KEGG   PATHWAY: vko04820
Entry
vko04820                    Pathway                                
Name
Cytoskeleton in muscle cells - Varanus komodoensis (Komodo dragon)
Class
Cellular Processes; Cell motility
Pathway map
vko04820  Cytoskeleton in muscle cells
vko04820

Organism
Varanus komodoensis (Komodo dragon) [GN:vko]
Gene
123023145  COL1A2; collagen alpha-2(I) chain [KO:K06236]
123030585  COL1A1; collagen alpha-1(I) chain [KO:K06236]
123021850  COL3A1; collagen alpha-1(III) chain [KO:K19720]
123035206  COL5A1; collagen alpha-1(V) chain [KO:K19721]
123021838  COL5A2; collagen alpha-2(V) chain isoform X1 [KO:K19721]
123024129  COL5A3; collagen alpha-3(V) chain [KO:K19721]
123028298  COL27A1; collagen alpha-1(XXVII) chain [KO:K19721]
123024498  COL11A1; collagen alpha-1(XI) chain [KO:K19721]
123021083  COL11A2; collagen alpha-2(XI) chain [KO:K19721]
123036130  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
123019009  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
123020787  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
123036482  DCN; decorin [KO:K04660]
123031339  VCAN; versican core protein [KO:K06793]
123036685  ELN; elastin [KO:K14211]
123036423  collagen alpha-6(VI) chain-like isoform X1 [KO:K06238]
123036443  collagen alpha-6(VI) chain-like isoform X1 [KO:K06238]
123036460  collagen alpha-6(VI) chain-like [KO:K06238]
123017648  collagen alpha-6(VI) chain-like [KO:K06238]
123024321  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
123024337  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
123024343  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
123026431  THBS1; thrombospondin-1 [KO:K16857]
123036589  cartilage oligomeric matrix protein [KO:K04659]
123032590  THBS3; thrombospondin-3 [KO:K04659]
123031382  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
123024037  THBS2; thrombospondin-2 [KO:K04659]
123027703  FBN1; fibrillin-1 [KO:K06825]
123031547  FBN2; fibrillin-2 isoform X1 [KO:K23342]
123017587  FBN3; fibrillin-3 [KO:K23342]
123021959  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
123022099  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
123024236  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
123024237  collagen alpha-2(IV) chain-like [KO:K06237]
123024699  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
123024736  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
123033912  FBLN1; fibulin-1 isoform X1 [KO:K17307]
123034248  FBLN2; fibulin-2 isoform X1 [KO:K17307]
123018832  HSPG2; LOW QUALITY PROTEIN: basement membrane-specific heparan sulfate proteoglycan core protein [KO:K06255]
123018149  NID1; nidogen-1 [KO:K06826]
123026531  NID2; nidogen-2 [KO:K06826]
123024256  FN1; fibronectin isoform X1 [KO:K05717]
123030866  SDC1; syndecan-1 [KO:K06257]
123020415  SDC2; syndecan-2 isoform X1 [KO:K16336]
123025824  SDC3; syndecan-3 isoform X1 [KO:K16337]
123028462  SDC4; syndecan-4 isoform X1 [KO:K16338]
123031022  AGRN; agrin isoform X1 [KO:K06254]
123030143  BGN; biglycan [KO:K08118]
123020529  desmocollin-1-like [KO:K07601]
123020533  desmocollin-1-like isoform X1 [KO:K07601]
123020557  desmoglein-2-like [KO:K07597]
123025374  PKP2; plakophilin-2 [KO:K12642]
123031787  junction plakoglobin [KO:K10056]
123036303  desmoplakin isoform X1 [KO:K10381]
123025432  vimentin-like [KO:K07606]
123020743  VIM; vimentin [KO:K07606]
123027421  DES; desmin [KO:K07610]
123021514  LAMA1; laminin subunit alpha-1 [KO:K05637]
123020696  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
123031236  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
123031378  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
123017359  ITGA2B; integrin alpha-IIb [KO:K06476]
123030541  ITGA3; integrin alpha-3 [KO:K06482]
