KEGG   PATHWAY: pmei04218
Entry
pmei04218                   Pathway                                
Name
Cellular senescence - Poecilia mexicana (shortfin molly)
Description
Cellular senescence is a state of irreversible cellular arrest and can be triggered by a number of factors, such as telomere shortening, oncogene activation, irradiation, DNA damage and oxidative stress. It is characterized by enlarged flattened morphology, senescence-associated beta-galactosidase (SA-b-gal) activity, secretion of inflammatory cytokines, growth factors and matrix metalloproteinases, as part of the senescence-associated secretory phenotype (SASP). Cellular senescence is functionally associated with many biological processes including aging, tumor suppression, placental biology, embryonic development, and wound healing.
Class
Cellular Processes; Cell growth and death
Pathway map
pmei04218  Cellular senescence
pmei04218

Other DBs
GO: 0090398
Organism
Poecilia mexicana (shortfin molly) [GN:pmei]
Gene
106903247  [KO:K04441] [EC:2.7.11.24]
106903329  [KO:K21124]
106903560  [KO:K17334]
106903669  lin52; protein lin-52 homolog [KO:K21775]
106903949  [KO:K21770]
106904031  [KO:K04348] [EC:3.1.3.16]
106904726  [KO:K07208]
106904799  [KO:K02183]
106904819  [KO:K10030]
106904866  [KO:K01367] [EC:3.4.22.52]
106904867  [KO:K01367] [EC:3.4.22.52]
106904962  lin9; protein lin-9 homolog [KO:K21773]
106904980  raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
106905184  ets1; protein C-ets-1 isoform X1 [KO:K02678]
106905783  rbl1; retinoblastoma-like protein 1 isoform X1 [KO:K04681]
106905808  [KO:K04377]
106906018  foxm1; forkhead box protein M1 [KO:K09406]
106906312  rhebl1; GTPase RhebL1 [KO:K07208]
106906339  [KO:K07206]
106906548  [KO:K00922] [EC:2.7.1.153]
106906595  ppp1cb; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
106906981  [KO:K04371] [EC:2.7.11.24]
106907033  [KO:K10994] [EC:3.1.11.2]
106907095  [KO:K09408]
106907457  [KO:K06269] [EC:3.1.3.16]
106907458  [KO:K04735]
106907484  [KO:K04674] [EC:2.7.11.30]
106907848  [KO:K04441] [EC:2.7.11.24]
106907915  [KO:K02649]
106908005  [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106908051  [KO:K04958]
106908122  [KO:K02649]
106908314  [KO:K04402]
106908633  ppp3r1; calcineurin subunit B type 1 [KO:K06268]
106908778  [KO:K18753]
106909249  e2f1; transcription factor E2F1 [KO:K17454]
106909348  [KO:K04500]
106909533  [KO:K06751]
106909720  [KO:K08826] [EC:2.7.11.1]
106909872  [KO:K21776]
106910011  [KO:K10151]
106910148  chek2; serine/threonine-protein kinase Chk2 isoform X1 [KO:K06641] [EC:2.7.11.1]
106910171  [KO:K01367] [EC:3.4.22.52]
106910271  [KO:K02649]
106910681  [KO:K07206]
106910885  mybl2; myb-related protein B [KO:K21769]
106911171  [KO:K07830]
106911450  [KO:K06751]
106911451  [KO:K06751]
106911452  [KO:K06751]
106911519  [KO:K06268]
106911618  ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
106911877  [KO:K07830]
106912044  [KO:K06751]
106912079  [KO:K06751]
106912093  [KO:K07830]
106912684  [KO:K06751]
106912816  atr; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
106912827  [KO:K07830]
106912898  nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 [KO:K17332]
106913258  [KO:K06751]
106913259  [KO:K06751]
106913905  [KO:K10752]
106913936  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106913966  smad2; mothers against decapentaplegic homolog 2 isoform X1 [KO:K04500]
106914435  igfbp6; insulin-like growth factor-binding protein 6 [KO:K10138]
106914462  [KO:K07201]
106914678  ccnb3; G2/mitotic-specific cyclin-B3 [KO:K21771]
106914859  ppid; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
106915265  gadd45g; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
106915443  [KO:K04441] [EC:2.7.11.24]
106915455  [KO:K15040]
106915730  [KO:K07201]
106915805  [KO:K13376]
106915806  [KO:K13376]
106915816  map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106915864  tgfbr2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
106916031  [KO:K10903]
