KEGG   PATHWAY: xla04141
Entry
xla04141                    Pathway                                
Name
Protein processing in endoplasmic reticulum - Xenopus laevis (African clawed frog)
Description
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
Class
Genetic Information Processing; Folding, sorting and degradation
Pathway map
xla04141  Protein processing in endoplasmic reticulum
xla04141

Other DBs
GO: 0030433 0034976
Organism
Xenopus laevis (African clawed frog) [GN:xla]
Gene
100036945  dnajb11.L; uncharacterized protein LOC100036945 [KO:K09517]
100037025  ganab.L; neutral alpha-glucosidase AB precursor [KO:K05546] [EC:3.2.1.207]
100037069  ubxn6.L; UBX domain protein 6 L homeolog [KO:K14011]
100037143  marchf6.L; E3 ubiquitin-protein ligase MARCH6 [KO:K10661] [EC:2.3.2.27]
100049091  ube2j1.L; ubiquitin conjugating enzyme E2 J1 L homeolog [KO:K10578] [EC:2.3.2.23]
100049149  edem1.L; ER degradation enhancing alpha-mannosidase like protein 1 L homeolog precursor [KO:K10084]
100049739  rnf5.L; ring finger protein 5 L homeolog [KO:K10666] [EC:2.3.2.27]
100049762  krtcap2.L; uncharacterized protein LOC100049762 [KO:K28202]
100101299  ube2d4.L; ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
100127267  XB5844015.L; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
100127315  ckap4.S; uncharacterized protein LOC100127315 [KO:K13999]
100137614  erlec1.L; endoplasmic reticulum lectin 1-like isoform X2 [KO:K14008]
100137648  os9.S; protein OS-9 isoform X1 [KO:K10088]
100144882  ubxn2a.S; UBX domain-containing protein 2A [KO:K24349]
100158335  plaa.L; phospholipase A2-activating protein L homeolog [KO:K14018]
100158355  hspbp1.L; HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 L homeolog [KO:K09562]
100158418  mogs.L; mannosyl-oligosaccharide glucosidase [KO:K01228] [EC:3.2.1.106]
100174792  bag1.L; BAG family molecular chaperone regulator 1 isoform X1 [KO:K09555]
100271914  bcl2.S; B-cell CLL/lymphoma 2 S homeolog [KO:K02161]
100329133  sec61g.S; Sec61 translocon gamma subunit S homeolog [KO:K07342]
100380973  stt3b.S; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
100381020  hspa1a.S; heat shock protein family A (Hsp70) member 1A S homeolog [KO:K03283]
100381029  derl2.L; derlin-2 [KO:K13989]
100381056  sec24a.S; protein transport protein Sec24A isoform X1 [KO:K14007]
108695318  dnajc5b.S; dnaJ homolog subfamily C member 5 [KO:K09525]
108696229  dnajb12.L; dnaJ homolog subfamily B member 12 [KO:K09518]
108696235  [KO:K07953] [EC:3.6.5.-]
108696249  sec24c.L; protein transport protein Sec24C isoform X1 [KO:K14007]
108696352  ube4b.L; ubiquitin conjugation factor E4 B isoform X1 [KO:K10597] [EC:2.3.2.27]
108696454  hyou1.L; hypoxia up-regulated protein 1-like isoform X1 [KO:K09486]
108696488  cryab.L; alpha-crystallin B chain isoform X1 [KO:K09542]
108696744  bax.L; apoptosis regulator BAX-like [KO:K02159]
108696811  hspa1a.L; heat shock cognate 71 kDa protein-like isoform X1 [KO:K03283]
108696873  ddost.L; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit-like [KO:K12670]
108697361  [KO:K06689] [EC:2.3.2.23]
108697559  fbxo2.S; F-box only protein 2 isoform X1 [KO:K10099]
108697581  cryab.S; LOW QUALITY PROTEIN: alpha-crystallin B chain [KO:K09542]
108697591  [KO:K08860] [EC:2.7.11.1]
