KEGG   PATHWAY: sasa04150
Entry
sasa04150                   Pathway                                
Name
mTOR signaling pathway - Salmo salar (Atlantic salmon)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
sasa04150  mTOR signaling pathway
sasa04150

Organism
Salmo salar (Atlantic salmon) [GN:sasa]
Gene
106567382  large neutral amino acids transporter small subunit 1-like [KO:K13780]
106573635  large neutral amino acids transporter small subunit 1-like [KO:K13780]
106572151  large neutral amino acids transporter small subunit 1-like [KO:K13780]
106595801  large neutral amino acids transporter small subunit 1-like [KO:K13780]
106587978  large neutral amino acids transporter small subunit 1-like [KO:K13780]
106560933  slc7a5; solute carrier family 7 member 5 [KO:K13780]
106603161  4F2 cell-surface antigen heavy chain-like [KO:K06519]
106563501  slc3a2; solute carrier family 3 member 2 [KO:K06519]
106578137  4F2 cell-surface antigen heavy chain-like [KO:K06519]
100195278  4f2; 4F2 cell-surface antigen heavy chain [KO:K06519]
106571479  slc38a9; solute carrier family 38 member 9 [KO:K14995]
106603053  VATA; V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
106563593  VATA; V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
106579446  VATA; V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
106590474  VATA; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
100136392  vat1; V-type proton ATPase subunit B, brain isoform [KO:K02147]
106563054  V-type proton ATPase subunit B, brain isoform [KO:K02147]
100196724  vatb2; Vacuolar ATP synthase subunit B, brain isoform [KO:K02147]
106579140  V-type proton ATPase subunit C 1-A [KO:K02148]
106605527  V-type proton ATPase subunit C 1-A [KO:K02148]
106608215  VATD; V-type proton ATPase subunit D-like [KO:K02149]
106571673  VATD; V-type proton ATPase subunit D [KO:K02149]
106609471  V-type proton ATPase subunit E 1-like [KO:K02150]
106561370  VATE1; V-type proton ATPase subunit E 1-like [KO:K02150]
106576269  VATE1; V-type proton ATPase subunit E 1-like [KO:K02150]
106609141  V-type proton ATPase subunit F [KO:K02151]
100196208  atp6v1f; ATPase H+ transporting V1 subunit F [KO:K02151]
106567829  VATG1; V-type proton ATPase subunit G 1-like [KO:K02152]
106563029  VATG1; V-type proton ATPase subunit G 1-like [KO:K02152]
106595987  V-type proton ATPase subunit H-like [KO:K02144]
100194974  vath; Vacuolar proton pump subunit H [KO:K02144]
106613227  lamtor1; late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 [KO:K20397]
106581407  ragulator complex protein LAMTOR1-like [KO:K20397]
106580651  MAPIP; ragulator complex protein LAMTOR2 [KO:K20398]
106605307  MAPIP; ragulator complex protein LAMTOR2 [KO:K20398]
100196020  lamtor3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
106609143  ragulator complex protein LAMTOR4 [KO:K20399]
106576032  ragulator complex protein LAMTOR4-like [KO:K20399]
106566397  XIP; ragulator complex protein LAMTOR5-like [KO:K16344]
100196036  xip; Hepatitis B virus X-interacting protein [KO:K16344]
106577129  folliculin-like [KO:K09594]
106605767  folliculin-like [KO:K09594]
106603820  folliculin-interacting protein 1-like [KO:K20400]
106567520  folliculin-interacting protein 1-like [KO:K20400]
100196161  rraga; Ras-related GTP binding A [KO:K16185]
106602463  ras-related GTP-binding protein D-like [KO:K16186]
106605136  ras-related GTP-binding protein C-like [KO:K16186]
106570373  ras-related GTP-binding protein C [KO:K16186]
100380530  gats; opposite strand transcription unit to Stag3 [KO:K23080]
106585238  gatsl3; GATS protein like 3 [KO:K23080]
106603747  GATS-like protein 2 [KO:K23081]
106567563  GATS-like protein 2 [KO:K23081]
106582151  WD repeat-containing protein mio-like [KO:K20407]
106605261  WD repeat-containing protein mio [KO:K20407]
106594672  nucleoporin seh1-like [KO:K14299]
106594566  nucleoporin SEH1 [KO:K14299]
106578258  WD repeat-containing protein 24-like [KO:K20408]
106579219  wdr24; WD repeat domain 24 [KO:K20408]
106588117  WD repeat-containing protein 59-like [KO:K20409]
100195739  sec13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
106564929  depdc5; DEP domain containing 5 [KO:K20404]
106582798  nprl2; NPR2-like, GATOR1 complex subunit [KO:K20405]
100195496  tusc4; Tumor suppressor candidate 4 [KO:K20405]
106601082  nitrogen permease regulator 3-like protein [KO:K20406]
106607369  nitrogen permease regulator 3-like protein [KO:K20406]
106563829  S-phase kinase-associated protein 2-like [KO:K03875]
106568170  S-phase kinase-associated protein 2-like [KO:K03875]
106599351  E3 ubiquitin-protein ligase RNF152-like [KO:K15705] [EC:2.3.2.27]
