KEGG   PATHWAY: zvi04217
Entry
zvi04217                    Pathway                                
Name
Necroptosis - Zootoca vivipara (common lizard)
Description
Necroptosis is a programmed form of necrosis. It can be initiated by different stimuli, such as tumor necrosis factor (TNF), TNF-related apoptosis-inducing ligand (TRAIL), Fas ligand (FasL), interferon (IFN), LPS, viral DNA or RNA, DNA-damage agent and requires the kinase activity of receptor-interacting protein 1 (RIPK1) and RIPK3. Its execution involves ROS generation, calcium overload, the opening of the mitochondrial permeability transition pore, mitochondrial fission, inflammatory response and chromatinolysis. Necroptosis participates in many pathogenesis of diseases, including neurological diseases, retinal disorders, acute kidney injury, inflammatory diseases and microbial infections.
Class
Cellular Processes; Cell growth and death
Pathway map
zvi04217  Necroptosis
zvi04217

Organism
Zootoca vivipara (common lizard) [GN:zvi]
Gene
118076151  TNF; tumor necrosis factor [KO:K03156]
118097922  tumor necrosis factor receptor superfamily member 1A-like [KO:K03158]
118087169  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X1 [KO:K03171]
118076102  TNF receptor-associated factor 1-like [KO:K03173] [EC:2.3.2.27]
118077655  TNF receptor-associated factor 2-like [KO:K03173] [EC:2.3.2.27]
118078499  TNF receptor-associated factor 2-like isoform X1 [KO:K03173] [EC:2.3.2.27]
118083148  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
118090528  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
118084907  BIRC2; baculoviral IAP repeat-containing protein 2 isoform X1 [KO:K16060]
118084167  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
118088441  RBCK1; ranBP-type and C3HC4-type zinc finger-containing protein 1 [KO:K10630] [EC:2.3.2.31]
118089703  sharpin [KO:K10630] [EC:2.3.2.31]
118095161  E3 ubiquitin-protein ligase RNF31-like [KO:K11974] [EC:2.3.2.31]
118087091  uncharacterized protein LOC118087091 [KO:K17595]
118087244  SPATA2L; spermatogenesis-associated protein 2-like protein [KO:K17595]
118088773  SPATA2; spermatogenesis-associated protein 2 [KO:K17595]
118089226  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
118095149  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
118089857  ubiquitin carboxyl-terminal hydrolase CYLD-like [KO:K08601] [EC:3.4.19.12]
118086619  CYLD; ubiquitin carboxyl-terminal hydrolase CYLD isoform X1 [KO:K08601] [EC:3.4.19.12]
118085907  FADD; FAS-associated death domain protein [KO:K02373]
118095856  CASP8 and FADD-like apoptosis regulator [KO:K04724]
118078721  RIPK3; receptor-interacting serine/threonine-protein kinase 3 [KO:K08847] [EC:2.7.11.1]
118084761  cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]
118080422  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
118083949  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
118096405  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
118096835  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
118083716  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
118083926  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
118084360  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
118084911  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
118083324  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
118080354  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
118096309  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
118085968  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
118096434  GLUD1; glutamate dehydrogenase 1, mitochondrial isoform X1 [KO:K00261] [EC:1.4.1.3]
118088360  GLUL; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
118084393  glutamine synthetase-like [KO:K01915] [EC:6.3.1.2]
118075895  PYGM; glycogen phosphorylase, muscle form isoform X1 [KO:K00688] [EC:2.4.1.1]
118076071  PYGL; glycogen phosphorylase, liver form [KO:K00688] [EC:2.4.1.1]
118083041  PYGB; glycogen phosphorylase, brain form [KO:K00688] [EC:2.4.1.1]
118080395  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
118084127  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
118096231  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
118079055  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
118079085  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
118088422  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
118094239  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