108697639  ube2j2.S; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
108698135  traf2.L; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
108698555  atf6b.L; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
108698765  [KO:K10950] [EC:1.8.4.-]
108698781  [KO:K04079]
108699246  [KO:K14006]
108699292  [KO:K03237]
108699293  eif2s1.L; eukaryotic translation initiation factor 2 subunit 1 isoform X2 [KO:K03237]
108699823  atxn3.S; ataxin-3 isoform X3 [KO:K11863] [EC:3.4.22.-]
108700070  [KO:K19478]
108700226  atf6b.S; cyclic AMP-dependent transcription factor ATF-6 beta [KO:K09049]
108700309  [KO:K14006]
108700486  sel1l.S; protein sel-1 homolog 1 [KO:K14026]
108700946  [KO:K09525]
108701068  edem2.L; ER degradation-enhancing alpha-mannosidase-like protein 2 [KO:K10085]
108701211  ern1.L; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
108701283  ubxn4.L; UBX domain-containing protein 4 [KO:K24348]
108701402  dnajc10.L; dnaJ homolog subfamily C member 10-like [KO:K09530] [EC:1.8.4.-]
108701627  ern2.L; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
108702675  nsfl1c.S; NSFL1 cofactor p47 [KO:K14012]
108702862  ern1.S; serine/threonine-protein kinase/endoribonuclease IRE1 isoform X1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
108703244  stub1.S; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
108704101  mapk10.S; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108704603  rpn2.L; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 isoform X1 [KO:K12667]
108706536  wfs1.S; wolframin isoform X2 [KO:K14020]
108706602  [KO:K19478]
108706700  sec24b.S; protein transport protein Sec24B isoform X1 [KO:K14007]
108706719  sec24d.S; protein transport protein Sec24D [KO:K14007]
108706735  ube2d3.S; ubiquitin-conjugating enzyme E2 D2 isoform X2 [KO:K06689] [EC:2.3.2.23]
108706808  ubxn6.S; UBX domain-containing protein 6 isoform X1 [KO:K14011]
108706814  dnaja1.S; dnaJ homolog subfamily A member 1 [KO:K09502]
108706983  ubqln1.S; ubiquilin-1 [KO:K04523]
108707172  erp29.S; endoplasmic reticulum resident protein 29 [KO:K09586]
108707520  derl2l.L; derlin-2 [KO:K13989]
108707790  [KO:K09541]
108708013  mbtps2.L; membrane-bound transcription factor site-2 protease [KO:K07765] [EC:3.4.24.85]
108708264  man1c1.L; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [KO:K01230] [EC:3.2.1.113]
108708357  ube2g1.L; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
108708482  uggt2.L; UDP-glucose:glycoprotein glucosyltransferase 2 [KO:K11718] [EC:2.4.1.-]
108708596  os9.L; protein OS-9 [KO:K10088]
108709664  derl2.S; LOW QUALITY PROTEIN: derlin-2 [KO:K13989]
108709861  ddit3.S; DNA damage-inducible transcript 3 protein [KO:K04452]
108710148  sec24b.L; protein transport protein Sec24B isoform X1 [KO:K14007]
108710841  sec24a.L; protein transport protein Sec24A [KO:K14007]
108710987  lman2.L; vesicular integral-membrane protein VIP36 isoform X1 [KO:K10082]
108711320  cplx3.L; protein ERGIC-53 isoform X1 [KO:K10080]
108711434  pdia3.L; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
108711504  mapk10.L; mitogen-activated protein kinase 10 L homeolog isoform 1 [KO:K04440] [EC:2.7.11.24]
108711672  [KO:K14005]
108711682  dnajb1.L; dnaJ homolog subfamily B member 1 [KO:K09507]
