KEGG   PATHWAY: pyu04020
Entry
pyu04020                    Pathway                                
Name
Calcium signaling pathway - Herpailurus yagouaroundi (jaguarundi)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
pyu04020  Calcium signaling pathway
pyu04020

Other DBs
GO: 0019722
Organism
Herpailurus yagouaroundi (jaguarundi) [GN:pyu]
Gene
121009974  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
121010117  TPCN1; two pore calcium channel protein 1 [KO:K16896]
121010149  ADORA2A; adenosine receptor A2a isoform X1 [KO:K04266]
121010166  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
121010269  NOS1; nitric oxide synthase, brain isoform X1 [KO:K13240] [EC:1.14.13.39]
121010452  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
121010457  P2RX7; P2X purinoceptor 7 isoform X1 [KO:K05220]
121010460  P2RX4; P2X purinoceptor 4 isoform X1 [KO:K05218]
121010462  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
121010701  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
121010979  FGF18; fibroblast growth factor 18 [KO:K04358]
121011206  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
121011218  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
121011250  DRD1; D(1A) dopamine receptor isoform X1 [KO:K04144]
121011292  HRH2; histamine H2 receptor isoform X1 [KO:K04150]
121011339  RYR1; ryanodine receptor 1 [KO:K04961]
121011430  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
121011574  FGFR4; LOW QUALITY PROTEIN: fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
121011720  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G isoform X1 [KO:K08794] [EC:2.7.11.17]
121011805  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
121012031  [KO:K04282]
121012064  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
121012085  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
121012116  TNNC2; troponin C, skeletal muscle [KO:K12042]
121012188  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
121012339  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
121012476  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
121012479  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
121012552  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
121012732  FGF9; fibroblast growth factor 9 [KO:K04358]
121012786  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
121012949  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
121012964  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
121013347  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
121013601  [KO:K04634]
121013603  GNA14; guanine nucleotide-binding protein subunit alpha-14 isoform X1 [KO:K04636]
121013917  MCOLN1; mucolipin-1 isoform X1 [KO:K04992]
121014070  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
121014090  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
121014101  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
121014214  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
121014270  [KO:K03914]
121014449  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
121014811  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D isoform X1 [KO:K08794] [EC:2.7.11.17]
121014870  [KO:K02183]
121014873  [KO:K02183]
121015007  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
121015308  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121015457  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
121015510  CASQ1; calsequestrin-1 [KO:K23468]
121015846  ADORA2B; adenosine receptor A2b [KO:K04267]
121016305  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
121016318  CALM2; calmodulin-2 [KO:K02183]
121016402  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
121016834  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
121016874  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
121016945  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
121016977  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
121017018  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
121017178  NOS2; nitric oxide synthase, inducible isoform X1 [KO:K13241] [EC:1.14.13.39]
121017361  P2RX5; P2X purinoceptor 5 isoform X1 [KO:K05219]
121017368  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
121017369  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
121017370  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
121017467  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
121017690  ORAI2; protein orai-2 [KO:K16057]
121017789  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform [KO:K00871] [EC:2.7.11.19]
121017884  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
121017921  SMIM6; small integral membrane protein 6 [KO:K26468]
121017954  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
121018659  CALM3; calmodulin-3 isoform X1 [KO:K02183]
121018685  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
121018720  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
121018739  FGF21; fibroblast growth factor 21 [KO:K22429]
121018760  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein isoform X1 [KO:K23450]
121018827  PRKCG; protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
121018883  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
121019078  PPP3R1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
121019131  TGFA; protransforming growth factor alpha [KO:K08774]
121019206  TACR1; substance-P receptor [KO:K04222]
121019338  CALML6; calmodulin-like protein 6 [KO:K02183]
121019340  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
121019369  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
121019463  [KO:K05863]
121019534  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
121019600  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
121019701  ADRB3; beta-3 adrenergic receptor [KO:K04143]
121019943  [KO:K04632]
121019944  [KO:K04632]
121019973  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
121020017  NTSR1; neurotensin receptor type 1 [KO:K04211]
121020230  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
121020286  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
121020417  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
121020761  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
121021207  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
121021308  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
121021379  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
121021450  TBXA2R; thromboxane A2 receptor isoform X1 [KO:K04264]
121021509  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
121021567  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
121021691  AVPR1B; vasopressin V1b receptor [KO:K04227]
121021720  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
121021881  FGF22; fibroblast growth factor 22 [KO:K04358]
121021952  FGF23; fibroblast growth factor 23 [KO:K22428]
121021990  FGF6; fibroblast growth factor 6 [KO:K04358]
121022112  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
121022172  ORAI3; protein orai-3 [KO:K16058]
121022204  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
121022214  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
121022470  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
121022878  P2RX6; P2X purinoceptor 6 [KO:K05221]
121022952  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
121022974  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
121023156  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
121023215  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
121023725  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
121023732  VEGFB; vascular endothelial growth factor B [KO:K16858]
121023744  FGF19; fibroblast growth factor 19 [KO:K22603]
121023745  FGF4; fibroblast growth factor 4 [KO:K04358]
121023897  TPCN2; two pore calcium channel protein 2 isoform X1 [KO:K14077]
121023937  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
121024338  PTAFR; platelet-activating factor receptor [KO:K04279]
121024502  [KO:K05863]
121025071  ATP2B3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
121025257  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
121025330  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