123021829  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
123029770  integrin alpha-5-like isoform X1 [KO:K06484]
123017144  ITGA6; integrin alpha-6 [KO:K06485]
123033162  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
123020732  ITGA8; integrin alpha-8 [KO:K06584]
123036032  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
123032986  ITGA10; integrin alpha-10 [KO:K06586]
123030739  ITGA11; integrin alpha-11 [KO:K06587]
123030840  ITGAV; integrin alpha-V [KO:K06487]
123020659  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
123031724  ITGB3; integrin beta-3 [KO:K06493]
123035494  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
123027440  ITGB5; integrin beta-5 [KO:K06588]
123016972  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
123029808  ITGB7; integrin beta-7 [KO:K06590]
123022885  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
123027758  TLN2; talin-2 [KO:K06271]
123030195  TLN1; talin-1 isoform X1 [KO:K06271]
123018307  VCL; vinculin isoform X1 [KO:K05700]
123032654  ACTN3; alpha-actinin-3 [KO:K21073]
123018102  ACTN2; alpha-actinin-2 [KO:K21073]
123036901  ACTG1; actin, cytoplasmic 2 [KO:K05692]
123033814  actin, clone 302-like [KO:K05692]
123024932  ACTB; actin, cytoplasmic 1 [KO:K05692]
123016825  ACTG2; actin, gamma-enteric smooth muscle isoform X1 [KO:K12315]
123034348  DAG1; dystroglycan [KO:K06265]
123030586  SGCA; alpha-sarcoglycan isoform X1 [KO:K12565]
123022883  SGCE; epsilon-sarcoglycan isoform X1 [KO:K27061]
123016984  SGCB; beta-sarcoglycan [KO:K12566]
123034025  SGCD; delta-sarcoglycan [KO:K12563]
123029282  SGCG; gamma-sarcoglycan [KO:K12564]
123017092  SGCZ; zeta-sarcoglycan isoform X1 [KO:K27062]
123020083  SSPN; sarcospan [KO:K22194]
123028976  DMD; dystrophin isoform X1 [KO:K10366]
123031964  SNTA1; alpha-1-syntrophin [KO:K24063]
123022160  SNTB2; beta-2-syntrophin [KO:K24064]
123019178  SNTB1; beta-1-syntrophin [KO:K24064]
123020383  DTNA; dystrobrevin alpha isoform X1 [KO:K26998]
123023084  FLNC; filamin-C isoform X1 [KO:K27393]
123034800  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
123023542  sodium/potassium-transporting ATPase subunit alpha-2-like [KO:K01539] [EC:7.2.2.13]
123019603  sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
123025794  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
123022026  ATP1B4; protein ATP1B4 [KO:K01540]
123016684  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
123024668  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
123029063  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
123018376  ANK3; ankyrin-3 isoform X1 [KO:K09259]
123028283  SPTAN1; spectrin alpha chain, non-erythrocytic 1 isoform X1 [KO:K06114]
123023178  SPTBN1; spectrin beta chain, non-erythrocytic 1 isoform X1 [KO:K06115]
123026291  SPTBN5; spectrin beta chain, non-erythrocytic 5 [KO:K06115]
123021036  SPTBN4; LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 4 [KO:K06115]
123032671  SPTBN2; spectrin beta chain, non-erythrocytic 2 [KO:K23932]
123032273  CSRP1; cysteine and glycine-rich protein 1 [KO:K09377]
123036491  CSRP2; cysteine and glycine-rich protein 2 [KO:K09377]
123026947  CSRP3; cysteine and glycine-rich protein 3 [KO:K09377]
123035430  myosin-3 [KO:K24220]
123035431  LOW QUALITY PROTEIN: myosin-4-like [KO:K24220]
123031951  MYH7B; myosin-7B [KO:K24220]
123029028  MYH15; myosin-15 [KO:K24220]
123018648  myosin-7 [KO:K17751]
123018649  myosin-6-like [KO:K17751]
123035475  MYH10; myosin-10 isoform X1 [KO:K10352]
123032104  myosin-10-like isoform X1 [KO:K10352]
123028915  MYH9; myosin-9 [KO:K10352]
123025059  MYH11; myosin-11 isoform X1 [KO:K10352]
123024320  MYL1; myosin light chain 1/3, skeletal muscle isoform isoform X1 [KO:K05738]