118088994  FTH1; ferritin heavy chain [KO:K00522] [EC:1.16.3.1]
118096301  ferritin heavy chain-like [KO:K00522] [EC:1.16.3.1]
118086081  ferritin heavy chain A-like [KO:K00522] [EC:1.16.3.1]
118075436  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
118087182  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
118087251  cytosolic phospholipase A2 delta-like [KO:K16342] [EC:3.1.1.4]
118088567  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
118094147  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
118094148  cytosolic phospholipase A2 gamma-like isoform X1 [KO:K16342] [EC:3.1.1.4]
118094149  cytosolic phospholipase A2 gamma-like [KO:K16342] [EC:3.1.1.4]
118083493  cytosolic phospholipase A2 beta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
118083547  cytosolic phospholipase A2 beta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
118083562  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
118083572  cytosolic phospholipase A2 epsilon-like isoform X1 [KO:K16342] [EC:3.1.1.4]
118083582  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
118083588  cytosolic phospholipase A2 epsilon-like isoform X1 [KO:K16342] [EC:3.1.1.4]
118083601  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
118083607  PLA2G4F; LOW QUALITY PROTEIN: cytosolic phospholipase A2 zeta [KO:K16342] [EC:3.1.1.4]
118075673  CAPN1; calpain-1 catalytic subunit isoform X1 [KO:K01367] [EC:3.4.22.52]
118081772  CAPN11; calpain-11 [KO:K01367] [EC:3.4.22.52]
118083208  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
118085047  SMPD1; sphingomyelin phosphodiesterase [KO:K12350] [EC:3.1.4.12]
118086364  MLKL; mixed lineage kinase domain-like protein isoform X1 [KO:K08849] [EC:2.7.11.1]
118076512  PGAM5; serine/threonine-protein phosphatase PGAM5, mitochondrial isoform X1 [KO:K15637] [EC:3.1.3.16]
118075203  dynamin-1-like protein [KO:K17065] [EC:3.6.5.5]
118091485  DNM1L; dynamin-1-like protein isoform X1 [KO:K17065] [EC:3.6.5.5]
118077475  NLRP6; NACHT, LRR and PYD domains-containing protein 6 [KO:K12800]
118095381  apoptosis-associated speck-like protein containing a CARD [KO:K12799]
118097339  CASP4; caspase-4 isoform X1 [KO:K01370] [EC:3.4.22.36]
118087328  IL1B; interleukin-1 beta [KO:K04519]
118086854  interleukin-1 receptor antagonist protein-like [KO:K04519]
118095056  CHMP2A; charged multivesicular body protein 2a [KO:K12191]
118085331  CHMP2B; charged multivesicular body protein 2b [KO:K12192]
118094339  CHMP4A; charged multivesicular body protein 4a [KO:K12194]
118089257  CHMP4B; charged multivesicular body protein 4b [KO:K12194]
118089906  CHMP4C; charged multivesicular body protein 4c [KO:K24782]
118079693  CHMP6; charged multivesicular body protein 6 [KO:K12195]
118089881  VPS4B; vacuolar protein sorting-associated protein 4B [KO:K12196]
118086481  VPS4A; vacuolar protein sorting-associated protein 4A [KO:K12196]
118087733  CHMP1A; charged multivesicular body protein 1a [KO:K12197]
118093901  CHMP1B; charged multivesicular body protein 1b [KO:K12197]
118095325  CHMP5; charged multivesicular body protein 5 [KO:K12198]
118096969  CHMP7; charged multivesicular body protein 7 [KO:K15053]
118092703  TRPM7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
118085386  HMGB1; high mobility group protein B1 [KO:K10802]
118093614  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
118087838  tumor necrosis factor receptor superfamily member 10A-like [KO:K04722]
118097137  tumor necrosis factor receptor superfamily member 1A-like [KO:K04722]
118078298  FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389]
118096518  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
118075236  interferon beta-like [KO:K05414]
118077107  interferon type B-like [KO:K05414]
118075241  IFNK; interferon kappa [KO:K05414]
118091505  interferon gamma-like [KO:K04687]
118084974  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
118078074  uncharacterized protein LOC118078074 [KO:K05131]
118085357  interferon alpha/beta receptor 2-like [KO:K05131]
118085774  interferon alpha/beta receptor 2-like isoform X1 [KO:K05131]
118082067  IFNGR1; interferon gamma receptor 1 [KO:K05132]
118084879  IFNGR2; interferon gamma receptor 2 [KO:K05133]
118088746  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
118097550  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
118087504  JAK3; tyrosine-protein kinase JAK3 isoform X1 [KO:K11218] [EC:2.7.10.2]
118097506  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