106916041  kras; GTPase KRas isoform X1 [KO:K07827]
106916046  itpr2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
106916071  [KO:K04377]
106916201  [KO:K04682]
106916285  nbn; nibrin [KO:K10867]
106916628  [KO:K06625]
106916683  trpm7; transient receptor potential cation channel subfamily M member 7 isoform X1 [KO:K04982] [EC:2.7.11.1]
106916705  vdac1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
106916743  rbl2; retinoblastoma-like protein 2 isoform X1 [KO:K04681]
106917051  [KO:K02649]
106917126  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106917188  [KO:K18753]
106917342  hras; GTPase HRas [KO:K02833]
106917396  [KO:K04441] [EC:2.7.11.24]
106917549  [KO:K04388] [EC:2.7.11.30]
106917577  tsc2; tuberin isoform X1 [KO:K07207]
106917623  [KO:K10030]
106918048  [KO:K04851]
106918364  trpv4; transient receptor potential cation channel subfamily V member 4 isoform X1 [KO:K04973]
106918660  rad1; cell cycle checkpoint protein RAD1 [KO:K02830] [EC:3.1.11.2]
106919021  [KO:K02649]
106919132  tp53; cellular tumor antigen p53 [KO:K04451]
106919164  [KO:K04446]
106919309  slc25a4; ADP/ATP translocase 1 [KO:K05863]
106919335  [KO:K04685]
106919504  [KO:K06751]
106919524  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106919549  [KO:K15040]
106919679  [KO:K13377]
106919948  cacna1d; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
106919996  [KO:K13375]
106920063  [KO:K04433] [EC:2.7.12.2]
106920131  [KO:K04402]
106920233  cdk1; cyclin-dependent kinase 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
106920582  ccnb1; G2/mitotic-specific cyclin-B1 [KO:K05868]
106920607  [KO:K00922] [EC:2.7.1.153]
106920741  zfp36l1; zinc finger protein 36, C3H1 type-like 1 [KO:K18753]
106920801  nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
106920951  sirt1; NAD-dependent protein deacetylase sirtuin-1 [KO:K11411] [EC:2.3.1.286]
106921104  calml4; calmodulin-like protein 4 [KO:K02183]
106921165  [KO:K10151]
106921319  chek1; serine/threonine-protein kinase Chk1 [KO:K02216] [EC:2.7.11.1]
106921410  [KO:K04377]
106921447  [KO:K04348] [EC:3.1.3.16]
106921643  [KO:K04348] [EC:3.1.3.16]
106921756  vdac3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
106921915  foxo3; forkhead box protein O3 [KO:K09408]
106921954  [KO:K16332]
106921973  [KO:K04682]
106922087  cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
106922174  rb1; retinoblastoma-associated protein [KO:K06618]
106922228  ccna1; cyclin-A1 isoform X1 [KO:K06627]
106922371  e2f3; transcription factor E2F3 isoform X1 [KO:K06620]
106922390  [KO:K04348] [EC:3.1.3.16]
106922419  [KO:K04433] [EC:2.7.12.2]
106922651  [KO:K07205]
106922714  mdm2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
106922726  [KO:K04441] [EC:2.7.11.24]
106922728  [KO:K04441] [EC:2.7.11.24]
106922773  [KO:K18753]
106922882  nfkb1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
106922883  sqstm1; sequestosome-1 [KO:K14381]
106922942  [KO:K02183]
106923269  [KO:K02089] [EC:2.7.11.22]
106923441  [KO:K04446]
106923477  [KO:K05863]
106923532  tgfb3; transforming growth factor beta-3 [KO:K13377]
106924261  hipk3; homeodomain-interacting protein kinase 3 isoform X1 [KO:K08826] [EC:2.7.11.1]
106924289  ccnd3; G1/S-specific cyclin-D3 [KO:K10152]
106924292  [KO:K06625]
106924430  serpine1; plasminogen activator inhibitor 1 [KO:K03982]
106924700  [KO:K06269] [EC:3.1.3.16]
106924785  [KO:K23605]
106924888  map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
106925768  ccne1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
106925935  [KO:K10138]
106925947  [KO:K09408]
106926112  ccnd2; G1/S-specific cyclin-D2 isoform X1 [KO:K10151]
106926215  mras; ras-related protein M-Ras [KO:K07831]
106926441  [KO:K05863]
106926499  [KO:K05863]
106926763  [KO:K04402]
106926769  [KO:K04402]
106926925  lin54; protein lin-54 homolog [KO:K21776]
106927097  gadd45b; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
106927524  [KO:K04456] [EC:2.7.11.1]
106927669  [KO:K17332]
