KEGG   PATHWAY: aoce04140
Entry
aoce04140                   Pathway                                
Name
Autophagy - animal - Amphiprion ocellaris (clown anemonefish)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
aoce04140  Autophagy - animal
aoce04140

Other DBs
GO: 0006914
Organism
Amphiprion ocellaris (clown anemonefish) [GN:aoce]
Gene
111562391  [KO:K04724]
111562530  eif2ak4; eIF-2-alpha kinase GCN2 [KO:K16196] [EC:2.7.11.1]
111562580  c9orf72; guanine nucleotide exchange factor C9orf72 homolog isoform X1 [KO:K23609]
111562883  atg10; ubiquitin-like-conjugating enzyme ATG10 [KO:K17888]
111562910  atg7; ubiquitin-like modifier-activating enzyme ATG7 isoform X1 [KO:K08337]
111563037  [KO:K20868]
111563087  map1lc3c; microtubule-associated proteins 1A/1B light chain 3C isoform X1 [KO:K10435]
111563125  kras; GTPase KRas isoform X1 [KO:K07827]
111563272  rras2; ras-related protein R-Ras2 [KO:K07830]
111563689  hmgb1b; high mobility group protein B1b [KO:K10802]
111564302  [KO:K07874]
111564449  [KO:K17890]
111564603  eif2s1b; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
111565029  atg4b; cysteine protease ATG4B isoform X1 [KO:K08342] [EC:3.4.22.-]
111565328  zgc:55558; GTPase KRas [KO:K07827]
111565366  mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
111565545  dapk3; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
111565608  wdfy3; WD repeat and FYVE domain-containing protein 3 isoform X4 [KO:K22262]
111565697  lamp1b; lysosome-associated membrane glycoprotein 1b [KO:K06528]
111565807  si:ch73-234b20.5; vesicle-associated membrane protein 8 [KO:K08512]
111565916  supt20; transcription factor SPT20 homolog isoform X1 [KO:K21245]
111566069  map3k7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
111566093  akt2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
111566116  [KO:K08770]
111566177  [KO:K04526]
111566401  [KO:K08342] [EC:3.4.22.-]
111566501  rragd; ras-related GTP-binding protein D isoform X1 [KO:K16186]
111566526  ern1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
111566540  [KO:K07187]
111566595  irs2b; insulin receptor substrate 2 [KO:K07187]
111566615  prkcda; protein kinase C, delta a [KO:K06068] [EC:2.7.11.13]
111566628  rhebl1; ras homolog, mTORC1 binding like 1 [KO:K07208]
111566639  [KO:K07897]
111566696  rps6kb1a; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
111566699  [KO:K21248]
111566758  pik3r3b; phosphoinositide-3-kinase, regulatory subunit 3b (gamma) isoform X1 [KO:K02649]
111566849  pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
111566873  [KO:K02927]
111566894  bnip4; BCL2 interacting protein 4 [KO:K15464]
111567161  mtmr3; myotubularin-related protein 3 isoform X2 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
111567280  [KO:K26797]
111567294  becn1; beclin-1 [KO:K08334]
111567358  mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
111567444  rptor; regulatory-associated protein of mTOR isoform X2 [KO:K07204]
111567832  ykt6; synaptobrevin homolog YKT6 [KO:K08516]
111567937  mtmr4; myotubularin-related protein 4 isoform X1 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
111567968  tsc1b; TSC complex subunit 1b isoform X1 [KO:K07206]
111567977  [KO:K26797]
111567998  dapk2a; death-associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
111568133  map2k2a; dual specificity mitogen-activated protein kinase kinase 2a [KO:K04369] [EC:2.7.12.2]
111568147  ddit4; DNA damage-inducible transcript 4 protein [KO:K08270]
111568151  atg3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
111568270  pik3r4; phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [KO:K08333] [EC:2.7.11.1]