121025344  FGF16; fibroblast growth factor 16 [KO:K04358]
121025397  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
121025618  GRPR; gastrin-releasing peptide receptor isoform X1 [KO:K04169]
121025646  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform [KO:K07190]
121025662  VEGFD; vascular endothelial growth factor D [KO:K05449]
121025703  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
121026060  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
121027308  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
121027352  PTGFR; prostaglandin F2-alpha receptor [KO:K04262]
121027378  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
121027392  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
121027396  MCOLN3; mucolipin-3 [KO:K04994]
121027749  NGF; beta-nerve growth factor [KO:K02582]
121027752  CASQ2; calsequestrin-2 [KO:K23445]
121028117  PDGFC; platelet-derived growth factor C [KO:K05450]
121028280  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
121028446  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
121028517  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
121028796  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
121028820  EDNRA; endothelin-1 receptor [KO:K04197]
121028976  [KO:K10785]
121029298  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
121029435  TFEB; transcription factor EB isoform X1 [KO:K15590]
121029504  VEGFA; vascular endothelial growth factor A [KO:K05448]
121029907  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
121029977  PLN; cardiac phospholamban [KO:K05852]
121029999  TRDN; triadin isoform X1 [KO:K23449]
121030066  FGF2; fibroblast growth factor 2 isoform X1 [KO:K18497]
121030451  [KO:K04161]
121030499  CUNH4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
121030500  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
121030635  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
121030783  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
121031012  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
121031014  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
121031073  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 isoform X1 [KO:K05857] [EC:3.1.4.11]
121031448  [KO:K10784]
121031569  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
121031573  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
121031578  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
121031724  TACR3; neuromedin-K receptor [KO:K04224]
121031929  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121031984  SLC8A3; sodium/calcium exchanger 3 isoform X1 [KO:K05849]
121032181  CALM1; calmodulin-1 [KO:K02183]
121032260  BDKRB2; B2 bradykinin receptor isoform X1 [KO:K03915]
121033198  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
121033234  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
121033459  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
121033707  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
121033803  AGTR1; type-1 angiotensin II receptor [KO:K04166]
121034768  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X1 [KO:K05213]
121034769  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
121035344  SLN; sarcolipin [KO:K22642]
121035518  KDR; vascular endothelial growth factor receptor 2 isoform X1 [KO:K05098] [EC:2.7.10.1]
121035565  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
121036344  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
121036660  MRLN; myoregulin isoform X1 [KO:K22643]
121036728  TACR2; substance-K receptor [KO:K04223]
121036774  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
121036791  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121036802  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
121036822  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
121036853  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
121036970  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
121036980  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
121037018  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
121037143  STIM2; stromal interaction molecule 2 isoform X1 [KO:K18196]
121037192  CCKAR; cholecystokinin receptor type A isoform X1 [KO:K04194]
121037313  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
121037542  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
121037825  EDNRB; endothelin receptor type B [KO:K04198]
121038074  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
121038214  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
121038434  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
121038444  DRD5; D(1B) dopamine receptor [KO:K05840]
121038795  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
121038860  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 isoform X1 [KO:K05861] [EC:3.1.4.11]
121038896  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
121039179  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
121039211  STIM1; stromal interaction molecule 1 isoform X1 [KO:K16059]
121039432  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
121039641  VEGFC; vascular endothelial growth factor C [KO:K05449]
121039687  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
121039821  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
121039877  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
121039893  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
121039962  FGF20; fibroblast growth factor 20 [KO:K04358]
121040314  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
121040328  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
121040647  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
121040833  AVPR1A; vasopressin V1a receptor [KO:K04226]
121040944  ERBB3; receptor tyrosine-protein kinase erbB-3 isoform X1 [KO:K05084] [EC:2.7.10.1]
121041252  HRH1; histamine H1 receptor isoform X1 [KO:K04149]
121041261  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
121041290  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
121041310  OXTR; oxytocin receptor [KO:K04229]
121041326  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
121041441  RYR3; ryanodine receptor 3 [KO:K04963]
121041442  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
121041495  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [KO:K05858] [EC:3.1.4.11]
121041543  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
121041681  FGF7; fibroblast growth factor 7 isoform X1 [KO:K04358]
121041895  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
121042416  ADCY2; adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
121042420  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
121042523  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
121042865  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
121042990  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
121043417  P2RX3; P2X purinoceptor 3 isoform X1 [KO:K05217]
121043684  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
121044199  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
121044375  SLC8A1; sodium/calcium exchanger 1 isoform X1 [KO:K05849]
121044420  FGF10; fibroblast growth factor 10 [KO:K04358]
121044748  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
121044775  ADRB2; beta-2 adrenergic receptor [KO:K04142]
121044785  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
121044914  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
121045013  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
121045049  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
121045124  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 isoform X1 [KO:K05857] [EC:3.1.4.11]
121045237  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
121045244  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
121045271  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
121045484  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X4 [KO:K17333]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
pyu04010  MAPK signaling pathway
pyu04070  Phosphatidylinositol signaling system
pyu04210  Apoptosis
pyu04720  Long-term potentiation
pyu04730  Long-term depression
KO pathway
ko04020   

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