108712619  skp1.S; S-phase kinase-associated protein 1 isoform X2 [KO:K03094]
108712658  map2k7.S; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
108712728  ube2d4.S; ubiquitin-conjugating enzyme E2 D4 [KO:K06689] [EC:2.3.2.23]
108713226  lman2.S; vesicular integral-membrane protein VIP36 [KO:K10082]
108714315  calr3.L; calreticulin [KO:K08057]
108714482  rbx1.L; E3 ubiquitin-protein ligase RBX1 [KO:K03868] [EC:2.3.2.32]
108714495  atf6.L; cyclic AMP-dependent transcription factor ATF-6 alpha isoform X3 [KO:K09054]
108714639  [KO:K14004]
108714662  sec61a1.L; protein transport protein Sec61 subunit alpha [KO:K10956]
108714902  dad1.L; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad1-like [KO:K12668]
108714990  calr3.S; calreticulin-like [KO:K08057]
108715138  [KO:K05546] [EC:3.2.1.207]
108715294  svip.S; small VCP/p97-interacting protein [KO:K14014]
108715710  edem3.S; ER degradation-enhancing alpha-mannosidase-like protein 3 isoform X2 [KO:K10086]
108715730  rbx1.S; RING-box protein 1 [KO:K03868] [EC:2.3.2.32]
108715849  edem1.S; ER degradation-enhancing alpha-mannosidase-like protein 1 [KO:K10084]
108716102  [KO:K04079]
108716133  ero1b.L; ERO1-like protein beta isoform X1 [KO:K10976] [EC:1.8.4.-]
108716477  capn8.5.L; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
108716798  [KO:K01230] [EC:3.2.1.113]
108716921  bag2.L; BAG family molecular chaperone regulator 2 [KO:K09556]
108717160  uggt1.L; UDP-glucose:glycoprotein glucosyltransferase 1 isoform X1 [KO:K11718] [EC:2.4.1.-]
108717697  capn2.S; calpain-2 catalytic subunit isoform X1 [KO:K03853] [EC:3.4.22.53]
108717885  [KO:K04426] [EC:2.7.11.25]
108717911  man1a1.S; mannosyl-oligosaccharide 1,2-alpha-mannosidase IA [KO:K01230] [EC:3.2.1.113]
108717973  ube2j1.S; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
108718008  bag2.S; BAG family molecular chaperone regulator 2 [KO:K09556]
108718339  dnajc5g.S; dnaJ homolog subfamily C member 5 [KO:K09525]
108718427  lman1.L; protein ERGIC-53 [KO:K10080]
108718804  dnajc1.L; dnaJ homolog subfamily C member 1 [KO:K09521]
108718815  dnajc5b.L; dnaJ homolog subfamily C member 5 [KO:K09525]
108718919  vcp.L; transitional endoplasmic reticulum ATPase [KO:K13525]
108718927  ngly1.L; peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase [KO:K01456] [EC:3.5.1.52]
108718938  stt3b.L; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [KO:K07151] [EC:2.4.99.18]
108719105  bcl2.L; apoptosis regulator Bcl-2 [KO:K02161]
108720057  txndc5.S; thioredoxin domain-containing protein 5 [KO:K13984] [EC:5.3.4.1]
121393044  [KO:K03283]
121397593  [KO:K13250]
373637  bax.S; BCL2-associated X protein L homeolog [KO:K02159]
378668  cryaa.S; crystallin alpha A S homeolog [KO:K09541]
379102  canx.L; calnexin L homeolog precursor [KO:K08054]
379209  nfe2l2.L; nuclear factor, erythroid 2 like 2 L homeolog [KO:K05638]
379319  hspa8.L; heat shock protein family A (Hsp70) member 8 L homeolog [KO:K03283]
379348  rpn2.S; ribophorin II S homeolog precursor [KO:K12667]
379368  ssr2.S; signal sequence receptor, beta precursor [KO:K13250]
379373  dnaja2.L; DnaJ heat shock protein family (Hsp40) member A2 L homeolog [KO:K09503]
379415  ssr3.S; signal sequence receptor gamma subunit b [KO:K13251]
