KEGG   PATHWAY: sasa04150
Entry
sasa04150                   Pathway                                
Name
mTOR signaling pathway - Salmo salar (Atlantic salmon)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
sasa04150  mTOR signaling pathway
sasa04150

Organism
Salmo salar (Atlantic salmon) [GN:sasa]
Gene
100136351  raf1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
100136392  vat1; V-type proton ATPase subunit B, brain isoform [KO:K02147]
100136457  tnf-alpha-1; tumor necrosis factor alpha-1 precursor [KO:K03156]
100136458  tnf-alpha-2; tumor necrosis factor alpha-2 precursor [KO:K03156]
100136509  [KO:K03156]
100136517  [KO:K05459]
100194499  igf1r; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
100194533  eif4e1a; eukaryotic translation initiation factor 4e 1a [KO:K03259]
100194605  akt2; v-akt murine thymoma viral oncogene homolog 2 [KO:K04456] [EC:2.7.11.1]
100194780  mp2k2; Dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100194974  vath; Vacuolar proton pump subunit H [KO:K02144]
100195178  rheb; ras homolog enriched in brain [KO:K07208]
100195278  4f2; 4F2 cell-surface antigen heavy chain [KO:K06519]
100195332  if4ea; Eukaryotic translation initiation factor 4E-1A [KO:K03259]
100195496  tusc4; Tumor suppressor candidate 4 [KO:K20405]
100195739  sec13; SEC13 homolog, nuclear pore and COPII coat complex component [KO:K14004]
100196020  lamtor3; late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 [KO:K04370]
100196036  xip; Hepatitis B virus X-interacting protein [KO:K16344]
100196161  rraga; Ras-related GTP binding A [KO:K16185]
100196208  atp6v1f; ATPase H+ transporting V1 subunit F [KO:K02151]
100196384  if4e2; Eukaryotic translation initiation factor 4E type 2 [KO:K03259]
100196603  rash; GTPase HRas [KO:K02833]
100196724  vatb2; Vacuolar ATP synthase subunit B, brain isoform [KO:K02147]
100196751  tnr1a; Tumor necrosis factor receptor superfamily member 1A [KO:K03158]
100286559  prr5; proline-rich protein 5 [KO:K20411]
100286678  if4e; Eukaryotic translation initiation factor 4E [KO:K03259]
100306767  grb2; growth factor receptor-bound protein 2 [KO:K04364]
100380343  mapkap1; mitogen-activated protein kinase associated protein 1 [KO:K20410]
100380437  rask; GTPase KRas [KO:K07827]
100380484  akts1; Proline-rich AKT1 substrate 1 [KO:K16184]
100380511  mk03; Mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100380530  gats; opposite strand transcription unit to Stag3 [KO:K23080]
100380649  tsc1; hamartin [KO:K07206]
100380750  pdpk1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
100380849  mtor; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
100380867  if4b; eukaryotic translation initiation factor 4B [KO:K03258]
106560227  [KO:K07198] [EC:2.7.11.31]
106560529  [KO:K02649]
106560567  [KO:K04527] [EC:2.7.10.1]
106560701  prr5l; proline rich 5 like [KO:K20411]
106560933  slc7a5; solute carrier family 7 member 5 [KO:K13780]
106560964  [KO:K03068]
106560992  [KO:K00572]
106561138  [KO:K10421]
106561370  VATE1; V-type proton ATPase subunit E 1-like [KO:K02150]
106561428  [KO:K07827]
106561551  [KO:K00182]
106562970  prkaa1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
106563018  [KO:K02649]
106563029  VATG1; V-type proton ATPase subunit G 1-like [KO:K02152]
106563054  [KO:K02147]
106563157  [KO:K21357] [EC:2.7.11.1]
106563501  slc3a2; solute carrier family 3 member 2 [KO:K06519]
106563584  [KO:K04373] [EC:2.7.11.1]
106563593  VATA; V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
106563639  [KO:K03259]
106563815  [KO:K08267]
106563829  [KO:K03875]
106563990  [KO:K19662] [EC:2.7.11.13]
106563994  [KO:K19662] [EC:2.7.11.13]
106564303  [KO:K07207]
