KEGG   PATHWAY: xhe00230
Entry
xhe00230                    Pathway                                
Name
Purine metabolism - Xiphophorus hellerii (green swordtail)
Class
Metabolism; Nucleotide metabolism
Pathway map
xhe00230  Purine metabolism
xhe00230

Module
xhe_M00005  PRPP biosynthesis, ribose-5P => PRPP [PATH:xhe00230]
xhe_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:xhe00230]
xhe_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:xhe00230]
xhe_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:xhe00230]
xhe_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:xhe00230]
xhe_M00546  Purine degradation, xanthine => urea [PATH:xhe00230]
xhe_M00958  Adenine ribonucleotide degradation, AMP => Urate [PATH:xhe00230]
xhe_M00959  Guanine ribonucleotide degradation, GMP => Urate [PATH:xhe00230]
Other DBs
GO: 0006163 0042278
Organism
Xiphophorus hellerii (green swordtail) [GN:xhe]
Gene
116707648  [KO:K10807] [EC:1.17.4.1]
116707665  gmps; GMP synthase [glutamine-hydrolyzing] isoform X1 [KO:K01951] [EC:6.3.5.2]
116707949  [KO:K19021] [EC:3.1.4.17]
116707950  [KO:K01081] [EC:3.1.3.5]
116708568  ak7; adenylate kinase 7 [KO:K00939] [EC:2.7.4.3]
116708734  [KO:K01939] [EC:6.3.4.4]
116708839  [KO:K01511] [EC:3.6.1.6]
116709368  [KO:K12321] [EC:4.6.1.2]
116709452  [KO:K01081] [EC:3.1.3.5]
116710177  [KO:K03783] [EC:2.4.2.1]
116710222  [KO:K01490] [EC:3.5.4.6]
116710235  nudt2; bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] [KO:K01518] [EC:3.6.1.17]
116711118  [KO:K00088] [EC:1.1.1.205]
116711169  pde1b; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
116711185  [KO:K03783] [EC:2.4.2.1]
116711286  [KO:K07127] [EC:3.5.2.17]
116711624  urad; putative 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [KO:K13485] [EC:4.1.1.97]
116711785  pde7a; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1 [KO:K18436] [EC:3.1.4.53]
116712750  pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
116712800  aprt; adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
116712920  entpd6; ectonucleoside triphosphate diphosphohydrolase 6 isoform X1 [KO:K01511] [EC:3.6.1.6]
116713090  [KO:K01081] [EC:3.1.3.5]
116713195  [KO:K01939] [EC:6.3.4.4]
116713308  [KO:K00856] [EC:2.7.1.20]
116713757  [KO:K13811] [EC:2.7.7.4 2.7.1.25]
116713859  ntpcr; cancer-related nucleoside-triphosphatase [KO:K06928] [EC:3.6.1.15]
116714023  prps1; ribose-phosphate pyrophosphokinase 1 isoform X1 [KO:K00948] [EC:2.7.6.1]
116714480  [KO:K00760] [EC:2.4.2.8]
116714707  [KO:K08718] [EC:3.1.4.35]
116715587  enpp4; bis(5'-adenosyl)-triphosphatase ENPP4 [KO:K18424] [EC:3.6.1.29]
116715626  xdh; xanthine dehydrogenase/oxidase isoform X1 [KO:K00106] [EC:1.17.1.4 1.17.3.2]
116715629  [KO:K08048] [EC:4.6.1.1]
116715899  [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
116715900  [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
116716174  [KO:K00948] [EC:2.7.6.1]
116717093  adcy3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
116717142  [KO:K12323] [EC:4.6.1.2]
116717169  entpd3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510] [EC:3.6.1.5]
116717194  [KO:K08042] [EC:4.6.1.1]
116717650  ada; adenosine deaminase [KO:K01488] [EC:3.5.4.4]
116717841  [KO:K13298] [EC:3.1.4.17 3.1.4.35]
116717892  [KO:K03783] [EC:2.4.2.1]
116717900  prune1; exopolyphosphatase PRUNE1 [KO:K01514] [EC:3.6.1.11]
116718174  pde8a; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [KO:K18437] [EC:3.1.4.53]
116718247  atic; bifunctional purine biosynthesis protein PURH [KO:K00602] [EC:2.1.2.3 3.5.4.10]
116718282  hddc3; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 [KO:K21138] [EC:3.1.7.2]
116718405  adcy7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
116718854  [KO:K07127] [EC:3.5.2.17]
116718855  [KO:K07127] [EC:3.5.2.17]
116718915  pde3b; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
116718924  [KO:K13760]