118095191  STAT1; signal transducer and activator of transcription 1-alpha/beta isoform X1 [KO:K11220]
118079505  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
118095339  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
118095210  STAT4; signal transducer and activator of transcription 4 isoform X1 [KO:K11222]
118094191  signal transducer and activator of transcription 5B [KO:K11224]
118078286  STAT6; signal transducer and activator of transcription 6 isoform X1 [KO:K11225]
118095209  IRF9; interferon regulatory factor 9 [KO:K04693]
118081810  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase isoform X1 [KO:K16195] [EC:2.7.11.1]
118083676  TLR4; toll-like receptor 4 [KO:K10160]
118076881  TICAM2; TIR domain-containing adapter molecule 2 [KO:K05409]
118086905  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
118084174  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
118076291  USP21; ubiquitin carboxyl-terminal hydrolase 21 isoform X1 [KO:K21634] [EC:3.4.19.12]
118080412  SQSTM1; sequestosome-1 [KO:K14381]
118081768  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
118080471  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
118082066  TNFAIP3; tumor necrosis factor alpha-induced protein 3 [KO:K11859] [EC:3.4.19.12]
118077770  tumor necrosis factor alpha-induced protein 3-like [KO:K11859] [EC:3.4.19.12]
118083229  PARP1; poly [ADP-ribose] polymerase 1 [KO:K24070] [EC:2.4.2.30]
118090855  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
118095300  BAX; apoptosis regulator BAX [KO:K02159]
118088903  AIFM1; apoptosis-inducing factor 1, mitochondrial isoform X1 [KO:K04727] [EC:1.-.-.-]
118077767  histone H2A type 2-B [KO:K11251]
118077794  histone H2A type 2-C-like [KO:K11251]
118077804  histone H2A type 2-C-like [KO:K11251]
118079255  histone H2A type 2-C [KO:K11251]
118080370  core histone macro-H2A.1 isoform X1 [KO:K11251]
118080739  histone H2A type 2-B-like [KO:K11251]
118080945  histone H2A-like [KO:K11251]
118080947  histone H2A-like [KO:K11251]
118080948  histone H2A-like [KO:K11251]
118087468  histone H2A.V [KO:K11251]
118094263  histone H2A.J-like [KO:K11251]
118094837  histone H2A-IV [KO:K11251]
118094838  histone H2A type 2-C-like [KO:K11251]
118094839  histone H2A.J [KO:K11251]
118095385  histone H2A type 1-E [KO:K11251]
118084450  histone H2A.Z [KO:K11251]
118096315  core histone macro-H2A.2 [KO:K11251]
118091102  histone H2A-beta, sperm-like [KO:K11251]
118085519  histone H2A type 2-C-like isoform X1 [KO:K11251]
118085741  histone H2A, sperm-like [KO:K11251]
118096773  histone H2A.J [KO:K11251]
118097099  PPIA; peptidyl-prolyl cis-trans isomerase A [KO:K03767] [EC:5.2.1.8]
118090513  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
Compound
C00002  ATP
C00027  Hydrogen peroxide
C00076  Calcium cation
C00195  N-Acylsphingosine
C00219  Arachidonate
C00305  Magnesium cation
C00319  Sphingosine
C00550  Sphingomyelin
C14592  N-Methyl-N'-nitro-N-nitrosoguanidine
C16844  Hydroxyl radical
Reference
PMID:20823910
  Authors
Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G
  Title
Molecular mechanisms of necroptosis: an ordered cellular explosion.
  Journal
Nat Rev Mol Cell Biol 11:700-14 (2010)
DOI:10.1038/nrm2970
Reference
PMID:26008591
  Authors
Brenner D, Blaser H, Mak TW
  Title
Regulation of tumour necrosis factor signalling: live or let die.
  Journal
Nat Rev Immunol 15:362-74 (2015)
DOI:10.1038/nri3834
Reference
PMID:26775689
  Authors
Conrad M, Angeli JP, Vandenabeele P, Stockwell BR
  Title
Regulated necrosis: disease relevance and therapeutic opportunities.
  Journal
Nat Rev Drug Discov 15:348-66 (2016)
DOI:10.1038/nrd.2015.6
Reference
PMID:24129419
  Authors
Ofengeim D, Yuan J
  Title
Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death.
  Journal
Nat Rev Mol Cell Biol 14:727-36 (2013)
DOI:10.1038/nrm3683
Reference
PMID:27158445
  Authors
Murphy JM, Vince JE
  Title
Post-translational control of RIPK3 and MLKL mediated necroptotic cell death.
  Journal
F1000Res 4:F1000 Faculty Rev-1297 (2015)
DOI:10.12688/f1000research.7046.1
Reference
PMID:24452471
  Authors
Vanden Berghe T, Linkermann A, Jouan-Lanhouet S, Walczak H, Vandenabeele P
  Title
Regulated necrosis: the expanding network of non-apoptotic cell death pathways.
  Journal
Nat Rev Mol Cell Biol 15:135-47 (2014)
DOI:10.1038/nrm3737
Reference
PMID:27368376
  Authors
Dondelinger Y, Hulpiau P, Saeys Y, Bertrand MJ, Vandenabeele P
  Title
An evolutionary perspective on the necroptotic pathway.