111568461  zgc:101559; ras-related protein Rab-33B-like isoform X1 [KO:K07920]
111568509  nbr1a; NBR1 autophagy cargo receptor a isoform X1 [KO:K17987]
111568527  ptenb; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111568633  rb1cc1; RB1-inducible coiled-coil protein 1 [KO:K17589]
111568636  atg9b; autophagy-related protein 9B [KO:K17907]
111568877  gabarapl2; gamma-aminobutyric acid receptor-associated protein-like 2 [KO:K08341]
111568922  map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
111568932  zgc:92606; gamma-aminobutyric acid receptor-associated protein-like 1 [KO:K08341]
111569137  [KO:K02649]
111569316  eif2ak3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
111569514  atg5; autophagy protein 5 [KO:K08339]
111569535  mapk9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
111569582  cts12; procathepsin L isoform X2 [KO:K01365] [EC:3.4.22.15]
111569665  itpr1b; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
111569702  pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
111569939  [KO:K01363] [EC:3.4.22.1]
111570032  vps41; vacuolar protein sorting-associated protein 41 homolog isoform X2 [KO:K20184]
111570096  lamp2; lysosome-associated membrane glycoprotein 2 isoform X1 [KO:K06528]
111570159  atg4da; cysteine protease atg4da [KO:K08342] [EC:3.4.22.-]
111570277  tax1bp1a; tax1-binding protein 1 homolog A [KO:K21347]
111570335  smcr8a; guanine nucleotide exchange protein smcr8a [KO:K23611]
111570511  akt1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111570617  [KO:K07901]
111570706  ctsd; cathepsin D [KO:K01379] [EC:3.4.23.5]
111570712  dapk1; death-associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
111570713  ctsla; cathepsin La [KO:K01365] [EC:3.4.22.15]
111570810  vamp8; vesicle-associated membrane protein 8 isoform X1 [KO:K08512]
111571002  traf6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
111571021  nrbf2b; nuclear receptor-binding factor 2b [KO:K21246]
111571055  rragcb; ras-related GTP binding Cb isoform X1 [KO:K16186]
111571112  atg14; beclin 1-associated autophagy-related key regulator [KO:K17889]
111571678  atg9a; autophagy-related protein 9A [KO:K17907]
111571694  si:ch73-335l21.1; insulin receptor substrate 1-B [KO:K16172]
111571907  tsc2; tuberin isoform X2 [KO:K07207]
111571920  igf1ra; insulin-like growth factor 1a receptor [KO:K05087] [EC:2.7.10.1]
111572311  map2k2b; dual specificity mitogen-activated protein kinase kinase 2b [KO:K04369] [EC:2.7.12.2]
111572315  stk11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
111572630  wdr41; WD repeat-containing protein 41 [KO:K23610]
111572680  [KO:K17906]
111572712  vps11; vacuolar protein sorting-associated protein 11 homolog [KO:K20179]
111572742  akt1s1; uncharacterized protein akt1s1 [KO:K16184]
111572999  rraga; ras-related GTP-binding protein A [KO:K16185]
111573051  [KO:K07925]
111573164  map2k1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
111573324  ctsl.1; cathepsin L.1 [KO:K01365] [EC:3.4.22.15]
111573373  pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
111573542  vps39; vam6/Vps39-like protein isoform X3 [KO:K20183]
111573620  rab33ba; RAB33B, member RAS oncogene family a [KO:K07920]
111573654  prkacaa; protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a isoform X1 [KO:K04345] [EC:2.7.11.11]
111573872  [KO:K02927]
111573893  [KO:K08270]
111573943  [KO:K02649]
111573968  si:dkey-13a21.4; ras-related protein rab7 [KO:K07897]
111573969  [KO:K04570]
111573970  si:dkeyp-97e7.9; DEP domain-containing mTOR-interacting protein [KO:K20402]
111574009  [KO:K20402]
111574035  si:ch211-260e23.9; tumor protein p53-inducible nuclear protein 2 [KO:K21247]