106578589  E3 ubiquitin-protein ligase RNF152-like [KO:K15705] [EC:2.3.2.27]
106569247  E3 ubiquitin-protein ligase RNF152-like [KO:K15705] [EC:2.3.2.27]
106590060  E3 ubiquitin-protein ligase RNF152-like [KO:K15705] [EC:2.3.2.27]
106588110  regulatory-associated protein of mTOR [KO:K07204]
106564921  regulatory-associated protein of mTOR-like [KO:K07204]
106601514  uncharacterized LOC106601514 [KO:K16184]
106601546  uncharacterized LOC106601546 [KO:K16184]
106606916  akt1s1; AKT1 substrate 1 [KO:K16184]
106597455  uncharacterized LOC106597455 [KO:K16184]
100380484  akts1; Proline-rich AKT1 substrate 1 [KO:K16184]
100380849  mtor; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
106572931  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
106582886  DEP domain-containing mTOR-interacting protein-like [KO:K20402]
106589564  mlst8; MTOR associated protein, LST8 homolog [KO:K08266]
106578250  telo2; telomere maintenance 2 [KO:K11137]
106566905  tti1; TELO2 interacting protein 1 [KO:K20403]
106561138  CAP-Gly domain-containing linker protein 1-like [KO:K10421]
106568293  CAP-Gly domain-containing linker protein 1-like [KO:K10421]
106580364  CAP-Gly domain-containing linker protein 1-like [KO:K10421]
106585282  CAP-Gly domain-containing linker protein 1-like [KO:K10421]
106579904  growth factor receptor-bound protein 10-like [KO:K20064]
106605415  growth factor receptor-bound protein 10-like [KO:K20064]
106570349  growth factor receptor-bound protein 10-like [KO:K20064]
106588785  growth factor receptor-bound protein 10-like [KO:K20064]
106570052  phosphatidate phosphatase LPIN1-like [KO:K15728] [EC:3.1.3.4]
106610734  phosphatidate phosphatase LPIN1-like [KO:K15728] [EC:3.1.3.4]
106578699  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
106565215  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
106590143  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
106583597  phosphatidate phosphatase LPIN2-like [KO:K15728] [EC:3.1.3.4]
106566325  ulk1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
106563157  serine/threonine-protein kinase ULK1-like [KO:K21357] [EC:2.7.11.1]
106579916  serine/threonine-protein kinase ULK1-like [KO:K21357] [EC:2.7.11.1]
106581221  serine/threonine-protein kinase ULK2-like [KO:K08269] [EC:2.7.11.1]
106612954  serine/threonine-protein kinase ULK2-like [KO:K08269] [EC:2.7.11.1]
106580340  4EBP2; eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
106585258  4EBP2; eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
106600575  eif4e2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
106604514  IF4EA; eukaryotic translation initiation factor 4E-1A [KO:K03259]
106608398  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
106563639  eukaryotic translation initiation factor 4E-1B-like [KO:K03259]
106577251  IF4E; eukaryotic translation initiation factor 4E-like [KO:K03259]
100286678  if4e; Eukaryotic translation initiation factor 4E [KO:K03259]
100194533  eif4e1a; eukaryotic translation initiation factor 4e 1a [KO:K03259]
100195332  if4ea; Eukaryotic translation initiation factor 4E-1A [KO:K03259]
100196384  if4e2; Eukaryotic translation initiation factor 4E type 2 [KO:K03259]
106602694  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
106603521  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
106609967  ribosomal protein S6 kinase beta-2-like [KO:K04688] [EC:2.7.11.1]
106613000  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
106581130  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
106567964  ribosomal protein S6 kinase beta-1-like [KO:K04688] [EC:2.7.11.1]
106566970  eukaryotic translation initiation factor 4B-like [KO:K03258]
106572753  eukaryotic translation initiation factor 4B-like [KO:K03258]
106565230  eukaryotic translation initiation factor 4B-like [KO:K03258]
100380867  if4b; eukaryotic translation initiation factor 4B [KO:K03258]
106602804  RS6; 40S ribosomal protein S6 [KO:K02991]
106609995  RS6; 40S ribosomal protein S6-like [KO:K02991]
106601607  STE20-related kinase adapter protein alpha-like [KO:K08271]
106606872  STE20-related kinase adapter protein alpha-like [KO:K08271]
106574923  STE20-related kinase adapter protein beta-like [KO:K17532]
106573852  STE20-related kinase adapter protein beta-like [KO:K17532]
106599971  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
106569546  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
106573605  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
106613746  serine/threonine-protein kinase STK11-like [KO:K07298] [EC:2.7.11.1]
