Entry Name Axon guidance - Propithecus coquereli (Coquerel's sifaka)
Description Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class Organismal Systems; Development and regenerationBRITE hierarchy
Pathway map Other DBs Organism Propithecus coquereli (Coquerel's sifaka) [GN:
pcoq ]
Gene 105805988 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
105806240 PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
105809922 TRPC4; short transient receptor potential channel 4 isoform X1 [KO:K04967 ]
105810567 LRIG2; leucine-rich repeats and immunoglobulin-like domains protein 2 [KO:K24609 ]
105810737 TRPC5; short transient receptor potential channel 5 isoform X1 [KO:K04968 ]
105810828 ARHGEF12; LOW QUALITY PROTEIN: rho guanine nucleotide exchange factor 12 [KO:K07532 ]
105812226 SRGAP3; SLIT-ROBO Rho GTPase-activating protein 3 isoform X1 [KO:K07526 ]
105812493 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
105812762 NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334 ]
105812884 TRPC1; short transient receptor potential channel 1 isoform X1 [KO:K04964 ]
105813715 GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630 ]
105814042 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649 ]
105815218 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630 ]
105815261 TRPC3; short transient receptor potential channel 3 isoform X1 [KO:K04966 ]
105815695 CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393 ]
105816581 PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116 ] [EC:3.1.4.11 ]
105818191 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
105820432 NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332 ]
105821123 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630 ]
105821611 PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348 ] [EC:3.1.3.16 ]
105822222 TRPC6; short transient receptor potential channel 6 isoform X1 [KO:K04969 ]
105823326 PARD6A; partitioning defective 6 homolog alpha isoform X1 [KO:K06093 ]
105823351 NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333 ]
105824187 SRGAP1; SLIT-ROBO Rho GTPase-activating protein 1 isoform X1 [KO:K07526 ]
105824997 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
105825258 DPYSL2; dihydropyrimidinase-related protein 2 isoform X1 [KO:K07528 ]
105825283 PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348 ] [EC:3.1.3.16 ]
105825498 PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348 ] [EC:3.1.3.16 ]
105826540 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
105826612 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649 ]
Compound Reference Authors Guan KL, Rao Y.
Title Signalling mechanisms mediating neuronal responses to guidance cues.
Journal Reference Authors Govek EE, Newey SE, Van Aelst L.
Title The role of the Rho GTPases in neuronal development.
Journal Reference Authors Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
Title Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
Journal Reference Authors Negishi M, Oinuma I, Katoh H.
Title Plexins: axon guidance and signal transduction.
Journal Reference Authors Huot J.
Title Ephrin signaling in axon guidance.
Journal Reference Authors Patel BN, Van Vactor DL.
Title Axon guidance: the cytoplasmic tail.
Journal Reference Authors Yu TW, Bargmann CI.
Title Dynamic regulation of axon guidance.
Journal Reference Authors Dickson BJ.
Title Molecular mechanisms of axon guidance.
Journal Reference Authors Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
Title The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
Journal Reference Authors Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
Title The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
Journal Reference Authors Fujita Y, Yamashita T
Title Axon growth inhibition by RhoA/ROCK in the central nervous system.
Journal Reference Authors Yamashita T, Mueller BK, Hata K
Title Neogenin and repulsive guidance molecule signaling in the central nervous system.
Journal Reference Authors van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
Title Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
Journal Related pcoq04060 Cytokine-cytokine receptor interaction
KO pathway