123020771  MYL3; myosin light chain 3 [KO:K12749]
123031796  MYL4; myosin light chain 4 [KO:K12750]
123028625  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
123030174  MYL5; myosin light chain 5 [KO:K12753]
123027005  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
123031968  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
123032173  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
123028827  MYBPC1; myosin-binding protein C, slow-type isoform X1 [KO:K12557]
123030510  MYBPC2; myosin-binding protein C, fast-type [KO:K12558]
123026510  MYBPC3; myosin-binding protein C, cardiac-type isoform X1 [KO:K12568]
123031955  MYBPH; myosin-binding protein H [KO:K24494]
123018449  ACTA1; actin, alpha skeletal muscle [KO:K10354]
123026375  actin, alpha cardiac muscle 1-like [KO:K12314]
123026633  ACTC1; actin, alpha cardiac muscle 1 [KO:K12314]
123034330  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
123024424  TNNI1; LOW QUALITY PROTEIN: troponin I, slow skeletal muscle [KO:K10371]
123032082  TNNT1; troponin T, slow skeletal muscle [KO:K10372]
123018838  TNNC2; troponin C, skeletal muscle [KO:K12042]
123021321  TNNI2; troponin I, fast skeletal muscle [KO:K12043]
123021374  TNNT3; troponin T, fast skeletal muscle [KO:K12046]
123032274  TNNI3; troponin I, cardiac muscle [KO:K12044]
123032243  TNNT2; troponin T, cardiac muscle isoform X1 [KO:K12045]
123027649  TPM1; tropomyosin alpha-1 chain isoform X1 [KO:K10373]
123030226  TPM2; tropomyosin beta chain isoform X1 [KO:K10374]
123032519  tropomyosin alpha-3 chain isoform X1 [KO:K09290]
123016504  tropomyosin alpha-1 chain-like [KO:K10375]
123021802  TTN; titin isoform X1 [KO:K12567] [EC:2.7.11.1]
123035790  MYOT; myotilin isoform X1 [KO:K19875]
123031834  telethonin [KO:K19879]
123022707  SYNPO2; synaptopodin-2 [KO:K24066]
123020640  NEBL; nebulette isoform X1 [KO:K25865]
123018259  MYOZ1; myozenin-1 [KO:K26050]
123022952  MYOZ2; myozenin-2 [KO:K26050]
123035845  MYOZ3; myozenin-3 [KO:K26050]
123035798  PDLIM4; PDZ and LIM domain protein 4 [KO:K23353]
123036099  PDLIM3; PDZ and LIM domain protein 3 isoform X1 [KO:K23353]
123027091  PDLIM2; PDZ and LIM domain protein 2 [KO:K23353]
123018297  PDLIM1; PDZ and LIM domain protein 1 [KO:K23353]
123034659  CAPZA3; F-actin-capping protein subunit alpha-3 [KO:K10364]
123034704  F-actin-capping protein subunit alpha-1-like [KO:K10364]
123031869  CAPZA1; F-actin-capping protein subunit alpha-1 [KO:K10364]
123019864  CAPZA2; F-actin-capping protein subunit alpha-2 isoform X1 [KO:K10364]
123030977  CAPZB; F-actin-capping protein subunit beta isoform X1 [KO:K10365]
123020669  XIRP1; xin actin-binding repeat-containing protein 1 [KO:K27381]
123017091  XIRP2; xin actin-binding repeat-containing protein 2 [KO:K27381]
123027880  nebulin-related-anchoring protein isoform X1 [KO:K24421]
123018396  MYPN; myopalladin isoform X1 [KO:K22028]
123033960  PDLIM7; PDZ and LIM domain protein 7 isoform X1 [KO:K19867]
123022541  PDZ and LIM domain protein 5-like [KO:K19867]
123018367  LDB3; LIM domain-binding protein 3 isoform X1 [KO:K19867]
123032946  TMOD4; tropomodulin-4 [KO:K10370]
123027614  tropomodulin-3-like isoform X1 [KO:K10370]
123027615  tropomodulin-2 [KO:K10370]
123028052  TMOD1; tropomodulin-1 isoform X1 [KO:K10370]
123028100  ZYX; zyxin isoform X1 [KO:K06273]
123034898  FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365]
123022505  FHL2; four and a half LIM domains protein 2 [KO:K14380]
123018892  FHL3; four and a half LIM domains protein 3 [KO:K24414]
123034424  LMOD3; leiomodin-3 [KO:K22030]
123031943  LMOD1; leiomodin-1 [KO:K22030]
123019914  LMOD2; leiomodin-2 [KO:K22030]
123018479  ANKRD1; ankyrin repeat domain-containing protein 1 [KO:K21433]
123026684  ANKRD2; ankyrin repeat domain-containing protein 2 [KO:K21434]
