KEGG   PATHWAY: csab04810
Entry
csab04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Chlorocebus sabaeus (green monkey)
Class
Cellular Processes; Cell motility
Pathway map
csab04810  Regulation of actin cytoskeleton
csab04810

Other DBs
GO: 0030036
Organism
Chlorocebus sabaeus (green monkey) [GN:csab]
Gene
103214335  RGCC; regulator of cell cycle [KO:K26108]
103214511  DIAPH3; diaphanous related formin 3 [KO:K05745]
103214806  ARHGEF7; Rho guanine nucleotide exchange factor 7 [KO:K13710]
103215020  [KO:K05692]
103215165  C9; complement C9 [KO:K04000]
103215183  C7; complement C7 [KO:K03996]
103215186  C6; complement C6 [KO:K03995]
103215226  FGF10; fibroblast growth factor 10 [KO:K04358]
103215381  FGF20; fibroblast growth factor 20 [KO:K04358]
103215436  FGF17; fibroblast growth factor 17 [KO:K04358]
103215648  FGFR1; fibroblast growth factor receptor 1 [KO:K04362] [EC:2.7.10.1]
103215781  CXCL12; C-X-C motif chemokine ligand 12 [KO:K10031]
103215981  VCL; vinculin [KO:K05700]
103216414  FGF8; fibroblast growth factor 8 [KO:K04358]
103216486  MYL9; myosin light chain 9 [KO:K12755]
103216628  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
103216694  DOCK1; dedicator of cytokinesis 1 [KO:K13708]
103216959  ACTR3; ARP3 actin related protein 3 homolog [KO:K18584]
103216995  CXCR4; C-X-C motif chemokine receptor 4 [KO:K04189]
103217169  ITGB6; integrin subunit beta 6 [KO:K06589]
103217191  TIAM1; T-cell lymphoma invasion and metastasis 1 [KO:K05731]
103217237  [KO:K05692]
103217327  ITGA6; integrin subunit alpha 6 [KO:K06485]
103217451  ITGA4; integrin subunit alpha 4 [KO:K06483]
103217468  NCKAP1; NCK associated protein 1 [KO:K05750]
103217487  ITGAV; integrin subunit alpha V [KO:K06487]
103217682  ABI2; abl interactor 2 [KO:K05751]
103217737  PIKFYVE; phosphoinositide kinase, FYVE-type zinc finger containing [KO:K00921] [EC:2.7.1.150]
103217800  FN1; fibronectin 1 [KO:K05717]
103217860  ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
103218414  FGF23; fibroblast growth factor 23 [KO:K22428]
103218416  FGF6; fibroblast growth factor 6 [KO:K04358]
103218464  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
103218763  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
103218908  GSN; gelsolin [KO:K05768]
103218909  PPP1CA; protein phosphatase 1 catalytic subunit alpha [KO:K06269] [EC:3.1.3.16]
103218912  [KO:K05756]
103218914  C5; complement C5 [KO:K03994]
103219021  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
103219066  SSH3; slingshot protein phosphatase 3 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103219323  [KO:K05692]
103219545  PIP5K1B; phosphatidylinositol-4-phosphate 5-kinase type 1 beta [KO:K00889] [EC:2.7.1.68]
103219761  FGD3; FYVE, RhoGEF and PH domain containing 3 [KO:K05722]
103220048  ITGB2; integrin subunit beta 2 [KO:K06464]
103220149  ACTR2; ARP2 actin related protein 2 homolog [KO:K17260]
103220440  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
103220572  PPP1CB; protein phosphatase 1 catalytic subunit beta [KO:K06269] [EC:3.1.3.16]
103220765  FAM49A; family with sequence similarity 49 member A [KO:K27976]
103220805  ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.39]
103221076  ITGA9; integrin subunit alpha 9 [KO:K06585]
103221212  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
103221277  ITGA1; integrin subunit alpha 1 [KO:K06480]
103221285  ITGA2; integrin subunit alpha 2 [KO:K06481]
103221840  [KO:K05759]
103222295  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
103222594  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
103222670  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.39]