106564671  [KO:K04364]
106564790  [KO:K03099]
106564869  [KO:K04456] [EC:2.7.11.1]
106564882  [KO:K02677] [EC:2.7.11.13]
106564921  [KO:K07204]
106564929  depdc5; DEP domain containing 5 [KO:K20404]
106565140  RHOA; transforming protein RhoA-like [KO:K04513]
106565215  [KO:K15728] [EC:3.1.3.4]
106565230  [KO:K03258]
106565454  [KO:K07206]
106565616  [KO:K00408]
106566047  [KO:K00182]
106566325  ulk1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
106566397  XIP; ragulator complex protein LAMTOR5-like [KO:K16344]
106566524  [KO:K00444]
106566606  [KO:K00572]
106566757  RAF1a; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
106566794  RHOA; transforming protein RhoA-like [KO:K04513]
106566835  [KO:K04513]
106566905  tti1; TELO2 interacting protein 1 [KO:K20403]
106566970  [KO:K03258]
106567052  [KO:K03209]
106567053  [KO:K01357]
106567255  dvl1; dishevelled segment polarity protein 1 [KO:K02353]
106567382  [KO:K13780]
106567387  [KO:K03158]
106567474  INS; insulin [KO:K04526]
106567520  [KO:K20400]
106567563  [KO:K23081]
106567700  [KO:K02649]
106567714  [KO:K02842]
106567829  VATG1; V-type proton ATPase subunit G 1-like [KO:K02152]
106567885  [KO:K16172]
106567945  [KO:K01384]
106567964  [KO:K04688] [EC:2.7.11.1]
106568050  [KO:K01384]
106568168  [KO:K08267]
106568170  [KO:K03875]
106568293  [KO:K10421]
106568674  [KO:K07198] [EC:2.7.11.31]
106568747  [KO:K00922] [EC:2.7.1.153]
106568833  [KO:K02375]
106568930  [KO:K02353]
106568949  [KO:K02649]
106569247  [KO:K15705] [EC:2.3.2.27]
106569340  wnt9a; Wnt family member 9A [KO:K01064]
106569341  wnt3a; Wnt family member 3A [KO:K00312]
106569403  [KO:K02649]
106569535  [KO:K04369] [EC:2.7.12.2]
106569546  [KO:K07298] [EC:2.7.11.1]
106569856  [KO:K02432]
106570052  [KO:K15728] [EC:3.1.3.4]
106570349  [KO:K20064]
106570356  SGK1; serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
106570373  [KO:K16186]
106570952  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106571436  [KO:K02329]
106571474  [KO:K04456] [EC:2.7.11.1]
106571479  slc38a9; solute carrier family 38 member 9 [KO:K14995]
106571591  fzd3; frizzled class receptor 3 [KO:K02329]
106571673  VATD; V-type proton ATPase subunit D [KO:K02149]
106571899  [KO:K00572]
106571905  RAF1b; RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
106572042  RHOA; transforming protein RhoA-like [KO:K04513]
106572046  pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
106572151  [KO:K13780]
106572261  RHOA; transforming protein RhoA [KO:K04513]
106572388  [KO:K02353]
106572674  [KO:K03209]
106572675  [KO:K01357]
106572753  [KO:K03258]
106572931  [KO:K20402]
106572962  [KO:K04513]
106573123  [KO:K00182]
106573361  [KO:K02833]
106573370  PRR5; proline-rich protein 5-like [KO:K20411]
106573605  [KO:K07298] [EC:2.7.11.1]
106573620  [KO:K03068]
106573635  [KO:K13780]
106573762  [KO:K05087] [EC:2.7.10.1]
106573852  [KO:K17532]
106573900  [KO:K02649]
106574245  [KO:K02432]
106574304  [KO:K03083] [EC:2.7.11.26]
106574888  [KO:K02375]
106574923  [KO:K17532]
106575154  [KO:K03083] [EC:2.7.11.26]
106575172  [KO:K02432]
106575188  [KO:K03158]
106575510  [KO:K08272]
106575554  [KO:K08272]
106575957  [KO:K00572]
106576032  [KO:K20399]
106576171  [KO:K01558]
106576269  VATE1; V-type proton ATPase subunit E 1-like [KO:K02150]
106576365  [KO:K20411]
106576564  [KO:K00408]
106577009  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106577129  [KO:K09594]
106577209  [KO:K00714]
106577211  [KO:K08270]
106577251  IF4E; eukaryotic translation initiation factor 4E-like [KO:K03259]
106577395  [KO:K08270]
106577633  [KO:K16172]
106577635  [KO:K02353]
106578137  [KO:K06519]
106578250  telo2; telomere maintenance 2 [KO:K11137]
106578258  [KO:K20408]
