KEGG   PATHWAY: pgeo03013
Entry
pgeo03013                   Pathway                                
Name
Nucleocytoplasmic transport - Pseudochaenichthys georgianus (South Georgia icefish)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
pgeo03013  Nucleocytoplasmic transport
pgeo03013

Other DBs
GO: 0050658
Organism
Pseudochaenichthys georgianus (South Georgia icefish) [GN:pgeo]
Gene
117439049  phax; phosphorylated adapter RNA export protein [KO:K14291]
117439091  [KO:K14327]
117439176  nup37; nucleoporin Nup37 [KO:K14302]
117439662  ahctf1; protein ELYS isoform X1 [KO:K25129]
117439916  nup43; nucleoporin Nup43 [KO:K14305]
117440773  xpot; exportin-T [KO:K14288]
117440794  eif4a3; eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
117440887  sumo1; small ubiquitin-related modifier 1 [KO:K12160]
117440972  [KO:K14300]
117441087  [KO:K18655] [EC:5.6.2.7]
117441103  tnpo3; transportin-3 [KO:K15436]
117441139  nup160; nuclear pore complex protein Nup160 [KO:K14303]
117441203  nup98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
117444690  ipo9; importin-9 [KO:K20224]
117444751  xpo7; exportin-7 [KO:K18460]
117445149  kpna7; importin subunit alpha-8 [KO:K15043]
117445259  [KO:K14326] [EC:5.6.2.5 5.6.2.3]
117445280  [KO:K25202]
117445465  magoh; LOW QUALITY PROTEIN: protein mago nashi homolog [KO:K12877]
117445489  ncbp2; nuclear cap-binding protein subunit 2 [KO:K12883]
117446020  tprb; translocated promoter region b, nuclear basket protein isoform X1 [KO:K09291]
117446284  ddx19b; ATP-dependent RNA helicase DDX19B [KO:K18655] [EC:5.6.2.7]
117446563  sec13; protein SEC13 homolog [KO:K14004]
117446696  thoc7; THO complex subunit 7 homolog [KO:K13176]
117446734  cse1l; exportin-2 [KO:K18423]
117447160  [KO:K15043]
117447431  rae1; mRNA export factor isoform X1 [KO:K14298]
117447864  nup205; nuclear pore complex protein Nup205 isoform X1 [KO:K14310]
117448037  snupn; snurportin-1 isoform X1 [KO:K13151]
117448599  nup93; nuclear pore complex protein Nup93 [KO:K14309]
117449069  pym1; partner of Y14 and mago isoform X1 [KO:K14294]
117449336  nup210; nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
117449649  aaas; LOW QUALITY PROTEIN: aladin [KO:K14320]
117450599  [KO:K14325]
117450762  xpo1a; exportin-1 [KO:K14290]
117450786  [KO:K13175]
117450803  nup85; nuclear pore complex protein Nup85 isoform X1 [KO:K14304]
117450804  [KO:K12160]
117450968  casc3; protein CASC3 [KO:K14323]
117451014  [KO:K14319]
117451077  [KO:K13175]
117451132  [KO:K18727]
117451281  alyref; THO complex subunit 4 [KO:K12881]
117451540  kpna2; importin subunit alpha-1 [KO:K15043]
117451578  [KO:K10577]
117451632  xpo6; exportin-6 [KO:K25204]
117452351  ipo11; importin-11 [KO:K25201]
117452395  thoc5; THO complex subunit 5 homolog [KO:K13174]
117452994  gle1; mRNA export factor GLE1 [KO:K18723]
117453355  nxt2; NTF2-related export protein 2 [KO:K14285]
117453636  sumo2a; small ubiquitin like modifier 2a [KO:K12160]
117453679  upf3b; regulator of nonsense transcripts 3B [KO:K14328]
117453703  nxf1a; nuclear RNA export factor 1 isoform X1 [KO:K14284]
117453778  ran; GTP-binding nuclear protein Ran [KO:K07936]