123027019  ANKRD23; ankyrin repeat domain-containing protein 23 [KO:K21438]
123031702  FMNL1; formin-like protein 1 isoform X1 [KO:K23957]
123017076  FMNL2; formin-like protein 2 isoform X1 [KO:K23957]
123019199  FMNL3; formin-like protein 3 isoform X1 [KO:K23957]
123026434  inverted formin-2-like isoform X1 [KO:K23958]
123029140  DAAM2; disheveled-associated activator of morphogenesis 2 isoform X1 [KO:K04512]
123026655  DAAM1; disheveled-associated activator of morphogenesis 1 isoform X1 [KO:K04512]
123029682  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
123021955  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
123032391  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
123034106  FMN2; formin-2 [KO:K02184]
123017431  MYOM3; myomesin-3 [KO:K24495]
123017686  MYOM2; myomesin-2 [KO:K24495]
123020333  MYOM1; myomesin-1 isoform X1 [KO:K24495]
123033238  ENO2; gamma-enolase [KO:K01689] [EC:4.2.1.11]
123016692  ENO3; beta-enolase [KO:K01689] [EC:4.2.1.11]
123031011  ENO1; alpha-enolase isoform X1 [KO:K01689] [EC:4.2.1.11]
123022993  ANK2; ankyrin-2 isoform X1 [KO:K09255]
123026160  CKM; creatine kinase M-type [KO:K27382] [EC:2.7.3.2]
123018751  TRIM54; tripartite motif-containing protein 54 isoform X1 [KO:K10653]
123036277  tripartite motif-containing protein 54-like [KO:K10654]
123020416  TRIM55; tripartite motif-containing protein 55 isoform X1 [KO:K10654]
123025939  TRIM63; E3 ubiquitin-protein ligase TRIM63 isoform X1 [KO:K10655] [EC:2.3.2.27]
123032066  AMPD1; AMP deaminase 1 [KO:K01490] [EC:3.5.4.6]
123029915  AMPD2; AMP deaminase 2 isoform X1 [KO:K01490] [EC:3.5.4.6]
123021117  AMPD3; AMP deaminase 3 isoform X1 [KO:K01490] [EC:3.5.4.6]
123020800  obscurin-like [KO:K17531] [EC:2.7.11.1]
123026806  CAPN3; calpain-3 isoform X1 [KO:K08573] [EC:3.4.22.54]
123035284  PLEC; plectin isoform X1 [KO:K10388]
123026475  SYNE3; nesprin-3 isoform X1 [KO:K21761]
123019591  SYNE1; nesprin-1 isoform X1 [KO:K19326]
123026242  SYNE2; nesprin-2 isoform X1 [KO:K19346]
123028897  SUN2; SUN domain-containing protein 2 isoform X1 [KO:K19347]
123025278  SUN1; SUN domain-containing protein 1 isoform X1 [KO:K19347]
123034352  TMEM43; transmembrane protein 43 isoform X1 [KO:K27488]
123029934  emerin-like isoform X1 [KO:K12569]
123030092  lamina-associated polypeptide 2-like [KO:K12569]
123025291  LBR; delta(14)-sterol reductase LBR isoform X1 [KO:K19532] [EC:1.3.1.70]
123032910  LMNA; lamin [KO:K12641]
123031475  LMNB1; lamin-B1 [KO:K07611]
123027681  lamin-L(III)-like [KO:K07611]
123018698  LMNB2; lamin-B2 [KO:K07611]
Reference
PMID:12142273
  Authors
Clark KA, McElhinny AS, Beckerle MC, Gregorio CC
  Title
Striated muscle cytoarchitecture: an intricate web of form and function.
  Journal
Annu Rev Cell Dev Biol 18:637-706 (2002)
DOI:10.1146/annurev.cellbio.18.012502.105840
Reference
PMID:31407867
  Authors
Mukund K, Subramaniam S
  Title
Skeletal muscle: A review of molecular structure and function, in health and disease.
  Journal
Wiley Interdiscip Rev Syst Biol Med 12:e1462 (2020)
DOI:10.1002/wsbm.1462
Reference
PMID:24481844
  Authors
Stroud MJ, Banerjee I, Veevers J, Chen J
  Title
Linker of nucleoskeleton and cytoskeleton complex proteins in cardiac structure, function, and disease.
  Journal
Circ Res 114:538-48 (2014)
DOI:10.1161/CIRCRESAHA.114.301236
Reference
PMID:28640448
  Authors
Henderson CA, Gomez CG, Novak SM, Mi-Mi L, Gregorio CC
  Title
Overview of the Muscle Cytoskeleton.
  Journal
Compr Physiol 7:891-944 (2017)
DOI:10.1002/cphy.c160033
Reference
PMID:32265741
  Authors
Csapo R, Gumpenberger M, Wessner B
  Title
Skeletal Muscle Extracellular Matrix - What Do We Know About Its Composition, Regulation, and Physiological Roles? A Narrative Review.