103222701  MYL12B; myosin light chain 12B [KO:K12757]
103222703  MYL12A; myosin light chain 12A [KO:K12757]
103222941  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
103222955  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
103223186  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
103223246  MYH9; myosin heavy chain 9 [KO:K10352]
103223272  RAC2; ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [KO:K07860]
103223339  PDGFB; platelet derived growth factor subunit B [KO:K17386]
103223348  IQGAP2; IQ motif containing GTPase activating protein 2 [KO:K05767]
103223358  F2R; coagulation factor II thrombin receptor [KO:K03914]
103223822  INSRR; insulin receptor related receptor [KO:K05086] [EC:2.7.10.1]
103223856  IQGAP3; IQ motif containing GTPase activating protein 3 [KO:K05767]
103224044  PIP5K1A; phosphatidylinositol-4-phosphate 5-kinase type 1 alpha [KO:K00889] [EC:2.7.1.68]
103224063  ITGA10; integrin subunit alpha 10 [KO:K06586]
103224167  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
103224335  VAV3; vav guanine nucleotide exchange factor 3 [KO:K05730]
103224649  GNG12; G protein subunit gamma 12 [KO:K04347]
103224737  C8B; complement C8 beta chain [KO:K03998]
103224738  C8A; complement C8 alpha chain [KO:K03997]
103224743  [KO:K05765]
103224900  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
103225285  WASF2; WAS protein family member 2 [KO:K05748]
103225299  SLC9A1; solute carrier family 9 member A1 [KO:K05742]
103225423  CDC42; cell division cycle 42 [KO:K04393]
103225637  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
103226055  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
103226143  MYL7; myosin light chain 7 [KO:K12754]
103226407  ITGB8; integrin subunit beta 8 [KO:K06591]
103226465  SCIN; scinderin [KO:K05768]
103226817  WASL; Wiskott-Aldrich syndrome like [KO:K23612]
103226965  CHRM2; cholinergic receptor muscarinic 2 [KO:K04130]
103227022  BRAF; B-Raf proto-oncogene, serine/threonine kinase [KO:K04365] [EC:2.7.11.1]
103227272  ACTR3B; ARP3 actin related protein 3 homolog B [KO:K18584]
103227629  RHOA; ras homolog family member A [KO:K04513]
103227981  ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
103227998  BRK1; BRICK1, SCAR/WAVE actin nucleating complex subunit [KO:K05752]
103228031  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
103228149  ITGB5; integrin subunit beta 5 [KO:K06588]
103228167  MYLK; myosin light chain kinase [KO:K00907] [EC:2.7.11.18]
103228808  CFL2; cofilin 2 [KO:K05765]
103228820  MYH11; myosin heavy chain 11 [KO:K10352]
103228953  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
103229232  ACTN1; actinin alpha 1 [KO:K05699]
103229642  BDKRB2; bradykinin receptor B2 [KO:K03916]
103229644  BDKRB1; bradykinin receptor B1 [KO:K03915]
103229784  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
103230007  ENAH; enabled homolog (Drosophila) [KO:K05746]
103230309  PPP1R12B; protein phosphatase 1 regulatory subunit 12B [KO:K12329]
103230451  ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
103230532  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
103230823  [KO:K05692]
103230829  CHRM3; cholinergic receptor muscarinic 3 [KO:K04131]
103230869  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
103230879  MYLPF; myosin light chain, phosphorylatable, fast skeletal muscle [KO:K12758]
103231194  [KO:K16848]
103231383  ITGAM; integrin subunit alpha M [KO:K06461]
103231395  ITGAD; integrin subunit alpha D [KO:K06594]
103231401  ITGAX; integrin subunit alpha X [KO:K06462]
103231603  TMSB4X; thymosin beta 4, X-linked [KO:K05764]
103231895  ARAF; A-Raf proto-oncogene, serine/threonine kinase [KO:K08845] [EC:2.7.11.1]