  Journal
Trends Cell Biol 26:721-32 (2016)
DOI:10.1016/j.tcb.2016.06.004
Reference
PMID:27746097
  Authors
Thapa RJ, Ingram JP, Ragan KB, Nogusa S, Boyd DF, Benitez AA, Sridharan H, Kosoff R, Shubina M, Landsteiner VJ, Andrake M, Vogel P, Sigal LJ, tenOever BR, Thomas PG, Upton JW, Balachandran S
  Title
DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.
  Journal
Cell Host Microbe 20:674-681 (2016)
DOI:10.1016/j.chom.2016.09.014
Reference
PMID:27984721
  Authors
Yuan J, Najafov A, Py BF
  Title
Roles of Caspases in Necrotic Cell Death.
  Journal
Cell 167:1693-1704 (2016)
DOI:10.1016/j.cell.2016.11.047
Reference
PMID:28138137
  Authors
Jorgensen I, Rayamajhi M, Miao EA
  Title
Programmed cell death as a defence against infection.
  Journal
Nat Rev Immunol 17:151-164 (2017)
DOI:10.1038/nri.2016.147
Reference
PMID:20354226
  Authors
Vandenabeele P, Declercq W, Van Herreweghe F, Vanden Berghe T
  Title
The role of the kinases RIP1 and RIP3 in TNF-induced necrosis.
  Journal
Sci Signal 3:re4 (2010)
DOI:10.1126/scisignal.3115re4
Reference
PMID:22075985
  Authors
Vanlangenakker N, Vanden Berghe T, Vandenabeele P
  Title
Many stimuli pull the necrotic trigger, an overview.
  Journal
Cell Death Differ 19:75-86 (2012)
DOI:10.1038/cdd.2011.164
Reference
PMID:23913919
  Authors
Moriwaki K, Chan FK
  Title
RIP3: a molecular switch for necrosis and inflammation.
  Journal
Genes Dev 27:1640-9 (2013)
DOI:10.1101/gad.223321.113
Reference
PMID:25146926
  Authors
Humphries F, Yang S, Wang B, Moynagh PN
  Title
RIP kinases: key decision makers in cell death and innate immunity.
  Journal
Cell Death Differ 22:225-36 (2015)
DOI:10.1038/cdd.2014.126
Reference
PMID:28126382
  Authors
Wegner KW, Saleh D, Degterev A
  Title
Complex Pathologic Roles of RIPK1 and RIPK3: Moving Beyond Necroptosis.
  Journal
Trends Pharmacol Sci 38:202-225 (2017)
DOI:10.1016/j.tips.2016.12.005
Reference
PMID:27545878
  Authors
Kupka S, De Miguel D, Draber P, Martino L, Surinova S, Rittinger K, Walczak H
  Title
SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes.
  Journal
Cell Rep 16:2271-80 (2016)
DOI:10.1016/j.celrep.2016.07.086
Reference
PMID:27219062
  Authors
Goodall ML, Fitzwalter BE, Zahedi S, Wu M, Rodriguez D, Mulcahy-Levy JM, Green DR, Morgan M, Cramer SD, Thorburn A
  Title
The Autophagy Machinery Controls Cell Death Switching between Apoptosis and Necroptosis.
  Journal
Dev Cell 37:337-49 (2016)
DOI:10.1016/j.devcel.2016.04.018
Reference
PMID:19910467
  Authors
Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J
  Title
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1.
  Journal
J Biol Chem 285:969-78 (2010)
DOI:10.1074/jbc.M109.042689
Reference
PMID:26971869
  Authors
Jacobsen AV, Silke J
  Title
The importance of being chaperoned: HSP90 and necroptosis.
  Journal
Cell Chem Biol 23:205-7 (2016)
DOI:10.1016/j.chembiol.2016.02.003
Reference
PMID:25988900
  Authors
Gurung P, Man SM, Kanneganti TD
  Title
A20 is a regulator of necroptosis.
  Journal
Nat Immunol 16:596-7 (2015)
DOI:10.1038/ni.3174
Reference
PMID:28025046
  Authors
Feng N, Anderson ME
  Title
CaMKII is a nodal signal for multiple programmed cell death pathways in heart.
  Journal
J Mol Cell Cardiol 103:102-109 (2017)
DOI:10.1016/j.yjmcc.2016.12.007
Reference
PMID:19696789
  Authors
Zhivotovsky B, Galluzzi L, Kepp O, Kroemer G
  Title
Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machinery.