111574060  prkcq; protein kinase C theta type [KO:K18052] [EC:2.7.11.13]
111574228  zfyve1; zinc finger FYVE domain-containing protein 1 isoform X1 [KO:K17603]
111574517  si:ch211-11n16.2; zinc finger FYVE domain-containing protein 1 [KO:K17603]
111574739  vps18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
111574778  prkaa1; 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
111575102  [KO:K04958]
111575192  ubb; polyubiquitin-B [KO:K08770]
111575196  atg101; autophagy-related protein 101 [KO:K19730]
111575407  [KO:K07187]
111575423  atg4c; cysteine protease ATG4C [KO:K08342] [EC:3.4.22.-]
111575493  rab8a; ras-related protein Rab-8A [KO:K07901]
111575580  bcl2l1; bcl-2-like protein 1 [KO:K04570]
111575648  mapk10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
111575755  tank; TRAF family member-associated NF-kappa-B activator [KO:K12650]
111575781  rab42a; ras-related protein Rab-42a [KO:K07925]
111576263  uvrag; UV radiation resistance-associated gene protein [KO:K21249]
111576282  [KO:K21247]
111576365  atg2a; autophagy-related protein 2 homolog A [KO:K17906]
111576480  smcr8b; guanine nucleotide exchange protein smcr8b [KO:K23611]
111576738  tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
111576980  [KO:K07208]
111577180  rab1ba; zRAB1B, member RAS oncogene family a [KO:K07874]
111577201  gabarapa; GABA(A) receptor-associated protein a [KO:K08341]
111577277  snap29; synaptosomal-associated protein 29 [KO:K08509]
111577431  mapk8a; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111577816  wdr45b; WD repeat domain phosphoinositide-interacting protein 3 [KO:K22991]
111577850  stx17; syntaxin-17 [KO:K08491]
111577890  epas1a; endothelial PAS domain-containing protein 1 isoform X2 [KO:K08268]
111577932  prkacab; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
111578061  ambra1b; activating molecule in BECN1-regulated autophagy protein 1B [KO:K17985]
111578314  [KO:K17908]
111578326  mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
111578833  ulk1b; serine/threonine-protein kinase ULK1 isoform X2 [KO:K21357] [EC:2.7.11.1]
111578922  hif1aa; hypoxia inducible factor 1 subunit alpha a [KO:K08268]
111579002  prkacbb; protein kinase, cAMP-dependent, catalytic, beta b isoform X1 [KO:K04345] [EC:2.7.11.11]
111579210  prkaa2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
111579410  nbr1b; next to BRCA1 gene 1 protein isoform X1 [KO:K17987]
111579421  rras; ras-related protein R-Ras isoform X1 [KO:K07830]
111579494  ern2; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
111579771  mrasa; ras-related protein M-Ras [KO:K07831]
111579842  [KO:K04688] [EC:2.7.11.1]
111579931  [KO:K02161]
111580036  hif1al; hypoxia inducible factor 1 subunit alpha, like [KO:K08268]
111580203  pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
111580290  lamp1a; lysosome-associated membrane glycoprotein 1a [KO:K06528]
111580374  vps33a; vacuolar protein sorting-associated protein 33A [KO:K20182]
111580598  rragca; ras-related GTP binding Ca [KO:K16186]
111581166  akt3a; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111581220  ulk2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
111581266  dapk2b; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
111581436  rheb; GTP-binding protein Rheb isoform X2 [KO:K07208]
111581473  [KO:K00922] [EC:2.7.1.153]
111581655  akt3b; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
111582245  [KO:K07359] [EC:2.7.11.17]
111582355  mapk8b; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
111582380  pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
111583080  ulk1a; serine/threonine-protein kinase ULK1a isoform X1 [KO:K21357] [EC:2.7.11.1]
