KEGG   PATHWAY: tmu00230
Entry
tmu00230                    Pathway                                
Name
Purine metabolism - Trichechus manatus latirostris (Florida manatee)
Class
Metabolism; Nucleotide metabolism
Pathway map
tmu00230  Purine metabolism
tmu00230

Module
tmu_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:tmu00230]
tmu_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:tmu00230]
tmu_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:tmu00230]
tmu_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:tmu00230]
tmu_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:tmu00230]
tmu_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:tmu00230]
tmu_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:tmu00230]
Other DBs
GO: 0006163 0042278
Organism
Trichechus manatus latirostris (Florida manatee) [GN:tmu]
Gene
101341968  ADP-ribose pyrophosphatase, mitochondrial isoform X1 [KO:K13988] [EC:3.6.1.13]
101361939  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase isoform X1 [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
101350654  ADP-sugar pyrophosphatase isoform X1 [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
101344997  phosphoglucomutase-1 isoform X3 [KO:K01835] [EC:5.4.2.2]
101341263  phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
101352195  ribose-phosphate pyrophosphokinase 3 [KO:K00948] [EC:2.7.6.1]
101348973  ribose-phosphate pyrophosphokinase 2 isoform X2 [KO:K00948] [EC:2.7.6.1]
101347261  ribose-phosphate pyrophosphokinase 1 isoform X2 [KO:K00948] [EC:2.7.6.1]
101346508  amidophosphoribosyltransferase isoform X1 [KO:K00764] [EC:2.4.2.14]
101354872  trifunctional purine biosynthetic protein adenosine-3 [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
101354335  phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
101346245  multifunctional protein ADE2 isoform X1 [KO:K01587] [EC:4.1.1.21 6.3.2.6]
101347072  adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
101360843  bifunctional purine biosynthesis protein PURH isoform X1 [KO:K00602] [EC:2.1.2.3 3.5.4.10]
101357298  adenine phosphoribosyltransferase isoform X1 [KO:K00759] [EC:2.4.2.7]
101357010  cytosolic purine 5'-nucleotidase isoform X1 [KO:K01081] [EC:3.1.3.5]
101353804  5'(3')-deoxyribonucleotidase, cytosolic type [KO:K01081] [EC:3.1.3.5]
101342914  uncharacterized protein LOC101342914 [KO:K01081] [EC:3.1.3.5]
101344819  cytosolic 5'-nucleotidase 1B isoform X2 [KO:K01081] [EC:3.1.3.5]
101355585  cytosolic 5'-nucleotidase 1A [KO:K01081] [EC:3.1.3.5]
101354022  5'(3')-deoxyribonucleotidase, mitochondrial [KO:K01081] [EC:3.1.3.5]
101361475  LOW QUALITY PROTEIN: 5'-nucleotidase domain-containing protein 4 [KO:K01081] [EC:3.1.3.5]
101342966  5'-nucleotidase isoform X1 [KO:K19970] [EC:3.1.3.5]
101344928  purine nucleoside phosphorylase [KO:K03783] [EC:2.4.2.1]
101341156  laccase domain-containing protein 1 isoform X1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
101359374  hypoxanthine-guanine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
101353348  inosine-5'-monophosphate dehydrogenase 2 isoform X2 [KO:K00088] [EC:1.1.1.205]
101341763  inosine-5'-monophosphate dehydrogenase 1 isoform X1 [KO:K00088] [EC:1.1.1.205]
101348353  nucleoside diphosphate kinase A [KO:K00940] [EC:2.7.4.6]
105755966  nucleoside diphosphate kinase B [KO:K00940] [EC:2.7.4.6]
101346953  nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
101358423  nucleoside diphosphate kinase 7 isoform X3 [KO:K00940] [EC:2.7.4.6]
101361334  nucleoside diphosphate kinase, mitochondrial isoform X2 [KO:K00940] [EC:2.7.4.6]
101354164  nucleoside diphosphate kinase 3 [KO:K00940] [EC:2.7.4.6]
101357538  adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
101351112  ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
101352957  ectonucleoside triphosphate diphosphohydrolase 8 isoform X1 [KO:K01510] [EC:3.6.1.5]
101351024  ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
101346902  soluble calcium-activated nucleotidase 1 isoform X1 [KO:K12304] [EC:3.6.1.6]
101341093  ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
101351128  ectonucleoside triphosphate diphosphohydrolase 5 [KO:K01511] [EC:3.6.1.6]
101344215  ectonucleoside triphosphate diphosphohydrolase 6 isoform X3 [KO:K01511] [EC:3.6.1.6]
101360252  U8 snoRNA-decapping enzyme [KO:K16855] [EC:3.6.1.62 3.6.1.64]
101345228  inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
101349074  xanthine dehydrogenase/oxidase [KO:K00106] [EC:1.17.1.4 1.17.3.2]
101361419  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
101358318  GMP synthase [glutamine-hydrolyzing] [KO:K01951] [EC:6.3.5.2]
101358418  GMP reductase 1 [KO:K00364] [EC:1.7.1.7]
101347982  GMP reductase 2 isoform X2 [KO:K00364] [EC:1.7.1.7]
101351169  guanine deaminase isoform X1 [KO:K01487] [EC:3.5.4.3]
101346166  guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
101347185  ribonucleoside-diphosphate reductase large subunit isoform X1 [KO:K10807] [EC:1.17.4.1]
101350939  ribonucleoside-diphosphate reductase subunit M2 B isoform X2 [KO:K10808] [EC:1.17.4.1]
101349095  ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
101343114  HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
101350421  deoxyguanosine kinase, mitochondrial isoform X1 [KO:K00904] [EC:2.7.1.113]
101361286  deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
101354393  guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 isoform X1 [KO:K21138] [EC:3.1.7.2]
101348320  exopolyphosphatase PRUNE1 isoform X1 [KO:K01514] [EC:3.6.1.11]
101354868  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101360334  adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101349290  adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101350438  adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
101346041  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101349243  adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
