KEGG   PATHWAY: pvt04148
Entry
pvt04148                    Pathway                                
Name
Efferocytosis - Pogona vitticeps (central bearded dragon)
Class
Cellular Processes; Transport and catabolism
Pathway map
pvt04148  Efferocytosis
pvt04148

Organism
Pogona vitticeps (central bearded dragon) [GN:pvt]
Gene
110083865  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
110084328  caspase-7-like [KO:K04397] [EC:3.4.22.60]
110071974  CASP7; caspase-7 [KO:K04397] [EC:3.4.22.60]
110084544  caspase-1-like [KO:K01370] [EC:3.4.22.36]
110070778  PANX1; pannexin-1 [KO:K03443]
110090177  P2RY2; P2Y purinoceptor 2 isoform X1 [KO:K04269]
110087426  P2Y purinoceptor 2-like [KO:K04269]
110090175  P2RY6; P2Y purinoceptor 6 [KO:K04272]
110073071  P2RY12; P2Y purinoceptor 12 [KO:K04298]
110085912  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
110081807  SPHK2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
110076502  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
110083188  ABCA1; ATP-binding cassette sub-family A member 1 isoform X1 [KO:K05641]
110090586  ATP-binding cassette sub-family A member 1-like [KO:K05641]
110090956  GPR132; probable G-protein coupled receptor 132 [KO:K08426]
110080585  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
110079237  disintegrin and metalloproteinase domain-containing protein 10-like [KO:K06704] [EC:3.4.24.81]
110074537  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
110071195  mucin-5AC-like isoform X1 [KO:K05508]
110090767  CX3CR1; CX3C chemokine receptor 1 isoform X1 [KO:K04192]
110071809  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
110072900  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
110085488  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
110091693  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
110090015  HIF1A; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
110081480  ARNT; aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
110082356  EPO; erythropoietin isoform X1 [KO:K05437]
110078014  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
110083245  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
110081803  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
110088651  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
110071801  CEBPB; LOW QUALITY PROTEIN: CCAAT/enhancer-binding protein beta [KO:K10048]
110083807  PPARG; peroxisome proliferator-activated receptor gamma isoform X1 [KO:K08530]
110089296  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
110072964  MFGE8; lactadherin isoform X1 [KO:K17253]
110074131  GAS6; growth arrest-specific protein 6 [KO:K05464]
110087020  MERTK; tyrosine-protein kinase Mer [KO:K05117] [EC:2.7.10.1]
110077191  CD36; platelet glycoprotein 4 isoform X1 [KO:K06259]
110080127  THBS1; thrombospondin-1 isoform X1 [KO:K16857]
110085468  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
110072466  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
110079773  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
110073915  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
110086977  DNMT3A; DNA (cytosine-5)-methyltransferase 3A isoform X1 [KO:K17398] [EC:2.1.1.37]
110072401  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
110088538  TGFB1; transforming growth factor beta-1 [KO:K13375]
110089239  sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
110078558  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
110083889  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
110077789  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
110083899  calcium/calmodulin-dependent protein kinase type II delta chain [KO:K04515] [EC:2.7.11.17]
110086082  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
110084335  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
110089644  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
110089645  mitogen-activated protein kinase 12-like isoform X1 [KO:K04441] [EC:2.7.11.24]
110079793  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
110079814  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
110088404  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
110090785  arachidonate 5-lipoxygenase-like [KO:K00461] [EC:1.13.11.34]
110089720  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110074973  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110076535  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110072222  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110080632  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110071954  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
110079984  ANO6; anoctamin-6 [KO:K19500]
110077400  ANO3; anoctamin-3 [KO:K19498]
110089005  ANO4; anoctamin-4 [KO:K19499]
110085408  ANO5; anoctamin-5 isoform X1 [KO:K19480]
110073153  ANO7L1; anoctamin-7 isoform X1 [KO:K19501]
110075269  ANO7; anoctamin-7 isoform X1 [KO:K19501]
110074204  ANO9; anoctamin-9 isoform X1 [KO:K19503]
110079221  BSG; basigin [KO:K06535]
110088338  XKR8; XK-related protein 8 [KO:K26813]
110089503  XKR9; XK-related protein 9 isoform X1 [KO:K26814]
110086726  XKR7; XK-related protein 7 [KO:K26811]
110080227  XKR4; XK-related protein 4 [KO:K26811]
110070191  XKR6; XK-related protein 6 [KO:K26811]
110076458  ATP8A2; phospholipid-transporting ATPase IB [KO:K14802] [EC:7.6.2.1]
110075221  ATP8A1; phospholipid-transporting ATPase IA isoform X1 [KO:K14802] [EC:7.6.2.1]
110079340  ATP11A; probable phospholipid-transporting ATPase IH isoform X1 [KO:K26934] [EC:7.6.2.1]
110084959  ATP11C; phospholipid-transporting ATPase IG isoform X1 [KO:K26934] [EC:7.6.2.1]