379505  p4hb.S; uncharacterized protein LOC379505 precursor [KO:K09580] [EC:5.3.4.1]
379611  ssr1.L; signal sequence receptor, alpha (translocon-associated protein alpha) L homeolog precursor [KO:K13249]
379743  pdia3.S; protein disulfide isomerase family A member 3 S homeolog precursor [KO:K08056] [EC:5.3.4.1]
379756  hspa5.S; heat shock protein family A (Hsp70) member 5 S homeolog precursor [KO:K09490] [EC:3.6.4.10]
379760  hspa1l.S; heat shock protein family A (Hsp70) member 1 like S homeolog [KO:K03283]
379788  calr.S; calreticulin precursor [KO:K08057]
379791  dnajc3.L; DnaJ heat shock protein family (Hsp40) member C3 L homeolog precursor [KO:K09523]
379848  sec61b.L; SEC61 translocon beta subunit L homeolog [KO:K09481]
379876  mapk8.L; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
379879  nsfl1c.L; NSFL1 (p97) cofactor (p47) L homeolog [KO:K14012]
379936  sec61a1.S; Sec61 translocon alpha 1 subunit S homeolog [KO:K10956]
379997  pdia6.S; protein disulfide isomerase family A member 6 S homeolog precursor [KO:K09584] [EC:5.3.4.1]
380008  ssr3.L; signal sequence receptor gamma subunit a [KO:K13251]
380018  canx.S; calnexin S homeolog precursor [KO:K08054]
380057  dnaja1.L; DnaJ heat shock protein family (Hsp40) member A1 L homeolog [KO:K09502]
380119  nploc4.S; NPL4 homolog, ubiquitin recognition factor S homeolog [KO:K14015]
380134  sec13.S; SEC13 homolog, nuclear pore and COPII coat complex component S homeolog [KO:K14004]
380136  txndc5.L; thioredoxin domain containing 5 L homeolog precursor [KO:K13984] [EC:5.3.4.1]
380177  capn1.L; calpain 1, (mu/I) large subunit L homeolog [KO:K01367] [EC:3.4.22.52]
380215  xbp1.L; X-box binding protein 1 L homeolog [KO:K09027]
380317  dnaja2.S; DnaJ subfamily A member 2 [KO:K09503]
380444  eif2s1.S; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
380458  calr.L; calreticulin precursor [KO:K08057]
380491  vcp.S; transitional endoplasmic reticulum ATPase [KO:K13525]
380499  ubqln4.L; ubiquilin 4 L homeolog [KO:K04523]
380500  ube2g1.S; ubiquitin conjugating enzyme E2 G1 S homeolog [KO:K10575] [EC:2.3.2.23]
380538  skp1.L; S-phase kinase-associated protein 1 [KO:K03094]
387598  sar1b.L; secretion associated, Ras related GTPase 1B L homeolog [KO:K07953] [EC:3.6.5.-]
394295  lman1.S; lectin, mannose binding 1 S homeolog precursor [KO:K10080]
394391  map2k7.L; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
394410  herpud1.S; homocysteine inducible ER protein with ubiquitin like domain 1 S homeolog [KO:K14027]
394424  sec61g.L; protein transport protein Sec61 subunit gamma [KO:K07342]
397721  dad1.S; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad1 [KO:K12668]
397796  ubqln4.S; ubiquilin 4 S homeolog [KO:K04523]
397850  hspa5.L; endoplasmic reticulum chaperone BiP precursor [KO:K09490] [EC:3.6.4.10]
397945  ssr4.L; signal sequence receptor, delta L homeolog precursor [KO:K04571]
398230  tram1.S; translocation associated membrane protein 1 S homeolog [KO:K14010]
398288  capn11.S; calpain 11, (mu/I) large subunit a S homeolog [KO:K01367] [EC:3.4.22.52]
398343  hsp70.L; heat shock 70 kDa protein [KO:K03283]
398499  mapk8.S; mitogen-activated protein kinase 8-like isoform X1 [KO:K04440] [EC:2.7.11.24]
398507  rad23b.S; RAD23 homolog B, nucleotide excision repair protein S homeolog [KO:K10839]