101341715  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101350704  adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101344705  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101355469  adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
101357819  guanylate cyclase soluble subunit alpha-3 isoform X1 [KO:K12318] [EC:4.6.1.2]
101360343  guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
101347250  guanylate cyclase soluble subunit beta-2-like [KO:K12319] [EC:4.6.1.2]
101344143  guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
101340932  heat-stable enterotoxin receptor [KO:K12320] [EC:4.6.1.2]
101355713  LOW QUALITY PROTEIN: olfactory guanylyl cyclase GC-D-like [KO:K12321] [EC:4.6.1.2]
101355351  retinal guanylyl cyclase 1 [KO:K12321] [EC:4.6.1.2]
101350816  LOW QUALITY PROTEIN: retinal guanylyl cyclase 2 [KO:K12322] [EC:4.6.1.2]
101346990  LOW QUALITY PROTEIN: guanylate cyclase 2G-like [KO:K22600] [EC:4.6.1.2]
101346019  atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
101351573  atrial natriuretic peptide receptor 2 isoform X3 [KO:K12324] [EC:4.6.1.2]
101346598  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2 [KO:K13755] [EC:3.1.4.17]
101361935  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X2 [KO:K13755] [EC:3.1.4.17]
101349364  calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
101352129  cGMP-dependent 3',5'-cyclic phosphodiesterase [KO:K18283] [EC:3.1.4.17]
101356528  cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
101355565  cGMP-inhibited 3',5'-cyclic phosphodiesterase B isoform X1 [KO:K13296] [EC:3.1.4.17]
101346605  cGMP-specific 3',5'-cyclic phosphodiesterase isoform X5 [KO:K13762] [EC:3.1.4.35]
101361809  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha isoform X1 [KO:K08718] [EC:3.1.4.35]
101353583  rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta [KO:K13756] [EC:3.1.4.35]
101344182  cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
101354801  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
101343329  retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
101342955  retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13760]
101347868  high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [KO:K13761] [EC:3.1.4.35]
101361722  cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
101354922  dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
101351615  LOW QUALITY PROTEIN: adenylosuccinate synthetase isozyme 2-like [KO:K01939] [EC:6.3.4.4]
101359972  adenylosuccinate synthetase isozyme 1 [KO:K01939] [EC:6.3.4.4]
101353998  adenylosuccinate synthetase isozyme 2 isoform X1 [KO:K01939] [EC:6.3.4.4]
101345409  AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
101349755  AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
101344478  AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
101348960  adenosine kinase isoform X1 [KO:K00856] [EC:2.7.1.20]
101351984  adenosine deaminase-like [KO:K01488] [EC:3.5.4.4]
101352502  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
101355879  adenosine deaminase 2 [KO:K19572] [EC:3.5.4.4]
101359934  adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
101346867  adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
101354754  adenylate kinase 7 isoform X1 [KO:K00939] [EC:2.7.4.3]
101347160  adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
101348773  adenylate kinase isoenzyme 1-like [KO:K00939] [EC:2.7.4.3]
101353376  adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
101348429  adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
102314692  AK6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
101359179  GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
101351206  ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509] [EC:3.6.1.-]
101360478  cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
101354629  ectonucleotide pyrophosphatase/phosphodiesterase family member 1 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
101354222  ectonucleotide pyrophosphatase/phosphodiesterase family member 3 [KO:K01513] [EC:3.1.4.1 3.6.1.9]
101347326  ectonucleotide pyrophosphatase/phosphodiesterase family member 3-like [KO:K01513] [EC:3.1.4.1 3.6.1.9]
101348308  cAMP-specific 3',5'-cyclic phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
101356469  cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
101356814  cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
101343028  cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
101346864  cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
101346038  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
101358375  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
101359618  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [KO:K18437] [EC:3.1.4.53]
111819740  bis(5'-adenosyl)-triphosphatase isoform X1 [KO:K01522] [EC:3.6.1.29]
101346584  bis(5'-adenosyl)-triphosphatase ENPP4 isoform X2 [KO:K18424] [EC:3.6.1.29]
101354731  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
101343965  bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 isoform X1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
101357598  LOW QUALITY PROTEIN: uricase-like [KO:K00365] [EC:1.7.3.3]
101351791  putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
101354494  probable allantoicase [KO:K01477] [EC:3.5.3.4]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
tmu00030  Pentose phosphate pathway
tmu00220  Arginine biosynthesis
tmu00250  Alanine, aspartate and glutamate metabolism
tmu00260  Glycine, serine and threonine metabolism
tmu00340  Histidine metabolism
tmu00630  Glyoxylate and dicarboxylate metabolism
tmu00730  Thiamine metabolism
tmu00740  Riboflavin metabolism
tmu00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

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