Entry Name B cell receptor signaling pathway - Rattus norvegicus (rat)
Description B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class Organismal Systems; Immune systemBRITE hierarchy
Pathway map rno04662 B cell receptor signaling pathway
Other DBs Organism Rattus norvegicus (rat) [GN:
rno ]
Gene 100361818 Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform 1 [KO:K04446 ]
100363332 Card11; caspase recruitment domain-containing protein 11 [KO:K07367 ]
100912456 Lilrb1; leukocyte immunoglobulin-like receptor subfamily B member 3-like isoform X1 [KO:K06512 ]
100913063 Cd79a; B-cell antigen receptor complex-associated protein alpha chain precursor [KO:K06506 ]
170911 Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
171055 Cd79b; B-cell antigen receptor complex-associated protein beta chain precursor [KO:K06507 ]
171378 Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
24675 Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform [KO:K04348 ] [EC:3.1.3.16 ]
25513 Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
289211 Fcgr2b; low affinity immunoglobulin gamma Fc region receptor II [KO:K12560 ]
289395 Cr2; complement receptor type 2 precursor [KO:K04012 ]
292594 Lilrb4; leukocyte immunoglobulin like receptor B4 isoform 3 precursor [KO:K06512 ]
29337 Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859 ] [EC:3.1.4.11 ]
293618 Ifitm1; interferon-induced transmembrane protein 1 [KO:K19831 ]
294048 Pik3ap1; phosphoinositide 3-kinase adapter protein 1 isoform 2 [KO:K12230 ]
295378 Vav3; guanine nucleotide exchange factor VAV3 [KO:K05730 ]
296603 Vav2; guanine nucleotide exchange factor VAV2 [KO:K05730 ]
29741 Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
307366 Malt1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 isoform 1 [KO:K07369 ] [EC:3.4.22.-]
308350 Lilrb3; leukocyte immunoglobulin-like receptor subfamily B member 3 isoform X6 [KO:K06512 ]
311658 Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332 ]
313498 Cd72; B-cell differentiation antigen CD72 [KO:K06504 ]
361400 Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
361493 Pira2; paired-Ig-like receptor A2 precursor [KO:K06512 ]
362046 Dapp1; dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide [KO:K12229 ]
363875 Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392 ]
365367 Cd19; B-lymphocyte antigen CD19 precursor [KO:K06465 ]
365948 Bank1; B-cell scaffold protein with ankyrin repeats [KO:K26239 ]
366508 Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
366957 Rac2; ras-related C3 botulinum toxin substrate 2 [KO:K07860 ]
367858 Hrasl1; HRas proto-oncogene, GTPase like 1 [KO:K02833 ]
54259 Inpp5d; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 [KO:K03084 ] [EC:3.1.3.86 ]
58960 Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369 ] [EC:2.7.12.2 ]
60664 Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
65038 Inppl1; phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 isoform 1 [KO:K15909 ] [EC:3.1.3.86 ]
65146 Lilrb2; neutrophil immunoglobulin-like receptor 1 [KO:K06512 ]
683463 Pirb; leukocyte immunoglobulin-like receptor subfamily B member 3A precursor [KO:K06512 ]
688319 Rac3; ras-related C3 botulinum toxin substrate 3 [KO:K07861 ]
690906 Lilrc2; leukocyte immunoglobulin-like receptor, subfamily C, member 2 [KO:K06512 ]
691533 Lilra5; leukocyte immunoglobulin-like receptor subfamily A member 5 precursor [KO:K06512 ]
81504 Grb2; growth factor receptor-bound protein 2 [KO:K04364 ]
81736 Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform 2 [KO:K02580 ]
85243 Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
Compound C01245 D-myo-Inositol 1,4,5-trisphosphate
C05981 Phosphatidylinositol-3,4,5-trisphosphate
Reference Authors Niiro H, Clark EA.
Title Regulation of B-cell fate by antigen-receptor signals.
Journal Reference Authors Kurosaki T.
Title Genetic analysis of B cell antigen receptor signaling.
Journal Reference Authors Nitschke L.
Title The role of CD22 and other inhibitory co-receptors in B-cell activation.
Journal Reference Authors Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
Title Complement: central to innate immunity and bridging to adaptive responses.
Journal Reference Authors Kurosaki T.
Title Regulation of B-cell signal transduction by adaptor proteins.
Journal Reference Authors Nitschke L, Tsubata T.
Title Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
Journal Reference Authors Jumaa H, Hendriks RW, Reth M.
Title B cell signaling and tumorigenesis.
Journal Reference Authors Rickert RC.
Title Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
Journal Reference Authors Zouali M, Sarmay G
Title B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
Journal Reference Authors Chiles TC.
Title Regulation and function of cyclin D2 in B lymphocyte subsets.
Journal Reference Authors Allam A, Marshall AJ
Title Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
Journal Reference Authors Gold MR
Title To make antibodies or not: signaling by the B-cell antigen receptor.
Journal Reference Authors Fu C, Turck CW, Kurosaki T, Chan AC
Title BLNK: a central linker protein in B cell activation.
Journal Reference Authors Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
Title BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
Journal Reference Authors Shinohara H, Maeda S, Watarai H, Kurosaki T
Title IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
Journal Related rno04610 Complement and coagulation cascades
rno04810 Regulation of actin cytoskeleton
KO pathway
