Entry
Name
Cytokine-cytokine receptor interaction - Propithecus coquereli (Coquerel's sifaka)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
pcoq04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Propithecus coquereli (Coquerel's sifaka) [GN:
pcoq ]
Gene
105821018 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
105820330 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
105825541 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
105811983 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
105821114 FASLG; tumor necrosis factor ligand superfamily member 6 isoform X1 [KO:K04389 ]
105807728 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
105806953 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
105813945 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
105819481 TNFSF12; tumor necrosis factor ligand superfamily member 12 [KO:K05474 ]
105807726 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
105811849 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
105821122 TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469 ]
105821120 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
105819480 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475 ]
105805109 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
105809055 BMP15; LOW QUALITY PROTEIN: bone morphogenetic protein 15 [KO:K05498 ]
105805206 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
105810941 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
105820355 IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737 ]
105819031 CSF2RA; LOW QUALITY PROTEIN: granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066 ]
105808649 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
105821988 IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055 ]
105819129 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
105820331 IL11RA; interleukin-11 receptor subunit alpha isoform X1 [KO:K05056 ]
105820173 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
105819254 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
105820834 IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135 ]
105827167 IL20RA; interleukin-20 receptor subunit alpha isoform X1 [KO:K05136 ]
105815711 IL22RA1; interleukin-22 receptor subunit alpha-1 isoform X1 [KO:K05138 ]
105808785 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
105808306 IL18RAP; interleukin-18 receptor accessory protein isoform X1 [KO:K05174 ]
105805081 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
105824987 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141 ]
105805078 LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159 ]
105823464 TNFRSF14; tumor necrosis factor receptor superfamily member 14 isoform X1 [KO:K05152 ]
105818560 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
105822691 FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390 ]
105824904 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160 ]
105825241 tumor necrosis factor receptor superfamily member 10A-like [KO:K04722 ]
105826925 tumor necrosis factor receptor superfamily member 10B-like [KO:K04722 ]
105807185 tumor necrosis factor receptor superfamily member 10A-like [KO:K04722 ]
105826672 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
105826325 EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162 ]
105809527 EDA2R; tumor necrosis factor receptor superfamily member 27 isoform X1 [KO:K05163 ]
105825293 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
105812170 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
105811140 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
105813137 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
105824860 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
105807125 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
105824914 TNFRSF9; tumor necrosis factor receptor superfamily member 9 isoform X1 [KO:K05146 ]
105820953 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
105820906 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
105813035 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
105816082 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
105805260 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
105814786 TNFRSF19; tumor necrosis factor receptor superfamily member 19 isoform X1 [KO:K05155 ]
105811527 RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
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