Entry Name Staphylococcus aureus infection - Rattus norvegicus (rat)
Description Staphylococcus aureus can cause multiple forms of infections ranging from superficial skin infections to food poisoning and life-threatening infections. The organism has several ways to divert the effectiveness of the immune system: secreting immune modulating proteins that inhibit complement activation and neutrophil chemotaxis or lysis, modulating the sensitivity to cationic antimicrobial peptides (such as defensin) by increasing the positive net charge of its cytoplasmic membrane, and expression of superantigens that prevent development of a normal immune response or cause an emetic response when ingested.
Class Human Diseases; Infectious disease: bacterialBRITE hierarchy
Pathway map rno05150 Staphylococcus aureus infection
Ortholog table Organism Rattus norvegicus (rat) [GN:
rno ]
Gene 360623 Krt28; keratin, type I cytoskeletal 28 isoform 2 [KO:K07604 ]
683212 Krt18l1; keratin, type I cytoskeletal 18-like [KO:K07604 ]
24367 Fgg; fibrinogen gamma chain precursor [KO:K03905 ]
24548 Mbl1; mannose-binding protein A precursor [KO:K03991 ]
64668 Mbl2; mannose-binding protein C precursor [KO:K03991 ]
64023 Masp1; mannan-binding lectin serine protease 1 precursor [KO:K03992 ] [EC:3.4.21.-]
298566 C1qa; complement C1q subcomponent subunit A precursor [KO:K03986 ]
29687 C1qb; complement C1q subcomponent subunit B precursor [KO:K03987 ]
362634 C1qc; complement C1q subcomponent subunit C precursor [KO:K03988 ]
406161 C4b; complement component 4, gene 2 precursor [KO:K03989 ]
84007 C3ar1; C3a anaphylatoxin chemotactic receptor [KO:K04009 ]
113959 C5ar1; C5a anaphylatoxin chemotactic receptor 1 [KO:K04010 ]
295279 Fcgr1a; high affinity immunoglobulin gamma Fc receptor I precursor [KO:K06498 ]
134481532 low affinity immunoglobulin gamma Fc region receptor III isoform X1 [KO:K06472 ]
289211 Fcgr2b; low affinity immunoglobulin gamma Fc region receptor II [KO:K12560 ]
116591 Fcgr2a; low affinity immunoglobulin gamma Fc region receptor III isoform 1 [KO:K06463 ]
304966 Fcgr3a; low affinity immunoglobulin gamma Fc region receptor III-A precursor [KO:K06463 ]
365183 Fcar; immunoglobulin alpha Fc receptor precursor [KO:K06513 ]
690158 Fpr2; formyl peptide receptor, related sequence 2 [KO:K04173 ]
690198 Fpr2l2; formyl peptide receptor-related sequence 4 [KO:K04173 ]
690230 Fpr2l3; formyl peptide receptor-related sequence 7 [KO:K04173 ]
292419 Fpr2l1; formyl peptide receptor, related sequence 3 [KO:K04173 ]
363930 Selplg; P-selectin glycoprotein ligand 1 precursor [KO:K06544 ]
25464 Icam1; intercellular adhesion molecule 1 precursor [KO:K06490 ]
286995 Defa5; neutrophil antibiotic peptide NP-2 precursor [KO:K05230 ]
613220 Defal1; defensin alpha-like protein 1 precursor [KO:K05230 ]
498659 RatNP-3b; neutrophil antibiotic peptide NP-3B precursor [KO:K05230 ]
498658 Defa9; uncharacterized protein LOC498658 precursor [KO:K05230 ]
316010 Camp; cathelicidin antimicrobial peptide precursor [KO:K13916 ]
294274 RT1-DMa; RT1 class II, DM alpha precursor [KO:K06752 ]
24984 RT1-DOa; RT1 class II, locus DOa precursor [KO:K06752 ]
24986 RT1-Ha; RT1 class II, locus Ha precursor [KO:K06752 ]
294270 RT1-Db1; rano class II histocompatibility antigen, D-1 beta chain precursor [KO:K06752 ]
309621 RT1-Ba; rano class II histocompatibility antigen, B alpha chain precursor [KO:K06752 ]
309622 RT1-Bb; rano class II histocompatibility antigen, B-1 beta chain precursor [KO:K06752 ]
24981 RT1-Db2; RT1 class II, locus Db2 precursor [KO:K06752 ]
58949 Ptafr; platelet-activating factor receptor [KO:K04279 ]
Compound Reference Authors Foster TJ
Title Colonization and infection of the human host by staphylococci: adhesion, survival and immune evasion.
Journal Reference Authors Foster TJ
Title Immune evasion by staphylococci.
Journal Reference Authors Laarman A, Milder F, van Strijp J, Rooijakkers S
Title Complement inhibition by gram-positive pathogens: molecular mechanisms and therapeutic implications.
Journal Reference Authors Rooijakkers SH, van Kessel KP, van Strijp JA
Title Staphylococcal innate immune evasion.
Journal Reference Authors Iwatsuki K, Yamasaki O, Morizane S, Oono T
Title Staphylococcal cutaneous infections: invasion, evasion and aggression.
Journal Reference Authors Torres BA, Kominsky S, Perrin GQ, Hobeika AC, Johnson HM
Title Superantigens: the good, the bad, and the ugly.
Journal Reference Authors Atkins KL, Burman JD, Chamberlain ES, Cooper JE, Poutrel B, Bagby S, Jenkins AT, Feil EJ, van den Elsen JM
Title S. aureus IgG-binding proteins SpA and Sbi: host specificity and mechanisms of immune complex formation.