103231906  ITGAL; integrin subunit alpha L [KO:K05718]
103232024  FGD1; FYVE, RhoGEF and PH domain containing 1 [KO:K05720]
103232093  MSN; moesin [KO:K05763]
103232215  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
103232230  FGF16; fibroblast growth factor 16 [KO:K04358]
103232244  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
103232331  DIAPH2; diaphanous related formin 2 [KO:K05741]
103232488  PAK3; p21 (RAC1) activated kinase 3 [KO:K05733] [EC:2.7.11.1]
103232641  ARHGEF6; Rac/Cdc42 guanine nucleotide exchange factor 6 [KO:K05729]
103233309  BCAR1; BCAR1, Cas family scaffolding protein [KO:K05726]
103233582  FGF22; fibroblast growth factor 22 [KO:K04358]
103233690  PIP5K1C; phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [KO:K00889] [EC:2.7.1.68]
103233717  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
103233784  VAV1; vav guanine nucleotide exchange factor 1 [KO:K05730]
103233802  CHRM1; cholinergic receptor muscarinic 1 [KO:K04129]
103234222  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
103234321  APC2; APC2, WNT signaling pathway regulator [KO:K02085]
103234391  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
103234638  ACTN4; actinin alpha 4 [KO:K05699]
103234655  PAK4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1]
103234702  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
103234745  ARHGEF1; Rho guanine nucleotide exchange factor 1 [KO:K12330]
103234927  ARHGAP35; Rho GTPase activating protein 35 [KO:K05732]
103234997  FGF21; fibroblast growth factor 21 [KO:K22429]
103235048  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
103235290  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
103235544  MYH14; myosin heavy chain 14 [KO:K10352]
103235675  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
103235869  FGF5; fibroblast growth factor 5 [KO:K04358]
103236114  EGF; epidermal growth factor [KO:K04357]
103236354  [KO:K01313] [EC:3.4.21.5]
103236438  PDGFC; platelet derived growth factor C [KO:K05450]
103236497  CHRM4; cholinergic receptor muscarinic 4 [KO:K04132]
103236710  FGF2; fibroblast growth factor 2 [KO:K18497]
103236822  MOS; MOS proto-oncogene, serine/threonine kinase [KO:K04367] [EC:2.7.11.1]
103237440  FAM49B; family with sequence similarity 49 member B [KO:K27976]
103237724  PTK2; protein tyrosine kinase 2 [KO:K05725] [EC:2.7.10.2]
103237941  ITGA8; integrin subunit alpha 8 [KO:K06584]
103238000  PIP4K2A; phosphatidylinositol-5-phosphate 4-kinase type 2 alpha [KO:K00920] [EC:2.7.1.149]
103238098  ITGB1; integrin subunit beta 1 [KO:K05719]
103238384  ITGB7; integrin subunit beta 7 [KO:K06590]
103238438  ITGA5; integrin subunit alpha 5 [KO:K06484]
103238442  NCKAP1L; NCK associated protein 1 like [KO:K05750]
103238480  [KO:K06583]
103238583  PIP4K2C; phosphatidylinositol-5-phosphate 4-kinase type 2 gamma [KO:K00920] [EC:2.7.1.149]
103238782  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
103239029  INS; insulin [KO:K04526]
103239075  SSH1; slingshot protein phosphatase 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103239122  MYL2; myosin light chain 2 [KO:K10351]
103239245  PXN; paxillin [KO:K05760]
103239525  ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
103239526  PPP1CC; protein phosphatase 1 catalytic subunit gamma [KO:K06269] [EC:3.1.3.16]
103239674  VAV2; vav guanine nucleotide exchange factor 2 [KO:K05730]
103239843  RRAS2; related RAS viral (r-ras) oncogene homolog 2 [KO:K07830]
103239883  ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
103240591  WASF1; WAS protein family member 1 [KO:K05753]
103240807  EZR; ezrin [KO:K08007]
103240948  [KO:K05692]