106928122  fbxw11; F-box/WD repeat-containing protein 11 isoform X1 [KO:K03362]
106928197  [KO:K06625]
106928309  gata4; transcription factor GATA-4 [KO:K09183]
106928398  [KO:K08826] [EC:2.7.11.1]
106928420  lin37; protein lin-37 homolog [KO:K21774]
106928508  [KO:K02091] [EC:2.7.11.22]
106928656  hipk2; homeodomain-interacting protein kinase 2 [KO:K08826] [EC:2.7.11.1]
106928673  mre11a; double-strand break repair protein MRE11A [KO:K10865]
106928690  atm; serine-protein kinase ATM isoform X1 [KO:K04728] [EC:2.7.11.1]
106928883  [KO:K02649]
106928990  [KO:K00922] [EC:2.7.1.153]
106929020  [KO:K17332]
106929121  pten; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106929307  [KO:K15041]
106929365  rheb; GTP-binding protein Rheb [KO:K07208]
106929419  [KO:K01367] [EC:3.4.22.52]
106929428  [KO:K03853] [EC:3.4.22.53]
106929429  [KO:K03853] [EC:3.4.22.53]
106929452  cdk2; cyclin-dependent kinase 2 [KO:K02206] [EC:2.7.11.22]
106929497  [KO:K18753]
106929910  e2f2; transcription factor E2F2 isoform X1 [KO:K09389]
106929973  [KO:K06751]
106929982  [KO:K06751]
106930400  [KO:K07205]
106930415  calm2; calmodulin [KO:K02183]
106930500  [KO:K04500]
106930552  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
106930758  [KO:K04377]
106931170  [KO:K08826] [EC:2.7.11.1]
106931194  [KO:K07827]
106931279  [KO:K04433] [EC:2.7.12.2]
106931298  ccne2; G1/S-specific cyclin-E2 [KO:K06626]
106931374  [KO:K04441] [EC:2.7.11.24]
106931438  rad9b; cell cycle checkpoint control protein RAD9B isoform X1 [KO:K10995]
106931439  ppp1cc; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
106931775  [KO:K01367] [EC:3.4.22.52]
106931777  [KO:K03853] [EC:3.4.22.53]
106931834  smad3; mothers against decapentaplegic homolog 3 [KO:K23605]
106931917  mcu; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
106931920  [KO:K06269] [EC:3.1.3.16]
106932106  [KO:K04456] [EC:2.7.11.1]
106932221  [KO:K04348] [EC:3.1.3.16]
106932289  itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
106932372  ccna2; cyclin-A2 [KO:K06627]
106932430  rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
106932448  [KO:K06269] [EC:3.1.3.16]
106933439  gadd45a; growth arrest and DNA damage-inducible protein GADD45 alpha isoform X1 [KO:K04402]
106933447  e2f4; transcription factor E2F4 isoform X1 [KO:K04682]
106933514  [KO:K21124]
106933633  [KO:K04456] [EC:2.7.11.1]
106933653  itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
106933928  mapkapk2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
106933944  rassf5; ras association domain-containing protein 5 [KO:K08015]
106934105  mtor; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
106934245  calm3; calmodulin [KO:K02183]
106934274  [KO:K06751]
Compound
C00027  Hydrogen peroxide
C00076  Calcium cation
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C07909  Sirolimus
C16844  Hydroxyl radical
Reference
PMID:24954210
  Authors
Munoz-Espin D, Serrano M
  Title
Cellular senescence: from physiology to pathology.
  Journal
Nat Rev Mol Cell Biol 15:482-96 (2014)
DOI:10.1038/nrm3823
Reference
PMID:26646499
  Authors
Childs BG, Durik M, Baker DJ, van Deursen JM
  Title
Cellular senescence in aging and age-related disease: from mechanisms to therapy.
  Journal
Nat Med 21:1424-35 (2015)
DOI:10.1038/nm.4000
Reference
PMID:26105537
  Authors
Sharpless NE, Sherr CJ
  Title
Forging a signature of in vivo senescence.
  Journal
Nat Rev Cancer 15:397-408 (2015)
DOI:10.1038/nrc3960
Reference
PMID:26435346
  Authors
Fridlyanskaya I, Alekseenko L, Nikolsky N
  Title
Senescence as a general cellular response to stress: A mini-review.
  Journal
Exp Gerontol 72:124-8 (2015)
DOI:10.1016/j.exger.2015.09.021
Reference
PMID:27417123
  Authors
Lujambio A
  Title
To clear, or not to clear (senescent cells)? That is the question.
  Journal
Bioessays 38 Suppl 1:S56-64 (2016)
DOI:10.1002/bies.201670910
Reference
PMID:26564316
  Authors
Di Mitri D, Alimonti A
  Title
Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer.
