KEGG PATHWAY: xhe03420

KEGG

PATHWAY: xhe03420

Entry

xhe03420                    Pathway

Name

Nucleotide excision repair - Xiphophorus hellerii (green swordtail)

Description

Nucleotide excision repair (NER) is a mechanism to recognize and repair bulky DNA damage caused by compounds, environmental carcinogens, and exposure to UV-light. In humans hereditary defects in the NER pathway are linked to at least three diseases: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). The repair of damaged DNA involves at least 30 polypeptides within two different sub-pathways of NER known as transcription-coupled repair (TCR-NER) and global genome repair (GGR-NER). TCR refers to the expedited repair of lesions located in the actively transcribed strand of genes by RNA polymerase II (RNAP II). In GGR-NER the first step of damage recognition involves XPC-hHR23B complex together with XPE complex (in prokaryotes, uvrAB complex). The following steps of GGR-NER and TCR-NER are similar.

Class

Genetic Information Processing; Replication and repair

Pathway map

Nucleotide excision repair

Other DBs

GO:

Organism

Xiphophorus hellerii (green swordtail) [GN:xhe]

Gene

polr2d; DNA-directed RNA polymerase II subunit RPB4 [KO:K03012]

rpa1; replication protein A 70 kDa DNA-binding subunit [KO:K07466]

polr2i; DNA-directed RNA polymerase II subunit RPB9 isoform X1 [KO:K03017]

mnat1; LOW QUALITY PROTEIN: CDK-activating kinase assembly factor MAT1 [KO:K10842]

pole2; LOW QUALITY PROTEIN: DNA polymerase epsilon subunit 2 [KO:K02325] [EC:2.7.7.7]

polr2c; DNA-directed RNA polymerase II subunit RPB3 [KO:K03011]

polr2j; DNA-directed RNA polymerase II subunit RPB11-a [KO:K03008]

gtf2h1; LOW QUALITY PROTEIN: general transcription factor IIH subunit 1 [KO:K03141]

ercc6; DNA excision repair protein ERCC-6 isoform X1 [KO:K10841]

polr2g; DNA-directed RNA polymerase II subunit RPB7 [KO:K03015]

uvssa; UV-stimulated scaffold protein A isoform X1 [KO:K23720]

cul4b; cullin-4B [KO:K10609]

polr2b; DNA-directed RNA polymerase II subunit RPB2 isoform X1 [KO:K03010] [EC:2.7.7.6]

rpa2; replication protein A 32 kDa subunit [KO:K10739]

polr2l; DNA-directed RNA polymerases I, II, and III subunit RPABC5 [KO:K03007]

ercc5; DNA repair protein complementing XP-G cells [KO:K10846]

ddb1; DNA damage-binding protein 1 [KO:K10610]

polr2m; protein GRINL1A [KO:K21987]

ercc3; general transcription and DNA repair factor IIH helicase subunit XPB [KO:K10843] [EC:5.6.2.4]

cul4a; cullin-4A [KO:K10609]

pole3; DNA polymerase epsilon subunit 3 [KO:K02326] [EC:2.7.7.7]

rfc1; replication factor C subunit 1 isoform X1 [KO:K10754]

pold4; DNA polymerase delta subunit 4 isoform X1 [KO:K03505]

xpa; DNA repair protein complementing XP-A cells [KO:K10847]

xpc; LOW QUALITY PROTEIN: DNA repair protein complementing XP-C cells [KO:K10838]

lig1; DNA ligase 1 [KO:K10747] [EC:6.5.1.1 6.5.1.6 6.5.1.7]

pold3; DNA polymerase delta subunit 3 isoform X1 [KO:K03504]

rfc2; replication factor C subunit 2 [KO:K10755]

ercc1; DNA excision repair protein ERCC-1 [KO:K10849]

pole4; DNA polymerase epsilon subunit 4 [KO:K03506] [EC:2.7.7.7]

polr2h; DNA-directed RNA polymerases I, II, and III subunit RPABC3 [KO:K03016]

polr2e; DNA-directed RNA polymerases I, II, and III subunit RPABC1 [KO:K03013]

rfc4; replication factor C subunit 4 [KO:K10755]

ercc4; DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]

rfc3; replication factor C subunit 3 [KO:K10756]

pold2; DNA polymerase delta subunit 2 [KO:K02328]

gtf2h3; general transcription factor IIH subunit 3 [KO:K03143]

ercc8; DNA excision repair protein ERCC-8 [KO:K10570]

pole; DNA polymerase epsilon catalytic subunit A [KO:K02324] [EC:2.7.7.7]

pcna; proliferating cell nuclear antigen [KO:K04802]

rfc5; replication factor C subunit 5 [KO:K10756]

ccnh; cyclin-H [KO:K06634]

cdk7; cyclin-dependent kinase 7 [KO:K02202] [EC:2.7.11.22 2.7.11.23]

rpa3; replication protein A 14 kDa subunit [KO:K10740]

polr2k; DNA-directed RNA polymerases I, II, and III subunit RPABC4 [KO:K03009]

gtf2h4; general transcription factor IIH subunit 4 [KO:K03144]

polr2a; DNA-directed RNA polymerase II subunit RPB1 [KO:K03006] [EC:2.7.7.6]

gtf2h5; general transcription factor IIH subunit 5 [KO:K10845]

rad23a; UV excision repair protein RAD23 homolog A [KO:K10839]

polr2f; DNA-directed RNA polymerases I, II, and III subunit RPABC2 [KO:K03014]

rbx1; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]

pold1; DNA polymerase delta catalytic subunit [KO:K02327] [EC:2.7.7.7]

ddb2; LOW QUALITY PROTEIN: DNA damage-binding protein 2 [KO:K10140]

ercc2; general transcription and DNA repair factor IIH helicase subunit XPD [KO:K10844] [EC:5.6.2.3]

Reference

Authors

Sugasawa K.

Title

[Molecular mechanism of mammalian nucleotide excision repair]

Journal

Tanpakushitsu Kakusan Koso 46:893-901 (2001)

Reference

Authors

Nakatsu Y.

Title

[Transcription-coupled repair and Cockayne syndrome]

Journal

Tanpakushitsu Kakusan Koso 46:908-15 (2001)

Reference

Authors

Nakagawa N, Masui R, Kuramitsu S.

Title

[Structure and function of DNA repair enzyme UvrB from Thermus thermophilus HB8]

Journal

Tanpakushitsu Kakusan Koso 46:968-75 (2001)

Reference

Authors

Kraemer KH, Patronas NJ, Schiffmann R, Brooks BP, Tamura D, DiGiovanna JJ.

Title

Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship.

Journal

Neuroscience 145:1388-96 (2007)
DOI:10.1016/j.neuroscience.2006.12.020

Reference

Authors

Saldivar JS, Wu X, Follen M, Gershenson D.

Title

Nucleotide excision repair pathway review I: implications in ovarian cancer and platinum sensitivity.

Journal

Gynecol Oncol 107:S56-71 (2007)
DOI:10.1016/j.ygyno.2007.07.043

Reference

Authors

Sugasawa K.

Title

[DNA repair pathways involving Cul4A ubiquitin ligases]

Journal

Tanpakushitsu Kakusan Koso 51:1339-44 (2006)

Reference

Authors

Ito S, Ando D, Tanaka K.

Title

[Cross-talk between DNA repair and transcription: molecular mechanism and disorders]

Journal

Tanpakushitsu Kakusan Koso 52:1823-31 (2007)

Related
pathway

RNA polymerase

Ubiquitin mediated proteolysis

KO pathway

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