Journal Reference Authors Silverman GJ, Goodyear CS
Title Confounding B-cell defences: lessons from a staphylococcal superantigen.
Journal Reference Authors Goodyear CS, Silverman GJ
Title Staphylococcal toxin induced preferential and prolonged in vivo deletion of innate-like B lymphocytes.
Journal Reference Authors Haupt K, Reuter M, van den Elsen J, Burman J, Halbich S, Richter J, Skerka C, Zipfel PF
Title The Staphylococcus aureus protein Sbi acts as a complement inhibitor and forms a tripartite complex with host complement Factor H and C3b.
Journal Reference Authors Bokarewa MI, Jin T, Tarkowski A
Title Staphylococcus aureus: Staphylokinase.
Journal Reference Authors Rooijakkers SH, Ruyken M, Roos A, Daha MR, Presanis JS, Sim RB, van Wamel WJ, van Kessel KP, van Strijp JA
Title Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases.
Journal Reference Authors Rooijakkers SH, Wu J, Ruyken M, van Domselaar R, Planken KL, Tzekou A, Ricklin D, Lambris JD, Janssen BJ, van Strijp JA, Gros P
Title Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a staphylococcal inhibitor.
Journal Reference Authors Jongerius I, Kohl J, Pandey MK, Ruyken M, van Kessel KP, van Strijp JA, Rooijakkers SH
Title Staphylococcal complement evasion by various convertase-blocking molecules.
Journal Reference Authors Hair PS, Ward MD, Semmes OJ, Foster TJ, Cunnion KM
Title Staphylococcus aureus clumping factor A binds to complement regulator factor I and increases factor I cleavage of C3b.
Journal Reference Authors Higgins J, Loughman A, van Kessel KP, van Strijp JA, Foster TJ
Title Clumping factor A of Staphylococcus aureus inhibits phagocytosis by human polymorphonuclear leucocytes.
Journal Reference Authors Laursen NS, Gordon N, Hermans S, Lorenz N, Jackson N, Wines B, Spillner E, Christensen JB, Jensen M, Fredslund F, Bjerre M, Sottrup-Jensen L, Fraser JD, Andersen GR
Title Structural basis for inhibition of complement C5 by the SSL7 protein from Staphylococcus aureus.
Journal Reference Authors Ramsland PA, Willoughby N, Trist HM, Farrugia W, Hogarth PM, Fraser JD, Wines BD
Title Structural basis for evasion of IgA immunity by Staphylococcus aureus revealed in the complex of SSL7 with Fc of human IgA1.
Journal Reference Authors de Haas CJ, Veldkamp KE, Peschel A, Weerkamp F, Van Wamel WJ, Heezius EC, Poppelier MJ, Van Kessel KP, van Strijp JA
Title Chemotaxis inhibitory protein of Staphylococcus aureus, a bacterial antiinflammatory agent.
Journal Reference Authors Prat C, Bestebroer J, de Haas CJ, van Strijp JA, van Kessel KP
Title A new staphylococcal anti-inflammatory protein that antagonizes the formyl peptide receptor-like 1.
Journal Reference Authors Bestebroer J, Poppelier MJ, Ulfman LH, Lenting PJ, Denis CV, van Kessel KP, van Strijp JA, de Haas CJ
Title Staphylococcal superantigen-like 5 binds PSGL-1 and inhibits P-selectin-mediated neutrophil rolling.
Journal Reference Authors Chung MC, Wines BD, Baker H, Langley RJ, Baker EN, Fraser JD
Title The crystal structure of staphylococcal superantigen-like protein 11 in complex with sialyl Lewis X reveals the mechanism for cell binding and immune inhibition.
Journal Reference Authors Chavakis T, Hussain M, Kanse SM, Peters G, Bretzel RG, Flock JI, Herrmann M, Preissner KT
Title Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes.
Journal Reference Authors Li M, Lai Y, Villaruz AE, Cha DJ, Sturdevant DE, Otto M
Title Gram-positive three-component antimicrobial peptide-sensing system.
Journal Reference Authors Sieprawska-Lupa M, Mydel P, Krawczyk K, Wojcik K, Puklo M, Lupa B, Suder P, Silberring J, Reed M, Pohl J, Shafer W, McAleese F, Foster T, Travis J, Potempa J
Title Degradation of human antimicrobial peptide LL-37 by Staphylococcus aureus-derived proteinases.
Journal Reference Authors Fraser JD, Proft T
Title The bacterial superantigen and superantigen-like proteins.
Journal Reference Authors Yamaguchi T, Nishifuji K, Sasaki M, Fudaba Y, Aepfelbacher M, Takata T, Ohara M, Komatsuzawa H, Amagai M, Sugai M
Title Identification of the Staphylococcus aureus etd pathogenicity island which encodes a novel exfoliative toxin, ETD, and EDIN-B.
Journal Reference Authors Pazgier M, Hoover DM, Yang D, Lu W, Lubkowski J
Title Human beta-defensins.
Journal Reference Authors Zhang Q, Mousdicas N, Yi Q, Al-Hassani M, Billings SD, Perkins SM, Howard KM, Ishii S, Shimizu T, Travers JB
Title Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor.
Journal Reference Authors Lehrer RI
Title Primate defensins.
Journal Related rno04610 Complement and coagulation cascades
rno04660 T cell receptor signaling pathway
rno04662 B cell receptor signaling pathway
KO pathway LinkDB All DBs