106581356  calcium-binding protein 39 [KO:K08272]
106575510  calcium-binding protein 39-like [KO:K08272]
106575554  calcium-binding protein 39-like [KO:K08272]
106612044  calcium-binding protein 39-like [KO:K08272]
106613169  calcium-binding protein 39 [KO:K08272]
106568674  5'-AMP-activated protein kinase catalytic subunit alpha-1-like [KO:K07198] [EC:2.7.11.31]
106562970  prkaa1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
106584208  prkaa2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
106560227  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
106565454  hamartin-like [KO:K07206]
100380649  tsc1; hamartin [KO:K07206]
106587014  tsc1; tuberous sclerosis 1 [KO:K07206]
106564303  tuberin-like [KO:K07207]
106584071  tbc1d7; TBC1 domain family member 7 [KO:K20396]
106596806  GTP-binding protein Rheb-like [KO:K07208]
106579659  GTP-binding protein Rheb [KO:K07208]
106592571  GTP-binding protein Rheb-like [KO:K07208]
106590380  GTP-binding protein Rheb-like [KO:K07208]
100195178  rheb; ras homolog enriched in brain [KO:K07208]
106583224  rhebl1; Ras homolog enriched in brain like 1 [KO:K07208]
106577211  DNA damage-inducible transcript 4 protein-like [KO:K08270]
106577395  DNA damage-inducible transcript 4 protein-like [KO:K08270]
106592479  DNA damage-inducible transcript 4 protein-like [KO:K08270]
106572674  protein Wnt-1-like [KO:K03209]
106567052  protein Wnt-1 [KO:K03209]
106573123  protein Wnt-2-like [KO:K00182]
106566047  protein Wnt-2b-A-like [KO:K00182]
106561551  protein Wnt-2 [KO:K00182]
106582740  protein Wnt-2b-A-like [KO:K00182]
106599872  protein Wnt-3a [KO:K00312]
106569341  wnt3a; Wnt family member 3A [KO:K00312]
106579325  proto-oncogene Wnt-3-like [KO:K00312]
106589299  proto-oncogene Wnt-3 [KO:K00312]
106576564  protein Wnt-4-like [KO:K00408]
106605854  protein Wnt-4-like [KO:K00408]
106565616  protein Wnt-4a [KO:K00408]
106583123  protein Wnt-4a-like [KO:K00408]
106609811  protein Wnt-5b-like [KO:K00444]
106566524  protein Wnt-5a-like [KO:K00444]
106581837  wnt6; Wnt family member 6 [KO:K00445]
106586152  protein Wnt-6-like [KO:K00445]
106575957  protein Wnt-7b-like [KO:K00572]
106560992  protein Wnt-7b-like [KO:K00572]
106571899  protein Wnt-7a-like [KO:K00572]
106566606  protein Wnt-7a [KO:K00572]
106584495  protein Wnt-7b [KO:K00572]
106608511  protein Wnt-8b [KO:K00714]
106604409  protein Wnt-8a-like [KO:K00714]
106604410  protein Wnt-8a-like [KO:K00714]
106577209  protein Wnt-8b-like [KO:K00714]
106599874  protein Wnt-9a-like [KO:K01064]
106601131  protein Wnt-9b-like [KO:K01064]
106607324  protein Wnt-9b-like [KO:K01064]
106569340  wnt9a; Wnt family member 9A [KO:K01064]
106572675  protein Wnt-10b-like [KO:K01357]
106567053  protein Wnt-10b-like [KO:K01357]
106581835  protein Wnt-10a [KO:K01357]
106586153  protein Wnt-10a-like [KO:K01357]
106603540  protein Wnt-11-like [KO:K01384]
106603405  protein Wnt-11-like [KO:K01384]
106567945  protein Wnt-11-like [KO:K01384]
106568050  protein Wnt-11-like [KO:K01384]
106609305  protein Wnt-16-like [KO:K01558]
106576171  protein Wnt-16-like [KO:K01558]
106579053  frizzled-1-like [KO:K02432]
106605515  frizzled-1-like [KO:K02432]
106605516  frizzled-1-like [KO:K02432]
106569856  frizzled-1-like [KO:K02432]
106574245  frizzled-7-A-like [KO:K02432]
106575172  frizzled-7-A-like [KO:K02432]
106582548  frizzled-7-A-like [KO:K02432]
106588534  fzd1; frizzled class receptor 1 [KO:K02432]
106601035  frizzled-2-like [KO:K02235]
106607305  frizzled-2-like [KO:K02235]
106571436  frizzled-3-like [KO:K02329]
106608120  frizzled-3-like [KO:K02329]
106610748  frizzled-3-like [KO:K02329]
106571591  fzd3; frizzled class receptor 3 [KO:K02329]
106581418  fzd4; frizzled class receptor 4 [KO:K02354]
106599491  frizzled-8-like [KO:K02375]
106568833  frizzled-8-like [KO:K02375]
106578536  frizzled-8-like [KO:K02375]
106574888  frizzled-5-like [KO:K02375]
106582378  frizzled-5-like [KO:K02375]
106586337  frizzled-5-like [KO:K02375]
106578482  frizzled-6-like [KO:K02376]
106605646  frizzled-6-like [KO:K02376]
106603626  frizzled-9-like [KO:K02842]
106567714  frizzled-9 [KO:K02842]
106612580  frizzled-9-like [KO:K02842]
106579912  fzd10; frizzled class receptor 10 [KO:K02842]
106580877  frizzled-9-like [KO:K02842]
106585529  frizzled-10-like [KO:K02842]
106573620  low-density lipoprotein receptor-related protein 5-like [KO:K03068]
106560964  low-density lipoprotein receptor-related protein 5-like [KO:K03068]
106599063  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
106602818  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
106608773  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