  Journal
Front Physiol 11:253 (2020)
DOI:10.3389/fphys.2020.00253
Reference
PMID:27114860
  Authors
Pinch M, Guth R, Samanta MP, Chaidez A, Unguez GA
  Title
The myogenic electric organ of Sternopygus macrurus: a non-contractile tissue with a skeletal muscle transcriptome.
  Journal
PeerJ 4:e1828 (2016)
DOI:10.7717/peerj.1828
Reference
PMID:23860255
  Authors
Sequeira V, Nijenkamp LL, Regan JA, van der Velden J
  Title
The physiological role of cardiac cytoskeleton and its alterations in heart failure.
  Journal
Biochim Biophys Acta 1838:700-22 (2014)
DOI:10.1016/j.bbamem.2013.07.011
Reference
PMID:36960155
  Authors
Zhang B, Powers JD, McCulloch AD, Chi NC
  Title
Nuclear mechanosignaling in striated muscle diseases.
  Journal
Front Physiol 14:1126111 (2023)
DOI:10.3389/fphys.2023.1126111
Reference
PMID:21464301
  Authors
Al-Amoudi A, Castano-Diez D, Devos DP, Russell RB, Johnson GT, Frangakis AS
  Title
The three-dimensional molecular structure of the desmosomal plaque.
  Journal
Proc Natl Acad Sci U S A 108:6480-5 (2011)
DOI:10.1073/pnas.1019469108
Reference
PMID:33067392
  Authors
Sikora M, Ermel UH, Seybold A, Kunz M, Calloni G, Reitz J, Vabulas RM, Hummer G, Frangakis AS
  Title
Desmosome architecture derived from molecular dynamics simulations and cryo-electron tomography.
  Journal
Proc Natl Acad Sci U S A 117:27132-27140 (2020)
DOI:10.1073/pnas.2004563117
Reference
PMID:26910421
  Authors
Xu XP, Kim E, Swift M, Smith JW, Volkmann N, Hanein D
  Title
Three-Dimensional Structures of Full-Length, Membrane-Embedded Human alpha(IIb)beta(3) Integrin Complexes.
  Journal
Biophys J 110:798-809 (2016)
DOI:10.1016/j.bpj.2016.01.016
Reference
PMID:22945352
  Authors
Wang W, Shi Z, Jiao S, Chen C, Wang H, Liu G, Wang Q, Zhao Y, Greene MI, Zhou Z
  Title
Structural insights into SUN-KASH complexes across the nuclear envelope.
  Journal
Cell Res 22:1440-52 (2012)
DOI:10.1038/cr.2012.126
Reference
PMID:23597672
  Authors
Sosa BA, Kutay U, Schwartz TU
  Title
Structural insights into LINC complexes.
  Journal
Curr Opin Struct Biol 23:285-91 (2013)
DOI:10.1016/j.sbi.2013.03.005
Reference
PMID:33058875
  Authors
Cruz VE, Esra Demircioglu F, Schwartz TU
  Title
Structural Analysis of Different LINC Complexes Reveals Distinct Binding Modes.
  Journal
J Mol Biol 432:6028-6041 (2020)
DOI:10.1016/j.jmb.2020.09.019
Reference
PMID:36523505
  Authors
Schuler SC, Liu Y, Dumontier S, Grandbois M, Le Moal E, Cornelison D, Bentzinger CF
  Title
Extracellular matrix: Brick and mortar in the skeletal muscle stem cell niche.
  Journal
Front Cell Dev Biol 10:1056523 (2022)
DOI:10.3389/fcell.2022.1056523
Reference
PMID:30425656
  Authors
Brull A, Morales Rodriguez B, Bonne G, Muchir A, Bertrand AT
  Title
The Pathogenesis and Therapies of Striated Muscle Laminopathies.
  Journal
Front Physiol 9:1533 (2018)
DOI:10.3389/fphys.2018.01533
Reference
PMID:36552829
  Authors
Storey EC, Fuller HR
  Title
Genotype-Phenotype Correlations in Human Diseases Caused by Mutations of LINC Complex-Associated Genes: A Systematic Review and Meta-Summary.
  Journal
Cells 11:cells11244065 (2022)
DOI:10.3390/cells11244065
Related
pathway
vko04512  ECM-receptor interaction
vko04814  Motor proteins
KO pathway
ko04820   
LinkDB

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