106578264  [KO:K06276] [EC:2.7.11.1]
106578482  [KO:K02376]
106578536  [KO:K02375]
106578589  [KO:K15705] [EC:2.3.2.27]
106578699  [KO:K15728] [EC:3.1.3.4]
106578954  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106579053  [KO:K02432]
106579140  [KO:K02148]
106579219  wdr24; WD repeat domain 24 [KO:K20408]
106579286  [KO:K04467] [EC:2.7.11.10]
106579325  [KO:K00312]
106579422  [KO:K04467] [EC:2.7.11.10]
106579446  VATA; V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
106579471  [KO:K04373] [EC:2.7.11.1]
106579659  [KO:K07208]
106579904  [KO:K20064]
106579912  fzd10; frizzled class receptor 10 [KO:K02842]
106579916  [KO:K21357] [EC:2.7.11.1]
106580340  4EBP2; eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
106580364  [KO:K10421]
106580426  ikbkb; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
106580589  [KO:K08267]
106580651  MAPIP; ragulator complex protein LAMTOR2 [KO:K20398]
106580877  [KO:K02842]
106581130  [KO:K04688] [EC:2.7.11.1]
106581221  [KO:K08269] [EC:2.7.11.1]
106581334  [KO:K04456] [EC:2.7.11.1]
106581356  [KO:K08272]
106581359  [KO:K00922] [EC:2.7.1.153]
106581407  [KO:K20397]
106581418  fzd4; frizzled class receptor 4 [KO:K02354]
106581835  [KO:K01357]
106581837  wnt6; Wnt family member 6 [KO:K00445]
106582120  gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
106582151  [KO:K20407]
106582378  [KO:K02375]
106582548  [KO:K02432]
106582637  [KO:K04456] [EC:2.7.11.1]
106582735  RHOC; rho-related GTP-binding protein RhoC [KO:K04513]
106582740  [KO:K00182]
106582798  nprl2; NPR2-like, GATOR1 complex subunit [KO:K20405]
106582886  [KO:K20402]
106583123  [KO:K00408]
106583224  rhebl1; Ras homolog enriched in brain like 1 [KO:K07208]
106583462  RHOA; transforming protein RhoA-like [KO:K04513]
106583597  [KO:K15728] [EC:3.1.3.4]
106583950  [KO:K04527] [EC:2.7.10.1]
106584012  [KO:K02649]
106584071  tbc1d7; TBC1 domain family member 7 [KO:K20396]
106584208  prkaa2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
106584495  [KO:K00572]
106584773  [KO:K03099]
106584829  map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106585162  [KO:K08267]
106585238  gatsl3; GATS protein like 3 [KO:K23080]
106585258  4EBP2; eukaryotic translation initiation factor 4E-binding protein 2-like [KO:K07205]
106585282  [KO:K10421]
106585529  [KO:K02842]
106585772  [KO:K04456] [EC:2.7.11.1]
106586152  [KO:K00445]
106586153  [KO:K01357]
106586337  [KO:K02375]
106586650  [KO:K03083] [EC:2.7.11.26]
106587014  tsc1; tuberous sclerosis 1 [KO:K07206]
106587034  [KO:K02649]
106587111  [KO:K04364]
106587978  [KO:K13780]
106588078  [KO:K05087] [EC:2.7.10.1]
106588110  [KO:K07204]
106588117  [KO:K20409]
106588534  fzd1; frizzled class receptor 1 [KO:K02432]
106588785  [KO:K20064]
106589037  [KO:K13302] [EC:2.7.11.1]
106589058  [KO:K03156]
106589264  [KO:K04467] [EC:2.7.11.10]
106589299  [KO:K00312]
106589390  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106589564  mlst8; MTOR associated protein, LST8 homolog [KO:K08266]
106589689  [KO:K04456] [EC:2.7.11.1]
106589820  [KO:K04373] [EC:2.7.11.1]
106590060  [KO:K15705] [EC:2.3.2.27]
106590143  [KO:K15728] [EC:3.1.3.4]
106590380  [KO:K07208]
106590474  VATA; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
106590479  [KO:K04373] [EC:2.7.11.1]
106591125  SGK1; serine/threonine-protein kinase Sgk1-like [KO:K13302] [EC:2.7.11.1]
106592002  RHOA; transforming protein RhoA-like [KO:K04513]
106592057  [KO:K04371] [EC:2.7.11.24]
106592479  [KO:K08270]
106592571  [KO:K07208]
106592818  [KO:K13302] [EC:2.7.11.1]
106593510  [KO:K13302] [EC:2.7.11.1]
106593595  [KO:K13302] [EC:2.7.11.1]
106593748  [KO:K19662] [EC:2.7.11.13]
106594083  [KO:K13302] [EC:2.7.11.1]