106612406  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
106567255  dvl1; dishevelled segment polarity protein 1 [KO:K02353]
106568930  segment polarity protein dishevelled homolog DVL-3-like [KO:K02353]
106572388  segment polarity protein dishevelled homolog DVL-1-like [KO:K02353]
106577635  segment polarity protein dishevelled homolog DVL-2-like [KO:K02353]
106574304  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
106582120  gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
106586650  glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
106575154  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
100136457  tnf-alpha-1; tumor necrosis factor alpha-1 precursor [KO:K03156]
100136458  tnf-alpha-2; tumor necrosis factor alpha-2 precursor [KO:K03156]
100136509  tumor necrosis factor alpha [KO:K03156]
106589058  tumor necrosis factor-like [KO:K03156]
106575188  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
100196751  tnr1a; Tumor necrosis factor receptor superfamily member 1A [KO:K03158]
106567387  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
106580426  ikbkb; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
106603941  INS; insulin-like [KO:K04526]
106567474  INS; insulin [KO:K04526]
106612054  insulin-like [KO:K04526]
106609475  insulin-like growth factor I [KO:K05459]
100136517  insulin-like growth factor I [KO:K05459]
106583950  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
106560567  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
106600510  insulin receptor-like [KO:K04527] [EC:2.7.10.1]
106573762  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
106588078  insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100194499  igf1r; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
106587111  growth factor receptor-bound protein 2-like [KO:K04364]
106607067  growth factor receptor-bound protein 2 [KO:K04364]
106564671  growth factor receptor-bound protein 2-like [KO:K04364]
100306767  grb2; growth factor receptor-bound protein 2 [KO:K04364]
106601599  sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
106584773  son of sevenless homolog 1-like [KO:K03099]
106611443  son of sevenless homolog 2-like [KO:K03099]
106564790  son of sevenless homolog 1-like [KO:K03099]
106573361  GTPase HRas-like [KO:K02833]
100196603  rash; GTPase HRas [KO:K02833]
106601908  GTPase HRas-like [KO:K07827]
106606379  GTPase HRas-like [KO:K07827]
106561428  GTPase KRas [KO:K07827]
100380437  rask; GTPase KRas [KO:K07827]
106571905  RAF1b; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
106566757  RAF1a; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
100136351  raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
106584829  map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106600441  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
106613775  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106569535  dual specificity mitogen-activated protein kinase kinase 2-like [KO:K04369] [EC:2.7.12.2]
100194780  mp2k2; Dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106570952  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106600714  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
106592057  mitogen-activated protein kinase 1-like [KO:K04371] [EC:2.7.11.24]
100380511  mk03; Mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
106612640  ribosomal protein S6 kinase alpha-1 [KO:K04373] [EC:2.7.11.1]
106612512  ribosomal protein S6 kinase alpha-2-like [KO:K04373] [EC:2.7.11.1]
106603065  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
106604080  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
106610660  ribosomal protein S6 kinase 2 alpha-like [KO:K04373] [EC:2.7.11.1]
106563584  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
106579471  ribosomal protein S6 kinase alpha-3 [KO:K04373] [EC:2.7.11.1]
106589820  ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
106590479  ribosomal protein S6 kinase alpha-3-like [KO:K04373] [EC:2.7.11.1]
106567885  insulin receptor substrate 1-B-like [KO:K16172]
106577633  insulin receptor substrate 1-B-like [KO:K16172]
106612416  irs1; insulin receptor substrate 1 [KO:K16172]
106603593  insulin receptor substrate 1-B-like [KO:K16172]
106608778  insulin receptor substrate 1-B-like [KO:K16172]
106600405  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
106567700  phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
106599005  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
106560529  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