  Journal
Cell Death Differ 16:1419-25 (2009)
DOI:10.1038/cdd.2009.118
Reference
PMID:23898178
  Authors
Thapa RJ, Nogusa S, Chen P, Maki JL, Lerro A, Andrake M, Rall GF, Degterev A, Balachandran S
  Title
Interferon-induced RIP1/RIP3-mediated necrosis requires PKR and is licensed by FADD and caspases.
  Journal
Proc Natl Acad Sci U S A 110:E3109-18 (2013)
DOI:10.1073/pnas.1301218110
Reference
PMID:21576359
  Authors
Thapa RJ, Basagoudanavar SH, Nogusa S, Irrinki K, Mallilankaraman K, Slifker MJ, Beg AA, Madesh M, Balachandran S
  Title
NF-kappaB protects cells from gamma interferon-induced RIP1-dependent necroptosis.
  Journal
Mol Cell Biol 31:2934-46 (2011)
DOI:10.1128/MCB.05445-11
Reference
PMID:24565922
  Authors
Sridharan H, Upton JW
  Title
Programmed necrosis in microbial pathogenesis.
  Journal
Trends Microbiol 22:199-207 (2014)
DOI:10.1016/j.tim.2014.01.005
Reference
PMID:21738214
  Authors
Cabon L, Galan-Malo P, Bouharrour A, Delavallee L, Brunelle-Navas MN, Lorenzo HK, Gross A, Susin SA
  Title
BID regulates AIF-mediated caspase-independent necroptosis by promoting BAX activation.
  Journal
Cell Death Differ 19:245-56 (2012)
DOI:10.1038/cdd.2011.91
Reference
PMID:20697198
  Authors
Baritaud M, Boujrad H, Lorenzo HK, Krantic S, Susin SA
  Title
Histone H2AX: The missing link in AIF-mediated caspase-independent programmed necrosis.
  Journal
Cell Cycle 9:3166-73 (2010)
DOI:10.4161/cc.9.16.12887
Reference
PMID:28279333
  Authors
Upton JW, Kaiser WJ
  Title
DAI Another Way: Necroptotic Control of Viral Infection.
  Journal
Cell Host Microbe 21:290-293 (2017)
DOI:10.1016/j.chom.2017.01.016
Reference
PMID:26086143
  Authors
Silke J, Rickard JA, Gerlic M
  Title
The diverse role of RIP kinases in necroptosis and inflammation.
  Journal
Nat Immunol 16:689-97 (2015)
DOI:10.1038/ni.3206
Reference
PMID:28388403
  Authors
Guo H, Kaiser WJ
  Title
ESCRTing Necroptosis.
  Journal
Cell 169:186-187 (2017)
DOI:10.1016/j.cell.2017.03.030
Reference
PMID:28388412
  Authors
Gong YN, Guy C, Olauson H, Becker JU, Yang M, Fitzgerald P, Linkermann A, Green DR
  Title
ESCRT-III Acts Downstream of MLKL to Regulate Necroptotic Cell Death and Its Consequences.
  Journal
Cell 169:286-300.e16 (2017)
DOI:10.1016/j.cell.2017.03.020
Reference
PMID:27999433
  Authors
Petrie EJ, Hildebrand JM, Murphy JM
  Title
Insane in the membrane: a structural perspective of MLKL function in necroptosis.
  Journal
Immunol Cell Biol 95:152-159 (2017)
DOI:10.1038/icb.2016.125
Reference
PMID:24316671
  Authors
Cai Z, Jitkaew S, Zhao J, Chiang HC, Choksi S, Liu J, Ward Y, Wu LG, Liu ZG
  Title
Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis.
  Journal
Nat Cell Biol 16:55-65 (2014)
DOI:10.1038/ncb2883
Reference
PMID:25693118
  Authors
Lawlor KE, Khan N, Mildenhall A, Gerlic M, Croker BA, D'Cruz AA, Hall C, Kaur Spall S, Anderton H, Masters SL, Rashidi M, Wicks IP, Alexander WS, Mitsuuchi Y, Benetatos CA, Condon SM, Wong WW, Silke J, Vaux DL, Vince JE
  Title
RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL.
  Journal
Nat Commun 6:6282 (2015)
DOI:10.1038/ncomms7282
Reference
PMID:27974745
  Authors
Shlomovitz I, Zargrian S, Gerlic M
  Title
Mechanisms of RIPK3-induced inflammation.
  Journal
Immunol Cell Biol 95:166-172 (2017)
DOI:10.1038/icb.2016.124
Related
pathway
zvi00250  Alanine, aspartate and glutamate metabolism
zvi04210  Apoptosis
KO pathway
ko04217   
LinkDB

DBGET integrated database retrieval system