398514  rpn1.L; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 precursor [KO:K12666]
398521  rpn1.S; ribophorin I S homeolog precursor [KO:K12666]
398531  hyou1.S; hypoxia up-regulated protein 1 isoform X1 [KO:K09486]
398615  ddit3.L; DNA damage inducible transcript 3 L homeolog [KO:K04452]
398629  herpud1.L; homocysteine inducible ER protein with ubiquitin like domain 1 L homeolog [KO:K14027]
398737  rrbp1.L; ribosome-binding protein 1 [KO:K14000]
398753  hsp90b1.S; uncharacterized protein LOC398753 precursor [KO:K09487]
398772  capn11.L; calpain 11, (mu/I) large subunit a L homeolog [KO:K01367] [EC:3.4.22.52]
398777  amfr.L; autocrine motility factor receptor L homeolog [KO:K10636] [EC:2.3.2.36]
398804  atf4.L; activating transcription factor 4 L homeolog [KO:K04374]
399034  ufd1.S; ubiquitin fusion degradation protein 1 homolog [KO:K14016]
399075  capn2.L; calpain 2 L homeolog [KO:K03853] [EC:3.4.22.53]
399123  dnajc5.S; dnaJ homolog subfamily C member 5 [KO:K09525]
399159  ufd1.L; ubiquitin recognition factor in ER-associated degradation protein 1 [KO:K14016]
399231  ssr1.S; signal sequence receptor, alpha (translocon-associated protein alpha) S homeolog precursor [KO:K13249]
399234  stt3a.L; STT3A, subunit of the oligosaccharyltransferase complex (catalytic) L homeolog [KO:K07151] [EC:2.4.99.18]
399248  p4hb.L; prolyl 4-hydroxylase subunit beta L homeolog precursor [KO:K09580] [EC:5.3.4.1]
399408  hsp90b1.L; heat shock protein 90kDa beta family member 1 L homeolog precursor [KO:K09487]
403384  ube2d3.L; ubiquitin-conjugating enzyme E2 D2 [KO:K06689] [EC:2.3.2.23]
403386  eif2ak3.S; eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1 [KO:K08860] [EC:2.7.11.1]
414657  sil1.L; nucleotide exchange factor SIL1 precursor [KO:K14001]
431836  XB22063322.L; uncharacterized protein LOC431836 precursor [KO:K09523]
431869  syvn1.L; E3 ubiquitin-protein ligase synoviolin A [KO:K10601] [EC:2.3.2.27]
431910  man1c1.S; uncharacterized protein LOC431910 [KO:K01230] [EC:3.2.1.113]
431974  traf2.S; TNF receptor associated factor 2 S homeolog [KO:K03173] [EC:2.3.2.27]
431990  dnajc10.S; dnaJ homolog subfamily C member 10 precursor [KO:K09530] [EC:1.8.4.-]
432145  dnajb2.L; DnaJ heat shock protein family (Hsp40) member B2 L homeolog [KO:K09508]
432348  sec31b.S; SEC31 homolog B, COPII coat complex component S homeolog [KO:K14005]
443698  plaa.S; phospholipase A-2-activating protein isoform X1 [KO:K14018]
443813  amfr.S; autocrine motility factor receptor S homeolog [KO:K10636] [EC:2.3.2.36]
443814  ubxn1.S; UBX domain-containing protein 1-A [KO:K24348]
443827  [KO:K11519]
443902  sec63.S; SEC63 homolog, protein translocation regulator S homeolog [KO:K09540]
443907  edem3.L; ER degradation-enhancing alpha-mannosidase-like protein 3 precursor [KO:K10086]
444063  hsph1.L; heat shock 105kD [KO:K09485]
444075  ern2.S; endoplasmic reticulum to nucleus signaling 2 S homeolog precursor [KO:K08852] [EC:2.7.11.1 3.1.26.-]
444085  atxn3.L; ataxin-3 isoform X1 [KO:K11863] [EC:3.4.22.-]
444157  tmem258.L; transmembrane protein 258 [KO:K26502]
444229  ostc.L; oligosaccharyltransferase complex subunit ostc-A [KO:K26501]
444260  dnajc1.S; DnaJ heat shock protein family (Hsp40) member C1 S homeolog precursor [KO:K09521]