110086064  ATP11B; LOW QUALITY PROTEIN: probable phospholipid-transporting ATPase IF [KO:K26934] [EC:7.6.2.1]
110075021  TMEM30A; cell cycle control protein 50A [KO:K26935]
110088097  PROS1; vitamin K-dependent protein S [KO:K03908]
110089997  ITGAV; integrin alpha-V [KO:K06487]
110081384  ITGB3; integrin beta-3 [KO:K06493]
110090759  ITGB5; integrin beta-5 [KO:K06588]
110088529  AXL; tyrosine-protein kinase receptor UFO isoform X1 [KO:K05115] [EC:2.7.10.1]
110079014  TYRO3; tyrosine-protein kinase receptor TYRO3 isoform X1 [KO:K05116] [EC:2.7.10.1]
110090008  uncharacterized protein LOC110090008 [KO:K26936]
110080642  STAB1; stabilin-1 [KO:K19020]
110084770  STAB2; stabilin-2 isoform X1 [KO:K19013]
110084855  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
110081315  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
110084280  CRK; LOW QUALITY PROTEIN: adapter molecule crk [KO:K04438]
110081775  crk-like protein [KO:K04438]
110081994  CRKL; crk-like protein [KO:K04438]
110076188  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
110077909  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
110082204  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
110072231  disintegrin and metalloproteinase domain-containing protein 9-like [KO:K06834] [EC:3.4.24.-]
110087231  disintegrin and metalloproteinase domain-containing protein 9-like [KO:K06834] [EC:3.4.24.-]
110077979  CALR; calreticulin [KO:K08057]
110072552  CALR3; calreticulin-3 isoform X1 [KO:K08057]
110076170  calreticulin-like [KO:K08057]
110089367  C1QA; complement C1q subcomponent subunit A [KO:K03986]
110089371  C1QB; complement C1q subcomponent subunit B [KO:K03987]
110089370  C1QC; complement C1q subcomponent subunit C [KO:K03988]
110071004  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
110077545  MEGF10; multiple epidermal growth factor-like domains protein 10 isoform X1 [KO:K24068]
110085480  MEGF11; multiple epidermal growth factor-like domains protein 11 isoform X1 [KO:K24068]
110088889  GULP1; PTB domain-containing engulfment adapter protein 1 isoform X1 [KO:K23285]
110086461  RAB5A; ras-related protein Rab-5A [KO:K07887]
110073523  RAB5B; ras-related protein Rab-5B [KO:K07888]
110074881  RAB5C; ras-related protein Rab-5C [KO:K07889]
110074128  TGFBRAP1; transforming growth factor-beta receptor-associated protein 1 [KO:K20177]
110075828  VPS8; vacuolar protein sorting-associated protein 8 homolog isoform X1 [KO:K20178]
110079076  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
110086598  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
110079022  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
110083843  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
110090973  ras-related protein Rab-14-like [KO:K07881]
110082941  RAB14; ras-related protein Rab-14 [KO:K07881]
110079015  VPS39; vam6/Vps39-like protein isoform X1 [KO:K20183]
110076194  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
110078636  ras-related protein Rab-7a-like isoform X1 [KO:K07897]
110081407  RAB7A; ras-related protein Rab-7a [KO:K07897]
110081239  RAB7B; ras-related protein Rab-7b [KO:K07898]
110078070  PQLC2L; LOW QUALITY PROTEIN: putative uncharacterized protein PQLC2L [KO:K23678]
110073205  PQLC2; lysosomal amino acid transporter 1 homolog [KO:K23678]
110091418  ARG1; arginase-1 isoform X1 [KO:K01476] [EC:3.5.3.1]
110082392  ARG2; arginase-2, mitochondrial isoform X1 [KO:K01476] [EC:3.5.3.1]
110080591  ODC1; ornithine decarboxylase [KO:K01581] [EC:4.1.1.17]
110070876  CH25H; cholesterol 25-hydroxylase [KO:K10223] [EC:1.14.99.38]
110082017  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
110086944  NR1H2; oxysterols receptor LXR-beta [KO:K08535]
110079173  CPT1C; carnitine O-palmitoyltransferase 1, brain isoform [KO:K08765] [EC:2.3.1.21]
110074166  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
110084411  CPT1B; carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
110088927  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
110087595  SIRT1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
110087589  PBX1; pre-B-cell leukemia transcription factor 1 isoform X1 [KO:K09355]
110088413  IL10; interleukin-10 isoform X1 [KO:K05443]
110070875  putative lysosomal acid lipase/cholesteryl ester hydrolase [KO:K01052] [EC:3.1.1.13]
110083105  lysosomal acid lipase/cholesteryl ester hydrolase-like [KO:K01052] [EC:3.1.1.13]
110083117  gastric triacylglycerol lipase-like [KO:K01052] [EC:3.1.1.13]
110085503  PLA2G15; group XV phospholipase A2 [KO:K06129] [EC:3.1.1.5]
110072700  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
110072340  SLC16A1; monocarboxylate transporter 1 [KO:K08179]
110071906  SGK1; serine/threonine-protein kinase Sgk1 isoform X1 [KO:K13302] [EC:2.7.11.1]
110085851  CD47; leukocyte surface antigen CD47 isoform X1 [KO:K06266]
110088321  CD24; signal transducer CD24 [KO:K06469]
110073374  PECAM1; platelet endothelial cell adhesion molecule isoform X1 [KO:K06471]
110086508  sialic acid-binding Ig-like lectin 10 [KO:K06749]
110086039  tyrosine-protein phosphatase non-receptor type substrate 1-like [KO:K06551]
110078495  tyrosine-protein phosphatase non-receptor type substrate 1-like isoform X1 [KO:K06551]
110084628  PTPN6; tyrosine-protein phosphatase non-receptor type 6 isoform X1 [KO:K05697] [EC:3.1.3.48]
110073274  tyrosine-protein phosphatase non-receptor type 11-like isoform X1 [KO:K07293] [EC:3.1.3.48]
110083443  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
pvt00010  Glycolysis / Gluconeogenesis
pvt04140  Autophagy - animal
pvt04145  Phagosome
KO pathway
ko04148   
LinkDB

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