.2003.10.013
Reference
PMID:15813717
  Authors
Campos-Rodriguezp R, Jarillo-Luna A
  Title
The pathogenicity of Entamoeba histolytica is related to the capacity of evading innate immunity.
  Journal
Parasite Immunol 27:1-8 (2005)
DOI:10.1111/j.1365-3024.2005.00743.x
Reference
PMID:19207103
  Authors
Lejeune M, Rybicka JM, Chadee K
  Title
Recent discoveries in the pathogenesis and immune response toward Entamoeba histolytica.
  Journal
Future Microbiol 4:105-18 (2009)
DOI:10.2217/17460913.4.1.105
Reference
PMID:17576362
  Authors
Carrero JC, Cervantes-Rebolledo C, Aguilar-Diaz H, Diaz-Gallardo MY, Laclette JP, Morales-Montor J
  Title
The role of the secretory immune response in the infection by Entamoeba histolytica.
  Journal
Parasite Immunol 29:331-8 (2007)
DOI:10.1111/j.1365-3024.2007.00955.x
Reference
PMID:12660071
  Authors
Stanley SL Jr
  Title
Amoebiasis.
  Journal
Lancet 361:1025-34 (2003)
DOI:10.1016/S0140-6736(03)12830-9
Reference
PMID:14502002
  Authors
Stauffer W, Ravdin JI
  Title
Entamoeba histolytica: an update.
  Journal
Curr Opin Infect Dis 16:479-85 (2003)
DOI:10.1097/01.qco.0000092821.42392.ca
Reference
PMID:12142490
  Authors
Petri WA Jr, Haque R, Mann BJ
  Title
The bittersweet interface of parasite and host: lectin-carbohydrate interactions during human invasion by the parasite Entamoeba histolytica.
  Journal
Annu Rev Microbiol 56:39-64 (2002)
DOI:10.1146/annurev.micro.56.012302.160959
Reference
PMID:18725798
  Authors
Baxt LA, Singh U
  Title
New insights into Entamoeba histolytica pathogenesis.
  Journal
Curr Opin Infect Dis 21:489-94 (2008)
DOI:10.1097/QCO.0b013e32830ce75f
Reference
PMID:12160867
  Authors
Petri WA Jr
  Title
Pathogenesis of amebiasis.
  Journal
Curr Opin Microbiol 5:443-7 (2002)
DOI:10.1016/S1369-5274(02)00335-1
Reference
PMID:17702556
  Authors
Guo X, Houpt E, Petri WA Jr
  Title
Crosstalk at the initial encounter: interplay between host defense and ameba survival strategies.
  Journal
Curr Opin Immunol 19:376-84 (2007)
DOI:10.1016/j.coi.2007.07.005
Reference
PMID:20303955
  Authors
Mortimer L, Chadee K
  Title
The immunopathogenesis of Entamoeba histolytica.
  Journal
Exp Parasitol 126:366-80 (2010)
DOI:10.1016/j.exppara.2010.03.005
Reference
PMID:16380324
  Authors
Meza I, Talamas-Rohana P, Vargas MA
  Title
The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
  Journal
Arch Med Res 37:234-43 (2006)
DOI:10.1016/j.arcmed.2005.09.008
Reference
PMID:10637584
  Authors
Meza I
  Title
Extracellular matrix-induced signaling in Entamoeba histolytica: its role in invasiveness.
  Journal
Parasitol Today 16:23-8 (2000)
DOI:10.1016/S0169-4758(99)01586-0
Reference
PMID:11352795
  Authors
Stanley SL Jr, Reed SL
  Title
Microbes and microbial toxins: paradigms for microbial-mucosal interactions. VI. Entamoeba histolytica: parasite-host interactions.
  Journal
Am J Physiol Gastrointest Liver Physiol 280:G1049-54 (2001)
DOI:10.1152/ajpgi.2001.280.6.G1049
Reference
PMID:20145703
  Authors
Wong-Baeza I, Alcantara-Hernandez M, Mancilla-Herrera I, Ramirez-Saldivar I, Arriaga-Pizano L, Ferat-Osorio E, Lopez-Macias C, Isibasi A
  Title
The role of lipopeptidophosphoglycan in the immune response to Entamoeba histolytica.
  Journal
J Biomed Biotechnol 2010:254521 (2010)
DOI:10.1155/2010/254521
Related
pathway
pviv00330  Arginine and proline metabolism
pviv00590  Arachidonic acid metabolism
pviv04144  Endocytosis
pviv04210  Apoptosis
pviv04510  Focal adhesion
pviv04610  Complement and coagulation cascades
pviv04612  Antigen processing and presentation
pviv04620  Toll-like receptor signaling pathway
pviv04672  Intestinal immune network for IgA production
pviv04810  Regulation of actin cytoskeleton
KO pathway
ko05146   
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