444283  ddost.S; dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit precursor [KO:K12670]
444366  rrbp1.S; ribosome binding protein 1 S homeolog [KO:K14000]
444375  dnajb12.S; DnaJ heat shock protein family (Hsp40) member B12 S homeolog [KO:K09518]
444485  preb.L; prolactin regulatory element binding L homeolog [KO:K14003]
444602  [KO:K14009]
444614  prkcsh.S; protein kinase C substrate 80K-H S homeolog precursor [KO:K08288]
444653  ubxn1.L; UBX domain-containing protein 1-B [KO:K24348]
444664  rnf185.S; ring finger protein 185 S homeolog [KO:K10666] [EC:2.3.2.27]
444697  uggt2.S; UDP-glucose glycoprotein glucosyltransferase 2 S homeolog [KO:K11718] [EC:2.4.1.-]
444736  nfe2l2.S; nuclear factor, erythroid 2 like 2 S homeolog [KO:K05638]
444772  dnajb11.S; DnaJ heat shock protein family (Hsp40) member B11 S homeolog [KO:K09517]
444811  derl1.L; derlin 1 L homeolog [KO:K11519]
444834  sec23b.L; Sec23 homolog B, COPII coat complex component L homeolog [KO:K14006]
446223  ubxn4.S; UBX domain-containing protein 4 isoform X1 [KO:K24348]
446313  hspb6.L; heat shock protein family B (small) member 6 L homeolog [KO:K09542]
446331  bcap31.L; B cell receptor associated protein 31 L homeolog [KO:K14009]
446337  man1a2.L; mannosidase, alpha, class 1A, member 2 L homeolog [KO:K01230] [EC:3.2.1.113]
446340  ube2d1.L; ubiquitin conjugating enzyme E2 D1 L homeolog [KO:K06689] [EC:2.3.2.23]
446360  ube2g2.L; ubiquitin conjugating enzyme E2 G2 L homeolog [KO:K04555] [EC:2.3.2.23]
446459  hsp90ab1.S; heat shock protein 90kDa alpha family class B member 1 S homeolog [KO:K04079]
446460  tram1.L; translocating chain-associated membrane protein 1-like 1 [KO:K14010]
446478  pdia6.L; protein disulfide isomerase family A member 6 L homeolog precursor [KO:K09584] [EC:5.3.4.1]
446527  hsph1.S; heat shock 105kD [KO:K09485]
446589  ubxn2a.L; UBX domain protein 2A L homeolog [KO:K24349]
446660  sec62.L; SEC62 homolog, preprotein translocation factor L homeolog [KO:K12275]
446676  sec62.S; SEC62 homolog, preprotein translocation factor S homeolog [KO:K12275]
446945  sec24d.L; protein transport protein Sec24D [KO:K14007]
446946  ubxn8.L; UBX domain-containing protein 8 [KO:K24351]
446997  ubqln1.L; ubiquilin 1 L homeolog [KO:K04523]
447013  prkcsh.L; protein kinase C substrate 80K-H L homeolog precursor [KO:K08288]
447014  selenos.L; selenoprotein S L homeolog [KO:K14025]
447205  mbtps1.L; membrane-bound transcription factor site-1 protease preproprotein [KO:K08653] [EC:3.4.21.112]
447208  capn1.S; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
447223  dnajc5g.L; DnaJ heat shock protein family (Hsp40) member C5 gamma L homeolog [KO:K09525]
447291  man1b1.L; mannosidase, alpha, class 1B, member 1 L homeolog [KO:K23741]
447390  selenos.S; selenoprotein S S homeolog [KO:K14025]
447425  sec31b.L; SEC31 homolog B, COPII coat complex component L homeolog [KO:K14005]
447508  sar1a.S; secretion associated, Ras related GTPase 1A S homeolog [KO:K07953] [EC:3.6.5.-]
447693  sec24c.S; SEC24 homolog C, COPII coat complex component S homeolog [KO:K14007]
494750  magt1.L; magnesium transporter protein 1 precursor [KO:K19478]
494816  nploc4.L; uncharacterized protein LOC494816 [KO:K14015]