116718925  [KO:K13760]
116719247  ampd3; AMP deaminase 3 [KO:K01490] [EC:3.5.4.6]
116719384  nt5c2; cytosolic purine 5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
116719416  [KO:K13759]
116719515  [KO:K13762] [EC:3.1.4.35]
116719745  [KO:K12304] [EC:3.6.1.6]
116719875  [KO:K08049] [EC:4.6.1.1]
116719915  papss1; bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 [KO:K13811] [EC:2.7.7.4 2.7.1.25]
116720007  ampd1; AMP deaminase 1 isoform X1 [KO:K01490] [EC:3.5.4.6]
116720174  gucy1a1; guanylate cyclase soluble subunit alpha-1 [KO:K12318] [EC:4.6.1.2]
116720176  gucy1b1; guanylate cyclase soluble subunit beta-1 [KO:K12319] [EC:4.6.1.2]
116720300  [KO:K13293] [EC:3.1.4.53]
116720452  pgm2; phosphoglucomutase-2 [KO:K15779] [EC:5.4.2.2 5.4.2.7]
116720536  [KO:K16855] [EC:3.6.1.62 3.6.1.64]
116720923  adcy8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
116721195  [KO:K13293] [EC:3.1.4.53]
116721318  ak5; adenylate kinase isoenzyme 5 [KO:K00939] [EC:2.7.4.3]
116721342  [KO:K13293] [EC:3.1.4.53]
116721584  impdh2; inosine-5'-monophosphate dehydrogenase 2 [KO:K00088] [EC:1.1.1.205]
116721781  [KO:K08041] [EC:4.6.1.1]
116721864  pde1c; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1 [KO:K13755] [EC:3.1.4.17]
116721946  guk1; guanylate kinase isoform X1 [KO:K00942] [EC:2.7.4.8]
116721997  [KO:K03783] [EC:2.4.2.1]
116722262  [KO:K01835] [EC:5.4.2.2]
116722538  pde1a; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
116722540  [KO:K13761] [EC:3.1.4.35]
116722709  adcy5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
116722822  pde11a; dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A [KO:K13298] [EC:3.1.4.17 3.1.4.35]
116723111  lacc1; laccase domain-containing protein 1 [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
116723943  pde8b; high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1 [KO:K18437] [EC:3.1.4.53]
116724021  ak3; GTP:AMP phosphotransferase AK3, mitochondrial [KO:K00944] [EC:2.7.4.10]
116724229  [KO:K13756] [EC:3.1.4.35]
116724254  dck; deoxycytidine kinase [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
116724463  npr2; atrial natriuretic peptide receptor 2 [KO:K12324] [EC:4.6.1.2]
116724539  [KO:K01509] [EC:3.6.1.-]
116724877  [KO:K01081] [EC:3.1.3.5]
116724969  ak1; adenylate kinase isoenzyme 1 [KO:K00939] [EC:2.7.4.3]
116725359  pde4b; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
116725408  ak4; adenylate kinase 4, mitochondrial [KO:K00939] [EC:2.7.4.3]
116725449  [KO:K00942] [EC:2.7.4.8]
116725582  pde4c; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
116725610  [KO:K00365] [EC:1.7.3.3]
116725699  pgm1; phosphoglucomutase-1 isoform X1 [KO:K01835] [EC:5.4.2.2]
116725943  [KO:K01587] [EC:4.1.1.21 6.3.2.6]
116725945  ppat; amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
116726014  nme7; nucleoside diphosphate kinase 7 [KO:K00940] [EC:2.7.4.6]
116726062  pde6d; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [KO:K13758]
116726217  [KO:K01490] [EC:3.5.4.6]
116726227  [KO:K01466] [EC:3.5.2.5]
116726280  pfas; phosphoribosylformylglycinamidine synthase isoform X1 [KO:K01952] [EC:6.3.5.3]
116726292  [KO:K08041] [EC:4.6.1.1]
116726397  itpa; inosine triphosphate pyrophosphatase [KO:K01519] [EC:3.6.1.66]
116726440  adcy6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
116726648  pde6g; retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma [KO:K13759]
116726650  entpd1; ectonucleoside triphosphate diphosphohydrolase 1 isoform X1 [KO:K01510] [EC:3.6.1.5]
116726664  adprm; manganese-dependent ADP-ribose/CDP-alcohol diphosphatase [KO:K01517] [EC:3.6.1.13 3.6.1.16 3.6.1.53]
116726784  nt5m; 5'(3')-deoxyribonucleotidase, mitochondrial isoform X1 [KO:K01081] [EC:3.1.3.5]
116726867  [KO:K08046] [EC:4.6.1.1]
116726986  [KO:K22600] [EC:4.6.1.2]
116727114  [KO:K12320] [EC:4.6.1.2]
116727188  [KO:K00856] [EC:2.7.1.20]