106613635  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
106569403  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
106568949  phosphatidylinositol 3-kinase regulatory subunit beta-like [KO:K02649]
106573900  phosphatidylinositol 3-kinase regulatory subunit gamma-like [KO:K02649]
106563018  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
106584012  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
106587034  phosphatidylinositol 3-kinase regulatory subunit alpha-like [KO:K02649]
106598808  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
106568747  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like [KO:K00922] [EC:2.7.1.153]
106572046  pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
106581359  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
106613931  pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
106613172  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform-like [KO:K00922] [EC:2.7.1.153]
106607213  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106600774  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106578954  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106577009  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106589390  phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN-like [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106607353  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
100380750  pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
106578264  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
106582637  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106585772  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106602915  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106607890  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106610858  RAC-alpha serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106564869  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106613111  RAC-beta serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
106581334  RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106571474  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100194605  akt2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
106589689  RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106579286  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
106579422  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
106589264  inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
100380343  mapkap1; mitogen-activated protein kinase associated protein 1 [KO:K20410]
106563815  rapamycin-insensitive companion of mTOR-like [KO:K08267]
106568168  rapamycin-insensitive companion of mTOR-like [KO:K08267]
106585162  rapamycin-insensitive companion of mTOR-like [KO:K08267]
106580589  rapamycin-insensitive companion of mTOR-like [KO:K08267]
106573370  PRR5; proline-rich protein 5-like [KO:K20411]
106576365  proline-rich protein 5-like [KO:K20411]
100286559  prr5; proline-rich protein 5 [KO:K20411]
106560701  prr5l; proline rich 5 like [KO:K20411]
106566794  RHOA; transforming protein RhoA-like [KO:K04513]
106566835  transforming protein RhoA-like [KO:K04513]
106572042  RHOA; transforming protein RhoA-like [KO:K04513]
106565140  RHOA; transforming protein RhoA-like [KO:K04513]
106572261  RHOA; transforming protein RhoA [KO:K04513]
106572962  ras-like GTP-binding protein O-RHO [KO:K04513]
106582735  RHOC; rho-related GTP-binding protein RhoC [KO:K04513]
106592002  RHOA; transforming protein RhoA-like [KO:K04513]
106583462  RHOA; transforming protein RhoA-like [KO:K04513]
106564882  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
106594520  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
106563990  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
106563994  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
106593748  protein kinase C beta type-like [KO:K19662] [EC:2.7.11.13]
106570356  SGK1; serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
106589037  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
106592818  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
106593595  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
106591125  SGK1; serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
106594083  serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
106593510  serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
sasa00561  Glycerolipid metabolism
sasa04010  MAPK signaling pathway
sasa04140  Autophagy - animal
sasa04810  Regulation of actin cytoskeleton
sasa04910  Insulin signaling pathway
KO pathway
ko04150   
LinkDB

DBGET integrated database retrieval system