117453846  thoc3; THO complex subunit 3 [KO:K12880]
117454298  [KO:K12882]
117454331  [KO:K20724]
117454992  kpna6; importin subunit alpha-7 [KO:K15042]
117454998  nup153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
117455121  nup42; nucleoporin NUP42 [KO:K14321]
117455554  [KO:K03231]
117455555  [KO:K03231]
117455556  [KO:K03231]
117455948  nup214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
117455950  nup155; nuclear pore complex protein Nup155 [KO:K14312]
117456088  nup188; nucleoporin NUP188 [KO:K14311]
117456275  [KO:K14308]
117456323  [KO:K14308]
117456366  tnpo1; transportin-1 isoform X5 [KO:K18752]
117457013  sap18; histone deacetylase complex subunit SAP18 [KO:K14324]
117457079  nup88; nucleoporin 88 [KO:K14318]
117457838  nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
117457844  kpna4; importin subunit alpha-3 [KO:K23583]
117458156  thoc2; THO complex subunit 2 isoform X1 [KO:K12879]
117458300  pom121; nuclear envelope pore membrane protein POM 121 [KO:K14316]
117459560  xpo1b; exportin-1 isoform X1 [KO:K14290]
117459815  eef1a1a; elongation factor 1-alpha 1a [KO:K03231]
117459844  [KO:K14289]
117460238  kpnb3; importin-5 [KO:K20222]
117460762  tnpo2b; transportin-2 isoform X2 [KO:K18727]
117460965  [KO:K15042]
117461225  seh1l; nucleoporin SEH1 isoform X1 [KO:K14299]
117461502  rbm8a; RNA-binding protein 8A isoform X2 [KO:K12876]
117461807  tpra; LOW QUALITY PROTEIN: nucleoprotein TPR [KO:K09291]
117462000  [KO:K25202]
117462041  [KO:K14326] [EC:5.6.2.5 5.6.2.3]
117462460  acin1a; apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
117462774  ndc1; nucleoporin NDC1 isoform X1 [KO:K14315]
117462986  thoc1; THO complex subunit 1 [KO:K12878]
117463624  acin1b; apoptotic chromatin condensation inducer 1b isoform X1 [KO:K12875]
117464566  rangap1b; ran GTPase-activating protein 1b isoform X1 [KO:K14319]
117464820  ube2ib; SUMO-conjugating enzyme UBC9-A [KO:K10577]
117465567  nup58; LOW QUALITY PROTEIN: nucleoporin p58/p45 [KO:K14307]
117465724  ipo4; importin-4 [KO:K20221]
117465802  kpna1; importin subunit alpha-5 isoform X1 [KO:K23940]
117465842  [KO:K12881]
117465994  eef1a1l3; elongation factor 1-alpha-like [KO:K03231]
117465995  [KO:K03231]
117466503  xpo4; exportin-4 [KO:K25203]
117466593  kpna3; importin subunit alpha-4 isoform X1 [KO:K23583]
117466828  nup62l; nucleoporin 62 like [KO:K14306]
117467061  sumo3b; small ubiquitin-related modifier 3 [KO:K12160]
117467103  ranbp2; E3 SUMO-protein ligase RanBP2 [KO:K12172] [EC:2.3.2.-]
117467128  upf3a; regulator of nonsense transcripts 3A isoform X1 [KO:K14328]
117467494  ipo7; importin-7 [KO:K20223]
117467613  pnn; pinin [KO:K13114]
117467641  srrm1; serine/arginine repetitive matrix protein 1 isoform X1 [KO:K13171]
117467740  sumo3a; small ubiquitin-related modifier 3-like [KO:K12160]
117467858  senp2; sentrin-specific protease 2 [KO:K03345] [EC:3.4.22.68]
117468372  nup107; nuclear pore complex protein Nup107 [KO:K14301]
117468438  ipo8; importin-8 isoform X1 [KO:K18755]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
pgeo03015  mRNA surveillance pathway
KO pathway
ko03013   

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