494996  syvn1.S; E3 ubiquitin-protein ligase synoviolin B [KO:K10601] [EC:2.3.2.27]
495169  pdia4.L; protein disulfide isomerase family A member 4 L homeolog precursor [KO:K09582] [EC:5.3.4.1]
495261  rnf185.L; ring finger protein 185 L homeolog [KO:K10666] [EC:2.3.2.27]
495416  sec63.L; SEC63 homolog, protein translocation regulator L homeolog [KO:K09540]
495424  ube2j2.L; ubiquitin conjugating enzyme E2 J2 L homeolog [KO:K04554] [EC:2.3.2.23]
495428  fbxo6.S; F-box protein 6 S homeolog [KO:K10100]
495829  erlec1.S; endoplasmic reticulum lectin 1 precursor [KO:K14008]
496056  atf6.S; activating transcription factor 6 S homeolog [KO:K09054]
496140  ostc.S; oligosaccharyltransferase complex subunit ostc-B [KO:K26501]
733145  rnf5.S; E3 ubiquitin-protein ligase RNF5 [KO:K10666] [EC:2.3.2.27]
733299  ngly1.S; N-glycanase 1 S homeolog [KO:K01456] [EC:3.5.1.52]
733408  tusc3.L; tumor suppressor candidate 3 [KO:K19478]
733415  stub1.L; E3 ubiquitin-protein ligase CHIP [KO:K09561] [EC:2.3.2.27]
734165  atf4.S; activating transcription factor 4 S homeolog [KO:K04374]
734414  cul1.S; cullin 1 S homeolog [KO:K03347]
734416  ckap4.L; cytoskeleton-associated protein 4 L homeolog [KO:K13999]
734481  rad23b.L; uncharacterized protein LOC734481 [KO:K10839]
734526  cul1.L; uncharacterized protein LOC734526 [KO:K03347]
734644  bak1.S; BCL2 antagonist/killer 1 S homeolog [KO:K14021]
734911  wfs1.L; Wolfram syndrome 1 (wolframin) L homeolog [KO:K14020]
734993  MGC130950; uncharacterized protein LOC734993 [KO:K01230] [EC:3.2.1.113]
735099  sel1l.L; sSEL1L adaptor subunit of ERAD E3 ubiquitin ligase L homeolog precursor [KO:K14026]
779022  stt3a.S; dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A isoform X1 [KO:K07151] [EC:2.4.99.18]
779038  sec23a.S; protein transport protein Sec23B [KO:K14006]
779300  yod1.L; ubiquitin thioesterase OTU1 [KO:K13719] [EC:3.1.2.-]
Compound
C00076  Calcium cation
G00009  
G00010  
G00011  
G00012  
G10694  
Reference
PMID:19491040
  Authors
Naidoo N
  Title
ER and aging-Protein folding and the ER stress response.
  Journal
Ageing Res Rev 8:150-9 (2009)
DOI:10.1016/j.arr.2009.03.001
Reference
PMID:18023214
  Authors
Malhotra JD, Kaufman RJ
  Title
The endoplasmic reticulum and the unfolded protein response.
  Journal
Semin Cell Dev Biol 18:716-31 (2007)
DOI:10.1016/j.semcdb.2007.09.003
Reference
PMID:20347046
  Authors
Maattanen P, Gehring K, Bergeron JJ, Thomas DY
  Title
Protein quality control in the ER: the recognition of misfolded proteins.
  Journal
Semin Cell Dev Biol 21:500-11 (2010)
DOI:10.1016/j.semcdb.2010.03.006
Reference
PMID:20219571
  Authors
Stolz A, Wolf DH
  Title
Endoplasmic reticulum associated protein degradation: a chaperone assisted journey to hell.
  Journal
Biochim Biophys Acta 1803:694-705 (2010)
DOI:10.1016/j.bbamcr.2010.02.005
Reference
PMID:20112977
  Authors
Dejgaard K, Theberge JF, Heath-Engel H, Chevet E, Tremblay ML, Thomas DY
  Title
Organization of the Sec61 translocon, studied by high resolution native electrophoresis.
  Journal
J Proteome Res 9:1763-71 (2010)
DOI:10.1021/pr900900x
Related
pathway
xla00510  N-Glycan biosynthesis
xla03050  Proteasome
xla03060  Protein export
xla04210  Apoptosis
KO pathway
ko04141   

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