111583211  [KO:K04382] [EC:3.1.3.16]
111583301  [KO:K07874]
111583643  [KO:K17603]
111583947  ppp2cab; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
111584369  hrasa; HRas proto-oncogene, GTPase a [KO:K02833]
111584396  mtmr14; myotubularin-related protein 14 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
111584424  [KO:K04456] [EC:2.7.11.1]
111584456  vps16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
111584920  pdpk1b; 3-phosphoinositide dependent protein kinase 1b [KO:K06276] [EC:2.7.11.1]
111584965  igbp1; immunoglobulin-binding protein 1 [KO:K17606]
111585257  si:dkey-240h12.4; death-associated protein kinase 2 isoform X1 [KO:K08803] [EC:2.7.11.1]
111585315  wipi2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
111585345  sqstm1; sequestosome-1 isoform X1 [KO:K14381]
111585690  atg13; autophagy-related protein 13 isoform X1 [KO:K08331]
111585721  [KO:K07925]
111585793  rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
111586024  zgc:158659; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
111586240  gorasp1a; Golgi reassembly-stacking protein 1a [KO:K26797]
111586379  prkacba; protein kinase, cAMP-dependent, catalytic, beta a [KO:K04345] [EC:2.7.11.11]
111586466  [KO:K04382] [EC:3.1.3.16]
111586796  birc6; baculoviral IAP repeat-containing protein 6 isoform X1 [KO:K10586] [EC:2.3.2.23]
111587052  [KO:K02649]
111587054  map1lc3cl; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
111587073  sh3glb1a; endophilin-B1a [KO:K11248]
111587288  stx7l; syntaxin-7 isoform X2 [KO:K08488]
111587296  ins; insulin isoform X2 [KO:K04526]
111587416  igf1rb; insulin-like growth factor 1b receptor [KO:K05087] [EC:2.7.10.1]
111587458  plekhm1; pleckstrin homology domain-containing family M member 1 isoform X1 [KO:K23282]
111587795  epg5; ectopic P granules protein 5 homolog isoform X1 [KO:K23883]
111587836  zgc:73226; BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [KO:K15464]
111588046  insb; preproinsulin b [KO:K04526]
111588087  gorasp2; Golgi reassembly-stacking protein 2 [KO:K26797]
111588264  hmgb1a; high mobility group protein B1a [KO:K10802]
111588303  calcoco2; calcium-binding and coiled-coil domain-containing protein 2 isoform X1 [KO:K21348]
111588385  badb; BCL2 associated agonist of cell death b [KO:K02158]
111588438  mlst8; target of rapamycin complex subunit lst8 [KO:K08266]
111588464  [KO:K00922] [EC:2.7.1.153]
111588524  si:ch211-284e13.4; insulin receptor substrate 1-B [KO:K16172]
111588572  ptena; phosphatase and tensin homolog A isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
111588684  [KO:K02161]
111588716  raf1a; raf-1 proto-oncogene, serine/threonine kinase a isoform X3 [KO:K04366] [EC:2.7.11.1]
111588772  rab7a; ras-related protein Rab-7a [KO:K07897]
111588854  tax1bp1b; tax1-binding protein 1 homolog B isoform X1 [KO:K21347]
111588930  rps6kb1b; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
111588932  vmp1; vacuole membrane protein 1 isoform X1 [KO:K21248]
111589064  optn; optineurin isoform X2 [KO:K19946]
111589113  ctsba; cathepsin B [KO:K01363] [EC:3.4.22.1]
118469251  map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
118470511  [KO:K08512]
129348407  [KO:K04456] [EC:2.7.11.1]
129348539  [KO:K08341]
129349380  [KO:K17890]
129349650  atg12; ubiquitin-like protein ATG12 [KO:K08336]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
aoce04010  MAPK signaling pathway
aoce04141  Protein processing in endoplasmic reticulum
aoce04142  Lysosome biogenesis
aoce04150  mTOR signaling pathway
aoce04910  Insulin signaling pathway
KO pathway
ko04140   

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