103241599  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
103241604  MRAS; muscle RAS oncogene homolog [KO:K07831]
103241703  CFL1; cofilin 1 [KO:K05765]
103241872  KNG1; kininogen 1 [KO:K03898]
103242063  PAK2; p21 (RAC1) activated kinase 2 [KO:K04410] [EC:2.7.11.1]
103242119  CRK; CRK proto-oncogene, adaptor protein [KO:K04438]
103242213  PFN1; profilin 1 [KO:K05759]
103242362  MYH10; myosin heavy chain 10 [KO:K10352]
103242549  ITGAE; integrin subunit alpha E [KO:K06524]
103242651  GIT1; GIT ArfGAP 1 [KO:K05737]
103242660  SSH2; slingshot protein phosphatase 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
103242953  ITGA3; integrin subunit alpha 3 [KO:K06482]
103243035  ITGB4; integrin subunit beta 4 [KO:K06525]
103243186  GNA13; G protein subunit alpha 13 [KO:K04639]
103243277  ITGB3; integrin subunit beta 3 [KO:K06493]
103243322  ITGA2B; integrin subunit alpha 2b [KO:K06476]
103243560  PIP4K2B; phosphatidylinositol-5-phosphate 4-kinase type 2 beta [KO:K00920] [EC:2.7.1.149]
103243710  BAIAP2; BAI1 associated protein 2 [KO:K05627]
103243719  ACTG1; actin gamma 1 [KO:K05692]
103243748  RAC3; ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [KO:K07861]
103244338  APC; APC, WNT signaling pathway regulator [KO:K02085]
103244697  DIAPH1; diaphanous related formin 1 [KO:K05740]
103244714  FGF1; fibroblast growth factor 1 [KO:K18496]
103244790  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
103244865  CYFIP2; cytoplasmic FMR1 interacting protein 2 [KO:K05749]
103244968  FGF18; fibroblast growth factor 18 [KO:K04358]
103245042  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
103245051  PFN3; profilin 3 [KO:K05759]
103245421  ITGA11; integrin subunit alpha 11 [KO:K06587]
103245451  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
103245650  FGF7; fibroblast growth factor 7 [KO:K04358]
103245847  PAK6; p21 (RAC1) activated kinase 6 [KO:K05735] [EC:2.7.11.1]
103245911  CHRM5; cholinergic receptor muscarinic 5 [KO:K04133]
103245986  CYFIP1; cytoplasmic FMR1 interacting protein 1 [KO:K05749]
103246179  FGF3; fibroblast growth factor 3 [KO:K04358]
103246230  FGF4; fibroblast growth factor 4 [KO:K04358]
103246343  FGF19; fibroblast growth factor 19 [KO:K22603]
103246363  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
103246384  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
103246479  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
103246516  MYL5; myosin light chain 5 [KO:K12753]
103246560  PAK5; p21 (RAC1) activated kinase 5 [KO:K05736] [EC:2.7.11.1]
103246620  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
103246683  MYL10; myosin light chain 10 [KO:K12756]
103246791  [KO:K05757]
103246815  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
103246857  GNA12; G protein subunit alpha 12 [KO:K04346]
103246906  PDGFA; platelet derived growth factor subunit A [KO:K04359]
103246949  [KO:K05757]
103246953  ACTB; actin beta [KO:K05692]
103247115  ARHGEF4; Rho guanine nucleotide exchange factor 4 [KO:K05769]
103248051  MYLK2; myosin light chain kinase 2 [KO:K00907] [EC:2.7.11.18]
103248093  PAK1; p21 (RAC1) activated kinase 1 [KO:K04409] [EC:2.7.11.1]
103248362  PDGFD; platelet derived growth factor D [KO:K05450]
103248423  RDX; radixin [KO:K05762]
103248653  ARHGEF12; Rho guanine nucleotide exchange factor 12 [KO:K07532]
103248989  FGF9; fibroblast growth factor 9 [KO:K04358]
103249003  SPATA13; spermatogenesis associated 13 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
csab04010  MAPK signaling pathway
csab04510  Focal adhesion
csab04520  Adherens junction
KO pathway
ko04810   

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