106594520  [KO:K19662] [EC:2.7.11.13]
106594566  [KO:K14299]
106594672  [KO:K14299]
106595801  [KO:K13780]
106595987  [KO:K02144]
106596806  [KO:K07208]
106597455  [KO:K16184]
106598808  [KO:K00922] [EC:2.7.1.153]
106599005  [KO:K02649]
106599063  [KO:K02353]
106599351  [KO:K15705] [EC:2.3.2.27]
106599491  [KO:K02375]
106599872  [KO:K00312]
106599874  [KO:K01064]
106599971  [KO:K07298] [EC:2.7.11.1]
106600405  [KO:K02649]
106600441  [KO:K04369] [EC:2.7.12.2]
106600510  [KO:K04527] [EC:2.7.10.1]
106600575  eif4e2; eukaryotic translation initiation factor 4E family member 2 [KO:K03259]
106600714  [KO:K04371] [EC:2.7.11.24]
106600774  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106601035  [KO:K02235]
106601082  [KO:K20406]
106601131  [KO:K01064]
106601514  [KO:K16184]
106601546  [KO:K16184]
106601599  sos2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
106601607  [KO:K08271]
106601908  [KO:K07827]
106602463  [KO:K16186]
106602694  [KO:K04688] [EC:2.7.11.1]
106602804  RS6; 40S ribosomal protein S6 [KO:K02991]
106602818  [KO:K02353]
106602915  [KO:K04456] [EC:2.7.11.1]
106603053  VATA; V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
106603065  [KO:K04373] [EC:2.7.11.1]
106603161  [KO:K06519]
106603405  [KO:K01384]
106603521  [KO:K04688] [EC:2.7.11.1]
106603540  [KO:K01384]
106603593  [KO:K16172]
106603626  [KO:K02842]
106603747  [KO:K23081]
106603820  [KO:K20400]
106603941  INS; insulin-like [KO:K04526]
106604080  [KO:K04373] [EC:2.7.11.1]
106604409  [KO:K00714]
106604410  [KO:K00714]
106604514  IF4EA; eukaryotic translation initiation factor 4E-1A [KO:K03259]
106605136  [KO:K16186]
106605261  [KO:K20407]
106605307  MAPIP; ragulator complex protein LAMTOR2 [KO:K20398]
106605415  [KO:K20064]
106605515  [KO:K02432]
106605516  [KO:K02432]
106605527  [KO:K02148]
106605646  [KO:K02376]
106605767  [KO:K09594]
106605854  [KO:K00408]
106606379  [KO:K07827]
106606872  [KO:K08271]
106606916  akt1s1; AKT1 substrate 1 [KO:K16184]
106607067  [KO:K04364]
106607213  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106607305  [KO:K02235]
106607324  [KO:K01064]
106607353  [KO:K06276] [EC:2.7.11.1]
106607369  [KO:K20406]
106607890  [KO:K04456] [EC:2.7.11.1]
106608120  [KO:K02329]
106608215  VATD; V-type proton ATPase subunit D-like [KO:K02149]
106608398  [KO:K03259]
106608511  [KO:K00714]
106608773  [KO:K02353]
106608778  [KO:K16172]
106609141  [KO:K02151]
106609143  [KO:K20399]
106609305  [KO:K01558]
106609471  [KO:K02150]
106609475  [KO:K05459]
106609811  [KO:K00444]
106609967  [KO:K04688] [EC:2.7.11.1]
106609995  RS6; 40S ribosomal protein S6-like [KO:K02991]
106610660  [KO:K04373] [EC:2.7.11.1]
106610734  [KO:K15728] [EC:3.1.3.4]
106610748  [KO:K02329]
106610858  [KO:K04456] [EC:2.7.11.1]
106611443  [KO:K03099]
106612044  [KO:K08272]
106612054  [KO:K04526]
106612406  [KO:K02353]
106612416  irs1; insulin receptor substrate 1 [KO:K16172]
106612512  [KO:K04373] [EC:2.7.11.1]
106612580  [KO:K02842]
106612640  [KO:K04373] [EC:2.7.11.1]
106612954  [KO:K08269] [EC:2.7.11.1]
106613000  [KO:K04688] [EC:2.7.11.1]
106613111  [KO:K04456] [EC:2.7.11.1]
106613169  [KO:K08272]
106613172  [KO:K00922] [EC:2.7.1.153]
106613227  lamtor1; late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 [KO:K20397]
106613635  [KO:K02649]
106613746  [KO:K07298] [EC:2.7.11.1]
106613775  [KO:K04369] [EC:2.7.12.2]
106613931  pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
sasa00561  Glycerolipid metabolism
sasa04010  MAPK signaling pathway
sasa04140  Autophagy - animal
sasa04810  Regulation of actin cytoskeleton
sasa04910  Insulin signaling pathway
KO pathway
ko04150   

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