116727282  pde6c; cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' [KO:K13757] [EC:3.1.4.35]
116727470  [KO:K00940] [EC:2.7.4.6]
116727894  [KO:K00365] [EC:1.7.3.3]
116728086  [KO:K01939] [EC:6.3.4.4]
116728104  [KO:K10807] [EC:1.17.4.1]
116728625  [KO:K00893] [EC:2.7.1.74 2.7.1.76 2.7.1.113]
116729425  [KO:K00760] [EC:2.4.2.8]
116729602  pde4d; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
116729740  [KO:K00904] [EC:2.7.1.113]
116729770  ak8; adenylate kinase 8 [KO:K00939] [EC:2.7.4.3]
116730184  entpd4; ectonucleoside triphosphate diphosphohydrolase 4 isoform X1 [KO:K12305] [EC:3.6.1.6]
116730290  ak6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
116730353  gda; guanine deaminase [KO:K01487] [EC:3.5.4.3]
116730456  [KO:K01509] [EC:3.6.1.-]
116730661  [KO:K19572] [EC:3.5.4.4]
116730663  [KO:K01513] [EC:3.1.4.1 3.6.1.9]
116730667  rrm2b; ribonucleoside-diphosphate reductase subunit M2 B isoform X1 [KO:K10808] [EC:1.17.4.1]
116730971  [KO:K13760]
116730972  [KO:K13760]
116731152  [KO:K01081] [EC:3.1.3.5]
116731245  [KO:K08042] [EC:4.6.1.1]
116731497  ak2; adenylate kinase 2, mitochondrial isoform X1 [KO:K00939] [EC:2.7.4.3]
116731813  gmpr; GMP reductase 1 isoform X1 [KO:K00364] [EC:1.7.1.7]
116732126  [KO:K12322] [EC:4.6.1.2]
116732133  [KO:K00364] [EC:1.7.1.7]
116732472  pde5a; cGMP-specific 3',5'-cyclic phosphodiesterase isoform X1 [KO:K13762] [EC:3.1.4.35]
116732660  [KO:K12324] [EC:4.6.1.2]
116733501  [KO:K03783] [EC:2.4.2.1]
116733649  [KO:K11787] [EC:6.3.4.13 2.1.2.2 6.3.3.1]
116733701  [KO:K00939] [EC:2.7.4.3]
116733710  rrm2; ribonucleoside-diphosphate reductase subunit M2 [KO:K10808] [EC:1.17.4.1]
116733838  [KO:K08043] [EC:4.6.1.1]
116733846  [KO:K01513] [EC:3.1.4.1 3.6.1.9]
116733911  nt5e; 5'-nucleotidase [KO:K19970] [EC:3.1.3.5]
116734023  [KO:K08048] [EC:4.6.1.1]
116734035  pde7b; cAMP-specific 3',5'-cyclic phosphodiesterase 7B isoform X1 [KO:K18436] [EC:3.1.4.53]
116734104  allc; probable allantoicase [KO:K01477] [EC:3.5.3.4]
116734208  hddc2; HD domain-containing protein 2 [KO:K07023] [EC:3.1.3.89]
116734322  ak9; adenylate kinase 9 isoform X1 [KO:K18533] [EC:2.7.4.3 2.7.4.6]
116734360  [KO:K01081] [EC:3.1.3.5]
116734420  [KO:K01511] [EC:3.6.1.6]
116734527  nme6; nucleoside diphosphate kinase 6 [KO:K00940] [EC:2.7.4.6]
116734887  cant1; soluble calcium-activated nucleotidase 1 isoform X1 [KO:K12304] [EC:3.6.1.6]
116734997  [KO:K13760]
116735249  [KO:K00940] [EC:2.7.4.6]
116735486  [KO:K13759]
116735552  [KO:K12320] [EC:4.6.1.2]
116735600  [KO:K13293] [EC:3.1.4.53]
116735686  nudt9; ADP-ribose pyrophosphatase, mitochondrial [KO:K13988] [EC:3.6.1.13]
116735712  adcy9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
116735775  [KO:K00940] [EC:2.7.4.6]
116735989  adsl; adenylosuccinate lyase isoform X1 [KO:K01756] [EC:4.3.2.2]
116736209  nme3; nucleoside diphosphate kinase 3 isoform X1 [KO:K00940] [EC:2.7.4.6]
116736632  [KO:K00088] [EC:1.1.1.205]
116736820  nudt5; ADP-sugar pyrophosphatase [KO:K13987] [EC:3.6.1.13 3.6.1.58 2.7.7.96]
116736951  [KO:K19572] [EC:3.5.4.4]
116737166  [KO:K01490] [EC:3.5.4.6]
116737220  pde9a; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform X1 [KO:K13761] [EC:3.1.4.35]
116737348  pde2a; cGMP-dependent 3',5'-cyclic phosphodiesterase isoform X1 [KO:K18283] [EC:3.1.4.17]
116737505  gucy1a2; guanylate cyclase soluble subunit alpha-2 [KO:K12318] [EC:4.6.1.2]
116737605  pde3a; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
xhe00030  Pentose phosphate pathway
xhe00220  Arginine biosynthesis
xhe00250  Alanine, aspartate and glutamate metabolism
xhe00260  Glycine, serine and threonine metabolism
xhe00340  Histidine metabolism
xhe00630  Glyoxylate and dicarboxylate metabolism
xhe00730  Thiamine metabolism
xhe00740  Riboflavin metabolism
xhe00790  Folate biosynthesis
KO pathway
ko00230   

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