  Journal
Trends Cell Biol 26:215-26 (2016)
DOI:10.1016/j.tcb.2015.10.005
Reference
PMID:27574725
  Authors
Francica P, Aebersold DM, Medova M
  Title
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer.
  Journal
Biochem Pharmacol 126:1-12 (2017)
DOI:10.1016/j.bcp.2016.08.022
Reference
PMID:23982440
  Authors
Bartling B
  Title
Cellular senescence in normal and premature lung aging.
  Journal
Z Gerontol Geriatr 46:613-22 (2013)
DOI:10.1007/s00391-013-0543-3
Reference
PMID:24238962
  Authors
Munoz-Espin D, Canamero M, Maraver A, Gomez-Lopez G, Contreras J, Murillo-Cuesta S, Rodriguez-Baeza A, Varela-Nieto I, Ruberte J, Collado M, Serrano M
  Title
Programmed cell senescence during mammalian embryonic development.
  Journal
Cell 155:1104-18 (2013)
DOI:10.1016/j.cell.2013.10.019
Reference
PMID:26697828
  Authors
Herranz N, Gallage S, Gil J
  Title
TORn about SASP regulation.
  Journal
Cell Cycle 14:3771-2 (2015)
DOI:10.1080/15384101.2015.1105694
Reference
PMID:28410770
  Authors
Martin N, Bernard D
  Title
Calcium signaling and cellular senescence.
  Journal
Cell Calcium S0143-4160(17)30049-0 (2017)
DOI:10.1016/j.ceca.2017.04.001
Reference
PMID:25764980
  Authors
Farfariello V, Iamshanova O, Germain E, Fliniaux I, Prevarskaya N
  Title
Calcium homeostasis in cancer: A focus on senescence.
  Journal
Biochim Biophys Acta 1853:1974-9 (2015)
DOI:10.1016/j.bbamcr.2015.03.005
Reference
PMID:24062309
  Authors
McCarthy DA, Clark RR, Bartling TR, Trebak M, Melendez JA
  Title
Redox control of the senescence regulator interleukin-1alpha and the secretory phenotype.
  Journal
J Biol Chem 288:32149-59 (2013)
DOI:10.1074/jbc.M113.493841
Reference
PMID:27288568
  Authors
Donninger H, Schmidt ML, Mezzanotte J, Barnoud T, Clark GJ
  Title
Ras signaling through RASSF proteins.
  Journal
Semin Cell Dev Biol 58:86-95 (2016)
DOI:10.1016/j.semcdb.2016.06.007
Reference
PMID:28455242
  Authors
Barnoud T, Schmidt ML, Donninger H, Clark GJ
  Title
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence.
  Journal
Cancer Lett 400:30-36 (2017)
DOI:10.1016/j.canlet.2017.04.030
Reference
PMID:26404840
  Authors
Kang C, Xu Q, Martin TD, Li MZ, Demaria M, Aron L, Lu T, Yankner BA, Campisi J, Elledge SJ
  Title
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
  Journal
Science 349:aaa5612 (2015)
DOI:10.1126/science.aaa5612
Reference
PMID:26777575
  Authors
Cao X, Li M
  Title
A New Pathway for Senescence Regulation.
  Journal
Genomics Proteomics Bioinformatics 13:333-5 (2015)
DOI:10.1016/j.gpb.2015.11.002
Reference
PMID:25564883
  Authors
Gire V, Dulic V
  Title
Senescence from G2 arrest, revisited.
  Journal
Cell Cycle 14:297-304 (2015)
DOI:10.1080/15384101.2014.1000134
Reference
PMID:24981831
  Authors
Mowla SN, Lam EW, Jat PS
  Title
Cellular senescence and aging: the role of B-MYB.
  Journal
Aging Cell 13:773-9 (2014)
DOI:10.1111/acel.12242
Reference
PMID:22546858
  Authors
Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, McBurney MW, Guarente L, Gu W, Ronty M, Kinnula VL, Rahman I
  Title
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice.
  Journal
J Clin Invest 122:2032-45 (2012)
DOI:10.1172/JCI60132
Reference
PMID:23542362
  Authors
Hwang JW, Yao H, Caito S, Sundar IK, Rahman I
  Title
Redox regulation of SIRT1 in inflammation and cellular senescence.
  Journal
Free Radic Biol Med 61:95-110 (2013)
DOI:10.1016/j.freeradbiomed.2013.03.015
Related
pathway
pmei04020  Calcium signaling pathway
pmei04068  FoxO signaling pathway
pmei04110  Cell cycle
pmei04115  p53 signaling pathway
pmei04150  mTOR signaling pathway
KO pathway
ko04218   

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